CN103372186A - Polymer plant gel - Google Patents

Abstract

The invention discloses a polymer plant gel, a preparation method of the same and application of the gel in abatement of fever. The polymer plant gel comprises the following raw materials in parts by weight: 5-15 parts of Carbomer, 2-6 parts of hydroxybenzoic acid, 40-60 parts of alcohol, 10-30 parts of glycerol, 3-7 parts of borneol, 4-8 parts of mint extract solution, 3-7 parts of balsam pear extract solution and 3-7 parts of ginger extract solution; if necessary, the raw materials further include extract solution of one or more of Centipeda minima, Borneol leaves, honeysuckle pearl powder, herba leonuri, chrysanthemum, semen plantaginis, Chinese banana root, Oxalis corniculata and yellow ginger. The gel provided by the invention is free of hormone and stimulating substance, cannot hurt human visceral organs, such as liver and kidney, cannot cause drug resistance, has no side effect, is easy to carry and simple and convenient to use, thereby being a green plant natural fever-relieving antipyretic product.

Description

A kind of macromolecule plant gel

Technical field:

The present invention relates to the agent of a kind of hydrophilic macromolecule plant gel, its preparation method and application, belong to field of pharmaceutical preparations.

Background technology:

Its cooling extent of traditional physical cooling method less (average 0.26 ℃), radiating efficiency is low, and it is also lasting not to act on, and rubbing bath operation interference patient rest, and it is uncomfortable to increase the patient, also increases nursing work load.And Traditional Chinese medical theory has original curative effect for bringing down a fever, the present invention takes the theory of thought inner disease outer treat with the ancient traditional Chinese medical science of China as the leading factor with YIN and YANG balancing, use and used the external application elite in conjunction with integration of edible and medicinal herbs mechanism in thousand in the Chinese medicine, develop a kind of novel product of bringing down a fever-plant polymeric gel agent.Wherein:

Fructus Momordicae charantiae: have the heat clearing away heart-fire of dispelling, anti-inflammation and sterilization, the refreshment that makes eye bright, the QI invigorating benefit is smart, quenches the thirst and relieves summer heat, and controls carbuncle, summer boil, miliaria too much, remove the agitation of skin, the function such as enhance metabolism.

Rhizoma Zingiberis Recens: have cooling and refresh oneself, the sunstroke prevention emergency, anti-inflammation and sterilization, the effect that the cold expelling that induces sweat, preventing or arresting vomiting eliminate the phlegm by the taste cold-evil, helps the yang-energy of taste, with controlling the flu that wind and cold causes, vomiting, the diseases such as cough.

Borneolum Syntheticum: have the function that the refreshment of having one's ideas straightened out, clearing heat for detumescence, pain relieving are arranged

Herba Menthae: have refrigerant, cooling, antipruritic, pain relieving, dispel the wind, go the miliaria effect.

The plants essential oil effect:

One, sterilization: because quintessence oil has antibiotic antiseptical composition, so that it has is antibiotic, antimicrobial and antiviral characteristic.

Two, provide cytotrophy: because quintessence oil contains vitamin, antibiotic, so can furnish us with soma nutrition.

Three, balance body, the heart, spirit: the most important material of quintessence oil is abnormal smells from the patient, and it can affect the limbic system of brain, acts in the olfactory sensation, and small aromatic molecules more can cause at nervus centralis the reaction of psychology and physiology different levels.Has calm auxiliaring effect.

Four, immunologic function: wherein most important characteristic is the immune system that volatile oil helps to strengthen health.Help the attack of the various pathogenic bacterias of opposing, virus.

Summary of the invention:

The purpose of this invention is to provide a kind of hydrophilic plant high-molecular gel, further, the invention provides a kind of gel with the effect of bringing down a fever.Gel of the present invention does not contain hormone or pungent.The internal organs such as body Liver and kidney of not hurting sb.'s feelings can not develop immunity to drugs, and have no side effect, and are easy to carry, and are easy to use, are the natural products of bringing down a fever of bringing down a fever of green plants.

