CN103298928B - 用于激活辅助性t细胞的方法 - Google Patents

用于激活辅助性t细胞的方法 Download PDF

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Publication number
CN103298928B
CN103298928B CN201180058552.2A CN201180058552A CN103298928B CN 103298928 B CN103298928 B CN 103298928B CN 201180058552 A CN201180058552 A CN 201180058552A CN 103298928 B CN103298928 B CN 103298928B
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hla
molecule
drb1
peptide
molecules
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CN103298928A (zh
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杉山治夫
十河真司
佐藤政芳
北本龙生
后藤义博
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International Institute of Cancer Immunology Inc
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Otsuka Pharmaceutical Co Ltd
International Institute of Cancer Immunology Inc
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    • A61K31/711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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CN201180058552.2A 2010-10-05 2011-10-04 用于激活辅助性t细胞的方法 Active CN103298928B (zh)

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JP2010-225806 2010-10-05
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PCT/JP2011/072874 WO2012046730A1 (ja) 2010-10-05 2011-10-04 ヘルパーt細胞の活性化方法

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EP (1) EP2626418B8 (OSRAM)
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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2544214C (en) 2003-11-05 2018-08-28 International Institute Of Cancer Immunology, Inc. Hla-dr-binding antigen peptide derived from wt1
EP1951281B1 (en) 2005-10-17 2015-04-15 Sloan Kettering Institute For Cancer Research Wt1 hla class ii-binding peptides and compositions and methods comprising same
EP3117836A1 (en) 2006-04-10 2017-01-18 Sloan Kettering Institute For Cancer Research Immunogenic wt-1 peptides and uses thereof
EP2119778B1 (en) 2007-02-27 2015-11-04 International Institute of Cancer Immunology, Inc. Method for activation of helper T cell and composition for use in the method
AR076349A1 (es) 2009-04-23 2011-06-01 Int Inst Cancer Immunology Inc Peptido auxiliar del antigeno del cancer
EP2626418B8 (en) * 2010-10-05 2021-03-24 International Institute of Cancer Immunology, Inc. Method for activating helper t cell
EP2802347B1 (en) 2012-01-13 2019-01-09 Memorial Sloan Kettering Cancer Center Immunogenic wt-1 peptides and methods of use thereof
CA2884366A1 (en) * 2012-09-12 2014-03-20 International Institute Of Cancer Immunology, Inc. Antigen-specific helper t-cell receptor genes
ES2805337T3 (es) * 2012-12-17 2021-02-11 Otsuka Pharma Co Ltd Método para activar células T auxiliares
US10815273B2 (en) 2013-01-15 2020-10-27 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
SI2945647T1 (sl) 2013-01-15 2021-01-29 Memorial Sloan Kettering Cancer Center Imunogeni peptidi WT-1 in postopki za uporabo le-teh
WO2014157692A1 (ja) 2013-03-29 2014-10-02 大日本住友製薬株式会社 Wt1抗原ペプチドコンジュゲートワクチン
WO2015129790A1 (ja) * 2014-02-26 2015-09-03 株式会社バイオイミュランス Wt1抗原性ポリペプチド、及び該ポリペプチドを含む抗腫瘍剤
CA2974066C (en) 2014-12-25 2025-05-06 International Institute Of Cancer Immunology, Inc. METHOD FOR MODIFYING A T LYMPHOCYTE POPULATION
CN106565836B (zh) * 2015-10-10 2020-08-18 中国科学院广州生物医药与健康研究院 高亲和力的可溶性pdl-1分子
WO2018088439A1 (ja) 2016-11-09 2018-05-17 国立大学法人大阪大学 T細胞集団の改変方法
WO2018101309A1 (ja) * 2016-11-30 2018-06-07 大日本住友製薬株式会社 Wt1ヘルパーペプチド及びこれと癌抗原ペプチドコンジュゲート体との組合せ
CN111741972A (zh) * 2017-12-27 2020-10-02 大日本住友制药株式会社 Wt1衍生肽的缀合物和包含其的组合物
WO2019160099A1 (ja) * 2018-02-15 2019-08-22 大塚製薬株式会社 がん抗原ペプチド
BR112021003031A8 (pt) * 2018-08-22 2023-05-02 Hutchinson Fred Cancer Res Imunoterapia direcionada a antígenos kras ou her2

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1696027A (zh) * 2004-05-12 2005-11-16 领先技术公司 封装套鼓

