CN103298928B - 用于激活辅助性t细胞的方法 - Google Patents
用于激活辅助性t细胞的方法 Download PDFInfo
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- CN103298928B CN103298928B CN201180058552.2A CN201180058552A CN103298928B CN 103298928 B CN103298928 B CN 103298928B CN 201180058552 A CN201180058552 A CN 201180058552A CN 103298928 B CN103298928 B CN 103298928B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4242—Transcription factors, e.g. SOX or c-MYC
- A61K40/4243—Wilms tumor 1 [WT1]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
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- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010-225806 | 2010-10-05 | ||
| JP2010225806 | 2010-10-05 | ||
| PCT/JP2011/072874 WO2012046730A1 (ja) | 2010-10-05 | 2011-10-04 | ヘルパーt細胞の活性化方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610191489.4A Division CN105802910A (zh) | 2010-10-05 | 2011-10-04 | 用于激活辅助性t细胞的方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103298928A CN103298928A (zh) | 2013-09-11 |
| CN103298928B true CN103298928B (zh) | 2016-04-20 |
Family
ID=45927725
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610191489.4A Pending CN105802910A (zh) | 2010-10-05 | 2011-10-04 | 用于激活辅助性t细胞的方法 |
| CN201180058552.2A Active CN103298928B (zh) | 2010-10-05 | 2011-10-04 | 用于激活辅助性t细胞的方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610191489.4A Pending CN105802910A (zh) | 2010-10-05 | 2011-10-04 | 用于激活辅助性t细胞的方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US10654892B2 (OSRAM) |
| EP (1) | EP2626418B8 (OSRAM) |
| JP (3) | JP6134139B2 (OSRAM) |
| KR (3) | KR20140009168A (OSRAM) |
| CN (2) | CN105802910A (OSRAM) |
| AR (1) | AR083295A1 (OSRAM) |
| AU (1) | AU2011313327B2 (OSRAM) |
| BR (1) | BR112013008230A2 (OSRAM) |
| CA (1) | CA2813557C (OSRAM) |
| CO (1) | CO6710946A2 (OSRAM) |
| EA (1) | EA037547B1 (OSRAM) |
| ES (1) | ES2849187T3 (OSRAM) |
| IL (2) | IL225536B (OSRAM) |
| MX (2) | MX361299B (OSRAM) |
| MY (1) | MY170306A (OSRAM) |
| NZ (2) | NZ609460A (OSRAM) |
| PH (1) | PH12013500654A1 (OSRAM) |
| SG (3) | SG189287A1 (OSRAM) |
| TW (2) | TWI608099B (OSRAM) |
| WO (1) | WO2012046730A1 (OSRAM) |
| ZA (1) | ZA201303056B (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2544214C (en) | 2003-11-05 | 2018-08-28 | International Institute Of Cancer Immunology, Inc. | Hla-dr-binding antigen peptide derived from wt1 |
| EP1951281B1 (en) | 2005-10-17 | 2015-04-15 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
| EP3117836A1 (en) | 2006-04-10 | 2017-01-18 | Sloan Kettering Institute For Cancer Research | Immunogenic wt-1 peptides and uses thereof |
| EP2119778B1 (en) | 2007-02-27 | 2015-11-04 | International Institute of Cancer Immunology, Inc. | Method for activation of helper T cell and composition for use in the method |
| AR076349A1 (es) | 2009-04-23 | 2011-06-01 | Int Inst Cancer Immunology Inc | Peptido auxiliar del antigeno del cancer |
| EP2626418B8 (en) * | 2010-10-05 | 2021-03-24 | International Institute of Cancer Immunology, Inc. | Method for activating helper t cell |
| EP2802347B1 (en) | 2012-01-13 | 2019-01-09 | Memorial Sloan Kettering Cancer Center | Immunogenic wt-1 peptides and methods of use thereof |
| CA2884366A1 (en) * | 2012-09-12 | 2014-03-20 | International Institute Of Cancer Immunology, Inc. | Antigen-specific helper t-cell receptor genes |
| ES2805337T3 (es) * | 2012-12-17 | 2021-02-11 | Otsuka Pharma Co Ltd | Método para activar células T auxiliares |
| US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| SI2945647T1 (sl) | 2013-01-15 | 2021-01-29 | Memorial Sloan Kettering Cancer Center | Imunogeni peptidi WT-1 in postopki za uporabo le-teh |
| WO2014157692A1 (ja) | 2013-03-29 | 2014-10-02 | 大日本住友製薬株式会社 | Wt1抗原ペプチドコンジュゲートワクチン |
| WO2015129790A1 (ja) * | 2014-02-26 | 2015-09-03 | 株式会社バイオイミュランス | Wt1抗原性ポリペプチド、及び該ポリペプチドを含む抗腫瘍剤 |
| CA2974066C (en) | 2014-12-25 | 2025-05-06 | International Institute Of Cancer Immunology, Inc. | METHOD FOR MODIFYING A T LYMPHOCYTE POPULATION |
| CN106565836B (zh) * | 2015-10-10 | 2020-08-18 | 中国科学院广州生物医药与健康研究院 | 高亲和力的可溶性pdl-1分子 |
| WO2018088439A1 (ja) | 2016-11-09 | 2018-05-17 | 国立大学法人大阪大学 | T細胞集団の改変方法 |
| WO2018101309A1 (ja) * | 2016-11-30 | 2018-06-07 | 大日本住友製薬株式会社 | Wt1ヘルパーペプチド及びこれと癌抗原ペプチドコンジュゲート体との組合せ |
