CN103417553A - Composition for treating sow reproductive system infection and preparation method thereof - Google Patents
Composition for treating sow reproductive system infection and preparation method thereof Download PDFInfo
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- CN103417553A CN103417553A CN2013103911740A CN201310391174A CN103417553A CN 103417553 A CN103417553 A CN 103417553A CN 2013103911740 A CN2013103911740 A CN 2013103911740A CN 201310391174 A CN201310391174 A CN 201310391174A CN 103417553 A CN103417553 A CN 103417553A
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- taurine
- doxycycline hydrochloride
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- system infection
- dimetridazole
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses a composition for treating sow reproductive system infection and a preparation method thereof. The composition comprises, by weight, 5-15% of doxycycline hydrochloride, 10-30% of dimetronidazole, 5-15% of taurine and the balance anhydrous dextrose. The doxycycline hydrochloride and the dimetronidazole are used as antibiotic ingredients and make up for the defect of pathogenic microorganism resistant ranges of the doxycycline hydrochloride and the dimetronidazole, are effective in gram-positive bacteria, gram-negative bacteria, mycoplasmas, chlamydiae, spirochetes, trichomonads, anaerobic bacteria and the like, and avoid therapeutic errors. The taurine reduces inflammatory reaction after infection, controls body temperature effectively, reduces pessimal stimulation after attack and speeds up recovery. The composition combining the doxycycline hydrochloride, the dimetronidazole and the taurine improves the cure rate of sow reproductive system infection, speeds up recovery, and facilitates sow recovery.
Description
Technical field
The present invention relates to field of veterinary, relate to specifically a kind of composition and method of making the same that is used for the treatment of the sow genital system infection.
Background technology
The sow genital system infection is a kind of infection of complexity, it includes antibacterial, mycoplasma, chlamydia, infusorian, anaerobe and other cause pathogeny imcrobe infections, show as that the Gilt Uterus inner membrance is hemorrhage, edema, be diffusivity or focal flushing, swelling, be dispersed in petechia and ecchymosis, ulcer is arranged, the polyp hypertrophy; Be attended by addition serious vagina and flow out the rheuminess thing, secretions is yellow, yellow green or maroon, the dense thick courageous and upright mucus of linen muddiness or cheesy thing.The sow main manifestations is non-estrus or oestruses extremely, unmatches repeatly, causes very large loss.
At present, because disease is MOI, the present stage culturist also can't judge the cause of disease kind by means such as antibacterial culturing, microorganism separation by the laboratory means, easily treat and unsuccessfully cause that sb.'s illness took a turn for the worse, severe patient can cause sterile, and then can only eliminate sow, cause very large economic loss.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, provides a kind of and can treat sow genital system infection instant effect, treating both the principal and secondary aspects of a disease, the compositions of expansion antibacterial range.
It is simple that another object of the present invention is to provide a kind of technique, the preparation method of the above-mentioned composition of easily realizing.
The present invention is achieved through the following technical solutions:
A kind of compositions that is used for the treatment of the sow genital system infection, is characterized in that, following raw material, consists of by weight percentage: doxycycline hydrochloride 5～15%, and dimetridazole 10～30%, taurine 5～15%, surplus is anhydrous glucose.
The better composition of above-mentioned composition is by weight percentage: doxycycline hydrochloride 8～12%, and dimetridazole 15～25%, taurine 8～12%, surplus is anhydrous glucose.
The best of above-mentioned composition forms: doxycycline hydrochloride 10%, and dimetridazole 20%, taurine 10%, anhydrous glucose is 60%.
The above-mentioned preparation method that is used for the treatment of the compositions of sow genital system infection, is characterized in that, comprises the steps:
Doxycycline hydrochloride, dimetridazole, taurine were pulverized to No. 5 sieves and obtained the compositions of the present invention for the sow genital system infection afterwards with after anhydrous glucose fully mixes; wherein the mass percent of compositions is doxycycline hydrochloride 5～15%; dimetridazole 10～30%; taurine 5～15%, surplus is anhydrous glucose.
