CN103536759B - 一种治疗脾肾两虚证型不孕病的中药 - Google Patents
一种治疗脾肾两虚证型不孕病的中药 Download PDFInfo
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Abstract
本发明公开了一种治疗脾肾两虚证型不孕病的中药，其特征是由下列重量配比的原料制成的：人参10份、白术15份、黄芪30份、阿胶10份、半夏10份、菟丝子15份、覆盆子15份、续断12份、桑椹子10份、龟板15份、仙鹤草30份、淮山药15份、蚕蛾20份、五味子15份、黄精20份、芡实15份、益母草30份、淫羊藿15份。本发明采用合适的药材及其配比，各药物之间相互配合，协同作用，所制成的中药具有补肾健脾、温肾壮阳、养血益阴等功效，三年来通过对56名患者的使用表明，有效率达76.7%。
Description
技术领域
本发明涉及一种中药，特别是一种用于治疗脾肾两虚证型不孕病的中药。
背景技术
不孕症是指有正常规律性生活、未采取避孕措施两年未妊娠者。不孕是一种常见的问题，大约影响到至少10-15%的育龄夫妇。引起不孕的发病原因分为男性不孕和女性不孕，女性不孕主要以排卵障碍，输卵管因素，子宫内膜容受性异常为主。 中医将不孕病分为脾肾两虚证型不孕、肝郁型不孕、气滞血瘀型不孕、痰湿内阻型不孕、气血虚弱型不孕、阳虚寒凝型不孕等多个证型。目前，治疗不孕病大多数采用中药调理，但目前还没有一种专用于治疗脾肾两虚证型不孕病的中药。
发明内容
本发明旨在提供一种治疗脾肾两虚证型不孕病的中药，通过选择合适的药材及其配比，达到安全有效治疗脾肾两虚证型不孕病的目的。
为达到上述目的，本发明采用以下技术方案，一种治疗脾肾两虚证型不孕病的中药，其特征是由下列重量配比的原料制成的：
人参10份、白术15份、黄芪30份、阿胶10份、半夏10份、菟丝子15份、覆盆子15份、续断12份、桑椹子10份、龟板15份、仙鹤草30份、淮山药15份、蚕蛾20份、五味子15份、黄精20份、芡实15份、益母草30份、淫羊藿15份。
本发明配方中所述的各种药材的来源及功能主治如下：
人参【来源】 本品为五加科植物人参Panax ginseng C. A. Mey.的干燥根。【性味】 甘、微苦，平。【归经】 归脾、肺、心经。【功能主治】 大补元气，复脉固脱，补脾益肺，生津，安神。用于体虚欲脱，肢冷脉微，脾虚食少，肺虚喘咳，津伤口渴，内热消渴，久病虚羸，惊悸失眠，阳痿宫冷；心力衰竭，心源性休克。
白术【来源】 本品为菊科植物白术Atractylodes macrocephala Koidz.的干燥根茎。【性味】 苦、甘，温。【归经】 归脾、胃经。【功能主治】 健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。土白术健脾，和胃，安胎。用于脾虚食少，泄泻便溏，胎动不安。
阿胶【来源】为马科动物驴的皮，经漂泡去毛后熬制而成的胶质块。【性味】甘，平。【归经】入肺、肝、肾经。【功能主治】滋阴润肺，补血止血，定痛安胎。主治血虚萎黄，眩晕心悸。临床应用于血虚萎黄、眩晕心悸、肌痿无力、心烦失眠、虚风内动、肺燥咳嗽、劳咳咯血、 吐血、便血崩漏。
黄芪【来源】 本品为豆科植物蒙古黄芪 Astragalus membranaceus （Fisch.） Bge. var. mongholicus （Bge.）Hsiao 或膜荚黄芪 Astragalus membranaceus （Fisch.） Bge.的干燥根。【性味】 甘，温。【归经】 归肺、脾经。【功能主治】 补气固表，利尿托毒，排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴；慢性肾炎蛋白尿，糖尿病。
半夏【来源】 本品为天南星科植物半夏Pinellia ternata （Thunb.） Breit. 的干燥块茎。【性味】 辛，温；有毒。【归经】 归脾、胃、肺经。【功能主治】 燥湿化痰，降逆止呕，消痞散结。用于痰多咳喘，痰饮眩悸，风痰眩晕，痰厥头痛，呕吐反胃，胸脘痞闷，梅核气；生用外治痈肿痰核。姜半夏多用于降逆止呕。
