CN103563954A - Bactericidal composition containing thifluzamide and thiophanate methyl and application thereof - Google Patents
Bactericidal composition containing thifluzamide and thiophanate methyl and application thereof Download PDFInfo
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- CN103563954A CN103563954A CN201210276417.1A CN201210276417A CN103563954A CN 103563954 A CN103563954 A CN 103563954A CN 201210276417 A CN201210276417 A CN 201210276417A CN 103563954 A CN103563954 A CN 103563954A
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- thifluzamide
- methyl
- thiophanate
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Abstract
The invention belongs to the field of pesticides, and discloses a bactericidal composition containing thifluzamide and thiophanate methyl and an application thereof. The bactericidal composition takes thifluzamide and thiophanate methyl as main active ingredients, wherein the weight ratio of thifluzamide to thiophanate methyl is (1-70):(1-50). The bactericidal composition can be used for preventing the diseases of cereal, melon and fruit or vegetable crops, has relatively high synergistic effect, overcomes and delays the drug resistance of germs, and realizes high bactericidal speed and long duration while the application cost is reduced and the prevention effect is obviously better than that of using a single agent.
Description
Technical field:
The invention belongs to pesticide field, relate to a kind of bactericidal composition and uses thereof, be specifically related to a kind of bactericidal composition and application thereof containing thifluzamide and thiophanate-methyl.
Background technology
Thifluzamide (Trifluzamide), also claims thifluzamide, chemical name: 2', the bromo-2-methyl-4'-of 6'-bis-trifluoromethoxy-4-Trifluoromethyl-1,3-thiadiazoles-5-hydroxyl anilide, molecular formula C
13h
6br
2f
6n
2o
2s, chemical structural formula
Thifluzamide toxicity is low: rat acute LD50 of passing through mouth >5000mg/kg, and rat acute is through skin LD50>5000mg/kg, and rat acute sucks LC50>50001.4mg/L air.To lagophthalmos eyeball, there is moderate to stimulate, rabbit skin is had to minimal irritation.Belong to thiazole amide bactericide, there is strong interior conductivity and the long lasting effect of inhaling.Thifluzamide is succinate dehydrogenase inhibitor, and due to fluorine-containing, its its competitiveness in biochemical pathway is very strong, once be combined with substrate or enzyme, is just difficult for recovering.
Thifluzamide is for paddy rice, cereal crop and lawn, effective to pathomycetes such as black minute Pseudomonas of Rhizoctonia, Puccinia, raw meat, corticium, Ustilagos, to the fungus-caused disease of Basidiomycetes, as damping off, banded sclerotial blight etc. has special efficacy.For paddy rice, cereal crop, lawn cauline leaf, process, using dosage is 125～250g active ingredient/hm2, and for cereal crop and non-cereal crop Dressing, using dosage is 7～30g active ingredient/kg seed.Medicament has excellent preventive effect to rice banded sclerotial blight, using dosage 130～140g active ingredient/hm2, cereal crop rust 125～250g active ingredient/hm2.
Thiophanate-methyl (Thiophanate-Methyl), is also thiophanate methyl, chemical name: 1,2-bis-(3-carbometoxyl-2-ghiourea group) benzene, sterling is colourless crystallization, former powder (content approximately 93%) is micro-yellow crystal.Proportion 1.5 (20 ℃), 172 ℃ of fusing points (decomposition), vapour pressure 949.1 * 10-8Pa (25 ℃).Water-soluble hardly, dissolve in the organic solvents such as acetone, methyl alcohol, ethanol, chloroform.Acid, alkali are stablized.Molecular formula: C
12h
14n
4o
4s
2, chemical structural formula:
Rat acute per os LD
50be 6640～7500mg/kg, chmice acute per os LD
50be 3150～3400mg/kg; Rat, chmice acute are through skin LD
50>10000mg/kg.That animal experiment has no is carcinogenic, teratogenesis, mutagenesis.Carp LC
5011mg/L(48h), rainbow trout LC
508.8mg/L.To honeybee low toxicity.
