CN103493987B - A kind ofly prevent and treat water-soluble complex enzyme preparation of livestock and poultry diarrhea and growth promoting effects and preparation method thereof - Google Patents
A kind ofly prevent and treat water-soluble complex enzyme preparation of livestock and poultry diarrhea and growth promoting effects and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of water-soluble complex enzyme preparation of preventing and treating livestock and poultry diarrhea and growth promoting effects, it is mixed by water-soluble dilution carrier and active component; Described active component is made up of zytase, 'beta '-mannase, lipase, alpha-galactosidase, glucose oxidase.Water-soluble complex enzyme preparation of the present invention directly arrives stomach and intestine by drinking-water, the vigor of the various enzyme of quick active endogenous, participate in endocrine metabolic diseases, improve immunity of organisms, regulating intestinal canal micro-ecological environment, reduces chyme viscosity and improves livestock and poultry to the absorption of nutriment, improve the utilization rate of Dietary Energy and protein, reduce intestines problem, control livestock and poultry diarrhea; Improve the feed intake of livestock and poultry, growth promoting effects.
Description
Technical field
The present invention relates to veterinary drug field, be specifically related to a kind ofly prevent and treat water-soluble complex enzyme preparation of livestock and poultry diarrhea and growth promoting effects and preparation method thereof.
Background technology
Livestock and poultry diarrhea is one of principal disease of puzzlement aquaculture sound development.Livestock and poultry diarrhea can be divided into bacterial diarrhea according to its pathogenic factor, as: piglet yellow-white dysentery, dysentery characterized by white mucous stool, paratyphoid etc.; Virus diarrhea, such as: pig epidemic diarrhea, pig transmissible stomach and intestine etc.; Also have parasitic diarrhea, trophism diarrhea, irritability diarrhoea etc.Effectively to take precautions against livestock and poultry diarrhea, must adhere to preventing overweighting the principle controlled.Livestock and poultry are once suffer from diarrhoea, its intestines and stomach will inevitably be subject to impact in various degree, even if through treatment recovery from illness, its gastrointestinal function is also difficult to recover normal, and cause and affect body digesting and assimilating nutriment, and then cause weightening finish and the price of deed to be affected, carry out larger economic loss to cultivation industrial belt.
At present, often have antibiotic product, herbal product, probiotics, enzyme preparation etc. for preventing and treating livestock and poultry diarrhea, wherein antibiotic product uses more general.Antibiotic product is effective to bacterial diarrhea, but invalid to viral, trophism, irritability diarrhoea, and a large amount of antibiotic that uses easily makes pathogen produce drug resistance, threatens human health.Herbal product has certain effect to taste dysfunctional diarrhoea, uses and has significant limitation.Probiotics and enzyme preparation achieve better effects preventing and treating on livestock and poultry diarrhea, but because common probiotics and enzyme preparation are all used by spice, labour intensity is subject to the impact of feed environment greatly and easily and reduces activity or inactivation, and is difficult to meet using dosage when the ill appetite reduction of livestock and poultry or not material feeding and is difficult to reach desirable effect.
Summary of the invention
For overcoming the defect of prior art, of the present invention being provides a kind of water-soluble complex enzyme preparation of preventing and treating livestock and poultry diarrhea and growth promoting effects, directly arriving stomach and intestine by drinking water, the vigor of the various enzyme of quick active endogenous, participating in endocrine metabolic diseases, improve immunity of organisms, regulating intestinal canal micro-ecological environment, reduces chyme viscosity and improves livestock and poultry to the absorption of nutriment, improve the utilization rate of Dietary Energy and protein, reduce intestines problem, control livestock and poultry diarrhea; Improve the feed intake of livestock and poultry, growth promoting effects, improves hair color outward appearance; Reducing labour intensity because not needing spice, removing from because feed mixes the impact of the unfavorable factor caused.
Another object of the present invention is to provide a kind of preparation method preventing and treating the water-soluble complex enzyme preparation of livestock and poultry diarrhea and growth promoting effects, simple to operation, easy to utilize.
The technical solution adopted in the present invention is as follows for achieving the above object:
Prevent and treat a water-soluble complex enzyme preparation for livestock and poultry diarrhea and growth promoting effects, it is made up of water-soluble dilution carrier and active component; Described active component is made up of zytase, 'beta '-mannase, lipase, alpha-galactosidase, glucose oxidase, and above-mentioned active component calculates zytase 100-350 ten thousand U, 'beta '-mannase 10-50 ten thousand U, lipase 50-200 ten thousand U, alpha-galactosidase 1-8 ten thousand U, glucose oxidase 0.2-1 ten thousand U by water-soluble enzyme vigor in every kilogram of water-soluble complex enzyme preparation.
