CN103549222A - Compound feed additive for preventing piglet diarrhea and preparation method thereof - Google Patents
Compound feed additive for preventing piglet diarrhea and preparation method thereof Download PDFInfo
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- CN103549222A CN103549222A CN201310591867.4A CN201310591867A CN103549222A CN 103549222 A CN103549222 A CN 103549222A CN 201310591867 A CN201310591867 A CN 201310591867A CN 103549222 A CN103549222 A CN 103549222A
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Abstract
The invention provides a compound feed additive for preventing piglet diarrhea and a preparation method thereof. The compound feed additive comprises the following components in parts by weight: 28-60 parts of an echinacea extract, 3-7 parts of curcumin, 2-5 parts of berberine hydrochloride, 12-20 parts of sodium butyrate, 4-7 parts of zinc methionine, 2-23 parts of dark plums and 8-27 parts of acacia catechu. The additive integrates an immunopotentiator, an intestinal canal regulator and Chinese herbal medicines with the effects of inhibiting bacteria and astringing to arrest diarrhea and is added into the basis ration of piglets, so that the immune function and anti-stress ability of the piglets are improved, the pH value of the intestinal canal is lowered, the reproduction of harmful bacteria of the intestinal canal can be inhibited, the regeneration and restoration of the epithelial tissue cells of the intestinal canal are promoted, and the absorbing ability of the intestinal canal, particularly the water absorption of the hindgut, is enhanced. Thus, the piglet diarrhea can be effectively prevented and treated, and the survival rate of piglets is improved.
Description
technical field:
What the present invention relates to is a kind of feed addictive, is specifically related to composite feed additive of a kind of anti-grice diarrhoea and preparation method thereof.
background technology:
In China; grice diarrhoea is one of piglet diseases group the most serious under industrial pig working condition; China's large-scale pig farm grice diarrhoea incidence of disease is up to 50%-60% according to investigations; the death rate reaches 15%-20%; to pig industry, bring huge economic loss, seriously hindered the sound development of pig industry.
In Swine Production, prevent and treat grice diarrhoea at present and generally adopt antibiotic and chemical synthetic drug, but long-term a large amount of these medicines that use make pathogenic microorganism produce drug resistance and reduce curative effect of medication on the one hand, on the other hand medicament residue in fecaluria to environment.Therefore, increasing country has started to forbid or has limited and use antibiotic and chemical synthetic drug as feed addictive in the world.In addition, also someone proposes to apply probiotics (probiotic) control grice diarrhoea, but the microorganism of the work in probiotics product is in production, transportation and storage, its activity is subject to the impact of the environmental factors such as temperature, moisture, acid-base value, enter the destruction that also subjects to hydrochloric acid in gastric juice, cholate and digestive ferment after animal alimentary canal, its effect cannot be brought into play, and causes probiotics product effect in production practices extremely unstable.
summary of the invention:
The object of the present invention is to provide composite feed additive of a kind of anti-grice diarrhoea and preparation method thereof, by improving animal immunizing power, reduce enteron aisle pH value, the Absorption that improves intestinal mucosa suppresses harmful microorganism and breeds, thereby reach anti-diarrhea, growth promotion, raising feed efficiency and improve the aspect effects such as piglet fur sense organ.
Above-mentioned object realizes by following technical scheme:
A grice diarrhoea composite feed additive, described composite feed additive is prepared from by weight by following component:
28～60 parts of Echinacea Purpurea Herb P.Es
Bisdemethoxycurcumin～7 part
2～5 parts of Berberine hydrochlorides
12～20 parts of sodium butyrates
4～7 parts of zinc methionines
2～23 parts of dark plums
8～27 parts, catechu.
The preferred version of such scheme is that described composite feed additive is prepared from by weight by following component: 42 parts of Echinacea Purpurea Herb P.Es, 5.2 parts of curcumins, 3 parts of Berberine hydrochlorides, 17.6 parts of sodium butyrates, 5.2 parts of zinc methionines, 3 parts of dark plums, 24 parts, catechu.
The addition of described composite feed additive is the 0.3-0.5% of basal diet quality.
The preparation method of anti-grice diarrhoea composite feed additive in the present invention, comprises the following steps:
(1) according to mass fraction, take various raw materials;
(2) by the dark plum taking in step (1), catechu after pulverizer is pulverized, mix with other raw material again after crossing 60 mesh sieves, obtain this composite feed additive.
