CN103458923A - 用于产生蛋白复合物的方法和包含该蛋白复合物的疫苗组合物 - Google Patents

用于产生蛋白复合物的方法和包含该蛋白复合物的疫苗组合物 Download PDF

Info

Publication number
CN103458923A
CN103458923A CN2012800145739A CN201280014573A CN103458923A CN 103458923 A CN103458923 A CN 103458923A CN 2012800145739 A CN2012800145739 A CN 2012800145739A CN 201280014573 A CN201280014573 A CN 201280014573A CN 103458923 A CN103458923 A CN 103458923A
Authority
CN
China
Prior art keywords
stress
cell
protein complex
heat shock
exposed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2012800145739A
Other languages
English (en)
Chinese (zh)
Inventor
卡米洛·科拉科
伊恩·麦肯蒂
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunobiology Ltd
Original Assignee
Immunobiology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunobiology Ltd filed Critical Immunobiology Ltd
Publication of CN103458923A publication Critical patent/CN103458923A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0002—Fungal antigens, e.g. Trichophyton, Aspergillus, Candida
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001176—Heat shock proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Pulmonology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CN2012800145739A 2011-03-23 2012-03-23 用于产生蛋白复合物的方法和包含该蛋白复合物的疫苗组合物 Pending CN103458923A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1104897.2A GB201104897D0 (en) 2011-03-23 2011-03-23 Method for the production of protein complexes and vaccine compositions comprising the same
GB1104897.2 2011-03-23
PCT/GB2012/050650 WO2012127248A1 (en) 2011-03-23 2012-03-23 Method for the production of protein complexes and vaccine compositions comprising the same

Publications (1)

Publication Number Publication Date
CN103458923A true CN103458923A (zh) 2013-12-18

Family

ID=44013038

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2012800145739A Pending CN103458923A (zh) 2011-03-23 2012-03-23 用于产生蛋白复合物的方法和包含该蛋白复合物的疫苗组合物

Country Status (9)

Country Link
US (2) US10240179B2 (enExample)
EP (1) EP2688589B1 (enExample)
JP (1) JP6009532B2 (enExample)
CN (1) CN103458923A (enExample)
AU (2) AU2012232878A1 (enExample)
BR (1) BR112013024229A2 (enExample)
CA (1) CA2829678C (enExample)
GB (1) GB201104897D0 (enExample)
WO (1) WO2012127248A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108379553A (zh) * 2018-05-28 2018-08-10 上海市第人民医院 热休克蛋白20在氧化应激损伤疾病中的应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007285775B2 (en) * 2006-08-17 2011-03-03 Sanofi Pasteur Ltd. Immunogenic PcpA polypeptides and uses thereof
GB201104897D0 (en) * 2011-03-23 2011-05-04 Immunobiology Ltd Method for the production of protein complexes and vaccine compositions comprising the same
EP3896152A1 (en) * 2012-03-22 2021-10-20 Avita Medical Ltd Cell suspension and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001063278A2 (en) * 2000-02-23 2001-08-30 Immunobiology Limited Antigenic fragments associated with stress-induced proteins and their use as vaccines

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE175443T1 (de) * 1991-06-03 1999-01-15 Arch Dev Corp Verfahren und zusammensetzungen des genetischen stressantwortsystems
US5961979A (en) 1994-03-16 1999-10-05 Mount Sinai School Of Medicine Of The City University Of New York Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens
US5935576A (en) 1995-09-13 1999-08-10 Fordham University Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens
GB9818133D0 (en) * 1998-08-19 1998-10-14 Quadrant Holdings Cambridge Vaccine
US6495360B1 (en) 1999-05-28 2002-12-17 Photogen, Inc. Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins
GB9919734D0 (en) * 1999-08-19 1999-10-20 Colaco Camilo Vaccines from infectious agents
GB9919733D0 (en) 1999-08-19 1999-10-20 Colaco Camilo Vaccines against intracellular pathogens
WO2001026432A1 (fr) 1999-10-01 2001-04-12 Seiko Epson Corporation Plaquette imprimee, dispositif a semi-conducteur et son procede de fabrication, ses essais et sa mise en boitier, et circuit integre et equipement electronique
GB0021757D0 (en) 2000-09-04 2000-10-18 Colaco Camilo Vaccine against microbial pathogens
WO2002028407A1 (en) 2000-09-29 2002-04-11 University Of Connecticut Health Center Methods of recovering heat shock proteins and complexes thereof
WO2009148608A1 (en) * 2008-06-03 2009-12-10 Bin Zhang Screening methods for heat-shock response modulators
GB0816242D0 (en) 2008-09-05 2008-10-15 Immunobiology Ltd Method of purifying protien complexes
GB0910591D0 (en) 2009-06-19 2009-07-29 Immunobiology Ltd Method for the purification of protein complexes
GB0916557D0 (en) 2009-09-21 2009-10-28 Health Prot Agency Commensal neisserial stress protein complexes
GB201104897D0 (en) * 2011-03-23 2011-05-04 Immunobiology Ltd Method for the production of protein complexes and vaccine compositions comprising the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001063278A2 (en) * 2000-02-23 2001-08-30 Immunobiology Limited Antigenic fragments associated with stress-induced proteins and their use as vaccines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108379553A (zh) * 2018-05-28 2018-08-10 上海市第人民医院 热休克蛋白20在氧化应激损伤疾病中的应用

