CN108324825A - A kind of health care oral liquid and preparation method thereof - Google Patents
A kind of health care oral liquid and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a kind of health care oral liquid, active ingredient is：Radix Astragali, Chinese yam, Poria cocos, Radix Glycyrrhizae；45 55g containing Radix Astragali, 15 25g of Chinese yam, 15 25g of Poria cocos, 3 7g of Radix Glycyrrhizae in per 100mL oral solutions.The present invention has tonifying Qi and lifting yang, strengthening spleen and middle warmer, strengthening exterior and reducing sweat, swelling diuretic, shengjin nourishing, promoting pus discharge and tissue regeneration and other effects.For shortness of breath and palpitation, overstrain internal injury, physically weak spontaneous perspiration, the card of the various deficiency of vital energys such as physically weak edema, deficiency of qi and blood.It can restore body's immunity, resist exopathogen, promote the health-care efficacy that body is strong.In clinical practice, pass through the observation to patient, it was found that it has preferable invigorating the spleen to consolidate effect physically weak patient especially Patients of Spleen Deficiency, there is apparent immunoloregulation function to rhinitis and Bronchial Asthmas, and any side effect is had no during clinical application.
Description
Technical field
The present invention relates to Chinese medicine health-care technical field, more particularly to a kind of health care oral liquid and preparation method thereof, this is oral
Liquid has tonifying Qi and lifting yang, strengthening spleen and middle warmer, strengthening exterior and reducing sweat, swelling diuretic, shengjin nourishing, promoting pus discharge and tissue regeneration and other effects, can restore immune
Function resists exopathogen, promotes body strong.
Background technology
Chinese medicine is known as " in healthy tendency deposits, heresy can not be done, and heresy is gathered, and gas must be empty " discussion, and Chinese medicine " asthenic symptoms " has with being immunized
It closes, " then qi and blood is this for the life of people, and the disease of people, which does not have, does not hinder its qi and blood person "." qi and blood person, the institute of people rely survivor.Qi and blood fills
It is full of, then hundred is evil outer imperial, and disease peace is always；Qi and blood is deficient, then all evil influxs, all kinds of diseases and ailments are gathered together " (《Required Readings for Medical Professionals》).Traditional Chinese and western medicine in recent years
Binding proves, all diseases of the human body in addition to wound all with immunocompromised, imbalance and hyperfunction related, especially chronic disease
Disease.Body immunity is low or the most important feature of imbalance be have a delicate constitution, malnutritive, apathetic, fatigue and weak, therefrom
It cures and says it is for chronic diseases marked by deficiency of vital energy patient, a series of lower for the resistance or imbalance occurred due to positive unsaturated vapor, according to Syndrome Differentiation of Chinese Medicine on dialectical
Card treats principle " treatinging deficiency with tonification ", and after taking correct help healthy tendency to treat, immune function is restored.
Modern society people Working Life rhythm enhance, when have feeling unable to do what one wishes, for the existing health care of the symptom
The most complicated component of product, effect unobvious or unstable, it is difficult to meet the needs of people.
Invention content
In view of this, the present invention provides a kind of health care oral liquid and its systems for the shortcomings that in order to make up above-mentioned treatment and deficiency
Preparation Method, the oral liquid prescription is simple, and pharmacology is clear, stabilization with obvious effects.
First aspect present invention provides a kind of health care oral liquid, and active ingredient is：Radix Astragali, Chinese yam, Poria cocos, Radix Glycyrrhizae, institute
The weight part ratio for stating each active principle is：45-55 parts of Radix Astragali, 15-25 parts of Chinese yam, 15-25 parts of Poria cocos, 3-7 parts of Radix Glycyrrhizae.
Modern society people Working Life rhythm enhance, when have feeling unable to do what one wishes, must be solid with help treatment, QI invigorating
Sun improves human righteousness, restores immune function, resists exopathogen, promotes body strong, health care oral liquid provided by the invention
Reach said effect, compatibility of drugs of the invention and side's solution：
Radix Astragali is monarch, and benefiting qi and raising yang, supporing yang solid table, strengthen immunity, are important Qi-tonifying drug, vigour is weak, and sees body
Tired weak, speech is humble, and pulse condition delays weak or big and inability person, with benefit, can reinforce vital energy, particularly eak after being ill person is good
Tonifying recipes.Chinese yam is minister, and tonifying spleen nourishing the stomach, promote the production of body fluid foster lung, and assistant is adjusted with Poria cocos invigorating the spleen neutralization, antitoxic heart-soothing and sedative, Radix Glycyrrhizae invigorating the lung and benefiting vital QI,
All medicines share plays QI invigorating Guyang, nourishing invigorating the spleen, the work(for adjusting immunity altogether.
Radix Astragali master contains pachymaran, protein etc. containing Astragaloside IV etc., Chinese yam alkali containing Chinese yam, free amino acid etc., Poria cocos,
Containing glycyrrhizic acid, glycyrrhizin etc., four medicines play the role of enhancing Abwehrkraft des Koepers Radix Glycyrrhizae.
The pharmacological effect of bulk pharmaceutical chemicals of the present invention is as follows:
Monarch, Radix Astragali.It is recorded in《Sheng Nong's herbal classic》、《Mingyi Bielu》The equal classics of TCM.