In the present invention, Echinacea Purpurea Herb P.E can strengthen immunity and antibiotic, antiviral, the anti-infection ability of piglet significantly.Curcumin has and strengthens piglet body fluid and cellular immune function and anti-inflammatory, anti-oxidant, antibiotic effect, and a series of virus infections healthy cells of prevention that can wide spectrum.Berberine hydrochloride has a broad antifungal spectrum, to multiple Grain-positive and the equal tool bacteriostasis of negative bacterium, wherein Escherichia coli, shigella dysenteriae ,Jin Portugal bacterium, streptococcus, typhoid bacillus and Amoeba are had to stronger inhibitory action, therefore the gastroenteritis of weanling pig, bacillary dysentery etc. are had to prevention effect well.Sodium butyrate is the main energy source of Colon mucosa cell, can improve the propagation of weanling pig Duodenal villi and reduce the crypts degree of depth, expands the absorption area of small intestine.Sodium butyrate can suppress the inflammatory reaction of intestinal mucosa, alleviate bacterium and food antigens moves across mucous membrane, it can also suppress the growth of the harmful bacterias such as Escherichia coli, Salmonella, clostridium simultaneously, promote the breeding of the beneficial bacteriums such as the interior Bacillus acidi lactici of intestines and stomach, streptococcus fecalis, make micro ecology of gastrointestinal tract in positive balance, and promote the absorption of hindgut to moisture, thereby reduce grice diarrhoea.Zinc methionine has immunologic function and the resisting stress capability that strengthens weanling pig, and improves the duodenal height of naps of piglet and reduce the crypts degree of depth, to reduce grice diarrhoea.Dark plum taste acid, micro-puckery, property is flat, contains the compositions such as citric acid, malic acid, butanedioic acid, carbohydrate, sitosterol, vitamin C, has effect antibiotic, relieving diarrhea with astringents dysentery, thereby reduces grice diarrhoea rate.Catechu is bitter, puckery, is slightly cold, and contains catechutannic acid, left-handed and racemization cachou extract, left-handed and racemization epicatechin, tannic red tannin, and fisetin, Quercetin, the flavonols such as quercetagetin and Kaempferol, Dihydrokaempferol, texifolin, Isorhamnetin, dextrorotation afzelechin, the active ingredients such as the former Cyanidin of double focusing, it can suppress the wriggling of duodenum and small intestine, and can promote the anastalsis of caecum; It also has resisting pathogenic microbes effect simultaneously, Escherichia coli, staphylococcus aureus, proteus, shigella flexneri, typhoid bacillus and virus is all had to remarkable inhibitory action, thereby play the effect of anti-grice diarrhoea.
Effect from above-mentioned each component, anti-grice diarrhoea composite feed additive of the present invention can be brought into play the effect of taking advantage of that adds after by each component compatibility, and wherein Echinacea Purpurea Herb P.E, curcumin, zinc methionine are being brought into play humidification jointly improving aspect weanling pig immunity; Berberine hydrochloride, sodium butyrate, curcumin, dark plum, catechu can cooperative compensatings aspect resisting pathogenic microbes, make resisting pathogenic microbes expanded range; Sodium butyrate, zinc methionine are being safeguarded performance synergy aspect small intestine form and intestinal mucosa epithelial cell structural integrity.Said components use in conjunction is presenting additive effect aspect anti-grice diarrhoea, thus prevention of diarrhea in piglets effectively.
Beneficial effect of the present invention:
1, the present invention is mixed into composite feed additive according to a certain percentage by Echinacea Purpurea Herb P.E, curcumin, Berberine hydrochloride, sodium butyrate, zinc methionine, dark plum, catechu, then added in piglet basal diet, for piglet free choice feeding, effectively prevent and treat grice diarrhoea, also promoted growth, improved food conversion ratio and improve piglet coat condition, effectively solved a difficult problem for diarrhea of weaned piglets.
2, the present invention is theoretical according to nutrition regulation, and the nuisanceless immunologic facilitation factor, enteron aisle regulatory factor and Chinese herbal medicine are carried out to compatibility scientifically and rationally, to work in coordination with the effect of performance nutrition regulation, to piglet and environment, is all safety.Thereby the drug resistance and pollution drawback of using antibiotic and chemical synthetic drug to produce have been avoided.
3, in piglet basal ration, add after 0.3%-0.5% the anti-grice diarrhoea composite feed additive of the present invention, can improve piglet immunological function and anti-stress ability, reduce enteron aisle pH value, suppress the breeding of harmful intestinal tract bacteria, promote the histiocytic regeneration of gut epithelium and reparation, strengthen the absorbability of enteron aisle, especially the absorption of hindgut to moisture, thereby effectively prevent and treat grice diarrhoea, improve piglet survival ratio, daily gain and feed efficiency, and make the red hair of pigskin bright.
