CN103429101B - 用于饮料的铁补充的方法 - Google Patents
用于饮料的铁补充的方法 Download PDFInfo
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- CN103429101B CN103429101B CN201280012643.7A CN201280012643A CN103429101B CN 103429101 B CN103429101 B CN 103429101B CN 201280012643 A CN201280012643 A CN 201280012643A CN 103429101 B CN103429101 B CN 103429101B
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- ferric pyrophosphate
- citrate
- iron
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- 238000000034 method Methods 0.000 title claims abstract description 27
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title abstract description 42
- 235000013361 beverage Nutrition 0.000 title abstract description 25
- 229910052742 iron Inorganic materials 0.000 title abstract description 19
- 230000009469 supplementation Effects 0.000 title abstract 3
- CADNYOZXMIKYPR-UHFFFAOYSA-B ferric pyrophosphate Chemical compound [Fe+3].[Fe+3].[Fe+3].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O CADNYOZXMIKYPR-UHFFFAOYSA-B 0.000 claims abstract description 32
- 239000011706 ferric diphosphate Substances 0.000 claims abstract description 31
- 235000007144 ferric diphosphate Nutrition 0.000 claims abstract description 31
- 229940036404 ferric pyrophosphate Drugs 0.000 claims abstract description 31
- 239000012141 concentrate Substances 0.000 claims abstract description 11
- SXAWSYZURCZSDX-UHFFFAOYSA-B hydron;[hydroxy(oxido)phosphoryl] hydrogen phosphate;2-hydroxypropane-1,2,3-tricarboxylate;iron(3+);phosphonato phosphate Chemical compound [H+].[H+].[H+].[H+].[H+].[Fe+3].[Fe+3].[Fe+3].[Fe+3].OP([O-])(=O)OP(O)([O-])=O.OP([O-])(=O)OP(O)([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O SXAWSYZURCZSDX-UHFFFAOYSA-B 0.000 claims abstract description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 10
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 9
- 239000001509 sodium citrate Substances 0.000 claims description 8
- 229940038773 trisodium citrate Drugs 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 5
- 239000006185 dispersion Substances 0.000 claims description 4
- HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical group [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 claims description 4
- 229960002413 ferric citrate Drugs 0.000 claims description 3
- 239000002524 monosodium citrate Substances 0.000 claims description 3
- 235000018342 monosodium citrate Nutrition 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 abstract description 5