The present invention can also be realized by following scheme:
As preferred scheme of the present invention, described water-soluble dilution carrier is lactose or gluconic acid sodium salt.
As preferred scheme of the present invention, described active component calculates by water-soluble enzyme vigor in every kilogram of water-soluble complex enzyme preparation and is respectively zytase 1,600,000 U, 'beta '-mannase 350,000 U, lipase 1,600,000 U, alpha-galactosidase 50,000 U, glucose oxidase 0.6 ten thousand U.
Prevent and treat a water-soluble complex enzyme preparation for livestock and poultry diarrhea and growth promoting effects, comprise the following steps:
1) premix: the zytase in above-mentioned active component, 'beta '-mannase, lipase, alpha-galactosidase, glucose oxidase are mixed with the water-soluble dilution carrier of equivalent, obtains premix;
2) mix: add remaining water-soluble dilution carrier in above-mentioned premix, to mixing.
In the present invention, xylan degrading, as a kind of main non-starch polysaccharide enzyme, is become compound sugar and wood sugar by zytase, effectively eliminates the adverse effect of Main Antinutritional Factors xylan, the viscosity of food in intestines is reduced, improve the diffusion velocity of endogenous enzyme-to-substrate, promote that substrate is combined with endogenous enzymes, be of value to the stability and activity that improve various digestive ferment, thus the activity of endogenous digestive ferment can be improved, promote digesting and assimilating of nutrient, improve plant recovery of nutrient, improve production performance; Reduce chyme fermentation in enteron aisle, suppress anaerobe colony growth, reduce micro organism quantity in enteron aisle, reduce disease; Generation has some immunocompetent little peptide, improves the immunity of livestock and poultry.'beta '-mannase eliminates the anti-oxidant action of beta-mannase, promotes animal digesting and assimilating nutriment; Its product manna oligosacchride can improve enteric microorganism environment, improves Immune Function In Animals.Lipase can be hydrolyzed by catalytic long-chain fatty glyceride, plays an important role in Regulating Lipid Metabolism.It can maintain normal fat deposition, participates in lipometabolic whole process, the metabolic disorder preventing fat surplus or deficiency from causing or pathology; Strengthen young animal digestion power, reduce risk of diarrhoea, lipase is the most basic enzyme of fat metabolism, adds the deficiency that Exogenous Lipase enzyme can supplement the endogenous digestive ferment of young animal, improves fat utilization rate, promote growth of animal, reduce diarrhea rate.Alpha-galactosidase can effectively be degraded the ANFs such as galactoside, reduces chyme viscosity, reduces the generation of diarrhoea; Destroy cell wall structure, promote nutriment release, improve the utilization ratio of feed Middle nutrition material; Reduce the livestock and poultry diarrhea phenomenon in young age that bean material causes; Strengthen immunologic function and resistance against diseases, reduce antibiotic dosage; Alleviate or avoid digestive organs compensatory hypertrophy and hypertrophy, reducing animal and maintain requirement, improving fodder energy and tire.Glucose oxidase can under oxygen consumption condition in catalysis enteron aisle glucose degradation produce gluconic acid and hydrogen peroxide, remove with oxygen in intestines and concentration of hydrogen peroxide accumulation, suppress harmful bacteria as the growth such as Escherichia coli, salmonella, remove livestock and poultry a large amount of free radicals that intestinal epithelial cell produces when stress situation, protection intestinal epithelial cell is complete, suppresses pathogen invasion; The gluconic acid generated plays acidulant effect in enteron aisle, creates sour environment, reduces pH value in stomach, and activate pepsin, the growth of stimulating lactic acid bacteria etc., also can strengthen digesting and assimilating of enteron aisle Middle nutrition material simultaneously, reduces diarrhoea.
Compared to existing technology, beneficial effect of the present invention is:
1, water-soluble complex enzyme preparation of the present invention is different from other normal enzyme preparation, it is multiple superpower enzyme combination among the strong ones and directly arrives stomach and intestine by drinking-water, the vigor of the various enzyme of quick active endogenous, participate in endocrine metabolic diseases, improve immunity of organisms, regulating intestinal canal micro-ecological environment, reduce chyme viscosity and improve livestock and poultry to the absorption of nutriment, improve the utilization rate of Dietary Energy and protein, reduce intestines problem, control livestock and poultry diarrhea, can not cause bacterial drug resistance, do not affect food security, it is remarkable by effect;
2, water-soluble complex enzyme preparation of the present invention can also improve the feed intake of livestock and poultry, growth promoting effects, improves hair color outward appearance;
3, reducing labour intensity because of not needing spice, removing from because feed mixes the impact of the unfavorable factor caused, in appetite of livestock and poultry decline or a kind of good using method and effectively can meet the requirement of using dosage when not eating.
Below in conjunction with concrete embodiment, the present invention is described in further detail.
