CN103340340A - Immunity-improving health food - Google Patents
Immunity-improving health food Download PDFInfo
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- CN103340340A CN103340340A CN2013102245367A CN201310224536A CN103340340A CN 103340340 A CN103340340 A CN 103340340A CN 2013102245367 A CN2013102245367 A CN 2013102245367A CN 201310224536 A CN201310224536 A CN 201310224536A CN 103340340 A CN103340340 A CN 103340340A
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Abstract
Disclosed immunity-improving health food is prepared by the following raw materials in parts by weight: 20-30 parts of chitosan oligosaccharide, 25-35 parts of algal polysaccharide, 5-15 parts of lentinan, 8-18 parts of grape seed extract, 7-20 parts of American ginseng extract, and 10-20 parts of radix astragali extract. The provided immunity-improving health food helps to obviously improve immunity of the organism, mitigate organism oxidative damages caused by various free radicals, improve capabilities of disease prevention, disease resistance and aging resistance, and further enhance body physique.
Description
Technical field
The invention belongs to a kind of health food, be specifically related to a kind of enhancing immunity, oxidation-resisting health-care food.
Background technology
Immunologic hypofunction causes various diseases easily, is the modal health problem in the world today.Many reasons all can cause immunologic hypofunction, and dietary adjustments is to improve the effective ways of immunocompetence.Scientific circles are clear and definite, the puzzlement mankind nowadays a lot of chronic diseases, and the slow poisoning pathogenesis all " oxidative stress " cause, oxidative damage is the mother of all damages.If we just can effectively stop oxidative damage at the beginning of morbidity, then be expected to stop and delay generation and the development of such disease.
Summary of the invention
The objective of the invention is to, a kind of health food is provided, improve immunocompetence and the oxidation resistant ability of human body.
The health food of raising immunity provided by the invention, it comprises that the raw material of following weight parts makes:
Chitosan oligosaccharide 20-30 part, algal polysaccharides 25-35 part, lentinan 5-15 part, grape seed extract 8-18 part, American ginseng extract 7-20 part, Astragalus Root P.E 10-20 part.
Described chitosan oligosaccharide, prescription is selected the chitosan oligosaccharide of average molecular mass 1700 for use.
Described algal polysaccharides, be with derive from obtain behind the water-soluble acid polysaccharide hydrolysis of brown alga cell membrane 1,4-beta-D-mannuronic acid (M) fragment.
Also comprise a small amount of dolomol in the raw material, its consumption is the 0.5-1% of total amount.
The raw materials used source of the present invention and character are as follows:
Chitosan oligosaccharide: the catabolite that is chitin (chitin).Chitin extensively is present in insect, shellfish shell, fungal cell wall and some algae, is the polysaccharide that is polymerized by the N-acetylglucosamine, is a kind of alkaline polysaccharide.Chitin obtains shitosan (chitosan) after deacetylated processing, shitosan obtains chitosan oligosaccharide (chitosan oligosaccharide) through enzyme hydrolysis again.Recent two decades comes, and the research of chitin, shitosan, chitosan oligosaccharide at home and abroad extensively launches, and they more and more cause people's attention in the function that improves immunity, anti-tumor aspect.Bibliographical information, the BA of chitosan oligosaccharide are 14 times of equivalent weight shitosan; A lot of experiments have also proved the antioxidant effect of chitosan oligosaccharide.Studies show that (chitosan oligosaccharide COS) has different influences to immune function of mice to the chitosan oligosaccharide of two kinds of different relative molecular masses.B-COS (average molecular mass 1700) is better than S-COS (average molecular mass 800) to the regulating action of immune function of mice.
What this product obtained after selecting for use chitin to degrade passes through β-1 by Glucosamine, the chitosan oligosaccharide of the average molecular mass 1700 that the 4-glycosidic bond is formed by connecting, water-soluble greater than 99%, the absorption of human body utilization rate reaches 99.88%, its BA has obtained many studies confirm that, to the raising immunity of organisms, activating immune cell, the proliferative effect of probios such as promotion intestinal bifidobacteria is more excellent.