The better composition of above-mentioned composition is by weight percentage: doxycycline hydrochloride 8～12%, and dimetridazole 15～25%, taurine 8～12%, surplus is anhydrous glucose.
The best of above-mentioned composition forms: doxycycline hydrochloride 10%, and dimetridazole 20%, taurine 10%, anhydrous glucose is 60%.
The present invention has following technique effect:
Compositions of the present invention is compound preparation, adopts this broad ectrum antibiotic of doxycycline hydrochloride, for controlling the infection such as various gram positive bacterias, negative bacterium, mycoplasma, chlamydia; Adopt dimetridazole for controlling spirillum, infusorian, anaerobic infection; Both are used in conjunction with, and can effectively control the pathogenic microorganism of sow genital system infection, and the effect complementation enlarges therapeutic domain; The functions such as that taurine has is analgesic, antiinflammatory, for reducing metainfective inflammatory reaction, and have control body temperature, reduces the pessimal stimulation after morbidity, accelerates rehabilitation speed; The three share, and the sow genital system infection is improved to cure rate, accelerates rehabilitation, and is conducive to the sow rehabilitation.
The preparation method of composition technique that the present invention is used for the treatment of the sow genital system infection is simple, easily realizes.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described in further detail.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1-6 is that to produce the 100kg compositions be that example describes, and at first doxycycline hydrochloride, dimetridazole, taurine is pulverized after No. 5 sieves standby.
Embodiment 1
Accurately take doxycycline hydrochloride 15kg, dimetridazole 10kg, taurine 5kg, premix 20 minutes, mixture obtains the compositions of the present invention for the sow genital system infection again with after anhydrous glucose 70kg fully mixes.
Embodiment 2
Accurately take doxycycline hydrochloride 5kg, dimetridazole 30kg, taurine 15kg, premix 20 minutes, mixture obtains the compositions of the present invention for the sow genital system infection again with after anhydrous glucose 50kg fully mixes.
Embodiment 3
Accurately take doxycycline hydrochloride 12kg, dimetridazole 15kg, taurine 8kg, premix 20 minutes, mixture obtains the compositions of the present invention for the sow genital system infection again with after anhydrous glucose 65kg fully mixes.
Embodiment 4
Accurately take doxycycline hydrochloride 8kg, dimetridazole 25kg, taurine 12kg, premix 20 minutes, mixture obtains the compositions of the present invention for the sow genital system infection again with after anhydrous glucose 55kg fully mixes.
Embodiment 5
Accurately take doxycycline hydrochloride 9kg, dimetridazole 18kg, taurine 11kg, premix 20 minutes, mixture obtains the compositions of the present invention for the sow genital system infection again with after anhydrous glucose 62kg fully mixes.
Embodiment 6
Accurately take doxycycline hydrochloride 10kg, dimetridazole 20kg, taurine 10kg, premix 20 minutes, mixture obtains the compositions of the present invention for the sow genital system infection again with after anhydrous glucose 60kg fully mixes.
Clinical trial:
1. laboratory animal:
Choose at random 100 of ill sows.
2. Experimental agents
The compositions our unit development of the embodiment of the present invention 6 preparations;
10% doxycycline hydrochloride powder and 90% anhydrous glucose are mixed with our unit's laboratory preparation;
20% dimetridazole powder and 80% anhydrous glucose are mixed with our unit's laboratory preparation.
3. experimental technique:
100 sick pigs are divided into to four groups at random by body weight, 25 every group.
The A group, for the blank group, does not give Drug therapy.
B group is treated with 10% doxycycline hydrochloride powder and 90% anhydrous grape sugar mixture, and usage: take orally, every 1kg body weight 0.1g, 1 time on the 1st, be used in conjunction 4 days.
The C group is treated with the anhydrous grape sugar mixture of 20% dimetridazole powder and 80%, usage: for oral administration, every 1kg body weight 0.1g, 1 time on the 1st, be used in conjunction 4 days.
The D group is treated by the compositions of the embodiment of the present invention 6 preparations, usage: for oral administration, every 1kg body weight 0.1g, 1 time on the 1st, be used in conjunction 4 days.
