CN103494886B - Spray type beriberi liquid containing vinegar liquid and essential oil of bamboo and wood, nano-grade manufacturing method, and applications thereof - Google Patents

Abstract

The invention relates to a spray type beriberi liquid containing vinegar liquid and essential oil of bamboo and wood, a nano-grade manufacturing method, and applications thereof. The beriberi liquid is characterized by comprising the following components in parts by weight: 5 to 20 parts of plant essential oil for inhibiting and killing bacterium activity, 8 to 90 parts of vinegar liquid of bamboo and wood, and 2 to 20 parts of emulsifier; wherein the plant essential oil is a mixture comprising one or more components selected from following components: tea tree oil, eucalyptus oil, camphor tree oil, clove oil, and citronella oil, the vinegar liquid of bamboo and wood is a mixture comprising one or two components selected from following components: bamboo vinegar liquid and wood vinegar liquid, and the emulsifier is a mixture comprising one or more components selected from following components: OP-10, span 80, dodecyl benzene sulfonic acid, and tween 80. The beriberi liquid prepared by the invention has the characteristics of user-friendliness, non-toxicity, low cost, and high special effect, and develops a novel way for the utilization of vinegar liquid of bamboo and wood.

Description

A kind of direct injection beriberi liquid containing bamboo wood vinegar and quintessence oil and nanofabrication method thereof and purposes

Technical field

The invention belongs to health technology field, be specifically related to a kind of direct injection beriberi liquid containing bamboo wood vinegar and quintessence oil and nanofabrication method thereof and purposes.

Background technology

Along with people are to the reinforcement of own health and environmental protection consciousness, countries in the world all in development to the mankind i.e. health but also the product of environmental protection.The overwhelming majority activity of the mankind all be unable to do without walking, and visible foot should become one of emphasis of mankind's routine health and nursing.Beriberi is a kind of extremely common fungal infection dermatoses, it is reported that in being grown up, the people of 70-80% has beriberi, becomes the disease of serious puzzlement people toe.Beriberi is medically also known as tinea pedis, be commonly called as tinea pedis, that foot fungus infection shows as between toe or the decortication of vola skin pruritus erythematous papules, or have blister, seriously can be rotten to the corn, ooze out, as control can involve other positions not in time, cause that tinea corporis tinea cruris or tinea unguium are medically usual divides three types by beriberi: erosive type, vesicle, keratinization type beriberi.Common Therapeutic Method has western medicine and Chinese medicine formula to treat.Although western medicine instant effect, its be chemical synthetic drug to health toxic side effect, people should be worth to note, though and treatment by Chinese herbs to slow compared with Western medicine in its curative effect of human non-toxic's side effect.

Plant is the natural treasure-house of bioactive compound, its secondary metabolite produced is more than 400,000 kinds, and wherein most of chemical substances such as terpenes, alkaloid, flavonoid, steroidal, phenols, unique aminoacid and polysaccharide etc. all have sterilization and antibacterial activity.Wilkins and Board once reported there are 1389 kind of plant likely as antibacterial in 1989, wherein contained many dissimilar compounds.Current people are from plant, the natural active matter extracting antifungal, antibacterial, virus, nematicide, parasite killing, weeding.The research and development of natural plant source bactericide are the focuses of current new type natural antibacterial initiative.

Natural essential oil is mainly the compound of ester, aldehyde, ketone and terpenes, also has tannin, flavonoid, steroid, organic acid, protein etc. also to have antibacterial activity in addition.Someone studies and finds that the extract of the plants such as Nicotiana tabacum L., tea cake, Radix seu Caulis Derridis Trifoliatae, Radix Tripterygii Wilfordii can suppress germination and the growth of some pathogenic bacteria spore, or stops pathogenic bacteria to invade.A variety of millet figured woven silk material finds that the citral in cubeb litsen tree volatile oil is the effective ingredient suppressing Fusarium oxysporum, compacted spore bacterium, lattice spore chamber bacteria growing at age etc., and have obvious preservation, from Hongkong mangrove Luminitzera racemosa (olive Lee) extraction and isolation to tannin be antibacterial important activity composition, other flavones, fat etc. also have some bacteriostasis; Abroad, fennel Artemisia (Chrysanthemum coronarium) flower essential oil such as Alvarez-Castellanos carries out antibacterial tests to 12 kind of plant pathogen, all shows antifungal activity; Dev etc. have studied 16 kinds of aromatics in the inhibitory action of in vitro to the mould grade of wheat and barley root-rot De Shi 5 kinds of seed pathogenic fungi, and research finds that in plant fragrance composition, the mycelial growth of 6 kinds of compounds to the mould grade of wheat and barley root-rot De Shi 5 kinds of seed pathogenic fungi has strong inhibitory action; Isolated 3 kinds of new naphthoquinone-revandchinone-1, revandchinone-3 and the revandchinone-4 from Rheum emodi (Rheumemodi) such as Suresh has activity to Rhizopus Oryzae and Asperigillus Niger; Roxana etc. report and isolated invertase Profilin from Fruits of Tomatoes, and show the bacteriostatic activity to 5 kind of plant pathogenetic bacterias such as the 8 kind of plant pathogenic fungi such as Polyporaceae Ganoderma applanatum (Pers. Ex Wallr) Pat. (Ganoderma applanatum) and sarson bacillus (Xanthomonas campestris); Ratuayake isolates the color alkene with antibacterial activity from Eupatoricum Riparicum; Benner and Tahara finds that a kind of sesquiterpene in Herba Taraxaci has antibacterial activity.

