CN103396974B - 用于高效乳酸生产的材料和方法 - Google Patents

用于高效乳酸生产的材料和方法 Download PDF

Info

Publication number
CN103396974B
CN103396974B CN201310012065.3A CN201310012065A CN103396974B CN 103396974 B CN103396974 B CN 103396974B CN 201310012065 A CN201310012065 A CN 201310012065A CN 103396974 B CN103396974 B CN 103396974B
Authority
CN
China
Prior art keywords
lactate
lactic acid
coli
strain
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201310012065.3A
Other languages
English (en)
Chinese (zh)
Other versions
CN103396974A (zh
Inventor
周胜德
朗尼·奥尼尔·英格拉姆
基尔内塔姆·T·尚穆加姆
洛兰·P·约马诺
塔米·B·格拉巴尔
乔纳森·C·穆尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida Research Foundation Inc
Original Assignee
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida Research Foundation Inc filed Critical University of Florida Research Foundation Inc
Publication of CN103396974A publication Critical patent/CN103396974A/zh
Application granted granted Critical
Publication of CN103396974B publication Critical patent/CN103396974B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56Lactic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201310012065.3A 2005-08-10 2006-08-10 用于高效乳酸生产的材料和方法 Expired - Fee Related CN103396974B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US70688705P 2005-08-10 2005-08-10
US60/706,887 2005-08-10
US76157606P 2006-01-24 2006-01-24
US60/761,576 2006-01-24
US79961906P 2006-05-11 2006-05-11
US60/799,619 2006-05-11
CN2006101093329A CN1912107B (zh) 2005-08-10 2006-08-10 用于高效乳酸生产的材料和方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2006101093329A Division CN1912107B (zh) 2005-08-10 2006-08-10 用于高效乳酸生产的材料和方法

Publications (2)

Publication Number Publication Date
CN103396974A CN103396974A (zh) 2013-11-20
CN103396974B true CN103396974B (zh) 2016-12-07

Family

ID=37488414

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201310012065.3A Expired - Fee Related CN103396974B (zh) 2005-08-10 2006-08-10 用于高效乳酸生产的材料和方法
CN2006101093329A Expired - Fee Related CN1912107B (zh) 2005-08-10 2006-08-10 用于高效乳酸生产的材料和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2006101093329A Expired - Fee Related CN1912107B (zh) 2005-08-10 2006-08-10 用于高效乳酸生产的材料和方法

Country Status (8)