After treatment starts, every day entry affected pig health situation of change, treat after 7 days and add up therapeutic effect, successful number of breeding after 1 month, wherein:
Invalid: after referring to 7 days, the affected pig symptom, without obvious change, still keeps the front symptom for the treatment of.
Effectively: after referring to 7 days, the affected pig symptom changes, and symptom is better than the effect before treatment.
Cure: after referring to 7 days, transference cure, affected pig is got well.Its numeral is included in significant digits.
Symptom is arranged during end: after referring to 7 days, affected pig still has certain symptom, and before its Symptoms is better than treatment or without change, affected pig is not cured.Its numeral has been included in the numeral of invalid number of elements and effective number of elements.
Breed and successfully count: after referring to use medicine, breed successfully and a conceived sow number.
Result of the test is as shown in the table.
4. conclusion:
The result of the test statistical analysis, the embodiment of the present invention 6 is for combination treatment group, 10% doxycycline hydrochloride treated powder group and the 20% dimetridazole powder group of sow genital system infection and matched group difference extremely significantly (P<0.01).Curative effect of the present invention is better than existing two kinds of medicines.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (6)
1. be used for the treatment of the compositions of sow genital system infection, it is characterized in that, formed by following raw material by weight percentage: doxycycline hydrochloride 5～15%, dimetridazole 10～30%, taurine 5～15%, surplus is anhydrous glucose.
2. the compositions that is used for the treatment of the sow genital system infection according to claim 1 is characterized in that consisting of of each compositions in weight percentage: doxycycline hydrochloride 8～12%, and dimetridazole 15～25%, taurine 8～12%, surplus is anhydrous glucose.
3. the compositions that is used for the treatment of the sow genital system infection according to claim 1 is characterized in that consisting of of each compositions in weight percentage: doxycycline hydrochloride 10%, and dimetridazole 20%, taurine 10%, anhydrous glucose is 60%.
4. be used for the treatment of as claimed in claim 1 the preparation method of the compositions of sow genital system infection; it is characterized in that; comprise the steps: that doxycycline hydrochloride, dimetridazole, taurine were pulverized to No. 5 sieves obtains the compositions of the present invention for the sow genital system infection afterwards with after anhydrous glucose fully mixes; wherein the mass percent of compositions is doxycycline hydrochloride 5～15%; dimetridazole 10～30%; taurine 5～15%, surplus is anhydrous glucose.
5. the preparation method that is used for the treatment of the compositions of sow genital system infection according to claim 4; it is characterized in that consisting of of each compositions in weight percentage: doxycycline hydrochloride 8～12%; dimetridazole 15～25%, taurine 8～12%, surplus is anhydrous glucose.
6. the preparation method that is used for the treatment of the compositions of sow genital system infection according to claim 4 is characterized in that consisting of of each compositions in weight percentage: doxycycline hydrochloride 10%, and dimetridazole 20%, taurine 10%, anhydrous glucose is 60%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103911740A CN103417553A (en) | 2013-08-30 | 2013-08-30 | Composition for treating sow reproductive system infection and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2013103911740A CN103417553A (en) | 2013-08-30 | 2013-08-30 | Composition for treating sow reproductive system infection and preparation method thereof |
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| CN103417553A true CN103417553A (en) | 2013-12-04 |
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| CN2013103911740A Pending CN103417553A (en) | 2013-08-30 | 2013-08-30 | Composition for treating sow reproductive system infection and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105919942A (en) * | 2016-07-07 | 2016-09-07 | 杭州爱力迈动物药业有限公司 | Dimetridazole soluble powder and preparation method thereof |
-
2013
- 2013-08-30 CN CN2013103911740A patent/CN103417553A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105919942A (en) * | 2016-07-07 | 2016-09-07 | 杭州爱力迈动物药业有限公司 | Dimetridazole soluble powder and preparation method thereof |
| CN105919942B (en) * | 2016-07-07 | 2019-05-03 | 杭州爱力迈动物药业有限公司 | A kind of Dimetridazole soluble powder and preparation method thereof |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131204 |
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| WD01 | Invention patent application deemed withdrawn after publication |