CN103563934A - Bactericidal composition containing thifluzamide and amobam and application thereof - Google Patents
Bactericidal composition containing thifluzamide and amobam and application thereof Download PDFInfo
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- CN103563934A CN103563934A CN201210281734.2A CN201210281734A CN103563934A CN 103563934 A CN103563934 A CN 103563934A CN 201210281734 A CN201210281734 A CN 201210281734A CN 103563934 A CN103563934 A CN 103563934A
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Abstract
The invention belongs to the field of pesticides, and discloses a bactericidal composition containing thifluzamide and amobam and application thereof. The bactericidal composition uses thifluzamide and amobam as main effective components, wherein the weight ratio of the thifluzamide to the amobam is (1-70):(1-50). The bactericidal composition can be used for preventing and treating diseases on cereals, melons and fruits, or vegetable crops, has higher synergic effect, overcomes and postpones the drug resistance of pathogenic bacteria, has the advantages of high bactericidal speed and long duration time, lowers the use cost, and has obviously better preventing and treating effects than a single agent.
Description
Technical field:
The invention belongs to pesticide field, relate to a kind of bactericidal composition and uses thereof, be specifically related to a kind of bactericidal composition and application thereof containing thifluzamide and ambam.
Background technology
Thifluzamide (Trifluzamide), also claims thifluzamide, chemical name: 2', the bromo-2-methyl-4'-of 6'-bis-trifluoromethoxy-4-Trifluoromethyl-1,3-thiadiazoles-5-hydroxyl anilide, molecular formula C
13h
6br
2f
6n
2o
2s, chemical structural formula:
Thifluzamide toxicity is low: rat acute LD50 of passing through mouth >5000mg/kg, and rat acute is through skin LD50>5000mg/kg, and rat acute sucks LC50>50001.4mg/L air.To lagophthalmos eyeball, there is moderate to stimulate, rabbit skin is had to minimal irritation.Belong to thiazole amide bactericide, there is strong interior conductivity and the long lasting effect of inhaling.Thifluzamide is succinate dehydrogenase inhibitor, and due to fluorine-containing, its its competitiveness in biochemical pathway is very strong, once be combined with substrate or enzyme, is just difficult for recovering.
Thifluzamide is for paddy rice, cereal crop and lawn, effective to pathomycetes such as black minute Pseudomonas of Rhizoctonia, Puccinia, raw meat, corticium, Ustilagos, to the fungus-caused disease of Basidiomycetes, as damping off, banded sclerotial blight etc. has special efficacy.For paddy rice, cereal crop, lawn cauline leaf, process, using dosage is 125～250g active ingredient/hm2, and for cereal crop and non-cereal crop Dressing, using dosage is 7～30g active ingredient/kg seed.Medicament has excellent preventive effect to rice banded sclerotial blight, using dosage 130～140g active ingredient/hm2, cereal crop rust 125～250g active ingredient/hm2.
Ambam (Amobam), chemical name: 1,2-ethylenebis ammonium dithiocarbamate, molecular formula: C
4h
14n
4s
4, chemical structural formula:
Ambam belongs to organic sulfur preparation.Sterling is colourless crystallization, water soluble.Industrial goods are weak yellow liquid, are neutrality or alkalescent, have rotten-egg odour.Chemical property is more stable, but surpasses the high temperature easily decomposition later of 40 ℃.Ambam is prevented and treated disease and is mainly shielded, and because liquid can infiltrate plant epidermis, has again therapeutic action concurrently.Its mechanism of action be with somatic cells in the required trace element of eubolism process (as iron contained in enzyme or coenzyme etc.) form chelation compound, make metabolism not normal.Belong to low toxicity bactericide, rat acute Oral toxicity LD
50for 395mg/kg, to people and animals' low toxicity.Effective to various crop fungal disease, can be for seed treatment, foliar spray and soil disinfection.Be used for preventing and treating bacterial blight of rice, banded sclerotial blight, rice blast, cucumber downy mildew, powdery mildew, sweet potato black rot, cotton anthracnose, corn northern leaf blight and southern leaf blight, rubber bark canker, cotton seedling blight and vegetables, fruit tree pest insect etc.