The syndrome frequency of prescription containing Radix Astragali is as follows：
From the point of view of above-mentioned card type, Radix Astragali is main for various empty venereal disease diseases.
Source：For the dry root of legume astragalus mongolicus or Astragalus membranacus, wild or cultivation.Main product is in Shanxi, black dragon
The ground such as river, the Inner Mongol, Hubei are also distributed.Spring, autumn excavation, remove soil, fibrous root and root head, shine to 6 seventy percent dry, by big
It is small to be bundled into wisp, then dry.It is slightly grown with item, matter is hard and continuous, and sweet person is preferred mealiness enough.
Traditional Chinese medicine thinks, the nature and flavor of Radix Astragali are sweet, tepor, play the role of tonifying middle-Jiao and Qi, hidroschesis, inducing diuresis for removing edema, except taking poison and growing muscle due,
It can be rated as " all medicines of tonifying Qi most ", have the characteristics that mend and oiliness.It is better if with the compatibilities such as Chinese yam, Poria cocos, Radix Glycyrrhizae.All medicines
With synthesis side, Gu table does not stay heresy, eliminating evil is without hindering just.To asthenia of pulmonosplenic qi, fleshy exterior is not solid, and when spontaneous perspiration goes out and deficiency of vital energy flu, uses
Quite preferably, so that the body of people is achieved the purpose that strong.
Clinical application
1. the sweet temperature of syndrome of deficiency of spleen qi this product is apt into taste, is tonifying middle-Jiao and Qi key medicine.Deficiency-weakness of spleen-QI, lassitude hypodynamia, deficiency of food is just
Half congealed person, can or with the air making-up and spleen enlivenings medicine compatibility such as Chinese yam.Because of its energy yang invigorating, therefore the chronic diarrhea for being longer than the treatment spleen deficiency sinking of qi of middle-jiao is sloughed off
Anus, splanchnoptosia.If the wet mistake fortune of spleen deficiency water, so that edema oliguria person, this product can invigorate the spleen and benefit qi and inducing diuresis to remove edema, sample
It is simultaneous to control, to control the key medicine of qi deficiency edema, often with the product compatibility of the inducing diuresis for removing edema such as Poria cocos.This product and energy qi-supplementing, blood-engendering, control syndrome of blood deficiency
Also often with antianaemics compatibility.It cannot unite card of losing blood caused by blood to spleen deficiency, the fine tonifying Qi of this product is to take the photograph blood.
2. syndrome of deficiency of lung qi this product enter lung again can replenishing and restoring lung qi, can be used for insufficiency of lung-QI, cough and asthma with the passing of time, shortness of breath and tired spirit person.
3. the people that spontaneous perspiration due to deficiency of vital energy is spleen-lung Qi deficiency often defensive Qi instability, exterior deficiency spontaneous perspiration.The gas of this product energy tonifying spleen lung, benefit are defended solid
Table.
4. deficiency of qi and blood, sore difficulty burst it is difficult rotten, or long difficulty of bursting hold back this product with the work(of its tonifying Qi can also admit a child into a nursery school taking poison and growing muscle due it
Effect.Sore mid-term, weakened body resistance poison, which is contained, to be unable to reach outside eliminating toxic, and sore shape is flat to collapse, the base of lesion spread, and the difficult difficult corruption person that bursts can use this product tonifying Qi to give birth to
Blood, building up healthful vital energy, joe pus poison are outgoing.In the ulcer later stage, because of deficient qi and blood, pus is thin, the open sore part difficulty person of holding back, and is given birth to this product tonifying Qi
Blood has the benefits of myogenic sore.
Pharmacological research confirms that Astragalus in Treating allergic rhinitis, asthma etc. are mainly following effect.
1, immunoregulation effect.Some researches show that astragalus polyoses by improving the expression of cell surface adhesion molecule, promoting
The adherency of lymphocyte and endothelial cell plays immunological enhancement to promote lymphocyte recirculation.Variability rhinitis is suffered from
The quantity of person's red blood cell and its abnormal quality of immune function affect IFN-γ generation, have been caused directly or indirectly change
The generation of answering property patients with rhinitis IgE increases, and leads to aggravation.Allergic rhinitis be mainly local inflammation, oedema pathology table
It is existing, may be abnormal due to red blood cell, lymphocyte immunity adhesion function, cause lesion local immunity compound gather and eliminate by
Resistance, to inspire local inflammation reaction.
2, enhance immune function, the generation of allergic rhinitis can be prevented.Research shows that Radix Astragali can enhance cell
Immune function reinforces humoral immunity, enhances non-specific immune function.Radix Astragali is various, body to the effect of T lymphocytes
Outer experiment shows that low concentration Radix Astragali can promote lymphocyte transformation ability, and to be allowed to vigor instead suppressed for high concentration, illustrates to have and exempt from
Epidemic disease adjustment effect.To the induction role in vivo studies of cell factor show Radix Astragali can significantly improve immunosuppressed mice IL-2,
TNF, IFN-γ induce level.Some researches show that, no matter internal injection or experiment in vitro, find Radix Astragali to splenocyte increase
Value has no significant effect, but PFC values can be improved, and promotes the removing of CIC ELISA.