The objective of the invention is to be achieved through the following technical solutions, one aspect of the present invention relates to this gel itself, it is characterized in that the raw material for preparing gel comprises,

Carbomer 5-15 weight portion;

Hydroxy benzoic acid 2-6 weight portion;

Ethanol 40-60 weight portion;

Glycerol 10-30 weight portion;

Borneolum Syntheticum 3-7 weight portion;

Herba Menthae extraction solution 4-8 weight portion;

Fructus Momordicae charantiae extraction solution 3-7 weight portion;

Rhizoma Zingiberis Recens extraction solution 3-7 weight portion;

Randomly, also comprise one or both or two or more extraction solutions in sanjiejian, borneol leaf, Flos Lonicerae Margarita powder, Herba Leonuri, Flos Chrysanthemi, Semen Plantaginis, Radix Musae, Vat slurry grass, the Dioscorea zingiberensis.

In a preferred embodiment of the present invention, described gel also comprises plants essential oil.

In a preferred embodiment of the present invention, described raw material also comprises alkali, and described alkali is sodium hydroxide or potassium hydroxide preferably.

The present invention also relates to the preparation method that contains above-mentioned gel on the other hand, it is characterized in that comprising the steps: Herba Menthae is prepared extraction solution through alcohol extraction; Fructus Momordicae charantiae and Rhizoma Zingiberis Recens prepare extraction solution through water extraction.By above-claimed cpd and conventional adjuvant are made regular dosage form.

In a preferred embodiment of the present invention, also comprise the steps:

Take by weighing carbomer and add the purified water mixing, make substrate; After P-hydroxybenzoic acid 4g being dissolved in the mixed liquor of ethanol and glycerol, add in the substrate, add the Herba Menthae extraction solution again, Borneolum Syntheticum adds the Fructus Momordicae charantiae extraction solution again, and the Rhizoma Zingiberis Recens extraction solution adds purified water, stirs evenly into the fruit jelly shape, sterilization, packing, packing.

The present invention also relates to the application of above-mentioned gel in the preparation antipyretic on the other hand, and described medicine is external used medicine preferably.

Gel of the present invention is taken the theory of thought inner disease outer treat with the ancient traditional Chinese medical science of China as the leading factor with YIN and YANG balancing, use and used the external application elite in conjunction with integration of edible and medicinal herbs mechanism in thousand in the Chinese medicine, have than other Physical temperature-lowering, the product of bringing down a fever such as bring down a fever, the speed of bringing down a fever faster, and more more scientific rationally than other product prescription of bringing down a fever, curative effect is more definite, in addition only once being coated with the mode of bringing down a fever that can take effect, makes the process of bringing down a fever be more prone to control.

The specific embodiment:

Concrete preparation technology is as follows

First Fructus Momordicae charantiae is made into 15% liquid filtering stand for standby use through water extraction, gingerade concentration degree is that 10% concentration filtering and standing is for subsequent use, and Herba Menthae is put forward pure 10% liquid filtering stand for standby use, takes by weighing carbomer 10g and adds the purified water mixing, makes substrate A; After sodium hydroxide 2g is dissolved in purified water, add among the substrate A, stir evenly and make gel substrate B; After P-hydroxybenzoic acid 4g being dissolved in the mixed liquor of ethanol 50g and glycerol 20g, add among the substrate B, add Herba Menthae solution 6g again, Borneolum Syntheticum 5g adds Fructus Momordicae charantiae solution 5g again, and Rhizoma Zingiberis Recens solution 5g adds purified water, stirs evenly into the fruit jelly shape, sterilization, packing, packing.

Clinical trial

125 routine patients are as object of study, (patient's normal therapeutic all continues, treatment group 80 examples wherein, matched group 45 examples)

Clinical experiment method: directly be applied in heating position (in temple, forehead, cervical region, the axillary fossa, popliteal, thigh and calf is inboard) and locate.But the time of smearing smears until remission continuously according to multiple location between the weight interval of patient's symptom 10 minutes-30 minutes.

Estimate statistical method: observe that curative effect refers to the heating paresthesia remission rate, the symptom of the bringing down a fever time plays rate.

Clinical evaluation standard: be divided into low grade fever, middle heat, high heat, excessive heat level Four according to different heat calibration symptom degree.

Low grade fever (37.4 ℃-38 ℃), middle heat (38.1 ℃-39 ℃),

High heat (39.1 ℃-41 ℃), excessive heat (more than 41 ℃).