The difficulty of prevention and cure of phytopathogen is increasing at present, and on the one hand, along with the change of pattern of farming, the economic crops cultivated areas such as melon and fruit, vegetables progressively expand, and disease occurrence degree, generation quantity all increase, and in control, difficulty strengthens; On the other hand, the resistance of pathogen rises year by year under lasting medicament selection pressure, and the control efficiency of single dose is had a greatly reduced quality, and control of plant disease is faced with significant challenge.
Summary of the invention
The object of the invention is for above-mentioned technical problem provide a kind of applied widely, cost is low, the effective bactericidal composition containing thifluzamide and ambam.
Another object of the present invention is to provide the application of this bactericidal composition.
The object of the invention is to realize by following measures:
, it take thifluzamide and ambam is main active ingredient, and wherein thifluzamide and ambam weight ratio are 1 ~ 70:1 ~ 50, and wherein in bactericidal composition, effective ingredient is present in composition with synergy effective dose.
Described bactericidal composition, wherein thifluzamide and ambam weight ratio are preferably 5 ~ 50:10 ~ 50, more preferably 5 ~ 40:10 ~ 30.
In the present composition, the two gross weight percentage composition in composition of thifluzamide and ambam is 2-80%, is preferably 5 ~ 50%, most preferably 8 ~ 40%.
Described bactericidal composition, wherein thifluzamide and ambam and known auxiliary agent and excipient are re-dubbed any one formulation allowing on agricultural chemicals.These known auxiliary agents, excipients have dispersant, diffusant, defoamer, wetting agent, disintegrant etc.Auxiliary agent can adopt calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, the rare block compound of polyoxyethylene polyoxy third (as agriculture breast 33
#), the one or more combinations in polyoxyethylene nonylphenol ether, excipient comprises cyclohexanone, dimethylbenzene, solvent naphtha, water, antifreezing agent (as propane diols), deionized water etc.Above auxiliary agent, excipient and other auxiliary material can alone or and use.
Described bactericidal composition, its formulation is missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion or water dispersion granule.
The application of the described compound biocide composite containing thifluzamide and ambam in the medicine of preparation control Cereal, melon and fruit or vegetable crop fungal disease.
Preferably described bactericidal composition is prevented and treated the application in the medicine of leaf blight, rust, powdery mildew, downy mildew, epidemic disease, anthracnose, S.scabies, brown spot, damping off, banded sclerotial blight or gray mold in preparation.
Beneficial effect of the present invention:
1, the present invention's thifluzamide used is thiazole amide bactericide, and ambam is organic sulfur series bactericidal agent, is mutually mixed and can not produces low touching, and can produce obvious synergistic function, reduces dosage, reduces costs.
2, the present composition scope of application increases, be applicable to prevent and treat the crop pest of Cereal, various melon and fruit, vegetables, particularly prevent and treat the crop pests such as paddy rice, wheat, capsicum, banana, mango, pineapple, cucumber, tomato, as leaf blight, rust, powdery mildew, downy mildew, epidemic disease, anthracnose, S.scabies, brown spot, damping off, banded sclerotial blight or gray mold.
Bactericidal composition of the present invention has good control efficiency to sac fungi, basidiomycetes, imperfect fungus and Oomycete fungal disease; And suppress insect or the drug-fast generation of fungi to unitary agent (thifluzamide and ambam are arbitrary).
" % " of the present invention is mass percent.
Embodiment
Below in conjunction with embodiment, the invention will be further described, and in embodiment, the preparation method of formulation is conventional method.
Embodiment 1:
By thifluzamide 5g, ambam 10g, detergent LS(to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and making main active ingredient weight percentage is 15% wetting powder.
Embodiment 2:
By thifluzamide 10g, ambam 40g, detergent LS 3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and making main active ingredient weight percentage is 50% wetting powder.
Embodiment 3:
By thifluzamide 4g, ambam 32g, detergent LS 3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and making main active ingredient weight percentage is 36% wetting powder.
Embodiment 4:
Take 5g thifluzamide, 50g ambam, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, adds water to 100g.The method of above raw material being prepared routinely to aqueous emulsion drops into the mixing of mixing kettle high speed, and making main active ingredient weight percentage is 55% thifluzamide-ambam aqueous emulsion.