3, to the effect of interferon.Radix Astragali has the ability of enhanced virus inducement interferon.Easy catching a cold person is popular in flu
Season takes Radix Astragali, can not only times of common cold be made to significantly reduce, but also cold symptoms can be made lighter, and the course of disease is shorter.Due to nose
Scorching patient easily catches a cold, so reducing rhinitis, the illness rate of asthma to a certain extent.
4, antibacterial and inhibition virus function.Radix Astragali is to shigella dysenteriae, Diplococcus pneumopniae, hemolytic streptococcus A, B, C and gold
Yellow, lemon yellow, staphylococcus albus etc. have inhibiting effect.Radix Astragali can enhance antiviral ability, and inducement interferon promotees
Into cell metabolism, enhance immunity of organisms.
Successive dynasties ancient books and records are selected to Radix Astragali remittance speech
《Sheng Nong's herbal classic》：It is sweet in flavor, tepor.Ulcer is cured mainly, loses sore Apocenosis pain relieving, strong wind leprosy disease, five hemorrhoid, mouse fistula, benefit long
Void, children's all kinds of diseases and ailments.
《Mingyi Bielu》：It is nontoxic.It curing mainly married woman's and hides ailment said due to cold or exposure gas, extravesated blood between being hidden by five, benefit husband is deficient, and the exhaustion or lesion of the five internal organs is thin thin,
Quench the thirst, abdominal pain lets out profit, QI invigorating, Li Yin gas.
《Haigoushen》：Carbuncle on the back is controlled, interior benefit, main empty asthma, renal failure is deaf, treats fever and chills.
《Japan hanako materia medica》：Dislike the root bark of shaggy-fruited dittany.Gas is helped, is strengthened the bone.It puts on flesh, enriches blood, break disease addiction, scrofula drips goitre and goes to live in the household of one's in-laws on getting married, intestines wind, metrorrhagia
Under band, dysentery, it is antenatal after all diseases, wait the moon irregular, quench one's thirst, phlegm is coughed, and controls intermittent headache heat toxin, Akamu etc..
《Kaibao Bencao》：Sweet in flavor, tepor is nontoxic.Married woman's hides ailment said due to cold or exposure gas, and by extravesated blood between the five internal organs, benefit husband is deficient, the exhaustion or lesion of the five internal organs
It is thin thin, quench the thirst, abdominal pain lets out dysentery, QI invigorating, Li Yin gas.
《Medicine class method as》：Control deficient spontaneous perspiration, tonifying lung gas, real fur, purging the lung of pathogenic fire moderate heat, such as veins string spontaneous perspiration.It is kind control it is weakness of the spleen and the stomach,
Sore blood vessels are not all right, and Neto the moon card sore must use it.
《Drug property cerse》：Sweet in flavor, temperature is nontoxic.It rises, sun.It is with having four：Warm boundary between muscles and real space between skin and muscles, beneficial vigour and mend
Three is burnt, the sore of Neto the moon card, the night sweat of outer solid exterior deficiency.
《The Decoction and Material Medica》：Temperature, sweet in flavor, pure sun.Sweet tepor, it is mild-natured, it is nontoxic.Enter meridian of Hand-SHAO YANG, meridian of Foot-TAI YIN, foot is few
Cloudy, the gate of vitality agent.
《Book on Chinese herbal medicine plays》：Clean Gu cloud：Control deficient spontaneous perspiration, tonifying lung gas, real fur, purging the lung of pathogenic fire moderate heat, veins string, spontaneous perspiration is kind to control spleen
Stomach is weak, sore, and blood vessels are not all right.Neto the moon demonstrate,prove sore, must with medicine.
《Cure mainly secret formula》Cloud：Warm-natured, sweet in flavor, gas is thin rich, and can rise can drop, cloudy middle-jiao yang, function of the spleen and stomach.It is with having five：It mends all empty insufficient
One, beneficial vigour two goes flesh heat three, sore Apocenosis pain relieving four to strengthen taste five.Go it is all through pain, remove abnormal heat, only steal
Sweat.
《Bencao Jingshu》：Radix Astragali reports the qi of chong channel ascending adversely of YANG in universe gas, ground with life.Therefore tepor sweet in flavor and it is nontoxic.Gas is thicker than taste, can rise
It can drop, sun.Start with positive bright, Taiyin channels.Sweet is the positive taste of soil, therefore can be detoxified.Sun can reach table, therefore can transport poison and walk table.Gan Nengyi
Blood, spleen governing muscles, therefore master loses sore, Apocenosis pain relieving long.Wind being YANG-pathogen, all harmful wind it is empty it is evil among people, then sick pestilential wind, through saying：It is evil
Institute gather, gas must be empty.Performance reality table, then can be by evil wind dispelling, therefore main strong wind leprosy disease, five hemorrhoid mouse fistulas, qi-restoratives, and main children day go
Variola is divided in sun, and exterior deficiency unsaturated vapor person, infant fetal toxin gives birth to boil.
Minister, Chinese yam also known as sweet potato, potato medicine.First recorded in《Dragon Lord book on Chinese herbal medicine passes through》.
