CN103445177A - Medicine capable of improving immunity and preparation method thereof - Google Patents
Medicine capable of improving immunity and preparation method thereof Download PDFInfo
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- CN103445177A CN103445177A CN2013104396906A CN201310439690A CN103445177A CN 103445177 A CN103445177 A CN 103445177A CN 2013104396906 A CN2013104396906 A CN 2013104396906A CN 201310439690 A CN201310439690 A CN 201310439690A CN 103445177 A CN103445177 A CN 103445177A
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Abstract
The invention discloses medicine capable of improving immunity and a preparation method thereof, and relates to health care medicine. The medicine capable of improving immunity comprises the following components, by weight, 22-26 parts of radix astragali, 35-45 parts of Chinese yam, 22-26 parts of fried hawthorn, 22-26 parts of poria cocos, and 8-12 parts of cervus elaphus linnaeus. The medicine is good in taste, easy to absorb, has the functions of improving immunity of human bodies, improving body health level, and eliminating sub-health, and is good and free of toxic side effect.
Description
Technical field
The present invention relates to a kind of health medicine, be specifically related to a kind of medicine that strengthens immunity and preparation method thereof.
Background technology
Along with social progress and economic development, the healthy growing interest of people to self.Because now social rhythm is fast, people are often for a long time in fatigue state, thereby are easy to be invaded and harassed by various diseases, and in order to strengthen the health of self, people have strengthened the demand to nutrient and healthcare products gradually.
Yet present health products on the market are various in style, but most health-care effect is general, and expensive, is difficult to universal.
Summary of the invention
The purpose of this invention is to provide a kind of medicine that strengthens immunity and preparation method thereof.
The present invention is achieved by the following technical solutions:
A kind of medicine that strengthens immunity comprises each component of following weight portion:
Radix Astragali 22-26 Chinese yam 35-45 stir-baked FRUCTUS CRATAEGI 22-26
Poria cocos 22-26 cervus elaphus linnaeus 8-12.
Further, above-mentioned for strengthening the medicine of immunity, comprise each component of following weight portion:
The Radix Astragali 24 Chinese yam 40 stir-baked FRUCTUS CRATAEGIs 24
Poria cocos 24 cervus elaphus linnaeus 10.
Further, said medicine, also comprise starch and dolomol, and wherein starch accounts for the 1-3% of medicine gross mass, and dolomol accounts for the 1-2.5% of medicine gross mass.
Above-mentioned raw materials is made to medicinal preparation for oral administration according to conventional method, i.e. the above tablet, pill, powder, capsule etc. of pharmacy, the preferred formulation of the present invention is capsule.
The preparation method of medicine capsule of the present invention is as follows:
(1) by the Poria cocos of the Radix Astragali, Chinese yam, stir-baked FRUCTUS CRATAEGI and 5/6 formula ratio, to soak and extract 2 times, twice decocting liquid merges filtration, is concentrated into the medicinal extract of relative density 1.2;
(2), by the pulverizer dry pulverization process Poria cocos powder that sieves to obtain for the Poria cocos of 1/6 formula ratio, after sterilizing, add in medicinal extract and mix, 60 ℃~80 ℃ vacuum drying, the dry extract obtained;
(3) cervus elaphus linnaeus is burned to the pilose antler fine hair with alcolhol burner, with bamboo cutter scraping, pilose antler is immersed in 50 ℃ of alcohol, infiltrate 0.5--l hour, treat the slightly soft taking-up of cutin, section, cross 80 mesh sieves after after drying, wild deer antler slice being pulverized, and obtains the cervus elaphus linnaeus powder, sterilizing;
(4) starch, dolomol are added in dry extract together with the cervus elaphus linnaeus powder, be mixed to evenly, in incapsulating, make capsule.
In prescription of the present invention, the Radix Astragali is relatively mended the flesh table and is defended gas, and the nutrition and health care beauty functions is very remarkable, and Glycerin is arranged, skin maintenance, recuperating qi-blood, the effect of the mood of releiving; The multiple efficacies such as Chinese yam has invigorating the spleen, tonifying lung, reinforces the kidney, benefit essence; Stir-baked FRUCTUS CRATAEGI has promoting digestion and removing indigestion, the effects such as lowering blood-fat and reducing weight; Poria cocos has clearing damp and promoting diuresis, mental-tranquilization, invigorating the spleen, the effect of reducing phlegm; Cervus elaphus linnaeus has invigorating kidney yang, benefiting essence-blood, strengthening the bones and muscles, adjust punching to appoint, the holder sore, also have anti-anoxic, increase intelligence, strong, promote glycolysis, promote nucleic acid and the effect such as protein is synthetic; In side, the Radix Astragali, Chinese yam, stir-baked FRUCTUS CRATAEGI, Poria cocos, pilose antler mix use, have the effect that strengthens immunity.