Thiophanate-methyl is efficient, low toxicity bactericide, has prevention and systemic action.Its mechanism of action is after this medicine is absorbed by plant corpus, in plant corpus, through a series of biochemical reactions, is broken down into tolimidazole-second-carbamate (being carbendazim).The formation of spindle in the mitosis of interference bacterium, the germ tube distortion that germ spore germination is grown is abnormal, germ tube cell wall distortion etc., thus make germ not reach bactericidal effect by normal growth.Because medicament can change into carbendazim after entering in plant corpus, therefore also belong to benzimidazole.Can be widely used in the multiple diseases such as grain, cotton, oil, vegetables, fruit tree.As prevent and treat gibberella zeaze petch of wheat and barley, stinking smut, wheat powdery mildew, the rice sheath blight, sclerotinia rot of colza, leaf spot of peanut, can be used for sweet potato black rot, the large leaf spot of corn, rice purple stalk disease, jowar head smut etc. in addition.Can not be mixed with copper agent during use.There is cross resistance with carbendazim.
The difficulty of prevention and cure of phytopathogen is increasing at present, and on the one hand, along with the change of pattern of farming, the economic crops cultivated areas such as melon and fruit, vegetables progressively expand, and disease occurrence degree, generation quantity all increase, and in control, difficulty strengthens; On the other hand, the resistance of pathogen rises year by year under lasting medicament selection pressure, and the control efficiency of single dose is had a greatly reduced quality, and control of plant disease is faced with significant challenge.
Summary of the invention
The object of the invention is for above-mentioned technical problem provide a kind of applied widely, cost is low, the effective plant bactericidal composition containing thifluzamide and thiophanate-methyl.
Another object of the present invention is to provide the application of this bactericidal composition.
The object of the invention is to realize by following measures:
, it is with the main active ingredient of thifluzamide and thiophanate-methyl, and wherein thifluzamide and thiophanate-methyl weight ratio are 1～70:1～50, and wherein in bactericidal composition, effective ingredient is present in composition with synergy effective dose.
Described bactericidal composition, wherein thifluzamide and thiophanate-methyl weight ratio are preferably 5～50:10～50, more preferably 5～40:10～30, particularly preferably 1:0.1～20.
In the present composition, the two percentage by weight in composition of thifluzamide and thiophanate-methyl is 2～80%.Be preferably 5～50%, most preferably 8～40%.
Described bactericidal composition, wherein thifluzamide and thiophanate-methyl and known auxiliary agent and excipient are re-dubbed any one formulation allowing on agricultural chemicals.These known auxiliary agents, excipients have dispersant, diffusant, defoamer, wetting agent, disintegrant etc.Auxiliary agent can adopt the one or more combinations in calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, the rare block compound of polyoxyethylene polyoxy third (as agriculture breast 33#), polyoxyethylene nonylphenol ether, and excipient comprises cyclohexanone, dimethylbenzene, solvent naphtha, water, antifreezing agent (as propane diols), deionized water etc.Above auxiliary agent, excipient and other auxiliary material can alone or and use.
Described bactericidal composition, its formulation is missible oil, pulvis, wetting powder, suspending agent, suspension emulsion or water dispersion granule.
The application of the described compound biocide composite containing thifluzamide and thiophanate-methyl on preparation control Cereal, melon and fruit or vegetable crop fungal disease.
Preferably the described compound biocide composite containing thifluzamide and thiophanate-methyl is prevented and treated the application in the medicine of leaf blight, stalk break, rust, powdery mildew, downy mildew, late blight, anthracnose, S.scabies, brown spot, damping off, scab, early blight, banded sclerotial blight, gray mold in preparation.
Beneficial effect of the present invention:
1, the present invention's thifluzamide used is thiazole amide bactericide, and thiophanate-methyl is benzimidazole germicide, is mutually mixed and can not produces low touch, can Synergistic, reduce dosage, and reduce costs.
2, the present composition scope of application increases, be applicable to prevent and treat the crop pest of Cereal, various melon and fruit, vegetables, particularly prevent and treat the crop pests such as paddy rice, wheat, capsicum, banana, mango, pineapple, cucumber, tomato, as leaf blight, stalk break, rust, powdery mildew, downy mildew, late blight, anthracnose, S.scabies, brown spot, damping off, scab, early blight, banded sclerotial blight, gray mold.
Bactericidal composition of the present invention has good control efficiency to sac fungi, basidiomycetes, imperfect fungus and Oomycete fungal disease; And suppress insect or the drug-fast generation of fungi to unitary agent (thifluzamide and thiophanate-methyl are arbitrary).
Embodiment
Below in conjunction with embodiment, the invention will be further described, and in embodiment, the preparation method of formulation is conventional method.
Embodiment 1:
By thifluzamide 5g, thiophanate-methyl 10g, detergent LS(to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and making main active ingredient weight percentage is 15% wetting powder.