Embodiment 5:
Take 2g thifluzamide, 30g ambam, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method that above raw material is prepared to microemulsion routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 32% thifluzamide-ambam microemulsion.
Embodiment 6:
Take 1g thifluzamide, 5g ambam, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, adds water to 100g.The method of above raw material being prepared routinely to aqueous emulsion drops into the mixing of mixing kettle high speed, and making main active ingredient weight percentage is 6% thifluzamide-ambam aqueous emulsion.
Embodiment 7:
Take 50g thifluzamide, 20g ambam, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, solvent naphtha are to 100g.The method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 70% thifluzamide-ambam missible oil.
Embodiment 8:
Take 2g thifluzamide, 40g ambam, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, solvent naphtha are to 100g.The method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 42% thifluzamide-ambam missible oil.
Embodiment 9:
Take 5g thifluzamide, 20g ambam, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method that above raw material is prepared to microemulsion routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 25% thifluzamide-ambam microemulsion.
Embodiment 10:
Take 5g thifluzamide, 0.5g ambam, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, solvent naphtha are to 100g.The method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 5.5% thifluzamide-ambam missible oil.
Embodiment 11:
Take 5g thifluzamide, 30g ambam, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, solvent naphtha are to 100g.The method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 35% thifluzamide-ambam missible oil.
Embodiment 12:
Take 10g thifluzamide, 10g ambam, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, water complements to 100g, and under the effect of sand mill, making main active ingredient weight percentage is 20% thifluzamide-ambam suspending agent.
Embodiment 13:
Take 30g thifluzamide, 12g ambam, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, water complements to 100g, and under the effect of sand mill, making main active ingredient weight percentage is 42% thifluzamide-ambam suspending agent.
Embodiment 13:
Take 2g thifluzamide, 5g ambam, the 8g of wooden sodium sulfonate, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite 28g complements to 100g, and it is 7% thifluzamide-ambam water dispersion granule that above raw material is made to main active ingredient weight percentage by water dispersible granular agent method.
Embodiment 14:
Take 4g thifluzamide, 13g ambam, the 8g of wooden sodium sulfonate, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite 28g complements to 100g, and it is 17% thifluzamide-ambam water dispersion granule that above raw material is made to main active ingredient weight percentage by water dispersible granular agent method.
Embodiment 15:
Take 5g thifluzamide, 15g ambam, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, water complements to 100g, and under the effect of sand mill, making main active ingredient weight percentage is 20% thifluzamide-ambam suspending agent.
Embodiment 16:
Indoor biometrics test:
In indoor employing mycelial growth rate method, measure different medicaments to wheat damping off pathogen
gaeumannomycethe EC of (Gaeumannomyces graminis (Sacc.) Arxet Olivier) bacterial strain
50be worth, adopt the coefficient calculations method of spending together of the abundant introduction of Sun Yun, calculate the co-toxicity coefficient (CTC) of mixture, determine the synergy of mixture, the results are shown in Table 1.
The a certain single dose of take in mixture (is selected EC conventionally as standard medicament
50junior), calculate:
Single dose toxicity index=standard medicament EC
50/ certain single dose EC50 * 100
Toxicity index * B single dose proportion in mixture of toxicity index * A single dose proportion+B single dose in mixture of theoretical toxicity index=A single dose
The EC of actual measurement toxicity index=standard single dose
50the EC of value/mixture
50value * 100
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index * 100
CTC is greater than 120 o'clock mixtures and has synergetic, and it is antagonism that CTC is less than at 80 o'clock, and CTC is summation action between 80-120.
Table 1: the indoor biometrics result of the different proportionings of thifluzamide+ambam to wheat damping off pathogen (Gaeumannomyces graminis (Sacc.) Arxet Olivier)
| Medicament | Virulence regression equation | EC50（mg/L） | Co-toxicity coefficient |
| 24% thifluzamide EC | Y=2.0355X+6.5438 | 0.1744 | - |
| 50% ambam WDG | Y=1.7931X+3.2596 | 9.3453 | - |
| Embodiment 1 | Y=1.5426X+5.7281 | 0.3373 | 149.55 |
| Embodiment 2 | Y=2.1877X+5.4633 | 0.6141 | 132.14 |
| Embodiment 3 | Y=2.3351X+4.9214 | 1.0806 | 126.38 |
Field control effectiveness test:
The pesticidal preparations control wheat damping off test making with above-described embodiment.