Bamboo (wood) vinegar liquid is the quite complicated Combination solution of a kind of composition, it is a kind of brown liquid that bamboo wood (timber) produces in pyrolysis or retort process, its volatile material has special smoke, and its main component is acids, phenols, aldehydes, ketone and esters etc.China to begin one's study bamboo (wood) vinegar liquid from late nineteen nineties in last century due to the impact by Japan, Korea S's bamboo charcoal Bamboo vinegar solution upsurge, and much researcher and the Application and Development of enterprise to bamboo (wood) vinegar liquid have done large quantity research up to now.There are some researches show; bamboo (wood) vinegar liquid agriculturally can be used as plant growth regulator use; as: promote the germination of plant and the growth etc. of root system; aquaculture can be used as animal feed additive to regulate growth of animal; medical and health and environmental conservation can be used as antibacterial, antibacterial use, there is the antibiotic property of wide spectrum.

Summary of the invention

In order to overcome the above-mentioned problems in the prior art, the object of the present invention is to provide the direct injection beriberi liquid of a kind of bamboo wood vinegar and quintessence oil and nanofabrication method thereof and purposes, easy to use, nontoxic, low cost, there is high specially good effect, its manufacture process environmental protection, using method are simple, consumption is low, effectively can be applied to various beriberic control.

For this reason, the present invention takes following technical scheme: a kind of direct injection beriberi liquid containing bamboo wood vinegar and quintessence oil, it is characterized in that the component comprising following weight portion: press down bactericidal activity plants essential oil 5-20 part, bamboo wood vinegar 8-90 part, emulsifying agent 2-20 part, described plants essential oil is tea tree oil, eucalyptus oil, Lignum cinnamomi camphorae oil, the mixture of one or more of Oleum Caryophylli or citronella oil, described bamboo wood vinegar is one or both the mixture in Bamboo vinegar solution or wood vinegar, described emulsifying agent is OP-10, class 80 of department, the mixture of one or more in DBSA or Tween 80.

As preferably, described plants essential oil content is 5-10 part.

As preferably, described bamboo wood vinegar is 40-90 part.

As preferably, described emulsifying agent is 5-15 part.

Contain a nanofabrication method for the direct injection beriberi liquid of bamboo wood vinegar and quintessence oil, it is characterized in that method is as follows:

(1) in the reactor of 200L, add 8-90 part bamboo wood vinegar, then slowly add 1-10 part emulsifying agent wherein, be stirred to dissolution homogeneity and stablize, be denoted as A liquid.

(2) in another reactor container, add 1-10 part emulsifying agent, then slowly add 5-20 part plants essential oil wherein, be stirred to dissolution homogeneity and stablize, be denoted as B liquid.

(3) under the effect of constantly stirring, B liquid is slowly added A liquid until two solution clears and uniform and stable till.

Said preparation of the present invention has good curative effect at vitamin B1 deficiency Common fungi such as control trichophyton, Candida albicans, acrothesium floccosum, trichophyton gypseums.

The present invention finds only have the quintessence oil of a small amount of kind to have higher bactericidal activity from numerous plants essential oils, such as: wintergreen oil, Lignum cinnamomi camphorae oil, Oleum Caryophylli, Oleum menthae, eucalyptus oil, citronella oil or tea tree oil; And find, same quintessence oil is also very large to the bactericidal activity difference in size of different pathogenic fungi, and the present invention only discloses active size can reach industrial applicibility and mainly for beriberi Common fungi target as trichophyton, Candida albicans, acrothesium floccosum, trichophyton gypseum etc.

