CN101224006A - Healthy capsule with anti-oxidation efficacy and preparing method thereof - Google Patents
Healthy capsule with anti-oxidation efficacy and preparing method thereof Download PDFInfo
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- CN101224006A CN101224006A CNA2008100639861A CN200810063986A CN101224006A CN 101224006 A CN101224006 A CN 101224006A CN A2008100639861 A CNA2008100639861 A CN A2008100639861A CN 200810063986 A CN200810063986 A CN 200810063986A CN 101224006 A CN101224006 A CN 101224006A
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Abstract
The invention discloses a health capsule with antioxidant efficacy and a preparation method thereof, which adopts chito-oligosaccharide, grape seeds, hippophae rhamnoides and agaric polysaccharide as raw materials. The weight percentages of the raw materials are as follows: 10-25 percent of the chito-oligosaccharide, 10-18 percent of hippophae rhamnoides extractive, 10-35 percent of grape seed extractive and the rest is the agaric polysaccharide. The preparation method of the invention comprises that the hippophae rhamnoides and the grape seeds are extracted by adopting a mixing extraction method and auricularia polysaccharide is prepared and fully mixed with the chito-oligosaccharide according to the weight percentage and then the mixture is bottle filled as the capsule. The health capsule can resist oxidation, eliminate free radicals, remove toxin, protect cells and improve the living environment of the cells. Furthermore, the invention has obvious immunity-adjusting and anti-aging efficacy for people who have low immunological competence and suffer from diseases such as diabetes, hypertension, hyperlipemia, cardio-cerebrovascular, etc.; meanwhile, the invention is also easy for absorption and utilization with stable efficacy for human bodies.
Description
Technical field
The present invention relates to a kind of health products, is the raw material mixed preparing with chitosan oligosaccharide, grape pip, sea-buckthorn, Auricularia polysaccharide particularly, has health products anti-oxidant, that remove free radical, get rid of toxin, regulate immunity, delay senility.
Background technology
Along with Chinese economic development, people's living standard improves constantly, and health maintains vigour becomes the fresh target that people pursue.But many reasons such as, operating pressure unbalance because of diet, a large amount of crowds are in sub-health state.Regulate organism balance, improve health, prevent and cure diseases, delay senility and mentioned critical positions.Therefore effectively removing interior free yl, repairing impaired sugar chain, improve immunologic function is prevention and the effective method for the treatment of the multiple because caused disease of oxidation.
This health-caring capsule, in conjunction with modern people's the life characteristic and the viewpoint of modern cell biology, make the chitosan oligosaccharide that carried the transmission of cell information, information representation function and have Proflavanol, sea-buckthorn Vc, a Hippophate flavone of superpower oxidation resistance and have biological immune to reply the perfect combination of fungi polysaccharide of the title of effector molecules, multi-efficiency, the acting in conjunction human body cell, reach anti-oxidant, remove free radical, the human activin immune system finally reaches comprehensive functions such as eliminating the health toxin.
Develop at present and commercially available many genus by one or both be the health product of raw material in chitosan oligosaccharide, grape pip, sea-buckthorn, the Auricularia polysaccharide, the composition formation is single.And this product is to carry out mixed preparing with above-mentioned four kinds of raw materials by certain component, produces with special extracting method, improves active component wherein greatly, and its effect is more remarkable.
Summary of the invention
The objective of the invention is to, adopt distinctive extractive technique, keep the active ingredient of chitosan oligosaccharide, grape pip, sea-buckthorn, black fungus, active component is wherein extracted to greatest extent.
Health-caring capsule of the present invention is achieved in that with chitosan oligosaccharide, grape pip, sea-buckthorn, Auricularia polysaccharide be raw material, and its percentage by weight is respectively: chitosan oligosaccharide 10～25%, and hippophae rhamnoides 10～18%, grape seed extract 10～35%, all the other are Auricularia polysaccharide.