1, test is processed: this test medicine consumption is established respectively three concentration for the treatment of according to the difference of each composition, and contrast medicament is respectively commercially available agricultural chemicals 50% ambam WDG and 24% thifluzamide EC and the test of blank clear water.
2, each community area of test method is 66.7m
2, repeat 3 times; Inspection drug effect method before dispenser after Investigation and Prevention is: random sampling 5 points in test treatment region, check damping off occurrence degree.
3, result of the test is in Table 2:
Table 2
Note: a is illustrated in the level of α=0.05 remarkable, and b is illustrated in the level of α=0.05 variant, and c is illustrated in the level of α=0.05 not remarkable.
By indoor biometrics and field efficacy result, show, thifluzamide and ambam composition have obvious synergistic function, and the control efficiency of composition is good, and control efficiency is all better than single dose kind, in agricultural application, have using value.
Claims (10)
1. a bactericidal composition, is characterized in that take that thifluzamide and ambam are as main active ingredient, and wherein the weight ratio of thifluzamide and ambam is 1～70:1～50.
2. bactericidal composition according to claim 1, the weight ratio that it is characterized in that thifluzamide and ambam is 5～50:10～50.
3. bactericidal composition according to claim 2, is characterized in that described thifluzamide and the weight ratio of ambam are 5～40:10～30, preferably 1: 0.1～20.
4. bactericidal composition according to claim 1, is characterized in that the two gross weight percentage composition in composition of thifluzamide and ambam is 2-80%.
5. bactericidal composition according to claim 4, is characterized in that the two gross weight percentage composition in composition of thifluzamide and ambam is 5-50%.
6. bactericidal composition according to claim 5, is characterized in that the two gross weight percentage composition in composition of thifluzamide and ambam is 8-40%.
7. bactericidal composition according to claim 1, is characterized in that take that thifluzamide and ambam are mixed with any one formulation allowing on agricultural chemicals as main active ingredient and insecticides adjuvant, excipients.
8. bactericidal composition according to claim 7, is characterized in that described formulation is missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion or water dispersion granule.
9. the application of the compound biocide composite containing thifluzamide and ambam claimed in claim 1 in the medicine of preparation control Cereal, melon and fruit or vegetable crop fungal disease.
10. application according to claim 9, is characterized in that described bactericidal composition prevents and treats the application in the medicine of leaf blight, rust, powdery mildew, downy mildew, epidemic disease, anthracnose, S.scabies, brown spot, damping off, banded sclerotial blight or gray mold in preparation.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111919640A (en) * | 2020-08-17 | 2020-11-13 | 福建省农业科学院果树研究所 | Application method of composite aluminized reflective film for protecting fruit tree branches |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102077831A (en) * | 2011-01-24 | 2011-06-01 | 青岛海利尔药业有限公司 | Sterilizing composition containing thifluzamide and ethylenebisdithiocarbomate |
-
2012
- 2012-08-04 CN CN201210281734.2A patent/CN103563934B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102077831A (en) * | 2011-01-24 | 2011-06-01 | 青岛海利尔药业有限公司 | Sterilizing composition containing thifluzamide and ethylenebisdithiocarbomate |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111919640A (en) * | 2020-08-17 | 2020-11-13 | 福建省农业科学院果树研究所 | Application method of composite aluminized reflective film for protecting fruit tree branches |
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Effective date of registration: 20180514 Address after: 211318 Dongfeng Road 9, Yalong Town, Gaochun, Nanjing, Jiangsu Co-patentee after: Nanjing Redsun Co., Ltd. Patentee after: Nanjing Huazhou Pharmaceutical Co., Ltd. Address before: 211318 Dongfeng Road 8, Yalong Town, Gaochun, Nanjing, Jiangsu Patentee before: Nanjing Huazhou Pharmaceutical Co., Ltd. |
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