4, in this composite feed additive, do not add chemical antibacterials, there is green, safety, the advantage such as efficient, and easy to use.
5, compare with probiotics, the biological action of this composite feed additive is not subject to environmental factor (as temperature, moisture, pH value etc.) impact, can tolerate HTHP in the processing modulated process of feed; Be not subject in feed, add or in therapeutic process, use antibiotic impact, after being searched for food by piglet, can effectively resist the effect of hydrochloric acid in gastric juice and cholate yet.
6, compare with pure Chinese herb feed additive, this composite feed additive is except having advantages of that mass effect is stable, adding proportion is little; In addition between each component strengthening piglet immunological function, resisting pathogenic microbes, safeguard in small intestine form and intestinal mucosa epithelial cell structural integrity and enteron aisle that the aspects such as beneficial microbe flora also have synergy significantly, thereby anti-grice diarrhoea function is further strengthened.
the specific embodiment:
Embodiment 1:
27 parts of 29 parts of Echinacea Purpurea Herb P.Es, bisdemethoxycurcumin part, 2 parts of Berberine hydrochlorides, 13 parts of sodium butyrates, 4 parts of zinc methionines, 22 parts of dark plums, catechu are mixed and are mixed with composite feed additive.Then in 0.5% ratio that accounts for basal diet quality, add in piglet basal diet, for its free choice feeding.
Embodiment 2:
By 57 parts of Echinacea Purpurea Herb P.Es, 6 parts of curcumins, 4.5 parts of Berberine hydrochlorides, 16 parts of sodium butyrates, 6 parts of zinc methionines, 2.5 parts of dark plums, 8 parts, catechu mixes and is mixed with composite feed additive, then in 0.3% ratio that accounts for basal diet quality, add in piglet basal diet, for its free choice feeding.
Embodiment 3:
By 42 parts of Echinacea Purpurea Herb P.Es, 5.2 parts of curcumins, 3 parts of Berberine hydrochlorides, 17.6 parts of sodium butyrates, 5.2 parts of zinc methionines, 3 parts of dark plums, 24 parts, catechu mixes and is mixed with composite feed additive, then in 0.4% ratio that accounts for basal diet quality, add in piglet basal diet, for its free choice feeding.
Embodiment 4:
By 28 parts of Echinacea Purpurea Herb P.Es, 7 parts of curcumins, 5 parts of Berberine hydrochlorides, 20 parts of sodium butyrates, 7 parts of zinc methionines, 23 parts of dark plums, 10 parts, catechu mixes and is mixed with composite feed additive, then in 0.32% ratio that accounts for basal diet quality, add in piglet basal diet, for its free choice feeding.
Embodiment 5:
By 60 parts of Echinacea Purpurea Herb P.Es, 4 parts of curcumins, 2.5 parts of Berberine hydrochlorides, 12 parts of sodium butyrates, 6.5 parts of zinc methionines, 2 parts of dark plums, 13 parts, catechu mixes and is mixed with composite feed additive, then in 0.48% ratio that accounts for basal diet quality, add in piglet basal diet, for its free choice feeding.
Test example:
Select 18 of the three way cross weanling pigs that parity, sex, body weight are close, be divided at random 3 groups, the blank group basal diet of feeding, positive controls is for add 100mg/kg olaquindox in basal diet, and test group for adding the composite feed additive of embodiment 3 in the present invention who accounts for basal diet quality 0.4% in basal diet.
30 days experimental periods.After feeding experiment finishes, every group selection body weight is close, 4 pigs of the identical piglet of sex, utilizes chrome green to carry out digestion trial as indicator.3 days preliminary trial periods, 4 days formal test phases.Result of the test is as follows:
Table 1, the impact of anti-grice diarrhoea composite feed additive on Production Performance of Weaning Pigs and diarrhea rate
| Project | Blank group | Positive controls | Test group |
| Average initial weight (kg/ head) | 7.13±1.09 a | 7.38±0.71 a | 7.25±0.78 a |
| Average end heavy (kg/ head) | 19.67±2.34 a | 21.08±2.06 a | 22.5±1.18 b |
| Daily gain (g/ days) | 418.07 a | 456.94 a | 508.33 b |
| Daily ingestion amount (g/ pcs/day) | 4445.57 a | 4841.03 a | 4886.4 a |
| Material anharmonic ratio | 1.77：1 a | 1.76：1 a | 1.60：1 b |
| Diarrhea rate (%) | 32.22% a | 28.33% a | 10.56% b |
Note: with takeing on marking-up parent phase in a line, with person, represent difference not remarkable (P>0.05), shoulder mark adjacent letters person represents significant difference (P<0.05).