Country Link
US (2) US7629162B2 (cg-RX-API-DMAC7.html)
EP (2) EP2305826B1 (cg-RX-API-DMAC7.html)
JP (2) JP4991205B2 (cg-RX-API-DMAC7.html)
CN (2) CN103396974B (cg-RX-API-DMAC7.html)
BR (1) BRPI0603072A (cg-RX-API-DMAC7.html)
DK (2) DK2305826T3 (cg-RX-API-DMAC7.html)
ES (2) ES2401339T3 (cg-RX-API-DMAC7.html)
PL (2) PL2305826T3 (cg-RX-API-DMAC7.html)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004044210A2 (en) * 2002-11-06 2004-05-27 University Of Florida Materials and methods for the efficient production of acetate and other products
WO2005033324A1 (ja) * 2003-09-30 2005-04-14 Mitsui Chemicals, Inc. D−乳酸菌生産用生体触媒
DK2305826T3 (en) * 2005-08-10 2016-06-27 Univ Florida Materials and methods for the efficient production of lactic acid
ES2389582T3 (es) * 2007-03-20 2012-10-29 University Of Florida Research Foundation, Inc. Materiales y métodos para la producción eficaz de succinato y malato
US20090082600A1 (en) * 2007-06-06 2009-03-26 Shengde Zhou Native homoethanol Pathway for ethanol production in E. coli
BRPI0913901A2 (pt) * 2008-06-17 2016-12-13 Genomatica Inc micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato
CN102333859B (zh) 2008-09-16 2015-04-22 三井化学株式会社 由来自植物的原料生产乳酸的方法及生产乳酸的细菌
US8993287B2 (en) * 2008-11-18 2015-03-31 University Of Florida Research Foundation, Inc. Biocatalysts and methods for conversion of hemicellulose hydrolysates to biobased products
US8715972B2 (en) * 2009-02-18 2014-05-06 Bio-Energy Corporation Homolactic fermentation from pentose
BRPI1009992A2 (pt) 2009-04-02 2020-08-18 University Of Florida Research Foundation, Inc. células bacterianas
US9169485B2 (en) 2009-06-23 2015-10-27 Bp Corporation North America Inc. Recombinant ethanologenic bacteria comprising a urease gene
US8497102B2 (en) 2009-07-30 2013-07-30 Metabolic Explorer Mutant methylglyoxal synthase (MGS) for the production of a biochemical by fermentation
US10017793B2 (en) 2009-11-18 2018-07-10 Myriant Corporation Metabolic evolution of Escherichia coli strains that produce organic acids
WO2011063157A2 (en) 2009-11-18 2011-05-26 Myriant Technologies Llc Organic acid production in microorganisms by combined reductive and oxidative tricarboxylic acid cycle pathways
AU2010349739B2 (en) 2009-11-18 2014-10-16 Ptt Global Chemical Public Company Limited Metabolic evolution of Escherchia coli strains that produce organic acids
US9017976B2 (en) 2009-11-18 2015-04-28 Myriant Corporation Engineering microbes for efficient production of chemicals
BR112013012630B1 (pt) 2010-11-22 2021-09-08 Novozymes, Inc. Célula de levedura geneticamente modificada, e, método para produzir 3-hp
US9347077B2 (en) 2011-07-08 2016-05-24 University Of Florida Research Foundation, Incorporated Over-expression of a putative oxidoreductase (UcpA) for increasing furfural or 5-hydroxymethylfurfural tolerance
KR20140083970A (ko) 2011-07-22 2014-07-04 미리안트 코포레이션 유기산으로의 글리세롤의 발효
JPWO2014017469A1 (ja) * 2012-07-23 2016-07-11 三井化学株式会社 D−乳酸の生産方法およびポリマーの生産方法
BR112015012409A2 (pt) 2012-11-30 2017-09-12 Novozymes Inc célula recombinante de levedura, e, método de produção de 3-hp
KR20140075044A (ko) 2012-12-07 2014-06-19 삼성전자주식회사 불포화 카르복실산의 제조방법
CN104278003B (zh) * 2013-07-12 2018-12-18 中国科学院天津工业生物技术研究所 生产d-乳酸的重组大肠杆菌及其应用
DK3027733T3 (en) 2013-07-31 2018-12-10 Novozymes As Preparation of 3-Hydroxypropionic Acid in Recombinant Yeast Expressing an Insect Aspartate-1 Decarboxylase
EP2977471A1 (en) * 2014-07-23 2016-01-27 PURAC Biochem BV Genetic modification of (S)-lactic acid producing thermophilic bacteria
CN106574236B (zh) * 2014-07-23 2020-12-11 普拉克生化公司 遗传修饰的产生(r)-乳酸的嗜热细菌
KR102581464B1 (ko) 2015-05-28 2023-09-21 삼성전자주식회사 락테이트 데히드로게나제 변이체를 스크리닝하는 방법, 락테이트 데히드로게나제 변이체, 상기 변이체를 포함하는 폴리뉴클레오티드, 벡터, 미생물, 및 상기 미생물을 이용하여 락테이트를 생산하는 방법
JP2017121184A (ja) * 2016-01-04 2017-07-13 花王株式会社 変異リゾプス属菌
WO2019159011A2 (en) 2018-02-16 2019-08-22 Ptt Global Chemical Public Company Limited Microorganisms and processes for lactic acid production
CN109280652A (zh) * 2018-09-13 2019-01-29 四川自豪时代药业有限公司 一种外源高表达乳酸脱氢酶突变体的高密度发酵方法
CN109321590B (zh) * 2018-10-19 2022-06-21 北京化工大学 利用乙酸生产l-乳酸的基因工程菌及其构建方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1156180A (zh) * 1995-09-05 1997-08-06 底古萨股份公司 用大肠杆菌生产色氨酸
CN1912107B (zh) * 2005-08-10 2013-03-13 佛罗里达大学研究基金会公司 用于高效乳酸生产的材料和方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821093A (en) * 1988-08-31 1998-10-13 University Of Florida Research Foundation, Inc. Recombinant cells that highly express chromosomally-integrated heterologous genes
US4963486A (en) 1989-04-21 1990-10-16 Cornell Research Foundation, Inc. Direct fermentation of corn to L(+)-lactic acid by Rhizopus oryzae
IT1294728B1 (it) 1997-09-12 1999-04-12 Biopolo S C A R L Ceppi di lievito per la riproduzione di acido lattico
WO2002088308A2 (en) 2001-04-26 2002-11-07 Archer-Daniels-Midland Company Novel strains of rhizopus oryzae and uses thereof
CN100335626C (zh) 2002-05-30 2007-09-05 卡吉尔道有限责任公司 在酵母中生产l-乳酸的方法与材料
US7300787B2 (en) 2002-07-05 2007-11-27 Archer-Daniels-Midland Company Lactobacillus strains and use thereof in fermentation for L-lactic acid production
WO2004044210A2 (en) * 2002-11-06 2004-05-27 University Of Florida Materials and methods for the efficient production of acetate and other products
US20050112737A1 (en) 2003-11-20 2005-05-26 A. E. Staley Manufacturing Co. Lactic acid producing yeast