- 229940036417 ferric pyrophosphate citrate Drugs 0.000 abstract description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 239000000243 solution Substances 0.000 description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 235000008504 concentrate Nutrition 0.000 description 9
- 238000009835 boiling Methods 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 230000007935 neutral effect Effects 0.000 description 5
- 239000013589 supplement Substances 0.000 description 5
- 235000013336 milk Nutrition 0.000 description 4
- 239000008267 milk Substances 0.000 description 4
- 210000004080 milk Anatomy 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 150000002505 iron Chemical class 0.000 description 3
- 235000015205 orange juice Nutrition 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 235000012174 carbonated soft drink Nutrition 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- -1 diphosphonic acid iron (III) salt Chemical class 0.000 description 1
- YSXLJTGZMRNQSG-UHFFFAOYSA-L disodium;6-amino-5-[[2-[4-[2-[4-[2-[(2-amino-5-sulfonatonaphthalen-1-yl)diazenyl]phenyl]sulfonyloxyphenyl]propan-2-yl]phenoxy]sulfonylphenyl]diazenyl]naphthalene-1-sulfonate Chemical compound [Na+].[Na+].C1=CC=C2C(N=NC3=CC=CC=C3S(=O)(=O)OC3=CC=C(C=C3)C(C)(C=3C=CC(OS(=O)(=O)C=4C(=CC=CC=4)N=NC=4C5=CC=CC(=C5C=CC=4N)S([O-])(=O)=O)=CC=3)C)=C(N)C=CC2=C1S([O-])(=O)=O YSXLJTGZMRNQSG-UHFFFAOYSA-L 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000011790 ferrous sulphate Substances 0.000 description 1
- 235000003891 ferrous sulphate Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000020509 fortified beverage Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1522—Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
本发明涉及以焦磷酸铁的形式用可溶的且生物可利用的铁补充饮料的新方法。该方法允许以低成本进行饮料的铁补充，而不影响饮料的原始味道或颜色。还涉及浓缩的焦磷酸铁-柠檬酸盐溶液，以及其在富含铁的饮料的制备中的用途。本发明还涉及通过该方法可获得的饮料。
Description
本发明涉及以焦磷酸铁的形式用可溶的且生物可利用的铁补充饮料的新方法。该方法允许以低成本进行饮料的铁补充，而不影响饮料的原始味道或颜色。还涉及浓缩的焦磷酸铁-柠檬酸盐溶液，以及其在富含铁的饮料的制备中的用途。本发明还涉及通过该方法可获得的饮料。
食物强化项目（Food fortification programmes）通常被认为是应对铁（Fe）缺乏的最具成本效益且可持续的方法。然而，铁强化项目的成功很大程度上取决于Fe化合物的仔细选择。不引起感官变化的便宜且高度生物可利用的Fe化合物将是理想的强化化合物。不幸的是，最具生物可利用的水溶性化合物（例如硫酸亚铁）常引起食物载剂中不可接受的颜色或风味变化，不可用于饮料中（Hurrel&Cook,1990,Trends Food Sci.Technol.1:56-61）。另一方面，已知在中性pH下焦磷酸铁是几乎不溶于水的Fe化合物，其常用于食品工业中用于强化婴儿谷物和巧克力饮料粉末。其主要优点是它对食物载剂不引起不良的颜色变化和引起有限的风味变化。然而，它难溶于有机酸如乙酸或柠檬酸，而溶于矿物酸如胃液。它在人体内（尤其是具有低胃液酸度的那些人）仅部分被吸收。焦磷酸铁的另一个缺点是由于其不溶于水，它不能用来强化饮料。
最近，已经开发了用于食物强化的可微粒化分散的焦磷酸铁（US6616955）。它是基于用乳化剂专门配制的焦磷酸铁颗粒。该产品可分散于水中，但尽管如此，由于颗粒不是真正地溶解，产品的生物可利用性仍然有限。此外，补充成本不允许饮料行业开发适合发展中国家或针对低收入人群的生物可利用铁补充的饮料。
