CN103370310A - 3-羟基-6H-苯并[c]色烯-6-酮衍生物及其制备方法 - Google Patents

3-羟基-6H-苯并[c]色烯-6-酮衍生物及其制备方法 Download PDF

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Publication number
CN103370310A
CN103370310A CN2012800082439A CN201280008243A CN103370310A CN 103370310 A CN103370310 A CN 103370310A CN 2012800082439 A CN2012800082439 A CN 2012800082439A CN 201280008243 A CN201280008243 A CN 201280008243A CN 103370310 A CN103370310 A CN 103370310A
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China
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salt
formula
copper
compound represented
carbonate
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CN2012800082439A
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English (en)
Chinese (zh)
Inventor
工藤一弘
山本悟功
伴正和
大野敦嗣
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Santen Pharmaceutical Co Ltd
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Santen Pharmaceutical Co Ltd
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Publication of CN103370310A publication Critical patent/CN103370310A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
CN2012800082439A 2011-02-09 2012-02-08 3-羟基-6H-苯并[c]色烯-6-酮衍生物及其制备方法 Pending CN103370310A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011026188 2011-02-09
JP2011-026188 2011-02-09
PCT/JP2012/052824 WO2012108455A1 (ja) 2011-02-09 2012-02-08 ３－ヒドロキシ－６Ｈ－ベンゾ［ｃ］クロメン－６－オン誘導体およびその製造方法

Publications (1)

Publication Number Publication Date
CN103370310A true CN103370310A (zh) 2013-10-23

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Family Applications (1)

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CN2012800082439A Pending CN103370310A (zh) 2011-02-09 2012-02-08 3-羟基-6H-苯并[c]色烯-6-酮衍生物及其制备方法

Country Status (8)

Country Link
US (2) US8802869B2 (enExample)
EP (1) EP2674422A4 (enExample)
JP (1) JP5921235B2 (enExample)
KR (1) KR20140002735A (enExample)
CN (1) CN103370310A (enExample)
CA (1) CA2826871A1 (enExample)
TW (1) TW201309663A (enExample)
WO (1) WO2012108455A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105884739A (zh) * 2016-04-14 2016-08-24 广西大学 一种苯并香豆素多环化合物的合成方法
CN111039913A (zh) * 2018-10-15 2020-04-21 韦忠友 一种具有抗肿瘤作用的化合物的制备方法
CN117756766A (zh) * 2023-12-20 2024-03-26 常州大学 3-羟基-8-氟-6H-苯并[c]色烯-6-酮类衍生物及其制备方法和应用
WO2025060978A1 (zh) * 2023-09-20 2025-03-27 科辉智药(深圳)新药研究中心有限公司 作为sarm1酶活性抑制剂的三环吡啶类化合物及其应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012112791A1 (en) 2011-02-16 2012-08-23 Paloma Pharmaceuticals, Inc. Radiation countermeasure agents
US9394269B2 (en) 2013-12-23 2016-07-19 Amazentis Sa Process-scale synthesis of urolithins
WO2015154047A1 (en) * 2014-04-03 2015-10-08 Restorgenex Corporation Novel methods
EP3639854A4 (en) 2017-06-16 2021-03-03 The Doshisha MTOR INHIBITIVE MEDICINAL PRODUCT FOR THE TREATMENT OR PREVENTION OF OPHTHALMIC SYMPTOMS, DISORDERS, OR DISEASES AND USE THEREOF
US20200121652A1 (en) 2017-06-16 2020-04-23 The Doshisha Compounds having caspase inhibitory activity, pharmaceutical agent containing said compounds and for treating or preventing corneal endothelial symptoms, disorders, or diseases, and application of said pharmaceutical agent
CN112074510A (zh) * 2018-02-27 2020-12-11 阿马曾提斯公司 尿石素a的工业规模合成
AU2022212883A1 (en) 2021-01-27 2023-08-17 Vandria Sa Urolithin derivatives and methods of use thereof
WO2024091983A1 (en) 2022-10-25 2024-05-02 Artus Therapeutics, Inc. Therapeutic agents for enhancing epithelial and/or endothelial barrier function