Direct injection beriberi liquid of the present invention is easy to use, nontoxic, low cost, have high specially good effect, and its manufacture process environmental protection, using method are simple, and consumption is low, effectively can be applied to various beriberic control.

Detailed description of the invention

Below just will further describe the present invention by example.

Example 1

In a reactor, add 30 parts, wood vinegar, slowly add 3 parts of emulsifying agent DBSA wherein more subsequently, be stirred to dissolution homogeneity and stablize, be denoted as A liquid.In another reactor container, add 2 parts of emulsifying agents, then slowly add 5 parts of tea tree oil wherein, be stirred to dissolution homogeneity and stablize, be denoted as B liquid.Under the effect of constantly stirring, B liquid is slowly added A liquid until two solution clears and uniform and stable till.

Embodiment 2

In a reactor, add Bamboo vinegar solution 50 parts, slowly add 5 parts of emulsifier tweens 80 wherein more subsequently, be stirred to dissolution homogeneity and stablize, be denoted as A liquid.In another reactor container, add 5 parts of emulsifying agents, then slowly add citronella oil 10 parts wherein, be stirred to dissolution homogeneity and stablize, be denoted as B liquid.Under the effect of constantly stirring, B liquid is slowly added A liquid until two solution clears and uniform and stable till.

Embodiment 3

In a reactor, add bamboo (wood) vinegar liquid 70 parts (wherein wood vinegar 50 parts+Bamboo vinegar solution 20 parts), slowly add 8 parts of emulsifying agent DBSA wherein more subsequently, be stirred to dissolution homogeneity and stablize, be denoted as A liquid.In another reactor container, add 7 parts of emulsifying agents, then slowly add eucalyptus oil 15 parts wherein, be stirred to dissolution homogeneity and stablize, be denoted as B liquid.Under the effect of constantly stirring, B liquid is slowly added A liquid until two solution clears and uniform and stable till.

Embodiment 4

In a reactor, add 90 parts, wood vinegar, slowly add 10 parts of emulsifier op-10s wherein more subsequently, be stirred to dissolution homogeneity and stablize, be denoted as A liquid.In another reactor container, add 10 parts of emulsifier op-10s, then slowly add Oleum Caryophylli 20 parts wherein, be stirred to dissolution homogeneity and stablize, be denoted as B liquid.Under the effect of constantly stirring, B liquid is slowly added A liquid until two solution clears and uniform and stable till.

Embodiment 5

In a reactor, add Bamboo vinegar solution 30 parts, slowly add 5 parts of emulsifying agent span-80 wherein more subsequently, be stirred to dissolution homogeneity and stablize, be denoted as A liquid.In another reactor container, add 5 parts of emulsifier tweens-80, then slowly add 10 parts of quintessence oils (tea tree oil 5 parts+Lignum cinnamomi camphorae oil 5 parts) wherein, be stirred to dissolution homogeneity and stablize, be denoted as B liquid.Under the effect of constantly stirring, B liquid is slowly added A liquid until two solution clears and uniform and stable till.

Embodiment 6

In a reactor, add bamboo (wood) vinegar liquid 50 parts (wherein wood vinegar 20 parts+Bamboo vinegar solution 30 parts), slowly add emulsifying agent span-80 and each 5 parts of tween 80 subsequently more wherein, be stirred to dissolution homogeneity and stablize, be denoted as A liquid.In another reactor container, add emulsifier op-10 and each 5 parts of DBSA, then slowly add 20 parts of quintessence oils (tea tree oil 6 parts+citronella oil 7 parts+eucalyptus oil 7 parts) wherein, be stirred to dissolution homogeneity and stablize, be denoted as B liquid.Under the effect of constantly stirring, B liquid is slowly added A liquid until two solution clears and uniform and stable till.

Embodiment 7

In a reactor, add bamboo (wood) vinegar liquid 90 parts (wherein wood vinegar 45 parts+Bamboo vinegar solution 45 parts), slowly add emulsifying agent span-80 and each 7 parts of tween 80 subsequently more wherein, be stirred to dissolution homogeneity and stablize, be denoted as A liquid.In another reactor container, add emulsifier op-10 and each 8 parts of DBSA, then slowly add 40 parts of quintessence oils (tea tree oil 10 parts+Oleum Caryophylli 10 parts+citronella oil 10 parts+eucalyptus oil 10 parts) wherein, be stirred to dissolution homogeneity and stablize, be denoted as B liquid.Under the effect of constantly stirring, B liquid is slowly added A liquid until two solution clears and uniform and stable till.

