CN103459430B - 生产具有高堆积密度和良好流动性的纤维素衍生物的方法 - Google Patents

生产具有高堆积密度和良好流动性的纤维素衍生物的方法 Download PDF

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Publication number
CN103459430B
CN103459430B CN201280015844.2A CN201280015844A CN103459430B CN 103459430 B CN103459430 B CN 103459430B CN 201280015844 A CN201280015844 A CN 201280015844A CN 103459430 B CN103459430 B CN 103459430B
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cellulose
cellulose derivative
gas
derivative
impact mill
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Chinese (zh)
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CN103459430A (zh
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Y.M.戈尔拉科-多特
J.赫曼斯
M.格罗斯图克
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Nutrition And Biotechnology Usa First LLC
Dow Chemical Co
DDP Specialty Electronic Materials US LLC
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Dow Global Technologies LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/124—Treatment for improving the free-flowing characteristics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C13/00—Disintegrating by mills having rotary beater elements ; Hammer mills
    • B02C13/26—Details
    • B02C13/288—Ventilating, or influencing air circulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
    • B02C23/18—Adding fluid, other than for crushing or disintegrating by fluid energy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
    • B02C23/18—Adding fluid, other than for crushing or disintegrating by fluid energy
    • B02C23/24—Passing gas through crushing or disintegrating zone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/193—Mixed ethers, i.e. ethers with two or more different etherifying groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers
    • C08L1/284—Alkyl ethers with hydroxylated hydrocarbon radicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C08J2301/08—Cellulose derivatives
    • C08J2301/26—Cellulose ethers
    • C08J2301/28—Alkyl ethers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Cosmetics (AREA)
CN201280015844.2A 2011-04-06 2012-03-29 生产具有高堆积密度和良好流动性的纤维素衍生物的方法 Active CN103459430B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610585804.1A CN106188581B (zh) 2011-04-06 2012-03-29 生产具有高堆积密度和良好流动性的纤维素衍生物的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161472225P 2011-04-06 2011-04-06
US61/472,225 2011-04-06
PCT/US2012/031111 WO2012138532A2 (en) 2011-04-06 2012-03-29 Process for producing cellulose derivatives of high bulk density and good flowability

Related Child Applications (1)

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CN201610585804.1A Division CN106188581B (zh) 2011-04-06 2012-03-29 生产具有高堆积密度和良好流动性的纤维素衍生物的方法

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CN103459430A CN103459430A (zh) 2013-12-18
CN103459430B true CN103459430B (zh) 2016-08-17

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CN201610585804.1A Active CN106188581B (zh) 2011-04-06 2012-03-29 生产具有高堆积密度和良好流动性的纤维素衍生物的方法

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Country Link
US (2) US9352330B2 (enExample)
EP (1) EP2694035B1 (enExample)
JP (1) JP5977331B2 (enExample)
KR (2) KR20180132952A (enExample)
CN (2) CN103459430B (enExample)
BR (1) BR112013023380B1 (enExample)
MX (1) MX343509B (enExample)
WO (1) WO2012138532A2 (enExample)

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KR101916010B1 (ko) * 2011-04-06 2018-11-08 다우 글로벌 테크놀로지스 엘엘씨 신규한 폴리사카라이드 유도체 및 제형
EP2694035B1 (en) 2011-04-06 2024-11-06 Nutrition & Biosciences USA 1, LLC Process for producing cellulose derivatives of high bulk density and good flowability
EP2812294B8 (en) * 2012-02-10 2021-03-31 Nutrition & Biosciences USA 1, LLC Use of a cellulose derivative for the production of extrusion-molded ceramic bodies and a method for producing
CN104812827B (zh) * 2012-09-25 2017-03-08 陶氏环球技术有限责任公司 制备具有高堆积密度、良好流动性和/或冷水中分散性以及低溶液颜色的纤维素衍生物的方法
JP6334542B2 (ja) * 2012-09-27 2018-05-30 ダウ グローバル テクノロジーズ エルエルシー フライ食品の油及び／又は脂肪吸収を低減する方法
US10596261B2 (en) 2013-03-12 2020-03-24 Hercules Incorporated Coprocessed silica coated polymer composition
WO2015041973A1 (en) * 2013-09-23 2015-03-26 Dow Global Technologies Llc A process for recovering an esterified cellulose ether from a reaction product mixture
MX386901B (es) 2014-04-25 2025-03-19 Chugai Pharmaceutical Co Ltd Formulacion que contiene una gran cantidad de compuesto tetraciclico.
BR112017025103B1 (pt) * 2015-06-05 2022-05-10 Nutrition & Biosciences Usa 1, Llc Composição em pó
EP3303406B1 (en) 2015-06-05 2019-06-26 Dow Global Technologies LLC Cellulose ether powders
KR102519850B1 (ko) * 2016-10-07 2023-04-10 신에쓰 가가꾸 고교 가부시끼가이샤 히드록시알킬 알킬 셀룰로오스 및 그의 제조 방법, 및 고형 제제
KR102519854B1 (ko) * 2016-10-07 2023-04-10 신에쓰 가가꾸 고교 가부시끼가이샤 히드록시알킬 알킬 셀룰로오스 및 그의 제조 방법, 및 고형 제제
CN113117131B (zh) * 2019-12-31 2023-01-03 广州迈普再生医学科技股份有限公司 一种纳米纤维微球材料及其制备方法和应用
CN116745343A (zh) * 2021-01-13 2023-09-12 营养与生物科学美国1有限责任公司 用于制备胶态微晶纤维素的改善方法

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EP0384046A1 (en) * 1986-05-01 1990-08-29 The Dow Chemical Company Grinding process for high viscosity cellulose ethers
GB2262527A (en) * 1992-07-02 1993-06-23 Dow Deutschland Inc Process for grinding cellulose compounds
CN1311259A (zh) * 2000-02-28 2001-09-05 沃尔夫瓦尔斯罗德有限公司 用含蒸汽的过热气体混合物制备粒状、水溶性纤维素衍生物的方法
CN1311258A (zh) * 2000-02-28 2001-09-05 沃尔夫瓦尔斯罗德有限公司 生产粒状水溶性纤维素衍生物的方法
CN101243131A (zh) * 2005-08-16 2008-08-13 陶氏沃尔弗纤维素有限公司 制备具有更高粘度和细度的纤维素醚产品的方法
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Also Published As

Publication number Publication date
EP2694035A2 (en) 2014-02-12
US9352330B2 (en) 2016-05-31
MX343509B (es) 2016-11-08
CN103459430A (zh) 2013-12-18
CN106188581B (zh) 2019-08-16
US20160256390A1 (en) 2016-09-08
JP2014510184A (ja) 2014-04-24
US20140017319A1 (en) 2014-01-16
BR112013023380A2 (pt) 2017-04-25
JP5977331B2 (ja) 2016-08-24
KR101960244B1 (ko) 2019-03-21
CN106188581A (zh) 2016-12-07
KR20140027132A (ko) 2014-03-06
BR112013023380B1 (pt) 2021-03-23
EP2694035B1 (en) 2024-11-06
WO2012138532A3 (en) 2013-02-28
MX2013011588A (es) 2013-12-09
KR20180132952A (ko) 2018-12-12
WO2012138532A2 (en) 2012-10-11

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