CN103420988A - 作为聚(adp-核糖)聚合酶(parp)抑制剂的吡啶酮和哒嗪酮衍生物 - Google Patents

作为聚(adp-核糖)聚合酶(parp)抑制剂的吡啶酮和哒嗪酮衍生物 Download PDF

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Publication number
CN103420988A
CN103420988A CN2013103167261A CN201310316726A CN103420988A CN 103420988 A CN103420988 A CN 103420988A CN 2013103167261 A CN2013103167261 A CN 2013103167261A CN 201310316726 A CN201310316726 A CN 201310316726A CN 103420988 A CN103420988 A CN 103420988A
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alkyl
compound
methyl
yuan
base
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Chinese (zh)
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P.琼斯
O.金策尔
G.佩斯卡托尔
L.劳格尔布菲
C.舒尔茨-费德姆勒希特
F.菲里诺
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MSD Italia SRL
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Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
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    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Neurosurgery (AREA)
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  • Cardiology (AREA)
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  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Molecular Biology (AREA)
  • Biochemistry (AREA)
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CN2013103167261A 2006-05-31 2007-05-25 作为聚(adp-核糖)聚合酶(parp)抑制剂的吡啶酮和哒嗪酮衍生物 Pending CN103420988A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0610680.1A GB0610680D0 (en) 2006-05-31 2006-05-31 Therapeutic compounds
GB0610680.1 2006-05-31

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CNA2007800201367A Division CN101501006A (zh) 2006-05-31 2007-05-25 作为聚(adp-核糖)聚合酶(parp)抑制剂的吡啶酮和哒嗪酮衍生物

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CNA2007800201367A Pending CN101501006A (zh) 2006-05-31 2007-05-25 作为聚(adp-核糖)聚合酶(parp)抑制剂的吡啶酮和哒嗪酮衍生物

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US (1) US8188084B2 (ja)
EP (1) EP2029551B1 (ja)
JP (1) JP5351755B2 (ja)
KR (1) KR101529891B1 (ja)
CN (2) CN103420988A (ja)
AU (1) AU2007266836B2 (ja)
BR (1) BRPI0711741B8 (ja)
CA (1) CA2653529C (ja)
ES (1) ES2702781T3 (ja)
GB (1) GB0610680D0 (ja)
IL (1) IL195113A (ja)
MX (1) MX2008015014A (ja)
NO (1) NO343950B1 (ja)
NZ (1) NZ572815A (ja)
WO (1) WO2007138351A2 (ja)
ZA (1) ZA200809238B (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109232575A (zh) * 2017-07-10 2019-01-18 中国科学院上海药物研究所 吡咯[1,2-b]哒嗪类化合物或其可药用盐及它们的用途
CN115785074A (zh) * 2022-04-01 2023-03-14 诺沃斯达药业(上海)有限公司 Parp7抑制剂及其用途

Families Citing this family (43)

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GB0622195D0 (en) * 2006-11-08 2006-12-20 Angeletti P Ist Richerche Bio Therapeutic agents
AU2008322676B9 (en) * 2007-11-15 2014-03-27 Msd Italia S.R.L. Pyridazinone derivatives as PARP inhibitors
DE102008019907A1 (de) * 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
JP5654001B2 (ja) * 2009-04-29 2015-01-14 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ Ｐ２Ｘ７調節因子としての５，６，７，８−テトラヒドロ［１，２，４］トリアゾロ［４，３−ａ］ピラジン誘導体
GB0907515D0 (en) * 2009-04-30 2009-06-10 Glaxo Group Ltd Compounds
ES2627688T3 (es) 2010-04-02 2017-07-31 Ogeda Sa Novedosos compuestos antagonistas selectivos del receptor de NK-3, composición farmacéutica y métodos para uso en trastornos mediados por los receptores de NK-3
US10065960B2 (en) 2010-04-02 2018-09-04 Ogeda Sa NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
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