Source：For the dry rhizome of Dioscoreaceae plant Chinese yam.It is cultivation.Main product is in the ground such as Henan, Guangxi, Hunan, lake
Also there is cultivation in north.Excavation cuts root head after winter cauline leaf is withered, cleans.Net crust and fibrous root are cut with bamboo knife, after being smoked with sulphur, is shone
Dry or drying, as hair Chinese yam.The loose straight drying hair Chinese yam of selection, sets in water, is dipped into without the dry heart, moisturizes, smoked with sulphur
Afterwards, both ends are trimmed, are twisted into plank cylindric, are dried, polishing, practises and claims light yam.It is thick with item.Matter is solid, mealiness is sufficient, the white person of color
It is preferred.
Chinese yam is sweet in flavor, nature and flavor sweet and neutral.The deficiency of food, the body that are not only suitable for taste deficiency of both vital energy and Yin be tired, the disease of loose stool or diarrhea.Again
Suitable for diseases such as the chronic cough and dyspnea of deficiency type of lung qi asthenic yin or dryness of the lung dry cough, it is also applied for the disease of emission due to the kidney deficiency, frequent micturition, leukorrhea.
Clinical application
It 1. controlling syndrome of spleen deficiency this product sweet in flavor and neutral in nature, can invigorate the spleen and benefit qi, it is cloudy to nourish spleen.It is chiefly used in deficiency-weakness of spleen-QI or deficiency of both qi and yin,
It becomes thin weak, deficiency of food, loose stool；Or spleen insufficiency, the women of wet turbid bet is under.Only it also eats also medicine, this product be all used as Radix Astragali,
The adjuvant of the medicines such as Rhizoma Atractylodis Macrocephalae.Because it contains compared with multi-nutrient, and it is easy digestion, food long-term use can be made, to chronic long
Disease or eak after being ill are thin thin, need nutrition tune to mend and dysfunction of the spleen person, are then good merchantable brands.
2. controlling the deficiency syndrome of the lung demonstrate,proves this product energy tonifying lung gas again, and can lung-yin nourishing.Though the power of its tonifying lung is relatively gentle, cloudy to lung temper
All void persons, mending soil also contributes to raw gold.The benefits of controlling deficiency syndrome of the lung cough and asthma, can using together with product such as Radix Astragali, adenophora tetraphyllas, play tonifying lung Dingchuan altogether.
3. control nephrasthenia syndrome this product can also kidney tonifying gas, and kidney yin can be nourished, all void person, benefit will also contribute to the day after tomorrow to kidney spleen
It supplements nutrition congenital.Suitable for the soreness and weakness of waist and knees of kidney qi deficiency, night dung frequency is more or the enuresis, involuntary emission premature ejaculation, and woman is thin under and kidney-yin deficiency
Body become thin, soreness and weakness of waist and knees, seminal emission etc. diseases.Successive dynasties many kidney tonifying recipes, as shenqi pill (《Gold is hidden outline》), Liuwei Dihuang Wan
(《Key to therapeutic of children's disease》) in be provided with this product.
4. control syndrome of deficiency of both qi and yin of quenching one's thirst quench one's thirst one disease, it is related with spleen and lung kidney, deficiency of both qi and yin be its main pathogenesis.This product was both
The gas of tonifying spleen lung kidney, and the moon of tonifying spleen lung kidney are often used together with product such as Radix Astragalis.
Assistant, Poria cocos also known as Fu Tu, Yun Ling, PORIA ALBA.First recorded in《Dragon Lord book on Chinese herbal medicine passes through》.
Source：For the dry sclerotia of On Polyporaceae Poria cocos, cultivation or wild.Main product is in Anhui, Hubei, Henan, cloud
The ground such as south.It is excavated more than autumn greatly, silt is removed after digging out, after banking up " sweating ", spread cool to dry tack free, then " sweating " out,
It is repeated several times to existing wrinkle and dries in the shade after internal moisture is largely scattered and disappeared, referred to as " Poria cocos ", fresh Poria cocos is cut by different parts
It is disconnected, it dries in the shade, is referred to as " fuling peel " and " Indian buead tablet " or " Poria cocos block ".Solid with weight, outer color of the leather is brown, without crack, disconnected
The viscosity powerhouse that pale complexion is fine and smooth, chews is preferred.
Slightly sweet flavor, it is mild-natured.Can eliminating evil and righting, still have the effect of strengthening spleen and middle warmer, antitoxic heart-soothing and sedative, for spleen deficiency not
Can transmitting and distributing the fluids and the diarrhea and the water drink that cause insults the cards such as insomnia of palpitating with fear caused by the heart.
Poria cocos sclerotium pachymaran containing volume, polyporic acid, protein etc..Poria cocos can enhance immunity of organisms, to rabbit from
Body intestinal tube has relexation, and being formed by gastric ulcer to rat ligation has preventive effect, and can reduce hydrochloric acid in gastric juice etc..
Make, Radix Glycyrrhizae also known as honeywort, state be old, Herba Hedyotis cantonensis.First recorded in《Dragon Lord book on Chinese herbal medicine passes through》.
Source：For the drying root and rhizome of glycyrrhizic legume Glycyrrhiza ur alensis Fisch..It is wild or
Cultivation.Main product is also distributed in the ground such as the Inner Mongol, northeast, northwest, Hubei.Spring, autumn excavation remove fibrous root etc., dry.With body
Dry, matter heavily fortified point, weight, the big person of mealiness are preferred.