By table 1, known, anti-grice diarrhoea composite feed additive group is compared with blank group, and daily gain has improved 21.59%(P < 0.05), material anharmonic ratio reduced 9.61%(P < 0.05), diarrhea rate reduced 67.23%(P < 0.05); Compare with positive controls, weightening finish has improved 11.25%(P < 0.05), material anharmonic ratio reduced respectively 9.09%(P < 0.05), diarrhea rate reduced 62.73%(P < 0.05), anti-grice diarrhoea composite feed additive prevention of diarrhea in piglets improve its growth performance is effectively added in this explanation in weanling pig daily ration.
Table 2, anti-grice diarrhoea composite feed additive are on the impact of weanling pig nutrient digestibility (%)
| Group | Dry | Crude protein | Calcium | Phosphorus |
| Blank group | 78.37±0.34a | 84.74±0.03a | 47.32±0.09a | 68.74±0.01a |
| Positive controls | 80.79±0.01ab | 87.31±0.04ab | 55.87±0.08c | 71.02±0.08ab |
| Test group | 86.25±0.01c | 89.86±0.02b | 57.02±0.01c | 73.10±0.01b |
Note: in same row, take on marking-up parent phase and represent difference not remarkable (P>0.05) with person, shoulder mark adjacent letters person represents significant difference (P<0.05), and the non-adjacent alphabetical person of shoulder mark represents difference extremely significantly (P<0.01).
By table 2, known, anti-grice diarrhoea composite feed additive group is compared with blank group, and dry, thick protein, calcium and phosphorus digestibility have improved respectively 10.05% (P<0.01), 6.04% (P<0.05), 20.50% (P<0.01), 6.34% (P<0.05).Compare with positive controls, dry digestibility has improved 6.8% (P<0.05), significant difference; CP, Ca and P digestibility have improved respectively 2.9% (P>0.05), 2.06% (P>0.05), 2.9% (P>0.05), but difference is not remarkable.In this explanation feed, add anti-grice diarrhoea element composite feed additive and can improve the digestibility of piglet to dry, protein, calcium, phosphorus.
Table 3, the impact of anti-grice diarrhoea composite feed additive on the weanling pig colour of skin and hair condition
| Project | Blank group | Positive controls | Test group |
| The colour of skin | 3.1±0.3 a | 4.3±0.7 a | 5.8±0.1 a |
| Hair condition | 3.4±0.2 a | 4.1±0.4 a | 6.1±0.2 b |
Note: with takeing on marking-up parent phase in a line, with person, represent difference not remarkable (P>0.05), shoulder mark adjacent letters person represents significant difference (P<0.05).
By table 3, known, compare with positive controls with blank group, add anti-grice diarrhoea mixed feed in weanling pig feed, the colour of skin of its piglet and hair condition all obtain improving comparatively significantly.
The above, be only preferred embodiment of the present invention, not technical scheme of the present invention done to any pro forma restriction.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements are all still in the scope of technical scheme of the present invention and belong to claimed scope of the present invention.
Claims (4)
1. an anti-grice diarrhoea composite feed additive, is characterized in that: described composite feed additive is prepared from by weight by following component:
28～60 parts of Echinacea Purpurea Herb P.Es
Bisdemethoxycurcumin～7 part
2～5 parts of Berberine hydrochlorides
12～20 parts of sodium butyrates
4～7 parts of zinc methionines
2～23 parts of dark plums
8～27 parts, catechu.
2. the composite feed additive of a kind of anti-grice diarrhoea according to claim 1, is characterized in that: described composite feed additive is prepared from by weight by following component: 42 parts of Echinacea Purpurea Herb P.Es, 5.2 parts of curcumins, 3 parts of Berberine hydrochlorides, 17.6 parts of sodium butyrates, 5.2 parts of zinc methionines, 3 parts of dark plums, 24 parts, catechu.
3. the composite feed additive of a kind of anti-grice diarrhoea according to claim 1, is characterized in that: the addition of described composite feed additive is the 0.3-0.5% of basal diet quality.
4. a method of preparing anti-grice diarrhoea composite feed additive as claimed in claim 1 or 2, is characterized in that: comprise the following steps:
(1) according to mass fraction, take various raw materials;
(2) by the dark plum taking in step (1), catechu after pulverizer is pulverized, mix with other raw material again after crossing 60 mesh sieves, obtain this composite feed additive.