Citations (4)

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Publication number Priority date Publication date Assignee Title
WO2004073612A2 (en) * 2003-02-13 2004-09-02 Merck & Co. Inc. Estrogen receptor modulators
US20050282781A1 (en) * 2004-06-18 2005-12-22 Shibnath Ghosal Compositions of stable bioactive metabolites of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids
WO2007032556A1 (ja) * 2005-09-14 2007-03-22 Santen Pharmaceutical Co., Ltd. グルココルチコイド受容体結合活性を有する新規１，２−ジヒドロキノリン誘導体
CN101535267A (zh) * 2006-11-14 2009-09-16 参天制药株式会社 具有取代苯基硫属原子代低级烷基和导入酯结构的苯基作为取代基的新型1，2-二氢喹啉衍生物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20146061B (en) * 2008-05-12 2014-03-25 Santen Pharmaceutical Co Ltd Glucocorticoid receptor agonist composed of 2,2,4-trimethyl-6-phenyl- 1,2-dihydroquinoline derivative having substituted oxy group

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004073612A2 (en) * 2003-02-13 2004-09-02 Merck & Co. Inc. Estrogen receptor modulators
US20050282781A1 (en) * 2004-06-18 2005-12-22 Shibnath Ghosal Compositions of stable bioactive metabolites of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids
WO2007032556A1 (ja) * 2005-09-14 2007-03-22 Santen Pharmaceutical Co., Ltd. グルココルチコイド受容体結合活性を有する新規１，２−ジヒドロキノリン誘導体
CN101535267A (zh) * 2006-11-14 2009-09-16 参天制药株式会社 具有取代苯基硫属原子代低级烷基和导入酯结构的苯基作为取代基的新型1，2-二氢喹啉衍生物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AKRITOPOULOU-ZANZE.ET AL,: "Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》, vol. 14, no. 9, 3 May 2004 (2004-05-03), pages 2079 - 2082 *
PANDEY,J.ET AL,: "Synthesis and biological activities of some new dibenzopyranones and dibenzopyrans: search for potential oestrogen receptor agonists and antagonists", 《BIOORGANIC & MEDICINAL CHEMISTRY》, vol. 12, no. 9, 1 May 2004 (2004-05-01), pages 2239 - 2249 *
SUN,W.ET AL: "6H-Benzo[c]chromen-6-one derivatives as selective ERb agonists", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》, vol. 16, no. 6, 18 January 2006 (2006-01-18), pages 1468 - 1472 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105884739A (zh) * 2016-04-14 2016-08-24 广西大学 一种苯并香豆素多环化合物的合成方法
CN111039913A (zh) * 2018-10-15 2020-04-21 韦忠友 一种具有抗肿瘤作用的化合物的制备方法
WO2025060978A1 (zh) * 2023-09-20 2025-03-27 科辉智药(深圳)新药研究中心有限公司 作为sarm1酶活性抑制剂的三环吡啶类化合物及其应用
CN117756766A (zh) * 2023-12-20 2024-03-26 常州大学 3-羟基-8-氟-6H-苯并[c]色烯-6-酮类衍生物及其制备方法和应用

Also Published As

Publication number Publication date
JP5921235B2 (ja) 2016-05-24
US8802869B2 (en) 2014-08-12
EP2674422A1 (en) 2013-12-18
JP2012180345A (ja) 2012-09-20
WO2012108455A1 (ja) 2012-08-16
TW201309663A (zh) 2013-03-01
US20140296540A1 (en) 2014-10-02
US20130310576A1 (en) 2013-11-21
CA2826871A1 (en) 2012-08-16
EP2674422A4 (en) 2015-01-21
KR20140002735A (ko) 2014-01-08
US9029572B2 (en) 2015-05-12

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Application publication date: 20131023