Radix Glycyrrhizae is sweet in flavor, mild-natured.The thoughts of returning home, stomach, lung, the spleen channel.It can reconcile the bias of various drugs, all medicines is enable preferably to play
Effect.Kind warmly invigorating spleen and stomach, QI invigorating, can also nourishing heart gas, stop palpitate with fear and dry moistening lung, coughs of only coughing in hard for this product toast；It is raw to use partially
Cool energy purging intense heat and detonicating, detumescence relieving sore-throat.
Radix Glycyrrhizae is containing glycyrrhizic acid, glycyrrhizin etc..Radix Glycyrrhizae can promote throat and bronchial secretion, and phlegm is made to be easy to expectoration.This hair
Bright second aspect provides the preparation method of above-mentioned health care oral liquid, and step includes：
S1, raw material Radix Astragali is weighed in proportion, the water of Poria cocos, Chinese yam, Radix Glycyrrhizae, 4~5 times of material qualities of addition impregnates 10~14
Hour, extraction three times, 0.8~1.2 hour every time, merges decoction liquor；
S2, ethyl alcohol is added after concentrating decoction liquor makes alcohol content up to 70%, precipitation solution is filtered into obtain supernatant, recycles supernatant
Ethyl alcohol obtains concentrate to no alcohol taste in liquid；
S3, water dilution is added into concentrate, refrigeration is filtered after 22~26 hours, and sodium benzoate, high temperature are added in filtrate
Sterilizing, sterilization drug liquid cooling are rear filling.
The beneficial effects of the invention are as follows：Health care oral liquid provided by the invention is directed to the system occurred due to positive unsaturated vapor
Arranging the pathological phenomenon that lower for the resistance, viscera function activity weakens has apparent adjustment effect, has tonifying middle-Jiao and Qi, warm lung strong
Spleen resists exopathogen, adjusts immunity, promotes the health-care efficacy that body is strong.In clinical practice, pass through the sight to patient
It examines, it is found that it has preferable invigorating the spleen to consolidate effect physically weak patient especially Patients of Spleen Deficiency, rhinitis and bronchial asthma are suffered from
Person has apparent immunoloregulation function, and any side effect is had no during clinical application.
Specific implementation mode
First aspect present invention provides a kind of health care oral liquid, and active ingredient is：Radix Astragali, Poria cocos, Chinese yam, Radix Glycyrrhizae, institute
The weight part ratio for stating each active principle is：45-55 parts of Radix Astragali, 15-25 parts of Poria cocos, 15-25 parts of Chinese yam, 3-7 parts of Radix Glycyrrhizae.
Preferably, the oral solution also contains additive sodium benzoate.
Preferably, 45-55g containing Radix Astragali, Poria cocos 15-25g, Chinese yam 15-25g, Radix Glycyrrhizae 3-7g in every 100mL oral solutions.
More preferred, 45-55g containing Radix Astragali, Poria cocos 15-25g, Chinese yam 15-25g, Radix Glycyrrhizae 3- in every 100mL oral solutions
7g, sodium benzoate 0.15g, surplus are water.
It is further preferred that 50g containing Radix Astragali, Poria cocos 20g, Chinese yam 20g in per 100mL oral solutions, Radix Glycyrrhizae 5g, sodium benzoate
0.15g, surplus are water.By clinical practice, adjusting is optimized to each group distribution ratio according to the above ratio, health-care efficacy is made to reach
Most preferably.
The health care oral liquid is used for the immunological regulation of human body.
Specifically, the health care oral liquid is used for the immunological regulation of rhinitis and Bronchial Asthmas.
Second aspect of the present invention provides the preparation method of above-mentioned health care oral liquid, and step includes：
S1, raw material Radix Astragali is weighed in proportion, the water of Poria cocos, Chinese yam, Radix Glycyrrhizae, 4~5 times of material qualities of addition impregnates 10~14
Hour, extraction three times, 0.8~1.2 hour every time, merges decoction liquor；
S2, ethyl alcohol is added after concentrating decoction liquor makes alcohol content up to 70%, precipitation solution is filtered into obtain supernatant, recycles supernatant
Ethyl alcohol obtains concentrate to no alcohol taste in liquid；
S3, water dilution is added into concentrate, refrigeration is filtered after 22~26 hours, and sodium benzoate, high temperature are added in filtrate
Sterilizing, sterilization drug liquid cooling are rear filling.
Preferably, sodium benzoate additive amount described in step S3 is per addition 0.15g sodium benzoates in 1000mL filtrates.
Preferably, high-temperature sterilization mode described in step S3 is to be boiled 30 minutes at 100 DEG C.
A kind of health care oral liquid provided by the invention is further described below in conjunction with specific embodiment.It retouches below
The embodiment stated is exemplary, and is only used for explaining the present invention, and is not considered as limiting the invention.
Experimental method in following embodiments is unless otherwise specified conventional method.Reality as used in the following examples
It tests material unless otherwise specified, is that market is commercially available.
Embodiment 1
A kind of health care oral liquid is present embodiments provided, proportioning is：50g containing Radix Astragali in per 100mL oral solutions, Poria cocos
20g, Chinese yam 20g, Radix Glycyrrhizae 5g, sodium benzoate 0.15g, surplus are water.The health care oral liquid, that is, Wei Fulu described hereinafter takes orally
Liquid.