Algal polysaccharides: be with derive from obtain behind the water-soluble acid polysaccharide hydrolysis of brown alga cell membrane 1,4-beta-D-mannuronic acid (M) fragment.Marine algae extract mainly contains alginic acid and algin.Alginic acid is by β-1, and 4-D-sweet mellow wine uronic acid and α-1, the macromolecule that 4-L-guluronic acid fragment alternately is formed by connecting, poorly water-soluble.Algin is alignic sodium salt or sylvite.Alginic acid and algin are as the water-soluble acid polysaccharide that derives from the brown alga cell membrane, mainly dwell from sea-tangle, bulk kelp, sargassum, sheep on extracting the brown algas such as dish and obtain, by 1,4-beta-D-mannuronic acid (M) and C5 epimer 1 thereof, 4-α-two kinds of uronic acid monomer polymerizations of L-guluronic acid (G) form.It is that a class has the big molecule of extensive bioactive natural biological, is the important composition composition of living organism and the requisite structural material that earns a bare living.After it is hydrolyzed into low molecular weight sugar, particularly obtain 1,4-beta-D-mannuronic acid (M) fragment after, then good water solubility is beneficial to absorption of human body.Effects such as anti-oxidant, whole intestines and detoxifcation, hypoglycemic, reducing blood lipid, anticoagulation, anti-inflammatory, immunological regulation are arranged according to its physiologically active.
Low-molecular-weight algal sugar M section main pharmacological:
Immunoregulatory activity: algin oligosaccharide M section can stimulate differentiation, maturation, the breeding of various immunocompetent cells (as macrophage, T lymphocyte, bone-marrow-derived lymphocyte etc.), the immune system of body is restored and strengthens, and can bring into play multiple physiologically active by immunoregulation effect.
Antitumor action: low-molecular-weight algal sugar M section has good activation and facilitation to nospecific immunity or specific immunity system, and the energy activating macrophage has CDCC, thereby can suppress the tumor cell proliferation kill tumor after the activation.
The Green Tea Extract oxidation: the active oxygen radical that internal metabolism produces has destruction to phagocyte itself and other cell, tissue and large biological molecule, and lipid peroxidation accelerates to cause Normocellular destruction and death.Studies show that oxygen radical plays an important role in the diseases such as the formation of atherosclerotic, thrombus, myocardial ischemia-reperfusion injury, diabetes and hepatitis.Carcinogenic, short cancer and cancer form generation and the participation that free radical is arranged.Algin oligosaccharide M section not only has the effect of removing active oxygen, can also significantly reduce the content of MDA, improves the activity of peroxidase and superoxide dismutase, has the effect of removing polyradical and anti peroxidation of lipid.
Mushroom: have very high edible and medical value, delicious flavour, nutritious not only, and have the function that integrates natural, nutrition, keeps healthy, be regarded as " king in the mushroom ".Studies have shown that lentinan is a kind of immunopotentiator, have anti-aging effects, lentinan can strengthen body opposing bacterium, virus and parasitic ability, can prevent and treat tumor recurrence, control Aids sx etc.The lentinan immunoregulation effect is mainly owing to activating a lot of immunocytes such as T cell, NK and macrophage, the phagocytic activity of increase immunocyte is killed the cancer cell in the human body, cancer cell to migration also has effect, and lentinan can also be regulated immunocyte and discharge for example cytokine class of cell messenger.
At present, research and development utilization to lentinan mainly concentrates on immunoregulation effect, and the research of its antioxygenic property is also increased day by day, the thick polysaccharide of mushroom has significant antioxygenic property, its oxidation resistance can obviously reduce the peroxide value of edible oil and fat a little less than Vc under the addition of 100mg/kg.The lentinan extracting method is: mushroom → pre-treatment → immersion → filtration → secondary soaks → merges clear liquid → concentrate → leave standstill → supernatant alcohol and analyses → reclaim pure liquid → drying precipitate → pulverizing → packing → finished product.