Also Published As

Publication number Publication date
BR112013024229A2 (pt) 2016-12-20
CA2829678C (en) 2019-07-09
JP6009532B2 (ja) 2016-10-19
EP2688589B1 (en) 2017-05-17
US10669563B2 (en) 2020-06-02
EP2688589A1 (en) 2014-01-29
US20190241923A1 (en) 2019-08-08
AU2017203173A1 (en) 2017-07-27
WO2012127248A1 (en) 2012-09-27
AU2012232878A1 (en) 2013-09-26
AU2017203173B2 (en) 2019-07-11
GB201104897D0 (en) 2011-05-04
JP2014510093A (ja) 2014-04-24
US10240179B2 (en) 2019-03-26
US20140017274A1 (en) 2014-01-16
CA2829678A1 (en) 2012-09-27

Similar Documents

Publication Publication Date Title
Hasson et al. The past, current and future trends in DNA vaccine immunisations
CN101524532B (zh) 单剂量猪肺炎支原体疫苗
US10669563B2 (en) Method for the production of protein complexes and vaccine compositions comprising the same
CN112159479B (zh) 一种鸡毒支原体多抗原表位融合蛋白pMG-mEA及其应用
CN102238960B (zh) 制造疫苗的方法
CN105497885B (zh) 一种亚单位疫苗及其制备方法和应用
CN108220183B (zh) 一株马流产沙门氏菌菌株smxj-97及其在马流产沙门氏菌疫苗中的应用
Rahman et al. Development of experimental oil based inactivated HS vaccine from field Isolates of Pasteurella multocida from Cattle in Bangladesh
JP2022520925A (ja) 弱毒化ボルデテラ・ブロンキセプチカ株、当該弱毒化株を含む経口ワクチン並びに前記の製造及び使用方法
RU2098127C1 (ru) Ассоциированная вакцина "нековак" против некробактериоза крупного рогатого скота
CN103497926B (zh) 表达分泌人类p53蛋白的重组BCG活菌菌株、活菌疫苗及其构建方法和应用
RU2529359C2 (ru) РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pPA-OPRF-ETA, КОДИРУЮЩАЯ СИНТЕЗ РЕКОМБИНАНТНОГО БЕЛКА OPRF-ETA Pseudomonas aeruginosa, ШТАММ Escherichia coli PA-OPRF-ETA - ПРОДУЦЕНТ РЕКОМБИНАНТНОГО БЕЛКА OPRF-ETA Pseudomonas aeruginosa И СПОСОБ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО БЕЛКА OPRF-ETA Pseudomonas aeruginosa
RU2263143C2 (ru) Штамм бактерий streptococcus pyogenes №289, используемый для изготовления вакцин против стрептококкоза пушных зверей
NL8020132A (nl) Een vaccin voor de bestrijding van pleuropneumonie bij varkens en een werkwijze en een substraat voor de aerobe fermentatie van haemophilus pleuropneumoniae.
RU2689903C1 (ru) Свежевыделенный штамм бактерий Bordetella pertussis - продуцент комплекса протективных антигенов для производства бесклеточной коклюшной вакцины
JP2011511630A (ja) Ｐ．ｍｕｌｔｏｃｉｄａのｆｕｒ細胞およびその外膜タンパク質の抽出物によるＰａｓｔｅｕｒｅｌｌａｍｕｌｔｏｃｉｄａに対する異種性の防御
JP6039648B2 (ja) 併用ワクチン
RU2098128C1 (ru) Ассоциированная вакцина "овикон" против инфекционных заболеваний конечностей овец
EP1204420B1 (en) Trehalose producing prokaryotic cells as vaccines
RU2391999C2 (ru) Способ повышения иммуногенности живых вакцин из rs (sr) штаммов бруцелл
RU2389505C1 (ru) Вакцина ассоциированная против псевдомоноза и энтерококковой инфекции нутрий
RU2540144C1 (ru) СПОСОБ ПОЛУЧЕНИЯ АНАТОКСИНА Bordetella pertussis
CN119775404A (zh) 猫过敏原Fel d1卵黄抗体及其制备方法、应用
RU2301681C1 (ru) Вакцина ассоциированная против колибактериоза, сальмонеллеза и стрептококкоза нутрий
Abdolmohammadi et al. Preparation of concentrated blackleg vaccine

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20131218