After testing, thick polysaccharide (in glucan) in medicine of the present invention, content >=1750mg/100g, Astragaloside IV >=16mg/100g.
In order to verify the curative effect of medicine of the present invention, carried out following test:
One, medicament capsule human body recommended amounts of the present invention is 2.8g/60kg.bw every day.Select female kunming mice, body weight 18-23g, totally 192, be divided into four groups, three dosage groups, i.e. 0.23g/60kg.bw group, 0.47g/kg.bw group, 1.4g/kg.bw group are established in experiment, the dosage of basic, normal, high dosage group is equivalent to respectively 5 times, 10 times, 30 times of human body recommended intake, with distilled water, sample is assigned to desired concn, sets up the distilled water control group simultaneously, by every day 0.2ml/10g.bw per os gavage to sample.Experimental result shows, medicine of the present invention can improve pedal swelling and the spleen lymphocyte proliferation ability of mouse, improve Peritoneal macrophage function, engulf index and NK cytoactive, antibody-producting cell number, serum hemolysin, the monocytes/macrophages carbon of mouse are cleaned up to index, spleen/body weight ratio and thymus gland/body weight ratio to be had no significant effect, according to " health food check and assessment technique standard " criterion, medicine of the present invention has the effect that strengthens immunity.
Two, medicament capsule human body recommended amounts of the present invention is 2.8g/60kg.bw every day.Select clean level kunming mice, clean level Wistar rat, feeding environment is room temperature 23-25 ℃, and relative humidity 52-68% carries out respectively the test of chmice acute Oral toxicity, Salmonella reversion test, mouse marrow cell micro nuclear test, mouse sperm deformity test, 30 days feeding trials of rat.
Through the test of chmice acute Oral toxicity, show that medicine of the present invention all is greater than 15g/kg.bw to male and female its mouse oral MTD, be nontoxic level material; Through Salmonella reversion test, mouse marrow cell micro nuclear test and mouse sperm deformity test, show that medicine of the present invention does not have mutagenicity; Through 30 days feeding trials of rat, show that medicine of the present invention has no adverse effects than all to activity, feed, body weight gain, red blood cell number, content of hemoglobin, leukocyte count and classification, hepatic and renal function, protein metabolism, fat metabolism, glycometabolism, internal organs weight in wet base and the dirty body of animal, substantially reaching under mirror of each main organs checks and has been showed no the specificity pathological change.
In sum, in order to verify the drug effect of medicine of the present invention, the inventor for this rubber of this life hall board capsule, has carried out a large amount of test and clinical by drug nomenclature of the present invention, and result shows that the medicine mouthfeel is good, easily absorb, there is the enhancing body immunity, improve body health level, eliminate the effect of inferior health, be a kind of health medicine of good enhancing immunity, and have no side effect.
The accompanying drawing explanation
The preparation flow block diagram that Fig. 1 is medicine of the present invention.
The specific embodiment
Below in conjunction with specific embodiment, the present invention will be further described.
Embodiment 1
Take Radix Astragali 24g, Chinese yam 40g, stir-baked FRUCTUS CRATAEGI 24g, Poria cocos 24g, cervus elaphus linnaeus 10g.