Grape seed extract: main component is grape seed polyphenols (being called for short OPC), be that a class is present in the natural polyphenol compounds that belongs to bisflavones in the plant, has extremely strong antioxidation activity, be a kind of good oxygen-cent red radical scavenger and lipid peroxidation inhibitor, have the immunity of organisms of raising simultaneously, improve effects such as peripheral circulation, softening blood vessel and anti-sudden change.One of physilogical characteristics of the elderly are the low inferior health problems of the power of exempting from that is easy to generate due to interior free yl accumulation, vascular sclerosis and the oxidative damage.Since excessive protease, oxidizing ferment, the existence of hydrolase and active oxygen, easy collagen to the blood vessel epimatrix, hyaluronic acid, elastin laminin and endothelial cell membrane etc. causes free radical injury.The antienzyme effect of grape seed polyphenols and removing free radical effect various enzymes capable of blocking and active oxygen are to the destruction of blood vessel, thereby elasticity and the permeability of increase capillary are not damaged the peripheral vascular normal function.This prescription uses grape seed extract, is because the effect of the raising immunity of organisms that itself has on the one hand, on the other hand, has considered that also the antioxidation biology of the polyphenol compound that wherein contains is learned active.The grape seed extract extracting method is: grape pip → pre-treatment → alcohol extract → recovery ethanol → add water to leave standstill cooling → centrifugal → extraction → concentrated → drying → packing → finished product.
American Ginseng: be Araliaceae, because this thing from the West, originates in the North America so gain the name, there is cultivation China some areas.The chemical composition of American Ginseng is mainly monose, polysaccharide, saponin, amino acid, protein, enzyme, organic acid and trace element etc., and the major function of American Ginseng is " beneficial lung yin, the clear fire of deficiency type; promote the production of body fluid to quench thirst ", cures mainly chronic cough of deficiency lung, loses blood, dry throat and mouth, abnormal heat is tired tired.In recent years, reach the research of using the immunity of organism regulating action with other drug matching about American ginseng extract and obtained remarkable progress.At present, people focus mostly in the immune pharmacological research to Radix Panacis Quinquefolii polysaccharide, American ginseng saponin and American Ginseng compound mixture.
American Ginseng has strengthening by means of tonics; the yin-nourishing of nourishing blood; the effect of strengthening the spleen and replenishing qi; and has a BA widely; main active ingredient is compound and trace elements such as Radix Panacis Quinquefolii polysaccharide, saponin; can act on the panimmunity competent cell, promote the secretion of some cell factor further to bring into play immunoregulation effect, it has significant protective effect to the immunocompromised that immunodepressant causes.Studies show that American Ginseng can promote the growth of young mouse thymus gland organ, enhancing mouse muscle power and raising hypoxia-bearing capability, by the atrophy of immune organ due to the inhibition CY, lifting carbon is cleaned up speed and is engulfed and refers to that effect improves immunologic function.Bibliographical information, American ginseng extract have effective antioxidation.The American ginseng extract extracting method is: American Ginseng → pre-treatment → alcohol extract → decompression recycling ethanol → concentrate → drying → packing → finished product.
The Radix Astragali: be the dry root of legume astragalus mongolicus or Astragalus membranacus.Spring, Qiu Erji excavate, and remove fibrous root and root head, dry.The Radix Astragali has another name called Huang Qi, wears mulberry, solely mulberry, another name for Sichuan Province fat etc., and the beginning is stated from " herbal classic ", classifies as top gradely, and " cure mainly the water of flesh table also, so can harness the Yellow River sweat, night sweat, the severe edema due to hypofunction of the spleen, the other health of controlling swells or meciless person ancients again with it." through checkings such as stilbene Chinese herbaceous peony cassia twig Bitters soup, tetrandra root Poria cocos soup, Huangqi Guizhi Wuwu Tangs, it has better curative effect to " health, edema of limbs, aqueous vapor are in skin, and perspiration and aversion to wind, sweat are stained with clothing, look true yellow such as tiller juice, body numbness, declining night sweat, waist hip relaxation pain ".The Radix Astragali contains trace elements such as astragalus polyose, 25 seed amino acids, astragaloside, flavonoids, alkaloid, protein, vitamin and selenium, silicon, cobalt, molybdenum.The Radix Astragali has multiple pharmacological effect, is a kind of effect immunomodulator widely.The Astragalus Root P.E extracting method is: the Radix Astragali → pre-treatment → extraction → concentrate → adding n-butanol dissolving → buck separates → filters → concentrate → extraction → concentrate → drying → packing → finished product.