菟丝子【来源】 本品为旋花科植物菟丝子Cuscuta chinensis Lam. 的干燥成熟种子。【性味】 甘，温。【归经】 归肝、肾、脾经。【功能主治】 滋补肝肾，固精缩尿，安胎，明目，止泻。用于阳痿遗精，尿有余沥，遗尿尿频，腰膝酸软，目昏耳鸣，肾虚胎漏，胎动不安，脾肾虚泻；外治白癜风。
覆盆子【来源】 本品为蔷薇科悬钩子属植物华东覆盆子Rubus chingii Hu的干燥果实。【性味】 甘、酸，温。【归经】 归肾、膀胱经。【功能主治】 益肾，固精，缩尿。用于肾虚遗尿，小便频数，阳痿早泄，遗精滑精。
续断【来源】 本品为川续断科多年生草本植物川续断的根。【性味】味苦，辛，性微温。【归经】归肝，肾经。【功能主治】补肝肾；强筋骨；调血脉；续折伤；止崩漏。用于腰背酸痛；肢节痿痹；跌扑创伤、损筋折骨、胎动漏红、血崩、遗精、带下、痈疽疮肿。
桑椹子【来源】 本品为桑科落叶乔木桑树的成熟果实。【性味】味甘，性寒。【归经】归肝、肾、心经。【功能主治】滋阴补血，生津，润肠。主治久病体虚，肝肾阴亏，腰膝酸软，目暗耳鸣，关节不利，肠燥便秘，津亏血少，潮热遗精，糖尿病等。
龟板【来源】本品为龟科动物乌龟的腹甲。【性味】甘咸、寒。【归经】归肝，肾经。【功能主治】具有滋肾潜阳，益肾健骨，养血补心之功效。主治阴虚阳亢、肾虚骨痿、阴血亏虚等症。
仙鹤草【来源】 本品为蔷薇科植物龙牙草Agrimonia pilosa Ledeb. 的干燥地上部分。【性味】 苦、涩，平。【归经】 归心、肝经。【功能主治】 收敛止血，截疟，止痢，解毒。用于咳血，吐血，崩漏下血，疟疾，血痢，脱力劳伤，痈肿疮毒，阴痒带下。
黄精【来源】 本品为百合科植物滇黄精Polygonatum kingianum Coll.et Hemsl.、黄精Polygonatum sibiricum Red.或多花黄精Polygonatum cyrtonema Hua 的干燥根茎。【性味】 甘，平。【归经】 归脾、肺、肾经。【功能主治】 补气养阴，健脾，润肺，益肾。用于脾胃虚弱，体倦乏力，口干食少，肺虚燥咳，精血不足，内热消渴。
芡实【来源】 本品为睡莲科植物芡Euryale ferox Salisb. 的干燥成熟种仁。【性味】 甘、涩，平。【归经】 归脾、肾经。【功能主治】 益肾固精，补脾止泻，祛湿止带。用于梦遗滑精，遗尿尿频，脾虚久泻，白浊，带下。
淮山药【来源】 本品淮山药指的是今江苏安徽等地所产山药。【性味】味甘，性平。【归经】归脾，肺，肾经。【功能主治】补脾养胃，生津益肺，补肾涩精。脾虚食少、久泻不止、肺虚喘咳、肾虚遗精、带下、尿频、虚热消渴。
蚕蛾【来源】为蚕蛾科昆虫家蚕蛾的雄性全虫。【性味】咸，温。【归经】入肝、肾经。【功能主治】补肝益肾，壮阳涩精。治阳痿，遗精，白浊，尿血，创伤，溃疡及烫伤。
五味子【来源】 本品为木兰科植物五味子Schisandra chinensis （Turcz.）Baill.或华中五味子Schisandra sphenanthera Rehd. et Wils.的干燥成熟果实。【性味】 酸、甘，温。【归经】 归肺，心、肾经。【功能主治】 收敛固涩，益气生津，补肾宁心。用于久嗽虚喘，梦遗滑精，遗尿尿频，久泻不止，自汗，盗汗，津伤口渴，短气脉虚，内热消渴，心悸失眠。
益母草【来源】 本品为唇形科植物益母草Leonurus japonicus Houtt. 的新鲜或干燥地上部分。【性味】 苦、辛，微寒。【归经】 归肝、心包经。【功能主治】 活血调经，利尿消肿。用于月经不调，痛经，经闭，恶露不尽，水肿尿少；急性肾炎水肿。
淫羊藿【来源】 本品为小檗科植物淫羊藿Epimedium brevicornum Maxim.、箭叶淫羊藿Epimedium sagittatum （Sieb.et Zucc.）Maxim. 、柔毛淫羊藿Epimedium pubescens Maxim.、巫山淫羊藿Epimedium wushanense T.S.Ying、或朝鲜淫羊藿pimedium koreanum Nakai的干燥地上部分。【性味】 辛、甘，温。【归经】 归肝、肾经。【功能主治】 补肾阳，强筋骨，祛风湿。用于阳痿遗精，筋骨痿软，风湿痹痛，麻木拘挛；更年期高血压。