Above-mentioned health care oral liquid is prepared as follows, and for preparing 1000mL health promoting liquids, step includes：
S1, raw material Radix Astragali is weighed in proportion, the water immersion 12 of Poria cocos, Chinese yam, Radix Glycyrrhizae, 4~5 times of material qualities of addition is small
When, extraction three times, 1 hour every time, merges decoction liquor；
S2, decoction liquor is concentrated into after 400mL and 95% ethyl alcohol is added makes alcohol content up to 70%, precipitation solution is filtered into obtain supernatant
Liquid recycles ethyl alcohol in supernatant and obtains concentrate to no alcohol taste；
S3, into concentrate, addition water is diluted to 600mL, and refrigeration is filtered after 24 hours, is added in every 1000mL filtrates
0.15g sodium benzoates, boil 30 minutes high-temperature sterilizations at 100 DEG C, sterilization drug liquid cooling but after it is filling.
By above-mentioned health care oral liquid carry out function of health food detection, detection project is immunoregulation effect, inspection according to
According to for《Function of health food assessment process and the method for inspection》Defend prison hair [1996] the 38th.
Immunoregulation effect examining report is as follows：
1, sample gives approach：It is made into corresponding dosage with distilled water and drinks liquid, daily administered by oral gavage corresponding dosage is continuously given
Following tests work is carried out after giving one month, Normal group gavages ordinary tap water.
2, animal：Male Kunming strain mice, 18-22g, Hubei Province's medical experiment animal center provide, and animal approval number is
The dynamic doctor's pipe word 19-007 in Hubei Province.
3, it is grouped：Day 30mL/kg.bw is drunk by crowd, expands 10,20,30 times, design low middle high three dosage groups, i.e.,
5mL, 10mL, 15mL/kg.bw are mixed by various dose and are drunk in water one month, then carry out the following terms experiment.
4, test method and result
The front and back the weight of animals record of 4.1 experiments：Weight no significant difference, concrete outcome are shown in Table 1 between each group animal.
Table 1 tests front and back the weight of animals record (g, χ ± S)
The influence of 4.2 pairs of animal lymph organ/weight ratio：Thymus gland/weight ratio and spleen/weight ratio between each group animal
It is worth no significant difference.Concrete outcome is shown in Table 2.
Influence (χ ± S) of the table 2 to animal lymph organ/weight ratio
The mouse spleen lymphocyte conversion test of 4.3ConA inductions
Method：Mtt assay (step congenerous experimental arrangement regulation)
As a result：3 are shown in Table, by table 3 as it can be seen that compared with blank group, the enhancing of " Wei Fulu oral solutions " high dose group conspicuousness
The mice spleen lymphocytes proliferation ability of ConA inductions
Table 3 " Wei Fulu oral solutions " is to mouse cell Immune Function
The * P ＜ 0.01#0.01 ＜ P ＜ 0.05 compared with blank group
Note：0.1mL is taken to measure OD570 values
4.4 dinitrofluorobenzene (DNFB) induce delayed allergy (DTH)
Method：Ear swelling method.After DNFB sensitized mices, auris dextra is attacked with DNFB within the 5th day, put to death animal afterwards for 24 hours and cut again
Bottom left auris dextra shell removes the auricle of diameter 8mm with card punch, weighs, and the degree of DTH is indicated with the difference of the weight of left and right ear.
As a result：3 are shown in Table, as seen from Table 3, compared with blank group, the enhancing of " Wei Fulu oral solutions " high dose group conspicuousness is small
Mouse reacts the DTH that DNFB induces.
The measurement of 4.5 serum hemolysins
Method：Hemagglutination Method.According to functional experiment procedure operation, the level calculation that degree is agglomerated according to serum goes out antibody product
Number.
As a result：As seen from Table 4, in " Wei Fulu oral solutions ", high dose group can conspicuousness raising serum hemolysis cellulose content
Influence of the table 4 " Wei Fulu oral solutions " to mouse humoral immune function
The * P ＜ 0.01 compared with blank group
4.6 peritoneal macrophages swallow chicken red blood cell experiment
Method：Half intracorporal method.Prepare 20% chicken erythrocyte suspension；Younger sister paper mouse is injected intraperitoneally the 1mL suspensions, after 30min
Animal is put to death, position is faced upward and is fixed on mouse plate, open abdomen, through Intraperitoneal injection physiological saline 2mL, rotates mouse plate 1min, then, is inhaled
Go out abdominal cavity washing lotion 1mL, for average mark drop on 2 glass slides, 37 DEG C incubate 30min；It educates to finish and be rinsed with physiological saline, dried, with
1:1 acetone methanol solution is fixed, and 4%Giemsa- phosphate buffers dye 3min, then are dried with distilled water rinsing, under oil mirror
100 macrophages are counted, phagocytic rate and phagocytic index is calculated as follows：
Phagocytic rate (%)=(number of macrophages that the number of macrophages ÷ of phagocytosis chicken red blood cell is counted) × 100
The number of macrophages of the chicken red blood cell sum/counting for phagocytic index=swallowed
As a result：5 are shown in Table, as seen from Table 5, in " Wei Fulu oral solutions ", high dose group phagocytic percentage, phagocytic index is bright
It is aobvious to be higher than blank control group
Influence of the table 5 " Wei Fulu oral solutions " to Phagocytosis By The Peritoneal Macrophages In Mice
The * P ＜ 0.01#0.01 ＜ P ＜ 0.05 compared with blank group
4.7 mouse carbonic clearance test
Method：According to the method for procedure stipulation, according to concentration of carbon (surveying light absorption value), meter in blood after injection prepared Chinese ink 2min, 10min
Calculate the phagocytic index of each group mouse.