The health food of raising immunity provided by the invention, its beneficial effect is, polysaccharide, polyphenol and saponin(e isoreactivity composition based on separate sources have different BAs, promote that mechanism and the mode of action of immunity of organism are different, the structure of each composition approaches, stable in properties, collaborative mutually.Chitosan oligosaccharide, glucide, grape seed extract, American ginseng extract, Astragalus Root P.E compatibility are used, obviously improved immunity of organisms, alleviated the oxidative damage that various radical pair bodies cause, improve the diseases prevention of body, disease-resistant and anti-ageing ability, significantly strengthened health physique.
The specific embodiment
Below in conjunction with an embodiment, the health food of raising immunity provided by the invention is described in detail.
Embodiment
Present embodiment improves the health food of immunity, and the batching that 1000g should improve in the health food of immunity comprises: chitosan oligosaccharide 220g, algal polysaccharides 270g, lentinan 90g, grape seed extract 120g, American ginseng extract 150g, Astragalus Root P.E 150g, dolomol 6g.
Improve the production of health food of immunity, specific as follows:
1, preliminary treatment: get material and check material code name, the name of an article, specification, numbering and weight etc. with producing instruction.
2, sieve: get chitosan oligosaccharide, algal polysaccharides, lentinan, grape seed extract, American ginseng extract, Astragalus Root P.E, dolomol by formula rate, cross 60 mesh sieves respectively, standby.
3, mix: the above-mentioned back chitosan oligosaccharide that sieves, algal polysaccharides, lentinan, grape seed extract, American ginseng extract, Astragalus Root P.E, dolomol are put in the mixer, mixed, get mixed powder, standby.
4, fill: above-mentioned mixed powder is got mixed material and Capsules after the assay was approved, fills with the automatic filling machine of capsule.
5, polishing: fill qualified capsule, put in the capsule polishing machine and polish, remove surperficial medicinal powder.
6, inner packing: divide the loading port oral solid medicinal high-density polyethylene bottle.
7, external packing: vanning (corrugated case).
8, warehouse-in: finished product enters the qualified district of product of storehouse through after the assay was approved.
9, remarks: sieve, mix, the air purity of production environment such as filling, polishing, inner packing requires 300,000 grades, meets GB 17405 requirements, other operation is in general control zone.
According to Example formulations, 1000 people try out, and wherein 935 people think the present invention to anti-oxidant, and the immunity that improves human body simultaneously has effect comparatively significantly, and satisfaction rate is up to 93.5%.
Claims (4)
1. health food that improves immunity is characterized in that: it comprises that the raw material of following weight parts makes:
Chitosan oligosaccharide 20-30 part, algal polysaccharides 25-35 part, lentinan 5-15 part, grape seed extract 8-18 part, American ginseng extract 7-20 part, Astragalus Root P.E 10-20 part.
2. the health food of raising immunity according to claim 1 is characterized in that: described chitosan oligosaccharide, prescription is selected the chitosan oligosaccharide of average molecular mass 1700 for use.
3. the health food of raising immunity according to claim 1 is characterized in that: described algal polysaccharides, be with derive from obtain behind the water-soluble acid polysaccharide hydrolysis of brown alga cell membrane 1,4-beta-D-mannuronic acid fragment is the M fragment.