The preparation method of health-caring capsule, sea-buckthorn and grape pip adopt and mix the method for extracting and extract, the Blackfungus polyhexose preparation, above raw material is with after chitosan oligosaccharide fully mixes in proportion, and can becomes capsule, and manufacturing health-caring capsule production stage is as follows:
One, sea-buckthorn and grape pip adopt and mix the method extraction of extracting: sea-buckthorn with after grape pip mixes in proportion, with the water refluxing extraction of 3～7 times of amounts 2～5 times, each 1～3 hour, is added 30～70% ethanolic solution refluxing extraction 2～5 times, each 1～3 hour again; Extract is leached, and decompression concentrates, and evaporates part moisture; Use 4000～10000 rev/mins of link-suspended basket centrifuges, centrifugal filtration 20～50 minutes obtains filtrate; The filtrate vacuum concentrates, and its vacuum is that 0.06～1mpa temperature is 40～80 ℃; The spray-dried mixed extract that obtains sea-buckthorn and grape pip of concentrate;
Two, the preparation of Auricularia polysaccharide:
1, remove impurity: black fungus is pulverized 10～30 orders, with the water refluxing extraction of 2～5 times of amounts 2～5 times, 1～3 hour for the first time, 1～3 hour second time, 0.5～3 hour for the third time;
2, extract: extracting temperature is 50～90 ℃, and link-suspended basket centrifuge filters, and collects filtrate, and filtrate is removed protein with the sevag method, and freezing 80～99% precipitation with alcohols obtain Blackfungus polyhexose;
Three, chitosan oligosaccharide is for shitosan is about 3000 through the molecular weight of product after degrading.
Four, above four kinds of components in certain proportion are joined the abundant mixing of carrying out in the blender 5～25 minutes.Obtain mixed material, the can capsule.
In the extracting method of sea-buckthorn and grape pip, important being controlled at below 1: 1 of ratio of described sea-buckthorn and grape pip concentrate.
Advantage of the present invention is:
1, the utilization of composite extracting method:
Adopted the method for compound extraction that grape pip is extracted with sea-buckthorn, made that the elite composition in the grape seed extract can protect the vitamin C in the hippophae rhamnoides not to be destroyed to greatest extent; Remove exclusive fungi polysaccharide and the adenosine composition of black fungus and extract, adopted isolation technics to overcome black fungus extraction back because viscosity is excessive, the not segregative characteristics of fungi polysaccharide, the active ingredient that has successfully kept black fungus, make its in product with the compound performance optimum efficiency of other compositions, be the once perfect utilization of modern biological project extractive technique.
2, the natural uniqueness of raw material
(1), chitosan oligosaccharide: chitosan oligosaccharide claims glucose oligosaccharide amine again, has the unique biological activity, it is the positively charged cationic alkaline animal food fiber of the unique existence of occurring in nature, the heavy metal lead ion had chelation, can adsorb effectively with trapping solution in heavy metal ion, the lead complex that forms low solubility with lead excretes.Have suicide defendance characteristic,, play the effect that protection cell surface sugar chain is not destroyed in case run into that harmful substances such as pathogen, free radical will be adsorbed, disengaging, metabolism.
(2), grape pip: the elite in the grape pip is effectively extracted, and this is the new and effective natural material that can not synthesize in a kind of human body.It is anti-oxidant, the strongest material of removing free radical ability that present occurring in nature is found, its antioxidation activity is 50 times, ascorbic 20 times of the plain E of dimension, it can effectively remove unnecessary free radical in the human body, has the superpower effect that delays senility and strengthen immunity.
(3), sea-buckthorn: comprise 6 kinds of liposoluble vitamins in the sea-buckthorn, 22 kinds in aliphatic acid, 42 kinds of lipids, 36 kinds of flavones and phenols.Wherein total seabuckthorn flavone can increase the myocardial nutrition CBF, improves myocardium microcirculation.Reduce myocardium keto consumption, reach 90%, improve the myocardial blood supply state preferably, promote heart function, strengthen the function of macrophage,, can improve the resistance against diseases of body again so both can supplement the nutrients to patient with angina pectoris is efficient.