The preparation method:
(1) take the Poria cocos of the Radix Astragali, Chinese yam, stir-baked FRUCTUS CRATAEGI, 5/6 formula ratio by formula ratio, soak approximately 30 minutes, extract 2 times, add for the first time 10 times of water gagings, extract 2 hours, add for the second time 8 times of water gagings and extract 1.5 hours, twice decocting liquid merges and filters, and is evaporated to the medicinal extract of relative density 1.2 under 0.08Mpa, 60 ℃;
(2) pulverizer dry pulverization process, mistake 80 mesh sieves for the Poria cocos of 1/6 formula ratio are obtained to Poria cocos powder, with after dosage 5KGy, Co60 irradiation sterilization, add in medicinal extract and mix, 60 ℃ ~ 80 ℃ lower vacuum drying, the dry extract obtained was pulverized 80 mesh sieves, standby;
(3) cervus elaphus linnaeus is burned to the pilose antler fine hair with alcolhol burner, with bamboo cutter scraping, pilose antler is immersed in 50 ℃ of alcohol, infiltrate 0.5--l hour, treat the slightly soft taking-up of cutin, section, cross 80 mesh sieves after after drying, wild deer antler slice being pulverized with ball mill, obtain the cervus elaphus linnaeus powder, auxiliary according to sterilizing with dosage 5KGy, Co60;
(4) the cervus elaphus linnaeus powder is added in dry extract, be mixed to evenly, in incapsulating, make capsule.
Embodiment 2
Take Radix Astragali 24g, Chinese yam 40g, stir-baked FRUCTUS CRATAEGI 24g, Poria cocos 24g, cervus elaphus linnaeus 10g, starch 2.5g, dolomol 2g.
The preparation method:
(1) take the Poria cocos of the Radix Astragali, Chinese yam, stir-baked FRUCTUS CRATAEGI, 5/6 formula ratio by formula ratio, soak approximately 30 minutes, extract 2 times, add for the first time 10 times of water gagings, extract 2 hours, add for the second time 8 times of water gagings and extract 1.5 hours, twice decocting liquid merges and filters, and is evaporated to the medicinal extract of relative density 1.2 under 0.08Mpa, 60 ℃;
(2) pulverizer dry pulverization process, mistake 80 mesh sieves for the Poria cocos of 1/6 formula ratio are obtained to Poria cocos powder, with after dosage 5KGy, Co60 irradiation sterilization, add in medicinal extract and mix, 60 ℃ ~ 80 ℃ lower vacuum drying, the dry extract obtained was pulverized 80 mesh sieves, standby;
(3) cervus elaphus linnaeus is burned to the pilose antler fine hair with alcolhol burner, with bamboo cutter scraping, pilose antler is immersed in 50 ℃ of alcohol, infiltrate 0.5--l hour, treat the slightly soft taking-up of cutin, section, cross 80 mesh sieves after after drying, wild deer antler slice being pulverized with ball mill, obtain the cervus elaphus linnaeus powder, auxiliary according to sterilizing with dosage 5KGy, Co60;
(4) by starch, dolomol adds in dry extract together with the cervus elaphus linnaeus powder, is mixed to evenly; During being incapsulated, the gained bulk drug makes capsule.
Preparation flow as shown in Figure 1.
Embodiment 3
Take Radix Astragali 22g, Chinese yam 45g, stir-baked FRUCTUS CRATAEGI 23g, Poria cocos 25g, cervus elaphus linnaeus 9g, starch 1.2g, dolomol 4.9g.
The preparation method:
(1) take the Poria cocos of the Radix Astragali, Chinese yam, stir-baked FRUCTUS CRATAEGI, 5/6 formula ratio by formula ratio, soak approximately 30 minutes, extract 2 times, add for the first time 10 times of water gagings, extract 2 hours, add for the second time 8 times of water gagings and extract 1.5 hours, twice decocting liquid merges and filters, and is evaporated to the medicinal extract of relative density 1.2 under 0.08Mpa, 60 ℃;
(2) pulverizer dry pulverization process, mistake 80 mesh sieves for the Poria cocos of 1/6 formula ratio are obtained to Poria cocos powder, with after dosage 5KGy, Co60 irradiation sterilization, add in medicinal extract and mix, 60 ℃ ~ 80 ℃ lower vacuum drying, the dry extract obtained was pulverized 80 mesh sieves, standby;
(3) cervus elaphus linnaeus is burned to the pilose antler fine hair with alcolhol burner, with bamboo cutter scraping, pilose antler is immersed in 50 ℃ of alcohol, infiltrate 0.5--l hour, treat the slightly soft taking-up of cutin, section, cross 80 mesh sieves after after drying, wild deer antler slice being pulverized with ball mill, obtain the cervus elaphus linnaeus powder, auxiliary according to sterilizing with dosage 5KGy, Co60;
(4) by starch, dolomol adds in dry extract together with the cervus elaphus linnaeus powder, is mixed to evenly; During being incapsulated, the gained bulk drug makes capsule.