4. the health food of raising immunity according to claim 1 is characterized in that: comprise also in the raw material that a small amount of dolomol, its consumption are the 0.5-1% of total amount.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103653144A (en) * | 2013-12-10 | 2014-03-26 | 济南凯因生物科技有限公司 | Healthcare drink capable of improving immunity and preparation method thereof |
| CN104042790A (en) * | 2014-06-19 | 2014-09-17 | 刘长喜 | Medicament composition for middle-aged and aged health care |
| CN105124582A (en) * | 2015-09-10 | 2015-12-09 | 青岛银色世纪健康产业集团有限公司 | Capsule having function of antioxidation and preparation method of capsule |
| CN107712886A (en) * | 2017-10-10 | 2018-02-23 | 林翠霞 | A kind of health food with enhancing female organism efficacy of immunity |
| CN107712911A (en) * | 2017-10-10 | 2018-02-23 | 林翠霞 | Female health food and preparation method thereof |
| CN108497489A (en) * | 2017-02-24 | 2018-09-07 | 深圳天基权健康科技集团股份有限公司 | A kind of composition and its preparation method and application improving immunity |
| CN108576792A (en) * | 2018-04-17 | 2018-09-28 | 江志正 | A kind of diet and preparation method thereof of compound chitosan oligosaccharide conditioning cancer |
| CN114133459A (en) * | 2021-11-23 | 2022-03-04 | 福建师范大学 | Preparation method and application of abalone polysaccharide |
| CN116686852A (en) * | 2023-06-09 | 2023-09-05 | 贵州贵旺生物科技有限公司 | Lentinus edodes growth promoter based on agricultural microbial agent and preparation method thereof |
| CN116763812A (en) * | 2023-08-17 | 2023-09-19 | 青岛农业大学 | American ginseng polysaccharide, osteoporosis treatment medicine prepared from American ginseng polysaccharide and application of American ginseng polysaccharide |
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| CN101224006A (en) * | 2008-02-04 | 2008-07-23 | 马宏达 | Healthy capsule with anti-oxidation efficacy and preparing method thereof |
| CN101544686A (en) * | 2008-03-28 | 2009-09-30 | 李勇 | Application of glycopeptide mixture in preparing adjuvant therapy medicaments of tumor and health food |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103653144A (en) * | 2013-12-10 | 2014-03-26 | 济南凯因生物科技有限公司 | Healthcare drink capable of improving immunity and preparation method thereof |
| CN103653144B (en) * | 2013-12-10 | 2015-05-13 | 徐真蕊 | Healthcare drink capable of improving immunity and preparation method thereof |
| CN104042790A (en) * | 2014-06-19 | 2014-09-17 | 刘长喜 | Medicament composition for middle-aged and aged health care |
| CN104042790B (en) * | 2014-06-19 | 2017-07-25 | 马伯艳 | A kind of pharmaceutical composition and its application for health care for the middle and old aged |
| CN105124582A (en) * | 2015-09-10 | 2015-12-09 | 青岛银色世纪健康产业集团有限公司 | Capsule having function of antioxidation and preparation method of capsule |
| CN108497489A (en) * | 2017-02-24 | 2018-09-07 | 深圳天基权健康科技集团股份有限公司 | A kind of composition and its preparation method and application improving immunity |
| CN107712911A (en) * | 2017-10-10 | 2018-02-23 | 林翠霞 | Female health food and preparation method thereof |
| CN107712886A (en) * | 2017-10-10 | 2018-02-23 | 林翠霞 | A kind of health food with enhancing female organism efficacy of immunity |
| CN108576792A (en) * | 2018-04-17 | 2018-09-28 | 江志正 | A kind of diet and preparation method thereof of compound chitosan oligosaccharide conditioning cancer |
| CN114133459A (en) * | 2021-11-23 | 2022-03-04 | 福建师范大学 | Preparation method and application of abalone polysaccharide |
| CN116686852A (en) * | 2023-06-09 | 2023-09-05 | 贵州贵旺生物科技有限公司 | Lentinus edodes growth promoter based on agricultural microbial agent and preparation method thereof |
| CN116763812A (en) * | 2023-08-17 | 2023-09-19 | 青岛农业大学 | American ginseng polysaccharide, osteoporosis treatment medicine prepared from American ginseng polysaccharide and application of American ginseng polysaccharide |
| CN116763812B (en) * | 2023-08-17 | 2023-11-03 | 青岛农业大学 | American ginseng polysaccharide, osteoporosis treatment medicine prepared from American ginseng polysaccharide and application of American ginseng polysaccharide |
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Address after: 266071, No. 23, Hongkong East Road, Laoshan District, Shandong, Qingdao Applicant after: Qingdao Silver Century Health Industry Group Co., Ltd. Address before: 266071, No. 23, Hongkong East Road, Laoshan District, Shandong, Qingdao Applicant before: Qingdao Silver Century US Marine Biotechnology Co., Ltd. |
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Application publication date: 20131009 |