Embodiment 2:
By thifluzamide 10g, thiophanate-methyl 40g, detergent LS3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and making main active ingredient weight percentage is 50% wetting powder.
Embodiment 3:
By thifluzamide 4g, thiophanate-methyl 32g, detergent LS3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds to 100g mixture and carries out air-flow crushing, and making main active ingredient weight percentage is 36% wetting powder.
Embodiment 4:
Take 5g thifluzamide, 50g thiophanate-methyl, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, adds water to 100g.The method of above raw material being prepared routinely to aqueous emulsion drops into the mixing of mixing kettle high speed, and making main active ingredient weight percentage is 55% thifluzamide-thiophanate-methyl aqueous emulsion.
Embodiment 5:
Take 2g thifluzamide, 30g thiophanate-methyl, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method that above raw material is prepared to microemulsion routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 32% thifluzamide-thiophanate-methyl microemulsion.
Embodiment 6:
Take 1g thifluzamide, 5g thiophanate-methyl, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, adds water to 100g.The method of above raw material being prepared routinely to aqueous emulsion drops into the mixing of mixing kettle high speed, and making main active ingredient weight percentage is 6% thifluzamide-thiophanate-methyl aqueous emulsion.
Embodiment 7:
Take 50g thifluzamide, 20g thiophanate-methyl, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, solvent naphtha are to 100g.The method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 70% thifluzamide-methyl sulfur bacterium missible oil.
Embodiment 8:
Take 2g thifluzamide, 40g thiophanate-methyl, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, solvent naphtha are to 100g.The method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 42% thifluzamide-methyl sulfur bacterium missible oil.
Embodiment 9:
Take 5g thifluzamide, 20g thiophanate-methyl, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropyl alcohol 10g, adds water to 100g.The method that above raw material is prepared to microemulsion routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 25% thifluzamide-thiophanate-methyl microemulsion.
Embodiment 10:
Take 5g thifluzamide, 0.5g thiophanate-methyl, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, solvent naphtha are to 100g.The method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 5.5% thifluzamide-methyl sulfur bacterium missible oil.
Embodiment 11:
Take 5g thifluzamide, 30g thiophanate-methyl, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, solvent naphtha are to 100g.The method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 35% thifluzamide-methyl sulfur bacterium missible oil.
Embodiment 12:
Take 10g thifluzamide, 10g thiophanate-methyl, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, water complements to 100g, and under the effect of sand mill, making main active ingredient weight percentage is 20% thifluzamide-thiophanate-methyl suspending agent.
Embodiment 13:
Take 30g thifluzamide, 12g thiophanate-methyl, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, water complements to 100g, and under the effect of sand mill, making main active ingredient weight percentage is 42% thifluzamide-thiophanate-methyl suspending agent.
Embodiment 13:
Take 2g thifluzamide, 5g thiophanate-methyl, the 8g of wooden sodium sulfonate, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite 28g complements to 100g, and it is 7% thifluzamide-thiophanate-methyl water dispersion granule that above raw material is made to main active ingredient weight percentage by water dispersible granular agent method.
Embodiment 14:
Take 4g thifluzamide, 13g thiophanate-methyl, the 8g of wooden sodium sulfonate, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite 28g complements to 100g, and it is 17% thifluzamide-thiophanate-methyl water dispersion granule that above raw material is made to main active ingredient weight percentage by water dispersible granular agent method.
Embodiment 15:
Take 5g thifluzamide, 15g thiophanate-methyl, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, water complements to 100g, and under the effect of sand mill, making main active ingredient weight percentage is 20% thifluzamide-thiophanate-methyl suspending agent.
Embodiment 16:
Indoor biometrics test:
In indoor employing mycelial growth rate method, measure the EC of different medicaments to bacterial strain
50be worth, adopt the coefficient calculations method of spending together of the abundant introduction of Sun Yun, calculate the co-toxicity coefficient (CTC) of mixture, determine the synergy of mixture.
The a certain single dose of take in mixture (is selected EC conventionally as standard medicament
50junior), calculate:
Single dose toxicity index=standard medicament EC
50/ certain single dose EC50 * 100
Toxicity index * B single dose proportion in mixture of toxicity index * A single dose proportion+B single dose in mixture of theoretical toxicity index=A single dose
The EC of actual measurement toxicity index=standard single dose
50the EC of value/mixture
50value * 100
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index * 100
CTC is greater than 120 o'clock mixtures and has synergetic, and it is antagonism that CTC is less than at 80 o'clock, and CTC is summation action between 80-120.