(4), Auricularia polysaccharide: Blackfungus polyhexose pair cell immunity and humoral immune function have good facilitation, have that anti-leucocyte reduces, antitumor, radioresistance, resist cytoprotections such as sudden change, anti-inflammatory; Have the blood fat of reduction, cholesterol, blood viscosity, anti-thrombosis function; Have the blood sugar of reduction, anti-diabetic and reduce lipofuscin content, enhancement of SOD vigor, the function of minimizing harmful substance free-radical generating; Simultaneously can also promote the biosynthesis of nucleic acid, protein and prevent and treat multiple geriatric disease.
3, prescription reasonable mixture ratio
Chitosan oligosaccharide, grape pip, sea-buckthorn, four kinds of raw materials of Auricularia polysaccharide, science collocation prescription has all adopted the plant material of pure natural integration of drinking and medicinal herbs to extract, without any side effects and excitant, effect behind combination collocation cooperatively interacts, make effective ingredient effect on human body more directly wherein, can take for a long time, improve the health, strengthen immunity.
This product has exclusive small-molecule substance; dissolubility is good; have very strong penetration and affinity, be very easy to see through the cell membrane of human body, active ingredient is written into cell; improve microcirculation; can fully play its antioxidation, the protection cell is avoided radical damage, and the while is the interior polyphenoils organized enzyme of human activin effectively; can more effectively bring into play its antioxidation, play the effect that the protection body is avoided encroaching on.
A large amount of SOD in this product are the highest active antioxidant contents, and it can directly remove interior free yl, and can improve body immunity, prevent aging, anti-inflammatory and anticancer.
The cation micro molecule alkaline matter that is rich in this product, its circulus has very powerful adsorptivity, by absorption harmful substance in the body is excreted with metabolism; The glycosaminoglycan molecule that contains, its circulus can with the divalence heavy metal chelating, together excrete by metabolism.
Ionomer in this product can disturb the cationic polymer cellulose, and disturbs the absorption of cholesterol, suppresses cholesterol in serum concentration and rises, and can promote the secretion of bile acid, thereby decompose unnecessary cholesterol.Help injured tissues in this product and recover, stop the hypodermis development of inflammation, the anti-inflammatory myogenic, and significantly promote ulcer healing.
Protonated ammonium in this product has positive charge, can interact with the electronegative cell membrane of bacterium, disturbs the bacterial cell membrane function, causes bacterial body inner cell matter to run off, the bacterium power that loses one's life.Small molecular sugar class material in this product can directly enter in the bacterial body simultaneously, upsets its eubolism, makes it to disintegrate decline by inside.
The specific embodiment
One, sea-buckthorn is adopted with grape pip and mixes the method extraction of extracting:
Sea-buckthorn with after grape pip mixes in proportion, with the water refluxing extraction of 5 times of amounts 3 times, each 2 hours, is added 50% ethanolic solution refluxing extraction 3 times, each 2 hours again; Extract is leached, and decompression concentrates, and evaporates part moisture; Use 6000 rev/mins of link-suspended basket centrifuges, centrifugal filtration 30 minutes obtains filtrate; The filtrate vacuum concentrates, and vacuum is 0.08mpa, and temperature is 60 ℃; The proportion of concentrate is below 1: 1, the spray-dried mixed extract that obtains sea-buckthorn and grape pip of concentrate.
Two, the preparation of Auricularia polysaccharide:
1, remove impurity: black fungus is pulverized 14 orders, with the water refluxing extraction of 40 times of amounts 3 times, 3.5 hours for the first time, 2 hours second time, 1 hour for the third time;
2, extract: extracting temperature is 90 ℃, and link-suspended basket centrifuge filters, and collects filtrate, and filtrate is removed protein with the sevag method, and freezing 99% precipitation with alcohol obtains Blackfungus polyhexose.
Three, chitosan oligosaccharide is for buying raw material.
Four, above components in certain proportion is joined the abundant mixing of carrying out in the blender 15 minutes, obtain mixed material, the can capsule.