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1156180A (zh) * 1995-09-05 1997-08-06 底古萨股份公司 用大肠杆菌生产色氨酸
CN1912107B (zh) * 2005-08-10 2013-03-13 佛罗里达大学研究基金会公司 用于高效乳酸生产的材料和方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Accumulation of Methylglyoxal in Anaerobically Grown Escherichia coli and Its Detoxification by Expression of the Pseudomonas putida Glyoxalase I Gene;Marie M. Zhu et al.;《Metabolic Engineering》;20011231;第3卷;第218-225页 *
From famine to feast: the role of methylglyoxal production in Escherichia coli;S. Totemeyer et al.;《Molecular Microbiology》;19981231;第27卷(第3期);第553-562页 *
Production of Optically Pure d-Lactic Acid in Mineral Salts Medium by Metabolically Engineered Escherichia coli W3110;Shengde Zhou et al.;《APPLIED AND ENVIRONMENTAL MICROBIOLOGY》;20030131;第69卷(第1期);第399-407页 *

Also Published As

Publication number Publication date
BRPI0603072A (pt) 2007-03-27
PL2305826T3 (pl) 2016-10-31
CN1912107A (zh) 2007-02-14
US8426191B2 (en) 2013-04-23
CN1912107B (zh) 2013-03-13
EP1760156A3 (en) 2007-04-04
ES2401339T3 (es) 2013-04-18
EP1760156B1 (en) 2012-12-19
US7629162B2 (en) 2009-12-08
JP5798441B2 (ja) 2015-10-21
EP2305826B1 (en) 2016-03-30
DK2305826T3 (en) 2016-06-27
EP2305826A1 (en) 2011-04-06
JP2007049993A (ja) 2007-03-01
US20100203602A1 (en) 2010-08-12
EP1760156A2 (en) 2007-03-07
DK1760156T3 (da) 2013-03-18
CN103396974A (zh) 2013-11-20
EP1760156A9 (en) 2007-04-25
ES2573980T3 (es) 2016-06-13
PL1760156T3 (pl) 2013-05-31
US20070037265A1 (en) 2007-02-15
JP2012010715A (ja) 2012-01-19
JP4991205B2 (ja) 2012-08-01

Similar Documents

Publication Publication Date Title
CN103396974B (zh) 用于高效乳酸生产的材料和方法
Zhang et al. Production of L-alanine by metabolically engineered Escherichia coli
Jantama et al. Combining metabolic engineering and metabolic evolution to develop nonrecombinant strains of Escherichia coli C that produce succinate and malate
CN101688196B (zh) 用于有效生产琥珀酸和苹果酸的材料和方法
US8900835B2 (en) Engineering of thermotolerant Bacillus coagulans for production of D(−)-lactic acid
WO2008119009A2 (en) Materials and methods for efficient alanine production
US20160304917A1 (en) Modified Microorganism for Improved Production of Alanine
US10287558B2 (en) Microorganisms for succinic acid production
US9850506B2 (en) Modified microorganism for improved production of fine chemicals on sucrose
JP7158107B2 (ja) 有機化合物の生産方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20161207

Termination date: 20190810

CF01 Termination of patent right due to non-payment of annual fee