本申请的发明人现已令人惊奇地发现增溶焦磷酸铁的新方法，该方法允许在接近中性pH（在pH5-7之间）下生成水性焦磷酸铁浓缩物，在所述接进中性pH下焦磷酸铁是完全溶解的，并且当用来补充包含至多15mg Fe/250ml饮料时不会产生任何异味或不愉快的颜色变化。这种方法不仅可以增溶焦磷酸铁，而且在冷却和储存时，焦磷酸铁保持在溶液中。此外，当与行业中目前可用的技术相比时，根据本发明生产的铁补充的饮料很便宜且与发展中国家中的铁补充相协调。
因此，本发明提供制备水性可溶焦磷酸铁浓缩物的方法，其中所述方法包含以下步骤：
（a）向水中加入0.1至5重量/体积%焦磷酸铁，
（b）向来自（a）的分散体中加入0.15至50重量/体积%柠檬酸盐，
（c）加热来自（b）的所得溶液，直到焦磷酸铁完全溶解。
作为比较，与柠檬酸一起煮的焦磷酸铁未完全溶解，因为在低酸性pH下煮时形成明显的不溶性正磷酸盐。令人惊奇地，在约6的pH下并且仅在上述条件下，焦磷酸铁完全溶解于柠檬酸三钠的热的水性溶液中。
水性可溶焦磷酸铁浓缩物的pH在4至8之间，优选地pH为中性至微酸性的并且在5至8之间。
本文中使用时，术语“水性溶液”指的是其中溶剂为水的溶液。“水性”一词指属于水、与水相关、类似于水或溶解于水中。水是一种随处可见的溶剂并且显然在饮料行业中是最优选的溶剂。
焦磷酸铁（也被称为二磷酸铁（III）盐，CAS:10058-44-3）、柠檬酸单钠（CAS:18996-35-5）、柠檬酸三钠（CAS:68-04-2）均可以从Spectrum Chemical购买到。
在一个优选的实施方式中，以在0.4和2重量/体积%之间的浓度、甚至更优选地浓度在0.5和0.8重量/体积%之间的浓度，将焦磷酸铁加入水中。在该浓度下，焦磷酸铁完全不溶于水，并形成白色浑浊分散体。
在另一个实施方式中，并且与焦磷酸铁浓度无关，柠檬酸盐的优选的量在4和20重量/体积%之间。甚至更优选地，它在4和10重量/体积%之间。
在另一个实施方式中，根据本发明的方法的特征在于，焦磷酸铁与柠檬酸盐的重量比在0.01和1之间、更优选地在0.05和0.5之间。选择该具体的比例，是为了使柠檬酸盐在中性pH或微碱性pH下有增溶焦磷酸铁的能力。
根据本发明的优选的柠檬酸盐选自柠檬酸一钠和柠檬酸三钠。鉴于加热时增溶焦磷酸铁的能力，最优选的盐是柠檬酸三钠。
在另一个实施方式中，根据本发明的方法的特征在于，步骤（c）的加热步骤是通过在80至120℃之间的温度下加热溶液10至120分钟来进行的。优选地，加热步骤是通过在大气压力下煮沸约100℃直至焦磷酸铁完全溶解来进行的。通常这在30至60分钟内完成。加热步骤可以任选地在加压下进行。在这种情况下，本领域技术人员当然会根据所施加的压强和温度来减少加热时间。
在另一个实施方式中，本发明还涉及通过本发明的方法可获得的水性可溶焦磷酸铁浓缩物。溶液的优选的pH在5和8之间。根据本发明的水性可溶焦磷酸铁浓缩物优选地包含0.25至12.5g Fe/l。
在另外一个实施方式中，本发明涉及根据本发明的水性浓缩物用于生产用1至60mg Fe/升补充的饮料的用途。根据本发明的优选的饮料选自汁、非碳酸软饮、牛奶和果汁。
通过下面实施例来进一步说明本发明。
实施例
实施例1：用可溶性焦磷酸铁补充的橙汁的制备
对于250升橙汁：
将18g焦磷酸铁和180g柠檬酸三钠溶解于3升沸水中。搅拌该铁浓缩物并加热直至完全溶解。然后将溶液冷却并加入到250升橙汁中。最终饮料可以被消毒。
该饮料在250ml即饮饮料（ready drink）中包含4.5mg生物可利用的且溶解的铁。
实施例2：用可溶性焦磷酸铁补充的牛奶的制备
对于250升牛奶：
将18g焦磷酸铁和180g柠檬酸三钠溶解于3升沸水中。搅拌该铁浓缩物并加热直至完全溶解。然后将溶液冷却，并且加入到250升牛奶中，然后马上消毒。
该饮料在250ml即饮饮料中包含4.5mg添加的铁和约0.2mg内在铁（intrinsic iron）。
实施例3：用可溶性焦磷酸铁补充的果汁饮料的制备
对于1000升果汁饮料
将72g焦磷酸铁和720g柠檬酸三钠溶解于12升沸水中。搅拌该铁浓缩物并加热直至完全溶解。然后将溶液冷却。
将156kg糖浆64°Bx、200g抗坏血酸、6kg柠檬酸50%水性溶液、适量风味香料（例如橙）和3kg的β-胡萝卜素10%CWS/S的1%水性原液逐步加入到200L水中，并在不使用高速混合器的条件下小心混合。然后加入冷却的铁溶液。将该糖浆混合、稀释至1000升并消毒。
Claims (7)
1.制备水性可溶焦磷酸铁浓缩物的方法，其中所述方法包含以下步骤：
(a)向水中加入0.1至5重量/体积％焦磷酸铁，
(b)向来自(a)的分散体中加入0.15至50重量/体积％柠檬酸盐，
(c)加热来自(b)的所得溶液，直到焦磷酸铁完全溶解。
2.如权利要求1所述的方法，其特征在于所述焦磷酸铁的浓度在0.4和2重量/体积％之间。
3.如权利要求1或2中任意一项所述的方法，其特征在于所述柠檬酸盐的浓度在4和20重量/体积％之间。
4.如权利要求1或2中任意一项所述的方法，其特征在于所述焦磷酸铁与柠檬酸盐的重量比在0.01和1之间。
5.如权利要求1或2中任意一项所述的方法，其特征在于所述焦磷酸铁与柠檬酸盐的重量比在0.05和0.5之间。
6.如权利要求1或2中任意一项所述的方法，其特征在于所述柠檬酸盐选自柠檬酸一钠和柠檬酸三钠。
7.如权利要求1或2中任意一项所述的方法，其特征在于步骤(c)的所述加热步骤是通过在80至120℃之间的温度下加热溶液10至120分钟来进行的。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11157624A EP2497380A1 (en) | 2011-03-10 | 2011-03-10 | Process for iron supplementation of beverages |