Claims (3)
1. health-caring capsule with anti-oxidation efficacy, it is characterized in that with chitosan oligosaccharide, grape pip, sea-buckthorn, Auricularia polysaccharide be raw material, its percentage by weight is respectively: chitosan oligosaccharide 10～25%, hippophae rhamnoides 10～18%, grape seed extract 10～35%, all the other are Auricularia polysaccharide.
2. a kind of preparation method according to claim 1 with health-caring capsule of anti-oxidation efficacy, sea-buckthorn is adopted with grape pip and mixes the method extraction of extracting, the Blackfungus polyhexose preparation, above raw material is with after chitosan oligosaccharide fully mixes in proportion, can becomes capsule, and it is as follows to make the health-caring capsule production stage:
(1) sea-buckthorn and grape pip adopt and mix the method extraction of extracting: sea-buckthorn with after grape pip mixes in proportion, with the water refluxing extraction of 3～7 times of amounts 2～5 times, each 1～3 hour, is added 30～70% ethanolic solution refluxing extraction 2～5 times, each 1～3 hour again; Extract is leached, and decompression concentrates, and evaporates part moisture; Use 4000～10000 rev/mins of link-suspended basket centrifuges, centrifugal filtration 20～50 minutes obtains filtrate; The filtrate vacuum concentrates, and its vacuum is that 0.06～1mpal temperature is 40～80 ℃; The spray-dried mixed extract that obtains sea-buckthorn and grape pip of concentrate;
(2) preparation of Auricularia polysaccharide:
Remove impurity: black fungus is pulverized 10～30 orders, use times water refluxing extraction of amount 2～5 times, 2～5 hours for the first time, 1～3 hour for the second time, 0.5～3 hour for the third time;
Extract: extracting temperature is 50～90 ℃, and link-suspended basket centrifuge filters, and collects filtrate, and filtrate is removed protein with the sevag method, and freezing 80～99% precipitation with alcohols obtain Blackfungus polyhexose;
(3) chitosan oligosaccharide is for shitosan is about 3000 through the molecular weight of product after degrading;
(4) above four kinds of components in certain proportion are joined the abundant mixing of carrying out in the blender 5～25 minutes, obtain mixed material, the can capsule.
3. a kind of preparation method with health-caring capsule of anti-oxidation efficacy according to claim 2 is characterized in that: the proportion of the described concentrate of step (1) is below 1: 1.
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| CNA2008100639861A CN101224006A (en) | 2008-02-04 | 2008-02-04 | Healthy capsule with anti-oxidation efficacy and preparing method thereof |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101439125B (en) * | 2008-12-30 | 2011-05-04 | 哈尔滨工业大学 | Composite big fruit sea-buckthorn anti-aging powder |
| CN101439124B (en) * | 2008-12-30 | 2011-05-04 | 哈尔滨工业大学 | Method for preparing composite big fruit sea-buckthorn anti-aging powder |
| CN102197863A (en) * | 2011-01-10 | 2011-09-28 | 解中伟 | Chitosanoligosaccharide capsule |
| CN102210699A (en) * | 2010-04-06 | 2011-10-12 | 北京联合大学应用文理学院 | Use of chitosan oligosaccharide in preparation of medicines for preventing and treating cardiovascular and cerebrovascular diseases |
| CN102670864A (en) * | 2012-06-01 | 2012-09-19 | 山东卫康生物医药科技有限公司 | Medicine composition with antioxidant function for treating cardiovascular and cerebrovascular diseases and sugar diabetes |
| WO2013053072A1 (en) * | 2011-10-10 | 2013-04-18 | Huang Daiyong | Gastrointestinal tract function improvement-based composition aiding reductions in blood sugar and in blood lipids |
| CN103340340A (en) * | 2013-06-07 | 2013-10-09 | 青岛银龄美海洋生物科技有限公司 | Immunity-improving health food |