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726288A (en) 1989-11-13 1998-03-10 Massachusetts Institute Of Technology Localization and characterization of the Wilms' tumor gene
CA2337743C (en) 1998-07-31 2015-07-07 Yoshihiro Oka Tumor antigen based on products of the tumor suppressor gene wt1
US20030235557A1 (en) 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
HK1039782B (en) 1998-09-30 2008-11-14 Corixa Corporation Compositions and methods for wt1 specific immunotherapy
US7063854B1 (en) 1998-09-30 2006-06-20 Corixa Corporation Composition and methods for WTI specific immunotherapy
NZ521430A (en) 2000-02-22 2004-04-30 Corixa Corp Compositions comprising 1-4 antigenic peptide fragments of the Wilms' tumour gene product for treatment or prevention of malignant mesothelioma
JP3728439B2 (ja) 2001-03-22 2005-12-21 治夫 杉山 Wt1改変ペプチド
GB0108491D0 (en) 2001-04-04 2001-05-23 Gendaq Ltd Engineering zinc fingers
JP4229832B2 (ja) 2001-06-29 2009-02-25 忠範 真弓 癌抑制遺伝子wt1の産物に基づく癌抗原とカチオン性リポソームとを含んで成る癌ワクチン
WO2003028757A1 (en) 2001-09-28 2003-04-10 Haruo Sugiyama Novel method of inducing antigen-specific t cells
JPWO2003028758A1 (ja) 2001-09-28 2005-01-13 治夫 杉山 抗原特異的t細胞の誘導方法
JP4365784B2 (ja) 2002-06-12 2009-11-18 株式会社癌免疫研究所 Hla−a24拘束性癌抗原ペプチド
ES2538486T3 (es) 2002-09-12 2015-06-22 International Institute Of Cancer Immunology, Inc. Preparación de péptidos antigénicos contra el cáncer
JP4480580B2 (ja) 2002-09-20 2010-06-16 株式会社癌免疫研究所 Wt1置換型ペプチド
KR20120054644A (ko) 2003-01-15 2012-05-30 추가이 세이야쿠 가부시키가이샤 이량체화 펩티드
ATE538809T1 (de) 2003-06-27 2012-01-15 Int Inst Cancer Immunology Inc Verfahren zur auswahl von geeigneten patienten für den wt1-impfstoff
CA2544214C (en) 2003-11-05 2018-08-28 International Institute Of Cancer Immunology, Inc. Hla-dr-binding antigen peptide derived from wt1
JP4886507B2 (ja) 2004-03-31 2012-02-29 株式会社癌免疫研究所 Wt1由来の癌抗原ペプチド
JP4719876B2 (ja) 2005-04-04 2011-07-06 国立大学法人愛媛大学 Hlaクラスii拘束性wt1抗原ペプチド
EP1951281B1 (en) 2005-10-17 2015-04-15 Sloan Kettering Institute For Cancer Research Wt1 hla class ii-binding peptides and compositions and methods comprising same
CN105315347A (zh) 2005-11-30 2016-02-10 株式会社癌免疫研究所 新型肽化合物
US7420880B2 (en) 2005-12-29 2008-09-02 Timex Group B.V. Multimode electronic device with calibrating/setting mechanism
EP2385117B1 (en) 2006-02-22 2016-07-27 International Institute of Cancer Immunology, Inc. HLA-A*3303-restricted WT1 peptide and pharmaceutical composition comprising the same
EP3117836A1 (en) 2006-04-10 2017-01-18 Sloan Kettering Institute For Cancer Research Immunogenic wt-1 peptides and uses thereof
EP2980219B1 (en) 2006-12-28 2018-11-14 International Institute of Cancer Immunology, Inc. Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same
EP2119778B1 (en) 2007-02-27 2015-11-04 International Institute of Cancer Immunology, Inc. Method for activation of helper T cell and composition for use in the method
KR101669279B1 (ko) 2007-03-05 2016-10-26 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 암 항원 특이적 t 세포의 수용체 유전자 및 그것에 따라 코드되는 펩티드 및 이들의 사용
AR076349A1 (es) 2009-04-23 2011-06-01 Int Inst Cancer Immunology Inc Peptido auxiliar del antigeno del cancer
EP2626418B8 (en) * 2010-10-05 2021-03-24 International Institute of Cancer Immunology, Inc. Method for activating helper t cell
ES2805337T3 (es) 2012-12-17 2021-02-11 Otsuka Pharma Co Ltd Método para activar células T auxiliares

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1696027A (zh) * 2004-05-12 2005-11-16 领先技术公司 封装套鼓

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Peptide Epitopes from the Wilms Tumor 1 Oncoprotein Stimulate CD4 + and CD8+ T Cells That Recognize and Kill Human Malignant Mesothelioma Tumor Cells";Rena J. May 等;《Clinical Cancer Research》;20070801;第13卷(第15期);摘要,表1,第4548页右栏最后一段-4549页左栏第一段 *
"The Wilms Tumor Antigen Is a Novel Target for Human CD4+ Regulatory T Cells: Implications for Immunotherapy";Cynthia Lehe 等;《Cancer Research》;20080801;第68卷(第15期);第6350-6359页 *

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