Table 1: the indoor biometrics result of the different proportionings of thifluzamide+thiophanate-methyl to Rhizoctonia solani Kuhn (Thanatephorus cucumeris (Frank) Donk)
| Medicament | Virulence regression equation | EC50（mg/L） | Co-toxicity coefficient |
| 24% thifluzamide EC | Y=2.0316X+6.2906 | 0.2316 | - |
| 50% thiophanate-methyl WDG | Y=2.3544X+3.8092 | 3.2047 | - |
| Embodiment 1 | Y=1.5641X+5.5520 | 0.4437 | 136.83 |
| Embodiment 2 | Y=1.7824X+5.4866 | 0.5333 | 168.44 |
| Embodiment 3 | Y=2.4771X+5.1013 | 0.9101 | 145.13 |
Field control effectiveness test:
Test is processed: this test medicine consumption is established respectively three concentration for the treatment of according to the difference of each composition, and contrast medicament is respectively commercially available agricultural chemicals 50% thiophanate-methyl WDG and 24% thifluzamide EC and the test of blank clear water.
Test method: each community area is 66.7m2, repeats 3 times; Inspection drug effect method before dispenser after Investigation and Prevention is: random sampling 5 points in test treatment region, check rice sheath blight disease occurrence degree.
Result of the test is in Table 2:
Table 2
Note: a is illustrated in the level of α=0.05 remarkable, and b is illustrated in the level of α=0.05 variant, and c is illustrated in the level of α=0.05 not remarkable.
By indoor biometrics and field efficacy result, show, thifluzamide and thiophanate-methyl composition have obvious synergistic function, and the control efficiency of composition is good, and control efficiency is all better than single dose kind, in agricultural application, have using value.
Claims (10)
1. a bactericidal composition, is characterized in that take that thifluzamide and thiophanate-methyl are as main active ingredient, and wherein the weight ratio of thifluzamide and thiophanate-methyl is 1～70:1～50.
2. bactericidal composition according to claim 1, is characterized in that described thifluzamide and the weight ratio of thiophanate-methyl are 5～50:10～50.
3. bactericidal composition according to claim 2, is characterized in that described thifluzamide and the weight ratio of thiophanate-methyl are 5～40:10～30, preferably 1: 0.1～20.
4. bactericidal composition according to claim 1, is characterized in that described thifluzamide and the gross weight percentage composition of thiophanate-methyl in composition are 2-80%.
5. bactericidal composition according to claim 4, is characterized in that thifluzamide and the thiophanate-methyl gross weight percentage composition in composition is 5-50%.
6. bactericidal composition according to claim 5, is characterized in that thifluzamide and the thiophanate-methyl gross weight percentage composition in composition is 8-40%.
7. bactericidal composition according to claim 1, is characterized in that take that thifluzamide and thiophanate-methyl are mixed with any one formulation allowing on agricultural chemicals as main active ingredient and insecticides adjuvant, excipients.
8. bactericidal composition according to claim 7, is characterized in that described formulation is missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion or water dispersion granule.
9. the application of the compound biocide composite containing thifluzamide and thiophanate-methyl claimed in claim 1 on preparation control Cereal, melon and fruit or vegetable crop fungal disease.
10. the compound biocide composite containing thifluzamide and thiophanate-methyl according to claim 9 is prevented and treated the application in the medicine of leaf blight, stalk break, rust, powdery mildew, downy mildew, late blight, anthracnose, S.scabies, brown spot, damping off, scab, early blight, banded sclerotial blight, gray mold in preparation.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102007929A (en) * | 2010-12-10 | 2011-04-13 | 青岛海利尔药业有限公司 | Thifluzamide-containing bactericidal composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102007929A (en) * | 2010-12-10 | 2011-04-13 | 青岛海利尔药业有限公司 | Thifluzamide-containing bactericidal composition |
Non-Patent Citations (2)
| Title |
|---|
| 刘步林: "《农药剂型加工技术》", 31 October 1998, article "乳油", pages: 357 * |
| 刘长令: "《世界农药大全杀菌剂卷》", 31 January 2008, article "噻氟菌胺，甲基硫菌灵", pages: 90-91 - 281-282 * |
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Application publication date: 20140212 |