| CN103653144A (en) * | 2013-12-10 | 2014-03-26 | 济南凯因生物科技有限公司 | Healthcare drink capable of improving immunity and preparation method thereof |
| CN103652859A (en) * | 2013-11-13 | 2014-03-26 | 西安医学院 | Health-care food with oxidation resistance and preparation method thereof |
| CN104489457A (en) * | 2014-11-27 | 2015-04-08 | 扬州日兴生物科技股份有限公司 | Dietary formula containing chitosan oligosaccharide and cordyceps militaris powder for liver cancer patients |
| CN106880047A (en) * | 2017-02-23 | 2017-06-23 | 广州市香雪制药股份有限公司 | Oxidation-resisting health-care product composition and its preparation method and application |
| CN108684884A (en) * | 2018-05-23 | 2018-10-23 | 南京中生生物科技有限公司 | A kind of composition and preparation method thereof of chitosan oligosaccharide, green-tea extract |
| CN110403005A (en) * | 2019-02-11 | 2019-11-05 | 权冉(银川)科技有限公司 | The food materials anti-metamorphic protection liquid and its preparation method of herbal medicine fruits and vegetables |
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2008
- 2008-02-04 CN CNA2008100639861A patent/CN101224006A/en active Pending
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101439125B (en) * | 2008-12-30 | 2011-05-04 | 哈尔滨工业大学 | Composite big fruit sea-buckthorn anti-aging powder |
| CN101439124B (en) * | 2008-12-30 | 2011-05-04 | 哈尔滨工业大学 | Method for preparing composite big fruit sea-buckthorn anti-aging powder |
| CN102210699A (en) * | 2010-04-06 | 2011-10-12 | 北京联合大学应用文理学院 | Use of chitosan oligosaccharide in preparation of medicines for preventing and treating cardiovascular and cerebrovascular diseases |
| CN102197863A (en) * | 2011-01-10 | 2011-09-28 | 解中伟 | Chitosanoligosaccharide capsule |
| WO2013053072A1 (en) * | 2011-10-10 | 2013-04-18 | Huang Daiyong | Gastrointestinal tract function improvement-based composition aiding reductions in blood sugar and in blood lipids |
| CN102670864A (en) * | 2012-06-01 | 2012-09-19 | 山东卫康生物医药科技有限公司 | Medicine composition with antioxidant function for treating cardiovascular and cerebrovascular diseases and sugar diabetes |
| CN102670864B (en) * | 2012-06-01 | 2014-05-21 | 山东卫康生物医药科技有限公司 | Medicine composition with antioxidant function for treating cardiovascular and cerebrovascular diseases and sugar diabetes |
| CN103340340A (en) * | 2013-06-07 | 2013-10-09 | 青岛银龄美海洋生物科技有限公司 | Immunity-improving health food |
| CN103652859A (en) * | 2013-11-13 | 2014-03-26 | 西安医学院 | Health-care food with oxidation resistance and preparation method thereof |
| CN103652859B (en) * | 2013-11-13 | 2016-03-09 | 西安医学院 | A kind of health food with anti-oxidation function and preparation method thereof |
| CN103653144A (en) * | 2013-12-10 | 2014-03-26 | 济南凯因生物科技有限公司 | Healthcare drink capable of improving immunity and preparation method thereof |
| CN103653144B (en) * | 2013-12-10 | 2015-05-13 | 徐真蕊 | Healthcare drink capable of improving immunity and preparation method thereof |
| CN104489457A (en) * | 2014-11-27 | 2015-04-08 | 扬州日兴生物科技股份有限公司 | Dietary formula containing chitosan oligosaccharide and cordyceps militaris powder for liver cancer patients |
| CN106880047A (en) * | 2017-02-23 | 2017-06-23 | 广州市香雪制药股份有限公司 | Oxidation-resisting health-care product composition and its preparation method and application |
| CN108684884A (en) * | 2018-05-23 | 2018-10-23 | 南京中生生物科技有限公司 | A kind of composition and preparation method thereof of chitosan oligosaccharide, green-tea extract |
| CN110403005A (en) * | 2019-02-11 | 2019-11-05 | 权冉(银川)科技有限公司 | The food materials anti-metamorphic protection liquid and its preparation method of herbal medicine fruits and vegetables |
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