Detailed description of the invention
Embodiment 1
A kind of water-soluble complex enzyme preparation of preventing and treating livestock and poultry diarrhea and growth promoting effects, calculate by water-soluble enzyme vigor in every kilogram of water-soluble complex enzyme preparation: zytase 1,000,000 U, 'beta '-mannase 200,000 U, lipase 1,000,000 U, alpha-galactosidase 40,000 U, glucose oxidase 10,000 U form, and dilution carrier is lactose;
Its preparation method is:
1) take zytase, 'beta '-mannase, lipase, alpha-galactosidase, glucose oxidase and same amount of lactose by above-mentioned water-soluble enzyme vigor and carry out premixed, obtain premix;
2) premix in above-mentioned steps is always mixed with remaining lactose, to obtain final product.
Embodiment 2
A kind of water-soluble complex enzyme preparation of preventing and treating livestock and poultry diarrhea and growth promoting effects, calculate by water-soluble enzyme vigor in every kilogram of water-soluble complex enzyme preparation: zytase 1,600,000 U, 'beta '-mannase 350,000 U, lipase 1,600,000 U, alpha-galactosidase 50,000 U, glucose oxidase 0.6 ten thousand U, dilution carrier is lactose.
Its preparation method is:
1) take zytase, 'beta '-mannase, lipase, alpha-galactosidase, glucose oxidase and same amount of lactose by above-mentioned water-soluble enzyme vigor and carry out premixed, obtain premix;
2) premix in above-mentioned steps is always mixed with remaining lactose, to obtain final product.
Embodiment 3
A kind of water-soluble complex enzyme preparation of preventing and treating livestock and poultry diarrhea and growth promoting effects, calculate by water-soluble enzyme vigor in every kilogram of water-soluble complex enzyme preparation: zytase 2,000,000 U, 'beta '-mannase 250,000 U, lipase 1,800,000 U, alpha-galactosidase 80,000 U, glucose oxidase 0.2 ten thousand U form, and dilution carrier is lactose.
Its preparation method is:
1) take zytase, 'beta '-mannase, lipase, alpha-galactosidase, glucose oxidase and same amount of lactose by above-mentioned water-soluble enzyme vigor and carry out premixed, obtain premix;
2) premix in above-mentioned steps is always mixed with remaining lactose, to obtain final product.
Embodiment 4
A kind of water-soluble complex enzyme preparation of preventing and treating livestock and poultry diarrhea and growth promoting effects, calculate by gram water-soluble enzyme vigor of water-soluble complex enzyme preparation in every thousand: zytase 2,500,000 U, 'beta '-mannase 150,000 U, lipase 800,000 U, alpha-galactosidase 30,000 U, glucose oxidase 0.5 ten thousand U form, and dilution carrier is gluconic acid sodium salt.
Its preparation method is:
1) take zytase, 'beta '-mannase, lipase, alpha-galactosidase, glucose oxidase and same amount of lactose by above-mentioned water-soluble enzyme vigor and carry out premixed, obtain premix;
2) premix in above-mentioned steps is always mixed with remaining lactose, to obtain final product.
Embodiment 5
A kind of water-soluble complex enzyme preparation of preventing and treating livestock and poultry diarrhea and growth promoting effects, calculate by gram water-soluble enzyme vigor of water-soluble complex enzyme preparation in every thousand: zytase 3,500,000 U, 'beta '-mannase 400,000 U, lipase 600,000 U, alpha-galactosidase 20,000 U, glucose oxidase 0.3 ten thousand U form, and dilution carrier is gluconic acid sodium salt.
Its preparation method is:
1) take zytase, 'beta '-mannase, lipase, alpha-galactosidase, glucose oxidase and same amount of lactose by above-mentioned water-soluble enzyme vigor and carry out premixed, obtain premix;
2) premix in above-mentioned steps is always mixed with remaining lactose, to obtain final product.
Effect example
1 experiment purpose
Investigate a kind of growth performance impact of water-soluble complex enzyme preparation on chicken preventing and treating livestock and poultry diarrhea and growth promoting effects and comprise daily gain, daily ingestion amount, feedstuff-meat ratio, ight soil situation, hair color outward appearance, mental status etc.
2 experiment materials and method
2.1 laboratory sample
Laboratory sample 1, the water-soluble complex enzyme preparation prepared by embodiment 2, prepares voluntarily, and drinking-water uses;
Laboratory sample 2, consistent with embodiment 2 enzyme activity and only containing zytase, lipase complex enzyme formulation, prepare voluntarily, spice uses.
2.2 animal used as test
The yellow cock seedling 300 of the short pin of 1 age in days, feeding and management and immunity, feed market is bought the product of Guangdong major company production and sales, free choice feeding and drinking-water routinely.Raising to starting experiment during 4 age in days, being divided into 3 groups at random, often organize 100,3 weeks experimental periods.Concrete grouping situation is in table 1.
