CN103316000A - 用作rock抑制剂的杂环酰胺 - Google Patents

用作rock抑制剂的杂环酰胺 Download PDF

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Publication number
CN103316000A
CN103316000A CN2013102026660A CN201310202666A CN103316000A CN 103316000 A CN103316000 A CN 103316000A CN 2013102026660 A CN2013102026660 A CN 2013102026660A CN 201310202666 A CN201310202666 A CN 201310202666A CN 103316000 A CN103316000 A CN 103316000A
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CN
China
Prior art keywords
alkyl
base
group
chemical compound
disease
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Pending
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CN2013102026660A
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English (en)
Chinese (zh)
Inventor
D·雷森
O·戴非尔特
N·卡瓦尔
P·布罗姆
S·波兰德
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Amakem NV
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Amakem NV
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Publication of CN103316000A publication Critical patent/CN103316000A/zh
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2013102026660A 2010-11-10 2011-03-04 用作rock抑制剂的杂环酰胺 Pending CN103316000A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201018996A GB201018996D0 (en) 2010-11-10 2010-11-10 Novel ROCK inhibitors
GB1018996.7 2010-11-10

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201180011949.6A Division CN102884049B (zh) 2010-11-10 2011-03-04 用作rock抑制剂的杂环酰胺

Publications (1)

Publication Number Publication Date
CN103316000A true CN103316000A (zh) 2013-09-25

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ID=43414658

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2013102026660A Pending CN103316000A (zh) 2010-11-10 2011-03-04 用作rock抑制剂的杂环酰胺
CN201180011949.6A Expired - Fee Related CN102884049B (zh) 2010-11-10 2011-03-04 用作rock抑制剂的杂环酰胺

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201180011949.6A Expired - Fee Related CN102884049B (zh) 2010-11-10 2011-03-04 用作rock抑制剂的杂环酰胺

Country Status (3)

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JP (1) JP5710650B2 (enExample)
CN (2) CN103316000A (enExample)
GB (1) GB201018996D0 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014004545A2 (pt) * 2011-08-31 2017-04-04 Amakem Nv inibidores leves de rock
CN107915717A (zh) * 2017-12-31 2018-04-17 佛山市赛维斯医药科技有限公司 一类含异丙基萘和丙二醇噻吩酰胺类化合物及其用途
CN108047195A (zh) * 2017-12-31 2018-05-18 佛山市赛维斯医药科技有限公司 一种含丙二醇腈基噻吩酰胺类化合物及其用途
CN107935986A (zh) * 2017-12-31 2018-04-20 佛山市赛维斯医药科技有限公司 异丙胺和卤代噻吩酰胺类结构化合物、其制备方法及用途
CN108191820A (zh) * 2017-12-31 2018-06-22 佛山市赛维斯医药科技有限公司 一种含异丙胺和噻吩酰胺类结构的化合物
CN108191821A (zh) * 2017-12-31 2018-06-22 佛山市赛维斯医药科技有限公司 一种含甲基萘和腈基噻吩酰胺类结构的rock抑制剂及用途
CN108047194A (zh) * 2017-12-31 2018-05-18 佛山市赛维斯医药科技有限公司 含甲基萘和丙二醇噻吩酰胺类化合物、制备方法及其用途
CN108047193A (zh) * 2017-12-31 2018-05-18 佛山市赛维斯医药科技有限公司 烷氧噻吩酰胺类rock抑制剂、制备方法及其用途
CN108129452A (zh) * 2017-12-31 2018-06-08 佛山市赛维斯医药科技有限公司 一种含异丙基萘和丙二醇硝基噻吩酰胺类化合物及其用途
CN107935987A (zh) * 2017-12-31 2018-04-20 佛山市赛维斯医药科技有限公司 含甲基萘和噻吩酰胺结构的rock抑制剂、制备方法及其用途
CN108101885A (zh) * 2017-12-31 2018-06-01 佛山市赛维斯医药科技有限公司 含异丙胺和硝基噻吩酰胺类结构化合物、其制备方法及用途
CN114956977B (zh) * 2022-06-09 2024-03-26 朗捷睿(苏州)生物科技有限公司 一种联苯类化合物、药物组合物及其制备方法和应用
CN120569383A (zh) * 2023-01-13 2025-08-29 武汉朗来科技发展有限公司 一种rock抑制剂中间体的制备方法
CN117126072B (zh) * 2023-08-24 2025-12-30 中国药科大学 一种含酯链pd-1/pd-l1小分子抑制剂及其制备方法和应用
CN119569655B (zh) * 2024-11-21 2025-11-11 西北大学 含吡唑甲酰胺基的苯甲酸氟甲基硫酯类化合物及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101287707A (zh) * 2005-10-13 2008-10-15 德福根有限公司 激酶抑制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101248046A (zh) * 2005-07-11 2008-08-20 德福根有限公司 作为激酶抑制剂的酰胺衍生物
WO2007006547A1 (en) * 2005-07-11 2007-01-18 Devgen N.V. Amide derivatives as kinase inhibitors
AU2007249891A1 (en) * 2006-05-12 2007-11-22 Vertex Pharmaceuticals Incorporated Selective inhibitors of ROCK protein kinase and uses thereof
US8445686B2 (en) * 2007-08-27 2013-05-21 Abbvie Inc. 4-(4-pyridinyl)-benzamides and their use as rock activity modulators
CN102159547A (zh) * 2008-09-18 2011-08-17 安斯泰来制药株式会社 杂环甲酰胺化合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101287707A (zh) * 2005-10-13 2008-10-15 德福根有限公司 激酶抑制剂

Also Published As

Publication number Publication date
GB201018996D0 (en) 2010-12-22
CN102884049A (zh) 2013-01-16
JP5710650B2 (ja) 2015-04-30
JP2013527136A (ja) 2013-06-27
CN102884049B (zh) 2016-08-24

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