As a result：6 are shown in Table, as seen from Table 6, " Wei Fulu oral solutions " low, middle and high dose groups can conspicuousness raising mouse carbon exterior feature
Clear phagocytic index.
Influence of the table 6 " Wei Fulu oral solutions " to mouse carbonic clearance function
The * P ＜ 0.01 compared with blank group
4.8 antibody-producting cell detection
Method：Improve Jerne slide methods
As a result：7 are shown in Table, as seen from Table 7, in " Wei Fulu oral solutions ", high dose group is obviously higher than Normal group, warp
Statistical analysis difference is significant (P ＜ 0.01).
Influence of the table 7 " Wei Fulu oral solutions " to antibody-producting cell function
The * P ＜ 0.01 compared with blank group
To sum up, tested material is continuously given using Kunming mouse after one month, through each functional detection experiment, test result
Show：Compared with blank group, the mice spleen lymphocytes proliferation ability of ConA inductions can be remarkably reinforced in (1) middle and high dosage group；
(2) the mouse delayed allergy of dinitrofluorobenzene induction can be remarkably reinforced in middle and high dosage group；(3) middle and high dosage group is bright
It is aobvious to increase mice serum haemolysis cellulose content；(4) Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell work(is remarkably reinforced in middle and high dosage group
Energy；(5) low, middle and high dose groups are remarkably reinforced mouse carbonic clearance ability (6) middle and high dosage group and antibody-producting cell are remarkably reinforced
Ability.It is provided according to immunoregulation effect assessment process, which has immunoregulation effect.
Further, health care oral liquid provided in this embodiment is observed into its clinical effectiveness, clinical observation for clinic
Journey and result are as follows：
In January, 2001 between in June, 2003, has carried out the present embodiment in the first attached medical college of Traditional Chinese Medicine University Of Guangzhou and has carried
The clinical observation of the Wei Fulu health care oral liquid bronchial asthmas of confession, during which the first attached medical college of Traditional Chinese Medicine University Of Guangzhou breathing
Meet Western medicine diagnostic criteria in section ward and breathing special outpatient clinic patient, meet Syndrome in TCM marquis diagnostic criteria and the age is in 16-65
30 patients (wherein man 13, female 17, average age 36 years old, average course of disease 5.5 years) of one full year of life are observation object.
Method using Wei Fulu oral solutions is to be included in case to take orally Wei Fulu oral solutions 2 (10mL × 2) every time, daily
Three times, the course for the treatment of 1 year, symptomatic condition, attack times and side effect during main detection patient takes medicine.
Guangzhou Zengcheng Mr. Xie patient asthma for many years, takes other medicines, symptom improves, but control time is shorter, meeting before
There is frequent recurrence to occur, it is very worried.It arrives afterwards after the first attached medical college of Traditional Chinese Medicine University Of Guangzhou takes Wei Fulu, doctor
Output prescription：3 times/day of po of Wei Fulu oral solutions 10ml, a month course for the treatment of totally 3 course for the treatment of.After January, follow-up patient has no bright
Aobvious malaise symptoms, nighttime sleep is all right, no nasal obstruction, sneezing, symptom snotty.Patient continues after taking half a year, stops
It only takes, disease does not recur in 2 years.
The child (at that time 4 years old) of Longgang District of Shenzhen City Mr. Liao suffers from allergic rhinitis 2 years, arrives Guangdong Province women and children, Shenzhen
City East Lake hospital (being now renamed as The Third People's Hospital of Shenzhen) went to a doctor, and symptom temporarily controls ten days and recurs again after treatment,
By doctor formula：" ten Wei Fulu of nasal spray " was controlled using ten days or so symptoms, stopped using " nasal spray " at this time, after
Continuous to use Wei Fulu 1 year, immunity greatly enhances, and has successfully tided over the SARS outbreak period.
The first Clinical Medical Institute of Traditional Chinese Medicine University Of Guangzhou provides observation brief summary and shows Wei Fulu oral solutions to bronchial asthma
Patient's curative effect is preferable, and the Patients Patients curative effect short to the course of disease is preferable, and the patient curative effect small to the age is preferable, and effective percentage is 87%,
There are apparent immunoloregulation function, the effect of also certain reduction recurrence that can generally postpone 1 severe Bronchial Asthmas
It recurs within~3 years, there is preferable invigorating the spleen to consolidate effect body tiger patient especially Patients of Spleen Deficiency, and had no during clinical application
Any side effect.