Embodiment 4
Take Radix Astragali 26g, Chinese yam 42g, stir-baked FRUCTUS CRATAEGI 22g, Poria cocos 23g, cervus elaphus linnaeus 11g, starch 3.7g, dolomol 2.4g.
The preparation method:
(1) take the Poria cocos of the Radix Astragali, Chinese yam, stir-baked FRUCTUS CRATAEGI, 5/6 formula ratio by formula ratio, soak approximately 30 minutes, extract 2 times, add for the first time 10 times of water gagings, extract 2 hours, add for the second time 8 times of water gagings and extract 1.5 hours, twice decocting liquid merges and filters, and is evaporated to the medicinal extract of relative density 1.2 under 0.08Mpa, 60 ℃;
(2) pulverizer dry pulverization process, mistake 80 mesh sieves for the Poria cocos of 1/6 formula ratio are obtained to Poria cocos powder, with after dosage 5KGy, Co60 irradiation sterilization, add in medicinal extract and mix, 60 ℃ ~ 80 ℃ lower vacuum drying, the dry extract obtained was pulverized 80 mesh sieves, standby;
(3) cervus elaphus linnaeus is burned to the pilose antler fine hair with alcolhol burner, with bamboo cutter scraping, pilose antler is immersed in 50 ℃ of alcohol, infiltrate 0.5--l hour, treat the slightly soft taking-up of cutin, section, cross 80 mesh sieves after after drying, wild deer antler slice being pulverized with ball mill, obtain the cervus elaphus linnaeus powder, auxiliary according to sterilizing with dosage 5KGy, Co60;
(4) by starch, dolomol adds in dry extract together with the cervus elaphus linnaeus powder, is mixed to evenly; During being incapsulated, the gained bulk drug makes capsule.
Embodiment 5
Take Radix Astragali 25g, Chinese yam 35g, stir-baked FRUCTUS CRATAEGI 26g, Poria cocos 26g, cervus elaphus linnaeus 12g, starch 1.2g, dolomol 5g.
The preparation method:
(1) take the Poria cocos of the Radix Astragali, Chinese yam, stir-baked FRUCTUS CRATAEGI, 5/6 formula ratio by formula ratio, soak approximately 30 minutes, extract 2 times, add for the first time 10 times of water gagings, extract 2 hours, add for the second time 8 times of water gagings and extract 1.5 hours, twice decocting liquid merges and filters, and is evaporated to the medicinal extract of relative density 1.2 under 0.08Mpa, 60 ℃;
(2) pulverizer dry pulverization process, mistake 80 mesh sieves for the Poria cocos of 1/6 formula ratio are obtained to Poria cocos powder, with after dosage 5KGy, Co60 irradiation sterilization, add in medicinal extract and mix, 60 ℃ ~ 80 ℃ lower vacuum drying, the dry extract obtained was pulverized 80 mesh sieves, standby;
(3) cervus elaphus linnaeus is burned to the pilose antler fine hair with alcolhol burner, with bamboo cutter scraping, pilose antler is immersed in 50 ℃ of alcohol, infiltrate 0.5--l hour, treat the slightly soft taking-up of cutin, section, cross 80 mesh sieves after after drying, wild deer antler slice being pulverized with ball mill, obtain the cervus elaphus linnaeus powder, auxiliary according to sterilizing with dosage 5KGy, Co60;
(4) by starch, dolomol adds in dry extract together with the cervus elaphus linnaeus powder, is mixed to evenly; During being incapsulated, the gained bulk drug makes capsule.
Embodiment 6
Take Radix Astragali 23g, Chinese yam 38g, stir-baked FRUCTUS CRATAEGI 25g, Poria cocos 22g, cervus elaphus linnaeus 8g, starch 3.5g, dolomol 1.2g.
