CN103415519B - 作为β-分泌酶(BACE)抑制剂有用的6，7-二氢-吡唑[1，5-a]吡嗪-4-基胺衍生物 - Google Patents

作为β-分泌酶(BACE)抑制剂有用的6，7-二氢-吡唑[1，5-a]吡嗪-4-基胺衍生物 Download PDF

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Publication number
CN103415519B
CN103415519B CN201280011146.5A CN201280011146A CN103415519B CN 103415519 B CN103415519 B CN 103415519B CN 201280011146 A CN201280011146 A CN 201280011146A CN 103415519 B CN103415519 B CN 103415519B
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compound
mixture
vacuo
phenyl
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CN103415519A (zh
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A.A.特拉班科-苏亚雷滋
H.J.M.吉森
M.L.M.范戈尔
J.A.维加拉米罗
F.德加多-吉梅内滋
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201280011146.5A 2011-03-01 2012-02-29 作为β-分泌酶(BACE)抑制剂有用的6，7-二氢-吡唑[1，5-a]吡嗪-4-基胺衍生物 Expired - Fee Related CN103415519B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11156463.9 2011-03-01
EP11156463 2011-03-01
PCT/EP2012/053455 WO2012117027A1 (en) 2011-03-01 2012-02-29 6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine derivatives useful as inhibitors of beta-secretase (bace)

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CN103415519A CN103415519A (zh) 2013-11-27
CN103415519B true CN103415519B (zh) 2016-03-02

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MY161407A (en) 2017-04-14
US20140005200A1 (en) 2014-01-02
JP2014506907A (ja) 2014-03-20
UA109800C2 (xx) 2015-10-12
IL228158A0 (en) 2013-11-25
CO6751282A2 (es) 2013-09-16
IL228158A (en) 2016-07-31
CA2824360A1 (en) 2012-09-07
CY1117663T1 (el) 2017-05-17
WO2012117027A1 (en) 2012-09-07
PH12013501807A1 (en) 2015-09-30
PL2681219T3 (pl) 2016-03-31
HRP20160030T1 (hr) 2016-02-12
JP5853033B2 (ja) 2016-02-09
HUE026338T2 (en) 2016-05-30
US9346811B2 (en) 2016-05-24
NZ614551A (en) 2014-06-27
BR112013022039A2 (pt) 2016-11-29
KR102012671B1 (ko) 2019-08-21
DK2681219T3 (en) 2016-01-18
EA201391251A1 (ru) 2014-01-30
KR20140010052A (ko) 2014-01-23
CL2013002486A1 (es) 2014-02-21
EP2681219B1 (en) 2015-10-28
MX338333B (es) 2016-04-11
SG192963A1 (en) 2013-09-30
ES2558779T3 (es) 2016-02-08
EA022649B1 (ru) 2016-02-29
ZA201306545B (en) 2015-03-25
AU2012222394B2 (en) 2016-06-16
PT2681219E (pt) 2016-02-10
AU2012222394A1 (en) 2013-07-25
SI2681219T1 (sl) 2016-02-29
CN103415519A (zh) 2013-11-27
MX2013010040A (es) 2013-11-04
EP2681219A1 (en) 2014-01-08
HK1188784A1 (zh) 2014-05-16

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