脾肾两虚证型不孕病患者，大多数临床上表现为面色苍白，爪甲、口唇、粘膜淡白，少气懒言，腰膝酸冷，头晕耳鸣，失眠多梦，便溏，舌质淡，苔薄，脉细弱，多见经期后错，量少色淡，腰膝酸困，倦怠喜唾，带多如注，婚久不孕，面色晦黯，腰膝酸软，性欲淡漠，入夜尿频，大便稀薄，舌淡苔白，脉沉迟。病机脾肾亏虚，气血失养，精血不足，难以摄系胚胎。本发明采用合适的药材及其配比，各药物之间相互配合，协同作用，所制成的中药具有补肾健脾、温肾壮阳、养血益阴等功效，三年来通过对56名患者的使用表明，有效率达76.7%。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2010年1月-2013年1月间共收集了102例脾肾两虚证型不孕病的门诊患者，年龄29-39岁，随机分为：治疗组56例，对照组46例。两组年龄等资料无显著性差异，具有可比性。
2、试验方法
2.1对照组口服助孕丸，按照说明书服用。疗程一个月经周期。
2.2治疗组口服本发明按照具体实施例1制得的胶囊，早、中、晚各一次。疗程一个月经周期。
3、疗效标准及治疗结果
3.1疗效标准：
痊愈：1-3个月过后，正常怀孕。无效：3-6个月仍没有怀孕。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 无效 | 总有效率（%） |
| 治疗组 | 30 | 23 | 7 | 76.7% |
| 对照组 | 46 | 15 | 31 | 32.6% |
由此可见，本发明制得的药物能够安全有效治疗脾肾两虚证型不孕病。
具体实施方式
为了更好地理解与实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取人参10克、白术15克、黄芪30克、半夏10克、菟丝子15克、覆盆子15克、续断12克、桑椹子10克、龟板15克、仙鹤草30克、淮山药15克、蚕蛾20克、五味子15克、黄精20克、芡实15克、益母草30克、淫羊藿15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，与10克阿胶粉混合均匀，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗脾肾两虚证型不孕病。口服，每日分早、中、晚三次服用。
具体实施例2
称取人参10克、白术15克、黄芪30克、半夏10克、菟丝子15克、覆盆子15克、续断12克、桑椹子10克、龟板15克、仙鹤草30克、淮山药15克、蚕蛾20克、五味子15克、黄精20克、芡实15克、益母草30克、淫羊藿15克，加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，与10克阿胶粉混合均匀，包装，即得符合正常成人1天用量的散剂。
用于治疗脾肾两虚证型不孕病。口服，每日分早、中、晚三次服用。
具体实施例3
称取人参10克、白术15克、黄芪30克、半夏10克、菟丝子15克、覆盆子15克、续断12克、桑椹子10克、龟板15克、仙鹤草30克、淮山药15克、蚕蛾20克、五味子15克、黄精20克、芡实15克、益母草30克、淫羊藿15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，与10克阿胶粉混合均匀，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即得符合正常成人1天用量的颗粒剂。
用于治疗脾肾两虚证型不孕病。口服，每日分早、中、晚三次服用。
Claims (1)
1.一种治疗脾肾两虚证型不孕病的中药，其特征是由下列重量配比的原料制成的：人参10份、白术15份、黄芪30份、阿胶10份、半夏10份、菟丝子15份、覆盆子15份、续断12份、桑椹子10份、龟板15份、仙鹤草30份、淮山药15份、蚕蛾20份、五味子15份、黄精20份、芡实15份、益母草30份、淫羊藿15份。
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