| CN111741972A (zh) * | 2017-12-27 | 2020-10-02 | 大日本住友制药株式会社 | Wt1衍生肽的缀合物和包含其的组合物 |
| WO2019160099A1 (ja) * | 2018-02-15 | 2019-08-22 | 大塚製薬株式会社 | がん抗原ペプチド |
| BR112021003031A8 (pt) * | 2018-08-22 | 2023-05-02 | Hutchinson Fred Cancer Res | Imunoterapia direcionada a antígenos kras ou her2 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1696027A (zh) * | 2004-05-12 | 2005-11-16 | 领先技术公司 | 封装套鼓 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5726288A (en) | 1989-11-13 | 1998-03-10 | Massachusetts Institute Of Technology | Localization and characterization of the Wilms' tumor gene |
| CA2337743C (en) | 1998-07-31 | 2015-07-07 | Yoshihiro Oka | Tumor antigen based on products of the tumor suppressor gene wt1 |
| US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| HK1039782B (en) | 1998-09-30 | 2008-11-14 | Corixa Corporation | Compositions and methods for wt1 specific immunotherapy |
| US7063854B1 (en) | 1998-09-30 | 2006-06-20 | Corixa Corporation | Composition and methods for WTI specific immunotherapy |
| NZ521430A (en) | 2000-02-22 | 2004-04-30 | Corixa Corp | Compositions comprising 1-4 antigenic peptide fragments of the Wilms' tumour gene product for treatment or prevention of malignant mesothelioma |
| JP3728439B2 (ja) | 2001-03-22 | 2005-12-21 | 治夫 杉山 | Wt1改変ペプチド |
| GB0108491D0 (en) | 2001-04-04 | 2001-05-23 | Gendaq Ltd | Engineering zinc fingers |
| JP4229832B2 (ja) | 2001-06-29 | 2009-02-25 | 忠範 真弓 | 癌抑制遺伝子wt1の産物に基づく癌抗原とカチオン性リポソームとを含んで成る癌ワクチン |
| WO2003028757A1 (en) | 2001-09-28 | 2003-04-10 | Haruo Sugiyama | Novel method of inducing antigen-specific t cells |
| JPWO2003028758A1 (ja) | 2001-09-28 | 2005-01-13 | 治夫 杉山 | 抗原特異的t細胞の誘導方法 |
| JP4365784B2 (ja) | 2002-06-12 | 2009-11-18 | 株式会社癌免疫研究所 | Hla−a24拘束性癌抗原ペプチド |
| ES2538486T3 (es) | 2002-09-12 | 2015-06-22 | International Institute Of Cancer Immunology, Inc. | Preparación de péptidos antigénicos contra el cáncer |
| JP4480580B2 (ja) | 2002-09-20 | 2010-06-16 | 株式会社癌免疫研究所 | Wt1置換型ペプチド |
| KR20120054644A (ko) | 2003-01-15 | 2012-05-30 | 추가이 세이야쿠 가부시키가이샤 | 이량체화 펩티드 |
| ATE538809T1 (de) | 2003-06-27 | 2012-01-15 | Int Inst Cancer Immunology Inc | Verfahren zur auswahl von geeigneten patienten für den wt1-impfstoff |
| CA2544214C (en) | 2003-11-05 | 2018-08-28 | International Institute Of Cancer Immunology, Inc. | Hla-dr-binding antigen peptide derived from wt1 |
| JP4886507B2 (ja) | 2004-03-31 | 2012-02-29 | 株式会社癌免疫研究所 | Wt1由来の癌抗原ペプチド |
| JP4719876B2 (ja) | 2005-04-04 | 2011-07-06 | 国立大学法人愛媛大学 | Hlaクラスii拘束性wt1抗原ペプチド |
| EP1951281B1 (en) | 2005-10-17 | 2015-04-15 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
| CN105315347A (zh) | 2005-11-30 | 2016-02-10 | 株式会社癌免疫研究所 | 新型肽化合物 |
| US7420880B2 (en) | 2005-12-29 | 2008-09-02 | Timex Group B.V. | Multimode electronic device with calibrating/setting mechanism |
| EP2385117B1 (en) | 2006-02-22 | 2016-07-27 | International Institute of Cancer Immunology, Inc. | HLA-A*3303-restricted WT1 peptide and pharmaceutical composition comprising the same |
| EP3117836A1 (en) | 2006-04-10 | 2017-01-18 | Sloan Kettering Institute For Cancer Research | Immunogenic wt-1 peptides and uses thereof |
| EP2980219B1 (en) | 2006-12-28 | 2018-11-14 | International Institute of Cancer Immunology, Inc. | Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same |
| EP2119778B1 (en) | 2007-02-27 | 2015-11-04 | International Institute of Cancer Immunology, Inc. | Method for activation of helper T cell and composition for use in the method |
| KR101669279B1 (ko) | 2007-03-05 | 2016-10-26 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | 암 항원 특이적 t 세포의 수용체 유전자 및 그것에 따라 코드되는 펩티드 및 이들의 사용 |
| AR076349A1 (es) | 2009-04-23 | 2011-06-01 | Int Inst Cancer Immunology Inc | Peptido auxiliar del antigeno del cancer |
| EP2626418B8 (en) * | 2010-10-05 | 2021-03-24 | International Institute of Cancer Immunology, Inc. | Method for activating helper t cell |
| ES2805337T3 (es) | 2012-12-17 | 2021-02-11 | Otsuka Pharma Co Ltd | Método para activar células T auxiliares |
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| CN1696027A (zh) * | 2004-05-12 | 2005-11-16 | 领先技术公司 | 封装套鼓 |
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