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| CN107535717A (en) * | 2017-09-07 | 2018-01-05 | 高计会 | It is a kind of to be used to treat solid feed of rabbit diarrheb and preparation method thereof |
| ES2681489A1 (en) * | 2017-03-06 | 2018-09-13 | Vall Garraf, S.L. | FATTENING ADDITIVE IN ANIMAL NUTRITIONAL COMPOSITION (Machine-translation by Google Translate, not legally binding) |
| CN109393187A (en) * | 2018-12-29 | 2019-03-01 | 福建傲农生物科技集团股份有限公司 | A kind of anti-diarrhea pig feed additive and the preparation method and application thereof |
| CN110478397A (en) * | 2019-09-18 | 2019-11-22 | 四川成康动物药业有限公司 | Pharmaceutical composition and preparation method thereof for preventing and treating animal diarrhea |
| CN110973356A (en) * | 2019-12-28 | 2020-04-10 | 河南德邻生物制品有限公司 | Additive for feed capable of replacing antibiotics and using method thereof |
| CN111011627A (en) * | 2019-12-18 | 2020-04-17 | 成都大帝汉克生物科技有限公司 | Feed additive capable of preventing diarrhea and preparation method thereof |
| CN112715756A (en) * | 2020-12-27 | 2021-04-30 | 福建傲农生物科技集团股份有限公司 | Compound for enhancing immune function and improving intestinal morphology and application thereof |
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Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105614113A (en) * | 2016-03-10 | 2016-06-01 | 徐杰 | Piglet anti-diarrhea compound Chinese herbal medicine feed and preparing method thereof |
| ES2681489A1 (en) * | 2017-03-06 | 2018-09-13 | Vall Garraf, S.L. | FATTENING ADDITIVE IN ANIMAL NUTRITIONAL COMPOSITION (Machine-translation by Google Translate, not legally binding) |
| CN107307214A (en) * | 2017-08-28 | 2017-11-03 | 朱伟 | A kind of feed addictive for treating diarrhea of pigs |
| CN107307214B (en) * | 2017-08-28 | 2018-11-06 | 宜春市茂盛饲料有限公司 | A kind of feed addictive for treating diarrhea of pigs |
| CN107535717A (en) * | 2017-09-07 | 2018-01-05 | 高计会 | It is a kind of to be used to treat solid feed of rabbit diarrheb and preparation method thereof |
| CN107535717B (en) * | 2017-09-07 | 2018-05-08 | 高计会 | It is a kind of to be used to treat solid feed of rabbit diarrheb and preparation method thereof |
| CN109393187A (en) * | 2018-12-29 | 2019-03-01 | 福建傲农生物科技集团股份有限公司 | A kind of anti-diarrhea pig feed additive and the preparation method and application thereof |
| CN110478397A (en) * | 2019-09-18 | 2019-11-22 | 四川成康动物药业有限公司 | Pharmaceutical composition and preparation method thereof for preventing and treating animal diarrhea |
| CN111011627A (en) * | 2019-12-18 | 2020-04-17 | 成都大帝汉克生物科技有限公司 | Feed additive capable of preventing diarrhea and preparation method thereof |
| CN110973356A (en) * | 2019-12-28 | 2020-04-10 | 河南德邻生物制品有限公司 | Additive for feed capable of replacing antibiotics and using method thereof |
| CN113367337A (en) * | 2020-03-10 | 2021-09-10 | 晨光生物科技集团股份有限公司 | A composition containing quercetagetin |
| CN113367337B (en) * | 2020-03-10 | 2023-02-24 | 晨光生物科技集团股份有限公司 | A composition containing quercetagetin |
| CN113615767A (en) * | 2020-05-06 | 2021-11-09 | 晨光生物科技集团股份有限公司 | Feed containing quercetagetin and application thereof |
| WO2021223682A1 (en) * | 2020-05-06 | 2021-11-11 | 晨光生物科技集团股份有限公司 | Quercetagetin-containing feed and use thereof |
| CN114073288A (en) * | 2020-08-14 | 2022-02-22 | 晨光生物科技集团股份有限公司 | Antioxidant composition containing quercitrin |
| CN114073288B (en) * | 2020-08-14 | 2023-11-24 | 晨光生物科技集团股份有限公司 | Antioxidant composition containing quercetin and marigold |
| CN112715756A (en) * | 2020-12-27 | 2021-04-30 | 福建傲农生物科技集团股份有限公司 | Compound for enhancing immune function and improving intestinal morphology and application thereof |
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