CN103476252B - 吡唑基胍f1f0‑atp酶抑制剂及其治疗用途 - Google Patents

吡唑基胍f1f0‑atp酶抑制剂及其治疗用途 Download PDF

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CN103476252B
CN103476252B CN201180065940.3A CN201180065940A CN103476252B CN 103476252 B CN103476252 B CN 103476252B CN 201180065940 A CN201180065940 A CN 201180065940A CN 103476252 B CN103476252 B CN 103476252B
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CN103476252A (zh
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G·D·格利克
A·R·赫德
C·B·泰勒
C·A·范于斯
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Lycera Corp
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CN201180065940.3A 2010-12-08 2011-12-08 吡唑基胍f1f0‑atp酶抑制剂及其治疗用途 Expired - Fee Related CN103476252B (zh)

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US42095010P 2010-12-08 2010-12-08
US61/420,950 2010-12-08
PCT/US2011/063950 WO2012078874A1 (en) 2010-12-08 2011-12-08 Pyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof

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CN103476252B true CN103476252B (zh) 2017-02-22

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US (4) US9139532B2 (de)
EP (1) EP2648511B1 (de)
JP (2) JP6096673B2 (de)
CN (1) CN103476252B (de)
AU (1) AU2011338309B2 (de)
CA (1) CA2820065C (de)
CY (1) CY1119432T1 (de)
DK (1) DK2648511T3 (de)
ES (1) ES2639439T3 (de)
HR (1) HRP20171280T1 (de)
HU (1) HUE035881T2 (de)
IL (1) IL226789A (de)
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PT (1) PT2648511T (de)
RS (1) RS56457B1 (de)
SI (1) SI2648511T1 (de)
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US9169199B2 (en) 2010-12-08 2015-10-27 Lycera Corporation Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
WO2012078869A1 (en) 2010-12-08 2012-06-14 Lycera Corporation Pyridonyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof
ES2639439T3 (es) 2010-12-08 2017-10-26 Lycera Corporation Inhibidores de F1F0-ATPasas de tipo pirazolilguanidina y sus usos terapéuticos de éstos
US9920012B2 (en) 2012-06-08 2018-03-20 Lycera Corporation Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
WO2013185048A2 (en) 2012-06-08 2013-12-12 Lycera Corporation Heterocyclic guanidine f1f0-atpase inhibitors and therapeutic uses thereof
EP2861225A4 (de) * 2012-06-08 2015-11-18 Lycera Corp Gesättigtes acylguanidin zur hemmung von f1f0-atpase
US9914706B2 (en) 2013-12-10 2018-03-13 Lycera Corporation N-substituted pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
US9266839B2 (en) * 2013-12-10 2016-02-23 Lycera Corporation Trifluoromethyl pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
CA2931850A1 (en) 2013-12-10 2015-06-18 Lycera Corporation Alkylpyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof
EP3412663B1 (de) * 2016-02-04 2022-09-07 Shionogi & Co., Ltd. Stickstoffhaltige heterozyklische und carbozyklische derivate mit trka-hemmender wirkung

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WO2010030891A2 (en) * 2008-09-11 2010-03-18 The Regents Of The University Of Michigan Aryl guanidine f1f0-atpase inhibitors and related methods
CN101855203A (zh) * 2007-09-14 2010-10-06 密执安州立大学董事会 F1f0-atp合成酶抑制剂以及相关的方法

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