| EP11157624.5 | 2011-03-10 | ||
| PCT/EP2012/054086 WO2012120110A1 (en) | 2011-03-10 | 2012-03-09 | Process for iron supplementation of beverages |
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| Publication Number | Publication Date |
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| CN103429101A CN103429101A (zh) | 2013-12-04 |
| CN103429101B true CN103429101B (zh) | 2015-04-22 |
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| Country | Link |
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| US (1) | US10602763B2 (zh) |
| EP (2) | EP2497380A1 (zh) |
| JP (1) | JP2014508526A (zh) |
| KR (1) | KR102130178B1 (zh) |
| CN (1) | CN103429101B (zh) |
| BR (1) | BR112013023127B1 (zh) |
| WO (1) | WO2012120110A1 (zh) |
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| CN105517454B (zh) * | 2013-08-28 | 2018-07-03 | 帝斯曼知识产权资产管理有限公司 | 肉汤浓缩物的铁补充 |
| US20160213044A1 (en) * | 2013-08-28 | 2016-07-28 | Dsm Ip Assets B.V. | Iron supplementation of a bouillon concentrate |
| US10456418B2 (en) | 2015-10-05 | 2019-10-29 | Navinta, Llc | Preparation of pharmaceutical dosage forms containing iron (III) salts |
| CN106619494A (zh) * | 2016-10-10 | 2017-05-10 | 泰州海达医药科技有限公司 | 枸橼酸焦磷酸铁溶液及其制备方法 |
| MX2019011725A (es) | 2017-03-31 | 2020-07-28 | Abbott Lab | Composiciones nutricionales liquidas que contienen aceite de pescado oxidable, acido rosmarinico y hierro ferrico. |
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| US6616955B2 (en) * | 2001-01-04 | 2003-09-09 | The Proctor & Gamble Co. | Beverage compositions comprising palatable calcium and magnesium sources |
| JP2006061064A (ja) * | 2004-08-26 | 2006-03-09 | Fuji Oil Co Ltd | ミネラル強化蛋白飲料及びその製造法 |
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| US20110021629A1 (en) * | 2009-07-21 | 2011-01-27 | Deanna Jean Nelson | Iron preparation suitable for pharmaceutical formulation and process for the preparation thereof |
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| JP3244264B2 (ja) * | 1997-12-22 | 2002-01-07 | 雪印乳業株式会社 | 鉄強化飲食品 |
| JP5300167B2 (ja) * | 2001-08-24 | 2013-09-25 | 太陽化学株式会社 | 気分障害治療用組成物 |
| TWI360395B (en) * | 2004-03-08 | 2012-03-21 | Fuji Oil Co Ltd | Acid prothin food with mineral |
| EP1743634A4 (en) * | 2004-05-06 | 2007-05-30 | Taiyokagaku Co Ltd | COMPOSITION FOR ACCELERATING THE ALCOHOL TOOL AND THE FOOD OR BEVERAGE CONTAINED IN THE COMPOSITION |
| US20090035385A1 (en) * | 2004-12-22 | 2009-02-05 | Drugtech Corporation | Compositions including iron |