The prevention effect of above-mentioned bactericidal agent is described below by way of test.

Table 1. trichophyton prevention effect (Rectifying efficacies %, 95% fiducial range)

	After medicine 1 day	After medicine 3 days	After medicine 7 days	After medicine 15 days
					Embodiment 1	62.9±4.2	75.6±4.6	83.5±5.5	91.3±3.8
Embodiment 2	60.6±3.2	74.6±4.5	85.8±6.2	93.8±4.9
					Embodiment 3	61.9±4.0	73.5±4.2	84.0±6.0	93.2±5.7
Embodiment 4	67.1±4.8	79.8±5.6	82.6±5.6	92.0±5.8
					Embodiment 5	76.6±5.2	82.0±5.1	91.2±7.1	98.2±6.4
Embodiment 6	73.4±5.0	86.9±3.8	90.2±2.9	97.8±6.5
					Embodiment 7	78.0±4.4	88.7±5.4	92.6±5.4	99.2±4.6

Table 1 data show, embodiment 1-7 all reaches more than 60%, 3d to the Rectifying efficacies of trichophyton 1d and all reaches more than 70%, 7d and reach more than 80%, 15d and reach more than 90%, and wherein embodiment 5-7 all reaches more than 97%, is the embodiment of optimum efficiency.

Table 2. Candida albicans prevention effect (Rectifying efficacies %, 95% fiducial range)

Table 2 data show, embodiment 1-7 all reaches more than 60%, 3d to the Rectifying efficacies of Candida albicans 1d and all reaches more than 70%, 7d and reach more than 80%, 15d and reach more than 90%, and wherein embodiment 5-7 all reaches more than 98%, is the embodiment of optimum efficiency.

Table 3. acrothesium floccosum prevention effect (Rectifying efficacies %, 95% fiducial range)

Table 3 data show, embodiment 1-7 all reaches more than 60%, 3d to the Rectifying efficacies of acrothesium floccosum 1d and all reaches more than 70%, 7d and reach more than 80%, 15d and reach more than 90%, and wherein embodiment 5-7 all reaches more than 99%, is the embodiment of optimum efficiency.

Table 4. trichophyton gypseum prevention effect (Rectifying efficacies %, 95% fiducial range)

Table 4 data show, embodiment 1-7 all reaches more than 60%, 3d to the Rectifying efficacies of trichophyton gypseum 1d and all reaches more than 70%, 7d and reach more than 80%, 15d and reach more than 90%, and wherein embodiment 5-7 all reaches more than 98%, is the embodiment of optimum efficiency.

In a word, show 1-4 result to show: the effect of Bamboo vinegar solution is better than wood vinegar, and the effect of bamboo (wood) vinegar liquid mixed liquor is better than single Bamboo vinegar solution or wood vinegar, and the concentration of bamboo (wood) vinegar liquid is higher, and effect is better.

Claims (3)

1. one kind contains the direct injection beriberi liquid of bamboo wood vinegar and quintessence oil, it is characterized in that being made up of the component of following weight portion: 40 parts of plants essential oils, comprise tea tree oil 10 parts, Oleum Caryophylli 10 parts, citronella oil 10 parts, eucalyptus oil 10 parts, emulsifying agent span-80 and each 7 parts of tween 80, emulsifier op-10 and each 8 parts of DBSA, 45 parts, wood vinegar, Bamboo vinegar solution 45 parts.

2. the nanofabrication method of a kind of direct injection beriberi liquid containing bamboo wood vinegar and quintessence oil as claimed in claim 1, is characterized in that method is as follows:

(1) in the reactor of 200L, add 45 parts, wood vinegar, Bamboo vinegar solution 45 parts, then slowly add emulsifying agent span-80 and each 7 parts of tween 80 wherein, be stirred to dissolution homogeneity and stablize, be denoted as A liquid.

(2) in another reactor container, add emulsifier op-10 and each 8 parts of DBSA, then slowly add 40 parts of quintessence oils wherein, wherein tea tree oil 10 parts, Oleum Caryophylli 10 parts, citronella oil 10 parts, eucalyptus oil 10 parts, be stirred to dissolution homogeneity to stablize, be denoted as B liquid.

(3) under the effect of constantly stirring, B liquid is slowly added A liquid until two solution clears and uniform and stable till.

3. a kind of direct injection beriberi liquid containing bamboo wood vinegar and quintessence oil as described in right 1 is preparing the purposes in control trichophyton, Candida albicans, acrothesium floccosum, trichophyton gypseum medicine.