CN103316000A - 用作rock抑制剂的杂环酰胺 - Google Patents
用作rock抑制剂的杂环酰胺 Download PDFInfo
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- CN103316000A CN103316000A CN2013102026660A CN201310202666A CN103316000A CN 103316000 A CN103316000 A CN 103316000A CN 2013102026660 A CN2013102026660 A CN 2013102026660A CN 201310202666 A CN201310202666 A CN 201310202666A CN 103316000 A CN103316000 A CN 103316000A
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Applications Claiming Priority (2)
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| GB201018996A GB201018996D0 (en) | 2010-11-10 | 2010-11-10 | Novel ROCK inhibitors |
| GB1018996.7 | 2010-11-10 |
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| CN201180011949.6A Division CN102884049B (zh) | 2010-11-10 | 2011-03-04 | 用作rock抑制剂的杂环酰胺 |
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| CN103316000A true CN103316000A (zh) | 2013-09-25 |
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| CN2013102026660A Pending CN103316000A (zh) | 2010-11-10 | 2011-03-04 | 用作rock抑制剂的杂环酰胺 |
| CN201180011949.6A Expired - Fee Related CN102884049B (zh) | 2010-11-10 | 2011-03-04 | 用作rock抑制剂的杂环酰胺 |
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| CN201180011949.6A Expired - Fee Related CN102884049B (zh) | 2010-11-10 | 2011-03-04 | 用作rock抑制剂的杂环酰胺 |
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| CN (2) | CN103316000A (enExample) |
| GB (1) | GB201018996D0 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014004545A2 (pt) * | 2011-08-31 | 2017-04-04 | Amakem Nv | inibidores leves de rock |
| CN107915717A (zh) * | 2017-12-31 | 2018-04-17 | 佛山市赛维斯医药科技有限公司 | 一类含异丙基萘和丙二醇噻吩酰胺类化合物及其用途 |
| CN108047195A (zh) * | 2017-12-31 | 2018-05-18 | 佛山市赛维斯医药科技有限公司 | 一种含丙二醇腈基噻吩酰胺类化合物及其用途 |
| CN107935986A (zh) * | 2017-12-31 | 2018-04-20 | 佛山市赛维斯医药科技有限公司 | 异丙胺和卤代噻吩酰胺类结构化合物、其制备方法及用途 |
| CN108191820A (zh) * | 2017-12-31 | 2018-06-22 | 佛山市赛维斯医药科技有限公司 | 一种含异丙胺和噻吩酰胺类结构的化合物 |
| CN108191821A (zh) * | 2017-12-31 | 2018-06-22 | 佛山市赛维斯医药科技有限公司 | 一种含甲基萘和腈基噻吩酰胺类结构的rock抑制剂及用途 |
| CN108047194A (zh) * | 2017-12-31 | 2018-05-18 | 佛山市赛维斯医药科技有限公司 | 含甲基萘和丙二醇噻吩酰胺类化合物、制备方法及其用途 |
| CN108047193A (zh) * | 2017-12-31 | 2018-05-18 | 佛山市赛维斯医药科技有限公司 | 烷氧噻吩酰胺类rock抑制剂、制备方法及其用途 |
| CN108129452A (zh) * | 2017-12-31 | 2018-06-08 | 佛山市赛维斯医药科技有限公司 | 一种含异丙基萘和丙二醇硝基噻吩酰胺类化合物及其用途 |
| CN107935987A (zh) * | 2017-12-31 | 2018-04-20 | 佛山市赛维斯医药科技有限公司 | 含甲基萘和噻吩酰胺结构的rock抑制剂、制备方法及其用途 |
| CN108101885A (zh) * | 2017-12-31 | 2018-06-01 | 佛山市赛维斯医药科技有限公司 | 含异丙胺和硝基噻吩酰胺类结构化合物、其制备方法及用途 |
| CN114956977B (zh) * | 2022-06-09 | 2024-03-26 | 朗捷睿(苏州)生物科技有限公司 | 一种联苯类化合物、药物组合物及其制备方法和应用 |
| CN120569383A (zh) * | 2023-01-13 | 2025-08-29 | 武汉朗来科技发展有限公司 | 一种rock抑制剂中间体的制备方法 |
| CN117126072B (zh) * | 2023-08-24 | 2025-12-30 | 中国药科大学 | 一种含酯链pd-1/pd-l1小分子抑制剂及其制备方法和应用 |
| CN119569655B (zh) * | 2024-11-21 | 2025-11-11 | 西北大学 | 含吡唑甲酰胺基的苯甲酸氟甲基硫酯类化合物及其制备方法与应用 |
Citations (1)
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| CN101287707A (zh) * | 2005-10-13 | 2008-10-15 | 德福根有限公司 | 激酶抑制剂 |
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| CN101248046A (zh) * | 2005-07-11 | 2008-08-20 | 德福根有限公司 | 作为激酶抑制剂的酰胺衍生物 |
| WO2007006547A1 (en) * | 2005-07-11 | 2007-01-18 | Devgen N.V. | Amide derivatives as kinase inhibitors |
| AU2007249891A1 (en) * | 2006-05-12 | 2007-11-22 | Vertex Pharmaceuticals Incorporated | Selective inhibitors of ROCK protein kinase and uses thereof |
| US8445686B2 (en) * | 2007-08-27 | 2013-05-21 | Abbvie Inc. | 4-(4-pyridinyl)-benzamides and their use as rock activity modulators |
| CN102159547A (zh) * | 2008-09-18 | 2011-08-17 | 安斯泰来制药株式会社 | 杂环甲酰胺化合物 |
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- 2010-11-10 GB GB201018996A patent/GB201018996D0/en not_active Ceased
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- 2011-03-04 CN CN2013102026660A patent/CN103316000A/zh active Pending
- 2011-03-04 CN CN201180011949.6A patent/CN102884049B/zh not_active Expired - Fee Related
- 2011-03-04 JP JP2012555446A patent/JP5710650B2/ja not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101287707A (zh) * | 2005-10-13 | 2008-10-15 | 德福根有限公司 | 激酶抑制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| GB201018996D0 (en) | 2010-12-22 |
| CN102884049A (zh) | 2013-01-16 |
| JP5710650B2 (ja) | 2015-04-30 |
| JP2013527136A (ja) | 2013-06-27 |
| CN102884049B (zh) | 2016-08-24 |
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