CN103432600B - 一种抗菌型医用超声耦合剂及其制备方法 - Google Patents
一种抗菌型医用超声耦合剂及其制备方法 Download PDFInfo
- Publication number
- CN103432600B CN103432600B CN201310374372.6A CN201310374372A CN103432600B CN 103432600 B CN103432600 B CN 103432600B CN 201310374372 A CN201310374372 A CN 201310374372A CN 103432600 B CN103432600 B CN 103432600B
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- coupling agent
- ultrasonic coupling
- preparation
- quaternary ammonium
- polyethylene glycol
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000007822 coupling agent Substances 0.000 title abstract description 21
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 24
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 23
- 229960000907 methylthioninium chloride Drugs 0.000 claims abstract description 23
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 23
- 238000003756 stirring Methods 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 239000012153 distilled water Substances 0.000 claims abstract description 11
- 230000006837 decompression Effects 0.000 claims abstract description 9
- 238000010438 heat treatment Methods 0.000 claims abstract description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 28
- 229920002125 Sokalan® Polymers 0.000 claims description 24
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 18
- 229960001631 carbomer Drugs 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 238000013329 compounding Methods 0.000 claims description 13
- 238000002604 ultrasonography Methods 0.000 claims description 13
- 238000004090 dissolution Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 230000008961 swelling Effects 0.000 claims description 8
- 239000012467 final product Substances 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 17
- 239000000243 solution Substances 0.000 description 14
- 239000000047 product Substances 0.000 description 11
- 239000011248 coating agent Substances 0.000 description 8
- 238000000576 coating method Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 230000001954 sterilising effect Effects 0.000 description 8
- 239000000499 gel Substances 0.000 description 7
- 238000004659 sterilization and disinfection Methods 0.000 description 7
- 230000001808 coupling effect Effects 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 239000012085 test solution Substances 0.000 description 6
- 206010011409 Cross infection Diseases 0.000 description 5
- 229920000742 Cotton Polymers 0.000 description 4
- 206010029803 Nosocomial infection Diseases 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000001408 fungistatic effect Effects 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002558 medical inspection Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 239000006916 nutrient agar Substances 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 229920000153 Povidone-iodine Polymers 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 229960002233 benzalkonium bromide Drugs 0.000 description 1
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 229960002152 chlorhexidine acetate Drugs 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 229960001621 povidone-iodine Drugs 0.000 description 1
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310374372.6A CN103432600B (zh) | 2013-08-26 | 2013-08-26 | 一种抗菌型医用超声耦合剂及其制备方法 |
| KR1020167008027A KR101990185B1 (ko) | 2013-08-26 | 2014-07-03 | 항균성 의료용 초음파 커플링제 및 이의 제조방법 |
| PCT/CN2014/081587 WO2015027752A1 (fr) | 2013-08-26 | 2014-07-03 | Agent de couplage ultrasonore médical antibactérien et procédé de préparation de celui-ci |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310374372.6A CN103432600B (zh) | 2013-08-26 | 2013-08-26 | 一种抗菌型医用超声耦合剂及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103432600A CN103432600A (zh) | 2013-12-11 |
| CN103432600B true CN103432600B (zh) | 2015-01-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310374372.6A Active CN103432600B (zh) | 2013-08-26 | 2013-08-26 | 一种抗菌型医用超声耦合剂及其制备方法 |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR101990185B1 (fr) |
| CN (1) | CN103432600B (fr) |
| WO (1) | WO2015027752A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104208726B (zh) * | 2014-02-28 | 2017-02-08 | 潍坊医学院 | 一种壳聚糖季铵盐耦合剂及其制备方法 |
| JP6130538B1 (ja) * | 2016-03-04 | 2017-05-17 | 伯東株式会社 | 超音波伝達効率向上組成物、超音波診断用ゲル組成物及び超音波撮影方法 |
| CN105832652A (zh) * | 2016-05-13 | 2016-08-10 | 沈阳赛镝医疗器械有限公司 | 超声耦合剂中介媒质 |
| CN106039330A (zh) * | 2016-06-16 | 2016-10-26 | 吉林医药学院 | 一种含中药成分的抗菌型医用超声耦合剂及其制备方法 |
| CN107648621B (zh) * | 2017-10-26 | 2018-11-27 | 广州华大生物科技有限公司 | 一种超声波探头耦合剂的辐照制备方法 |
| CN112741671A (zh) * | 2019-10-29 | 2021-05-04 | 王强 | 一种体外冲击波碎石用能量介导液及其制备方法 |
| CN112891567A (zh) * | 2021-01-29 | 2021-06-04 | 陈卫东 | 一种乳化剂 |
| CN117085151B (zh) * | 2023-10-18 | 2024-02-23 | 吉林省海卓生物科技有限公司 | 一种超声耦合贴片及其制备方法和应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247607A (zh) * | 2011-08-22 | 2011-11-23 | 江西三鑫医疗科技股份有限公司 | 一种抑菌耦合剂的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR910000026B1 (ko) * | 1989-03-21 | 1991-01-19 | 박수천 | 초음파 푸로브(probe)용 교화체(gel)의 제조방법 |
| KR100360278B1 (ko) * | 2000-03-10 | 2002-11-09 | 김정엽 | 초음파 프로브용 교화체 및 그 제조방법 |
| WO2012009794A1 (fr) | 2010-07-19 | 2012-01-26 | Brusells Ventures Corp. | Composition de gel médical antimicrobien comprenant de l'hydroxyéthylcellulose éthérifiée |
-
2013
- 2013-08-26 CN CN201310374372.6A patent/CN103432600B/zh active Active
-
2014
- 2014-07-03 KR KR1020167008027A patent/KR101990185B1/ko active IP Right Grant
- 2014-07-03 WO PCT/CN2014/081587 patent/WO2015027752A1/fr active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247607A (zh) * | 2011-08-22 | 2011-11-23 | 江西三鑫医疗科技股份有限公司 | 一种抑菌耦合剂的制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 季铵化聚乙烯亚胺的抗菌性能研究;张昕 等;《高分子学报》;20070731(第07期);第627-632页，标题、摘要，第631页右栏第1段 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103432600A (zh) | 2013-12-11 |
| KR101990185B1 (ko) | 2019-06-17 |
| KR20160046907A (ko) | 2016-04-29 |
| WO2015027752A1 (fr) | 2015-03-05 |
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