CN103491888A - 用于脊柱融合手术的组合物和方法 - Google Patents

用于脊柱融合手术的组合物和方法 Download PDF

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Publication number
CN103491888A
CN103491888A CN201180067451.1A CN201180067451A CN103491888A CN 103491888 A CN103491888 A CN 103491888A CN 201180067451 A CN201180067451 A CN 201180067451A CN 103491888 A CN103491888 A CN 103491888A
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CN
China
Prior art keywords
pdgf
scaffold material
bone
bone scaffold
microns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201180067451.1A
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English (en)
Chinese (zh)
Inventor
S.E.林奇
L.B.斯內尔
C.K.希
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Biomimetic Therapeutics LLC
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Biomimetic Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Biomimetic Therapeutics LLC filed Critical Biomimetic Therapeutics LLC
Priority to CN201810399549.0A priority Critical patent/CN108498873A/zh
Publication of CN103491888A publication Critical patent/CN103491888A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201180067451.1A 2010-12-13 2011-12-13 用于脊柱融合手术的组合物和方法 Pending CN103491888A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810399549.0A CN108498873A (zh) 2010-12-13 2011-12-13 用于脊柱融合手术的组合物和方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42264910P 2010-12-13 2010-12-13
US61/422649 2010-12-13
PCT/US2011/064698 WO2012082773A1 (en) 2010-12-13 2011-12-13 Compositions and methods for spine fusion procedures

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810399549.0A Division CN108498873A (zh) 2010-12-13 2011-12-13 用于脊柱融合手术的组合物和方法

Publications (1)

Publication Number Publication Date
CN103491888A true CN103491888A (zh) 2014-01-01

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CN201810399549.0A Pending CN108498873A (zh) 2010-12-13 2011-12-13 用于脊柱融合手术的组合物和方法

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Country Status (10)

Country Link
US (2) US20140308332A1 (https=)
EP (1) EP2651319A4 (https=)
JP (3) JP6116484B2 (https=)
KR (3) KR20180121674A (https=)
CN (2) CN103491888A (https=)
AU (1) AU2011343995A1 (https=)
BR (1) BR112013014686A2 (https=)
CA (1) CA2819258C (https=)
MX (1) MX362405B (https=)
WO (1) WO2012082773A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106999634A (zh) * 2014-08-28 2017-08-01 佰欧维恩图斯有限责任公司 改进的骨诱导基材及其制备方法

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JP5992435B2 (ja) 2010-12-21 2016-09-14 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 循環からの生体分子の除去剤
MX2017004520A (es) 2014-10-14 2018-03-15 Lynch Samuel Composiciones para tratar heridas.
AU2015374114B2 (en) 2014-12-29 2018-07-26 Bioventus, Llc Systems and methods for improved delivery of osteoinductive molecules in bone repair
WO2017019959A1 (en) * 2015-07-30 2017-02-02 Clarion Research Group Formulations and methods for recovery from spinal surgery
KR20180079368A (ko) 2015-10-30 2018-07-10 바이오벤터스 엘엘씨 골 복구에서 골유도 분자의 증진된 전달을 위한 매트릭스
WO2017209823A2 (en) 2016-03-14 2017-12-07 The University Of Chicago Injectable pastes based on oppositely charged polymer/calcium phosphate hybrid nanoparticles
EP3468626A1 (en) 2016-06-10 2019-04-17 Bioventus LLC Protein delivery with porous metallic structure
WO2019014576A1 (en) * 2017-07-14 2019-01-17 The University Of Chicago LYOPHILIZED FORMULATIONS COMPRISING NANOPARTICLES AND METHODS OF LYOPHILIZATION
WO2020186267A2 (en) * 2019-03-14 2020-09-17 Biomimetic Therapeutics, Llc Platelet-derived growth factor formulations for enhancing bone fusion
EP3795185A1 (en) * 2019-09-23 2021-03-24 Kuros Biosurgery AG Bone graft material for use in a spinal fusion method
CN111481741A (zh) * 2020-04-15 2020-08-04 花沐医疗科技(上海)有限公司 复合可吸收自锁定颈椎融合器及其制备方法
KR102667977B1 (ko) 2020-05-08 2024-05-22 주식회사 에이치엘클레무브 차량용 레이더 장치 및 제어방법
AU2024327164A1 (en) 2023-08-18 2026-02-26 Stryker Corporation Platelet-derived growth factor bone graft putty formulation

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US20060292200A1 (en) * 2005-06-22 2006-12-28 David Delaney Porous beta-tricalcium phosphate and methods for producing the same
CN101121753A (zh) * 2007-06-06 2008-02-13 天津溥瀛生物技术有限公司 对多种皮肤细胞修复具持续作用的人血清白蛋白重组融合蛋白
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WO2008134411A2 (en) * 2007-04-25 2008-11-06 Jmea Corporation Spinal fixation with selectively applied bone growth promoting agent
CN101820895A (zh) * 2007-06-04 2010-09-01 生物模拟治疗公司 用于治疗脊柱的组合物和方法

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KR20080084808A (ko) * 2005-11-17 2008-09-19 바이오미메틱 세라퓨틱스, 인크. ｒｈＰＤＧＦ-ＢＢ 및 생체적합성 매트릭스를 사용하는상악안면골 보강
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Publication number Priority date Publication date Assignee Title
US20060292200A1 (en) * 2005-06-22 2006-12-28 David Delaney Porous beta-tricalcium phosphate and methods for producing the same
WO2008073628A2 (en) * 2006-11-03 2008-06-19 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
WO2008134411A2 (en) * 2007-04-25 2008-11-06 Jmea Corporation Spinal fixation with selectively applied bone growth promoting agent
CN101820895A (zh) * 2007-06-04 2010-09-01 生物模拟治疗公司 用于治疗脊柱的组合物和方法
CN101121753A (zh) * 2007-06-06 2008-02-13 天津溥瀛生物技术有限公司 对多种皮肤细胞修复具持续作用的人血清白蛋白重组融合蛋白

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106999634A (zh) * 2014-08-28 2017-08-01 佰欧维恩图斯有限责任公司 改进的骨诱导基材及其制备方法

Also Published As

Publication number Publication date
JP2018161541A (ja) 2018-10-18
EP2651319A4 (en) 2016-08-17
US20140308332A1 (en) 2014-10-16
JP2017018710A (ja) 2017-01-26
CA2819258C (en) 2020-03-10
KR20200055149A (ko) 2020-05-20
CA2819258A1 (en) 2012-06-21
EP2651319A1 (en) 2013-10-23
US20190365946A1 (en) 2019-12-05
CN108498873A (zh) 2018-09-07
MX2013006697A (es) 2013-10-30
KR20180121674A (ko) 2018-11-07
JP2013545584A (ja) 2013-12-26
JP6116484B2 (ja) 2017-04-19
AU2011343995A1 (en) 2013-06-20
BR112013014686A2 (pt) 2016-10-04
MX362405B (es) 2019-01-15
WO2012082773A1 (en) 2012-06-21
KR20140038348A (ko) 2014-03-28

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Application publication date: 20140101