Curative effect determinate standard: clinical produce effects: clinical symptoms, sign disappear or basic the disappearance, and symptom, somatic feature score reduce 〉=95%; Clinical effective: clinical symptoms, sign are obviously improved, and symptom, somatic feature score reduce 〉=70%;

Clinical invalid: clinical symptoms, sign are without obvious improvement, and symptom, somatic feature score reduce less than 30%.

(treatment group adopts the treatment of hydrophilic plant high-molecular gel glue, and matched group adopts other different antipyretic gels)

Treatment group and matched group Data Comparison table.

Group number and standard	Clinical produce effects	Clinical effective	Clinical invalid	Total effective rate
					Treatment group (80 example)	(51 example) 64%	(27 example) 34%	(2 example) 2%	98％
Matched group (45 example)	(20 example) 45%	(20 example) 45%	(5 example) 10%	90％

The data conclusion: show that the auxiliary effect stability of bringing down a fever for the treatment of group hydrophilic plant high-molecular gel glue is reliable, data are presented as that total effective rate is 98%, and clinical obvious effective rate is 64%.

Treatment group and matched group doing well,improving situation contrast table after the treatment

Data conclusion: show other antipyretic gel cooling for the treatment of group hydrophilic plant high-molecular gel contrast group rapidly, effect is firm, minimumly all want high 1.8 percentage points, especially in Gao Re and excessive heat contrast, the data drop is larger, minimum drop value has 13.1 percentage points, and the treatment group curative effect is very outstanding.

Treatment group and the matched group contrast table between onset of bringing down a fever after the treatment

Group	The example number	＞60min(％)	＜60min(％)	＜30min(％)	＜20min(％)	Ratio (%) in the 30min
							Treatment group	80	0	2(2.5)	44(55)	34(42.5)	97.5
Matched group	45	2(4)	3(7)	22(49	18(40)	(89.0)

Data conclusion: show that other antipyretic gel for the treatment of group hydrophilic plant high-molecular gel contrast group is quick on temperature fall time, it is 9.5 percentage points than quantity drop always, drop is 2.5 percentage points in the 20min, drop is 6 percentage points in the 30min, and real data has been affirmed fully hydrophilic plant high-molecular gel glue at the practical therapeutic effect of having of physical heat relieving

Should be understood that; the above-mentioned specific embodiment only is exemplary explanation, rather than limitation of the present invention, for those of ordinary skills; can be improved according to the above description or conversion, and all these improvement and conversion all should belong to the protection domain of claims of the present invention.

Claims (6)

1. gel is characterized in that the raw material for preparing gel comprises,

Carbomer 5-15 weight portion;

Hydroxy benzoic acid 2-6 weight portion;

Ethanol 40-60 weight portion;

Glycerol 10-30 weight portion;

Borneolum Syntheticum 3-7 weight portion;

Herba Menthae extraction solution 4-8 weight portion;

Fructus Momordicae charantiae extraction solution 3-7 weight portion;

Rhizoma Zingiberis Recens extraction solution 3-7 weight portion;

Randomly, also comprise one or both or two or more extraction solutions in sanjiejian, borneol leaf, Flos Lonicerae Margarita powder, Herba Leonuri, Flos Chrysanthemi, Semen Plantaginis, Radix Musae, Vat slurry grass, the Dioscorea zingiberensis.

2. gel according to claim 1, described gel also comprises plants essential oil.

3. gel according to claim 1 and 2, described raw material also comprises alkali, described alkali is sodium hydroxide or potassium hydroxide preferably.

4. the preparation method of the described gel of claim 1-3 any one is characterized in that comprising the steps: Herba Menthae is prepared extraction solution through alcohol extraction; Fructus Momordicae charantiae and Rhizoma Zingiberis Recens prepare extraction solution through water extraction.By above-claimed cpd and conventional adjuvant are made regular dosage form.

5. preparation method according to claim 4 also comprises the steps:

Take by weighing carbomer and add the purified water mixing, make substrate; After P-hydroxybenzoic acid 4g being dissolved in the mixed liquor of ethanol and glycerol, add in the substrate, add the Herba Menthae extraction solution again, Borneolum Syntheticum adds the Fructus Momordicae charantiae extraction solution again, and the Rhizoma Zingiberis Recens extraction solution adds purified water, stirs evenly into the fruit jelly shape, sterilization, packing, packing.

6. the application of the described gel of claim 1-3 any one in the preparation antipyretic, described medicine is external used medicine preferably.