The experimental grouping of table 1 and disposal
2.3 testing index
2.3.1 measure the index of correlation of production performance, record the heavy and daily ingestion amount in each group of original body mass and end, calculate feedstuff-meat ratio;
2.3.2 ight soil situation, hair color, the state of mind of each group of every day is recorded.
3 experimental results
3.1 impacts on production performance
Table 2 affects the production performance of chicken
As can be seen from the table, namely group 1 employs water-soluble complex enzyme preparation, can significantly improve feed intake and daily gain, and reduce feedstuff-meat ratio, growth promoting effects, improves food conversion ratio, thus increases economic efficiency.
3.2 ight soil situations, hair color outward appearance, the state of mind are observed
That is blank group ight soil water content is more for ight soil situation group 3, and has the chicken of 42% to occur excrement phenomenon of having loose bowels; Group 2 i.e. laboratory sample 2 groups, comparatively the ight soil of group 3 is slightly good, has the chicken of 18% to occur excrement phenomenon of having loose bowels; Group 1 i.e. laboratory sample 1 group, comparatively the ight soil of group 2 is good, and ight soil drying is tangible, without having loose bowels excrement phenomenon.
Hair color outward appearance, state of mind group 3 i.e. blank group and group 2 i.e. laboratory sample 2 groups, chicken feather, cockscomb, shank paler colour, and group 3 i.e. blank group feather is not next to the skin and part chicken occurs that feather is slightly in disorder, in group 3, the irregular size of chicken individuals is uneven; And that is the good feather of laboratory sample 1 group of chicken outward appearance light next to the skin is neat to organize 1, and evenly individual, cockscomb is red, feather color is dark, shank bright yellow color, and eyes have god, movable brisk.
Show from above experimental result, water-soluble complex enzyme preparation can pre-anti-diarrhea and growth promoting effects, improve hair color outward appearance; In addition, this laboratory sample 1 i.e. water-soluble complex enzyme preparation group uses always under freely drinking water, reduce labour intensity because needing spice to bring, and remove from because feed mixes the impact of the unfavorable factor caused, better economic benefit can be brought for aquaculture in above aspect.
Above-mentioned embodiment is only the preferred embodiment of the present invention; can not limit the scope of protection of the invention with this, change and the replacement of any unsubstantiality that those skilled in the art does on basis of the present invention all belong to the present invention's scope required for protection.
Claims (1)
1. prevent and treat a water-soluble complex enzyme preparation for livestock and poultry diarrhea and growth promoting effects, it is characterized in that: it is made up of water-soluble dilution carrier and active component, described water-soluble dilution carrier is lactose or gluconic acid sodium salt; Described active component is made up of zytase, 'beta '-mannase, lipase, alpha-galactosidase, glucose oxidase, and above-mentioned active component calculates by water-soluble enzyme vigor in every kilogram of water-soluble complex enzyme preparation and is respectively zytase 1,600,000 U, 'beta '-mannase 350,000 U, lipase 1,600,000 U, alpha-galactosidase 50,000 U, glucose oxidase 0.6 ten thousand U;
Its preparation process is as follows:
1) premix: the zytase in above-mentioned active component, 'beta '-mannase, lipase, alpha-galactosidase, glucose oxidase are mixed with the water-soluble dilution carrier of equivalent, obtains premix;
2) mix: add remaining water-soluble dilution carrier in above-mentioned premix, to mixing.
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| CN105309773A (en) * | 2015-03-26 | 2016-02-10 | 上海欧耐施生物技术有限公司 | Complex enzyme improving broiler chicken breeding performance and application |
| CN107927382A (en) * | 2017-10-30 | 2018-04-20 | 山东弘德农牧科技有限公司 | A kind of complex enzyme preparation for feeding and preparation method and application |
| CN107772126A (en) * | 2017-11-24 | 2018-03-09 | 郑荣 | Ostrich young age feed and preparation method thereof |
| CN109645238A (en) * | 2018-12-11 | 2019-04-19 | 北京盛拓达生物技术有限公司 | It is a kind of promote animal diets cellulose effective use enzyme preparation product and its application |
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Effective date of registration: 20160623 Address after: 527400 Yunfu City, Xinxing County Province, the new town of North East embankment road, No. 6 Patentee after: GUANGDONG WENS DAHUANONG BIOTECHNOLOGY CO., LTD. Address before: 527400, No. 2, Wen Science Park, east north embankment road, Xinxing County new town, Guangdong, Yunfu, three Patentee before: Guangdong Dahuanong Animal Health Products Co., Ltd. Patentee before: Zhaoqing Dahuanong Biological Pharmaceutical Co., Ltd. |