CN103476252B - 吡唑基胍f1f0‑atp酶抑制剂及其治疗用途 - Google Patents

吡唑基胍f1f0‑atp酶抑制剂及其治疗用途 Download PDF

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CN103476252B
CN103476252B CN201180065940.3A CN201180065940A CN103476252B CN 103476252 B CN103476252 B CN 103476252B CN 201180065940 A CN201180065940 A CN 201180065940A CN 103476252 B CN103476252 B CN 103476252B
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CN103476252A (zh
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G·D·格利克
A·R·赫德
C·B·泰勒
C·A·范于斯
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Lycera Corp
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CN201180065940.3A 2010-12-08 2011-12-08 吡唑基胍f1f0‑atp酶抑制剂及其治疗用途 Expired - Fee Related CN103476252B (zh)

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US42095010P 2010-12-08 2010-12-08
US61/420,950 2010-12-08
PCT/US2011/063950 WO2012078874A1 (en) 2010-12-08 2011-12-08 Pyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof

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CN103476252B true CN103476252B (zh) 2017-02-22

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US (4) US9139532B2 (de)
EP (1) EP2648511B1 (de)
JP (2) JP6096673B2 (de)
CN (1) CN103476252B (de)
AU (1) AU2011338309B2 (de)
CA (1) CA2820065C (de)
CY (1) CY1119432T1 (de)
DK (1) DK2648511T3 (de)
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HR (1) HRP20171280T1 (de)
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PT (1) PT2648511T (de)
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LT2648511T (lt) 2010-12-08 2017-10-10 Lycera Corporation Pirazolil-guanidino f1f0-atpazės inhibitoriai ir jų terapinis panaudojimas
CN103458886B (zh) 2010-12-08 2016-06-08 莱斯拉公司 吡啶酮基胍f1f0-atp酶抑制剂及其治疗用途
US9169199B2 (en) 2010-12-08 2015-10-27 Lycera Corporation Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
WO2013185046A1 (en) * 2012-06-08 2013-12-12 Lycera Corporation Saturated acyl guanid1ne for inhibition of f1f0-atpase
WO2013185045A1 (en) 2012-06-08 2013-12-12 Lycera Corporation Indazole guanidine f1f0-atpase inhibitors and therapeutic uses thereof
US9221814B2 (en) 2012-06-08 2015-12-29 Lycera Corporation Heterocyclic guanidine F1F0-atpase inhibitors and therapeutic uses thereof
MX2016007445A (es) * 2013-12-10 2016-09-09 Lycera Corp Inhibidores de f1f0-atpasa de trifluorometil pirazolil guanidina y usos terapeuticos de los mismos.
EP3080088B1 (de) 2013-12-10 2019-07-31 Lycera Corporation Alkylpyrazolyl-guanidin-f1f0-atpase-hemmer und therapeutische verwendungen davon
JP2016539993A (ja) * 2013-12-10 2016-12-22 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ Ｎ−置換ピラゾリルグアニジンｆ１ｆ０−ａｔｐアーゼ阻害剤及びその治療用途
EP3412663B1 (de) * 2016-02-04 2022-09-07 Shionogi & Co., Ltd. Stickstoffhaltige heterozyklische und carbozyklische derivate mit trka-hemmender wirkung

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WO2010030891A2 (en) * 2008-09-11 2010-03-18 The Regents Of The University Of Michigan Aryl guanidine f1f0-atpase inhibitors and related methods
CN101855203A (zh) * 2007-09-14 2010-10-06 密执安州立大学董事会 F1f0-atp合成酶抑制剂以及相关的方法

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