The preparation method:
(1) take the Poria cocos of the Radix Astragali, Chinese yam, stir-baked FRUCTUS CRATAEGI, 5/6 formula ratio by formula ratio, soak approximately 30 minutes, extract 2 times, add for the first time 10 times of water gagings, extract 2 hours, add for the second time 8 times of water gagings and extract 1.5 hours, twice decocting liquid merges and filters, and is evaporated to the medicinal extract of relative density 1.2 under 0.08Mpa, 60 ℃;
(2) pulverizer dry pulverization process, mistake 80 mesh sieves for the Poria cocos of 1/6 formula ratio are obtained to Poria cocos powder, with after dosage 5KGy, Co60 irradiation sterilization, add in medicinal extract and mix, 60 ℃ ~ 80 ℃ lower vacuum drying, the dry extract obtained was pulverized 80 mesh sieves, standby;
(3) cervus elaphus linnaeus is burned to the pilose antler fine hair with alcolhol burner, with bamboo cutter scraping, pilose antler is immersed in 50 ℃ of alcohol, infiltrate 0.5--l hour, treat the slightly soft taking-up of cutin, section, cross 80 mesh sieves after after drying, wild deer antler slice being pulverized with ball mill, obtain the cervus elaphus linnaeus powder, auxiliary according to sterilizing with dosage 5KGy, Co60;
(4) by starch, dolomol adds in dry extract together with the cervus elaphus linnaeus powder, is mixed to evenly; During being incapsulated, the gained bulk drug makes capsule.
Claims (4)
1. a medicine that strengthens immunity, is characterized in that, comprises each component of following weight portion:
Radix Astragali 22-26 Chinese yam 35-45 stir-baked FRUCTUS CRATAEGI 22-26
Poria cocos 22-26 cervus elaphus linnaeus 8-12.
2. the medicine of enhancing immunity according to claim 1, is characterized in that, comprises each component of following weight portion:
The Radix Astragali 24 Chinese yam 40 stir-baked FRUCTUS CRATAEGIs 24
Poria cocos 24 cervus elaphus linnaeus 10.
3. the medicine of enhancing immunity according to claim 1, is characterized in that, also comprises starch and dolomol, and wherein starch accounts for the 1-3% of medicine gross mass, and dolomol accounts for the 1-2.5% of medicine gross mass.
4. the process for preparing medicine of enhancing immunity claimed in claim 3, is characterized in that, comprises the following steps:
(1) by the Poria cocos of the Radix Astragali, Chinese yam, stir-baked FRUCTUS CRATAEGI and 5/6 formula ratio, to soak and extract 2 times, twice decocting liquid merges filtration, is concentrated into the medicinal extract of relative density 1.2;
(2), by the pulverizer dry pulverization process Poria cocos powder that sieves to obtain for the Poria cocos of 1/6 formula ratio, after sterilizing, add in medicinal extract and mix, 60 ℃~80 ℃ vacuum drying, the dry extract obtained;
(3) cervus elaphus linnaeus is burned to the pilose antler fine hair with alcolhol burner, with bamboo cutter scraping, pilose antler is immersed in 50 ℃ of alcohol, infiltrate 0.5--l hour, treat the slightly soft taking-up of cutin, section, cross 80 mesh sieves after after drying, wild deer antler slice being pulverized, and obtains the cervus elaphus linnaeus powder, sterilizing;
(4) starch, dolomol are added in dry extract together with the cervus elaphus linnaeus powder, be mixed to evenly, in incapsulating, make capsule.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104771415A (en) * | 2015-04-20 | 2015-07-15 | 吉林省长生鹿业有限公司 | Processing method for maintaining activity of corn cervi pantotrichum and application |
CN105362594A (en) * | 2015-12-15 | 2016-03-02 | 李国深 | Conditioning traditional Chinese medicine composition |
CN108324825A (en) * | 2018-05-09 | 2018-07-27 | 武汉大白小白鼻科有限公司 | A kind of health care oral liquid and preparation method thereof |
-
2013
- 2013-09-25 CN CN201310439690.6A patent/CN103445177B/en active Active
Non-Patent Citations (1)
Title |
---|
国家食品药品监督管理总局: ""本生堂牌本生胶囊",批准文号 国食健字G20100258", 《"本生堂牌本生胶囊",批准文号 国食健字G20100258》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104771415A (en) * | 2015-04-20 | 2015-07-15 | 吉林省长生鹿业有限公司 | Processing method for maintaining activity of corn cervi pantotrichum and application |
CN104771415B (en) * | 2015-04-20 | 2020-07-21 | 吉林省长生鹿业有限公司 | Processing method for keeping activity of pilose antler and application thereof |
CN105362594A (en) * | 2015-12-15 | 2016-03-02 | 李国深 | Conditioning traditional Chinese medicine composition |
CN108324825A (en) * | 2018-05-09 | 2018-07-27 | 武汉大白小白鼻科有限公司 | A kind of health care oral liquid and preparation method thereof |
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