Wei Fulu health care oral liquids provided in this embodiment are made of with Radix Astragali, Chinese yam, Poria cocos, Radix Glycyrrhizae etc. for primary raw material
Health food, proved through functional experiment, the product have immunoregulatory healthcare function.The effect of oral solution, composition included Radix Astragali
First glycosides etc. is more than 8mL per 100mL contents, is suitable for hypoimmunity and imbalance person, and eating method is each 10mL, and daily 3
Secondary, the shelf-life is 24 months, and Wei Fulu oral solutions have certain curative effect in catabasis of bronchitis asthma by clinical observation, but cannot
Alternatives to medication uses.
Embodiment 2
A kind of health care oral liquid is present embodiments provided, proportioning is：55g containing Radix Astragali in per 100mL oral solutions, Poria cocos
20g, Chinese yam 15g, Radix Glycyrrhizae 5g, sodium benzoate 0.15g, surplus are water.Health care liquid and preparation method thereof is same as Example 1.
The health-care effect of the health care oral liquid and embodiment 1 are almost the same, all have immunoregulatory healthcare function, right
Physically weak patient especially Patients of Spleen Deficiency has preferable invigorating the spleen to consolidate effect, has one in catabasis of bronchitis asthma by clinical observation
Constant current modulation is imitated.
Embodiment 3
A kind of health care oral liquid is present embodiments provided, proportioning is：45g containing Radix Astragali in per 100mL oral solutions, Poria cocos
18g, Chinese yam 25g, Radix Glycyrrhizae 7g, sodium benzoate 0.15g, surplus are water.Health care liquid and preparation method thereof is same as Example 1.
The health-care effect of the health care oral liquid and embodiment 1 are almost the same, all have immunoregulatory healthcare function, right
Physically weak patient especially Patients of Spleen Deficiency has preferable invigorating the spleen to consolidate effect, has one in catabasis of bronchitis asthma by clinical observation
Constant current modulation is imitated.
Embodiment 4
A kind of health care oral liquid is present embodiments provided, proportioning is：43g containing Radix Astragali in per 100mL oral solutions, Poria cocos
15g, Chinese yam 22g, Radix Glycyrrhizae 3g, sodium benzoate 0.15g, surplus are water.Health care liquid and preparation method thereof is same as Example 1.
The health-care effect of the health care oral liquid and embodiment 1 are almost the same, all have immunoregulatory healthcare function, right
Physically weak patient especially Patients of Spleen Deficiency has preferable invigorating the spleen to consolidate effect, has one in catabasis of bronchitis asthma by clinical observation
Constant current modulation is imitated.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.
Claims (9)
1. a kind of health care oral liquid, it is characterised in that：Active ingredient is：Radix Astragali, Poria cocos, Chinese yam, Radix Glycyrrhizae；Each active principle
Weight part ratio be：45-55 parts of Radix Astragali, 15-25 parts of Poria cocos, 15-25 parts of Chinese yam, 3-7 parts of Radix Glycyrrhizae.
2. health care oral liquid as described in claim 1, it is characterised in that：The oral solution also contains additive sodium benzoate.
3. health care oral liquid as claimed in claim 2, it is characterised in that：45-55g containing Radix Astragali in per 100mL oral solutions, Poria cocos
15-25g, Chinese yam 15-25g, Radix Glycyrrhizae 3-7g, sodium benzoate 0.15g, surplus are water.
4. health care oral liquid as claimed in claim 3, it is characterised in that：50g containing Radix Astragali in per 100mL oral solutions, Poria cocos
20g, Chinese yam 20g, Radix Glycyrrhizae 5g, sodium benzoate 0.15g, surplus are water.
5. health care oral liquid as described in claim 1, it is characterised in that：The health care oral liquid is used for the immune tune of human body
Section.
6. health care oral liquid as claimed in claim 5, it is characterised in that：The health care oral liquid is roared for rhinitis and bronchus
Breathe heavily the immunological regulation of patient.
7. the preparation method of health care oral liquid described in claim 1, step include：
S1, raw material Radix Astragali is weighed in proportion, the water immersion 10~14 of Poria cocos, Chinese yam, Radix Glycyrrhizae, 4~5 times of material qualities of addition is small
When, extraction three times, 0.8~1.2 hour every time, merges decoction liquor；
S2, ethyl alcohol is added after concentrating decoction liquor makes alcohol content up to 70%, precipitation solution is filtered into obtain supernatant, is recycled in supernatant
Ethyl alcohol obtains concentrate to no alcohol taste；
S3, water dilution being added into concentrate, refrigeration is filtered after 22~26 hours, is added sodium benzoate in filtrate, high-temperature sterilization,
Sterilization drug liquid cooling is rear filling.
8. the preparation method of health care oral liquid as claimed in claim 7, it is characterised in that：Sodium benzoate described in step S3 adds
Amount is addition 0.15g sodium benzoates in every 1000mL filtrates.
9. the preparation method of health care oral liquid as claimed in claim 7, it is characterised in that：High-temperature sterilization mode described in step S3
It is to be boiled at 100 DEG C 30 minutes.
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| CN101019921A (en) * | 2006-02-15 | 2007-08-22 | 李佳旺 | Medicine composition for invigorating spleen and benefiting lung |
| CN102085235A (en) * | 2009-12-02 | 2011-06-08 | 李丹 | Composition having immunity-enhancing effect |
| CN103445177A (en) * | 2013-09-25 | 2013-12-18 | 王辉 | Medicine capable of improving immunity and preparation method thereof |
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