| US20060134227A1 (en) * | 2004-12-22 | 2006-06-22 | Bortz Jonathan D | Compositions including iron |
| JP4785673B2 (ja) | 2006-08-23 | 2011-10-05 | キヤノン株式会社 | 情報処理装置及びその制御方法、プログラム |
| JP2008052442A (ja) | 2006-08-23 | 2008-03-06 | Fuji Xerox Co Ltd | バーコードデータ解析プログラムおよびバーコードデータ解析装置 |
| US7816404B2 (en) * | 2007-07-20 | 2010-10-19 | Rockwell Medical Technologies, Inc. | Methods for the preparation and use of ferric pyrophosphate citrate chelate compositions |
| US20090124572A1 (en) * | 2007-11-09 | 2009-05-14 | Deanna Jean Nelson | Iron-containing nutritional supplement |
| JP4888363B2 (ja) | 2007-12-05 | 2012-02-29 | カルピス株式会社 | 飲料の退色防止法 |
| JP4206428B1 (ja) | 2008-06-09 | 2009-01-14 | 正樹 今川 | 認知症を処置するための組成物及びその利用 |
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2011
- 2011-03-10 EP EP11157624A patent/EP2497380A1/en not_active Ceased
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2012
- 2012-03-09 US US13/985,775 patent/US10602763B2/en not_active Expired - Fee Related
- 2012-03-09 BR BR112013023127-0A patent/BR112013023127B1/pt not_active IP Right Cessation
- 2012-03-09 EP EP12707773.3A patent/EP2683257B1/en not_active Not-in-force
- 2012-03-09 JP JP2013557109A patent/JP2014508526A/ja active Pending
- 2012-03-09 WO PCT/EP2012/054086 patent/WO2012120110A1/en active Application Filing
- 2012-03-09 KR KR1020137022982A patent/KR102130178B1/ko active IP Right Grant
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6616955B2 (en) * | 2001-01-04 | 2003-09-09 | The Proctor & Gamble Co. | Beverage compositions comprising palatable calcium and magnesium sources |
| JP2006061064A (ja) * | 2004-08-26 | 2006-03-09 | Fuji Oil Co Ltd | ミネラル強化蛋白飲料及びその製造法 |
| CN101384295A (zh) * | 2005-12-23 | 2009-03-11 | 阿贾伊·古普塔 | 含铁的肠胃外营养组合物 |
| US20110021629A1 (en) * | 2009-07-21 | 2011-01-27 | Deanna Jean Nelson | Iron preparation suitable for pharmaceutical formulation and process for the preparation thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| KR102130178B1 (ko) | 2020-07-06 |
| US20130330459A1 (en) | 2013-12-12 |
| EP2497380A1 (en) | 2012-09-12 |
| CN103429101A (zh) | 2013-12-04 |
| KR20140009330A (ko) | 2014-01-22 |
| BR112013023127B1 (pt) | 2020-02-11 |
| BR112013023127A2 (pt) | 2016-08-09 |
| JP2014508526A (ja) | 2014-04-10 |
| WO2012120110A1 (en) | 2012-09-13 |
| EP2683257B1 (en) | 2015-01-21 |
| US10602763B2 (en) | 2020-03-31 |
| EP2683257A1 (en) | 2014-01-15 |
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