PL2648511T3 - Pirazoliloguanidynowe inhibitory F1F0-ATPaz i ich zastosowania terapeutyczne - Google Patents

Pirazoliloguanidynowe inhibitory F1F0-ATPaz i ich zastosowania terapeutyczne

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Publication number
PL2648511T3
PL2648511T3 PL11846595T PL11846595T PL2648511T3 PL 2648511 T3 PL2648511 T3 PL 2648511T3 PL 11846595 T PL11846595 T PL 11846595T PL 11846595 T PL11846595 T PL 11846595T PL 2648511 T3 PL2648511 T3 PL 2648511T3
Authority
PL
Poland
Prior art keywords
therapeutic uses
atpase inhibitors
pyrazolyl guanidine
guanidine
pyrazolyl
Prior art date
Application number
PL11846595T
Other languages
English (en)
Inventor
Gary D. Glick
Alexander R. Hurd
Clarke B. Taylor
Chad A. Vanhuis
Original Assignee
Lycera Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lycera Corporation filed Critical Lycera Corporation
Publication of PL2648511T3 publication Critical patent/PL2648511T3/pl

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    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
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    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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PL11846595T 2010-12-08 2011-12-08 Pirazoliloguanidynowe inhibitory F1F0-ATPaz i ich zastosowania terapeutyczne PL2648511T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42095010P 2010-12-08 2010-12-08
EP11846595.4A EP2648511B1 (en) 2010-12-08 2011-12-08 Pyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof
PCT/US2011/063950 WO2012078874A1 (en) 2010-12-08 2011-12-08 Pyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
PL2648511T3 true PL2648511T3 (pl) 2017-12-29

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PL11846595T PL2648511T3 (pl) 2010-12-08 2011-12-08 Pirazoliloguanidynowe inhibitory F1F0-ATPaz i ich zastosowania terapeutyczne

Country Status (19)

Country Link
US (4) US9139532B2 (pl)
EP (1) EP2648511B1 (pl)
JP (2) JP6096673B2 (pl)
CN (1) CN103476252B (pl)
AU (1) AU2011338309B2 (pl)
CA (1) CA2820065C (pl)
CY (1) CY1119432T1 (pl)
DK (1) DK2648511T3 (pl)
ES (1) ES2639439T3 (pl)
HR (1) HRP20171280T1 (pl)
HU (1) HUE035881T2 (pl)
IL (1) IL226789A (pl)
LT (1) LT2648511T (pl)
MX (1) MX344590B (pl)
PL (1) PL2648511T3 (pl)
PT (1) PT2648511T (pl)
RS (1) RS56457B1 (pl)
SI (1) SI2648511T1 (pl)
WO (1) WO2012078874A1 (pl)

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Publication number Priority date Publication date Assignee Title
LT2648511T (lt) 2010-12-08 2017-10-10 Lycera Corporation Pirazolil-guanidino f1f0-atpazės inhibitoriai ir jų terapinis panaudojimas
CN103458886B (zh) 2010-12-08 2016-06-08 莱斯拉公司 吡啶酮基胍f1f0-atp酶抑制剂及其治疗用途
US9169199B2 (en) 2010-12-08 2015-10-27 Lycera Corporation Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
WO2013185046A1 (en) * 2012-06-08 2013-12-12 Lycera Corporation Saturated acyl guanid1ne for inhibition of f1f0-atpase
WO2013185045A1 (en) 2012-06-08 2013-12-12 Lycera Corporation Indazole guanidine f1f0-atpase inhibitors and therapeutic uses thereof
US9221814B2 (en) 2012-06-08 2015-12-29 Lycera Corporation Heterocyclic guanidine F1F0-atpase inhibitors and therapeutic uses thereof
MX2016007445A (es) * 2013-12-10 2016-09-09 Lycera Corp Inhibidores de f1f0-atpasa de trifluorometil pirazolil guanidina y usos terapeuticos de los mismos.
EP3080088B1 (en) 2013-12-10 2019-07-31 Lycera Corporation Alkylpyrazolyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof
JP2016539993A (ja) * 2013-12-10 2016-12-22 リセラ・コーポレイションLycera Corporation N−置換ピラゾリルグアニジンf1f0−atpアーゼ阻害剤及びその治療用途
EP3412663B1 (en) * 2016-02-04 2022-09-07 Shionogi & Co., Ltd. Nitrogen-containing heterocycle and carbocycle derivatives having trka inhibitory activity

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DK2648511T3 (en) 2017-09-18
EP2648511A4 (en) 2014-07-09
US20180334438A1 (en) 2018-11-22
US20170267643A1 (en) 2017-09-21
EP2648511A1 (en) 2013-10-16
CN103476252B (zh) 2017-02-22
CA2820065C (en) 2019-04-02
AU2011338309B2 (en) 2016-04-21
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US9139532B2 (en) 2015-09-22
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US9580388B2 (en) 2017-02-28
LT2648511T (lt) 2017-10-10
WO2012078874A1 (en) 2012-06-14
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US20130324536A1 (en) 2013-12-05
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IL226789A (en) 2015-07-30
EP2648511B1 (en) 2017-06-28
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