CN103284897A - 化妆品制剂 - Google Patents
化妆品制剂 Download PDFInfo
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- CN103284897A CN103284897A CN2013101281900A CN201310128190A CN103284897A CN 103284897 A CN103284897 A CN 103284897A CN 2013101281900 A CN2013101281900 A CN 2013101281900A CN 201310128190 A CN201310128190 A CN 201310128190A CN 103284897 A CN103284897 A CN 103284897A
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- skin
- extract
- oil
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Abstract
本发明公开了化妆爽肤水制剂及其使用方法,所述制剂包含80至95%重量的水、水飞蓟果实提取物、罗汉果果实提取物和柳珊瑚提取物。
Description
相关申请的交叉引用
本申请要求2012年1月27日提交的美国临时申请号61/591,665和2012年1月27日提交的美国临时申请号61/591,743的权益。将两篇参考申请的内容并入本申请作为参考。
发明背景
A.发明领域
本发明一般涉及可用于干性皮肤、油性皮肤、中性皮肤或混合性皮肤的化妆品组合物。在特定实施方案中,所述组合物为化妆爽肤水(toner)或清新剂(freshener)。
B.相关现有技术的说明
存在数千种消费者可获得的皮肤制剂。进一步,人群间存在多种不同的皮肤类型。这样的皮肤类型为中性皮肤、干性皮肤、油性皮肤和混合性皮肤(例如,中性/干性、中性/油性、干性/油性)。这导致对不同应用的不同产品的混乱和无穷尽的研究。
化妆爽肤水是已知的且用于销售。例如,一些爽肤水包括高水平的丙酮或醇(例如至少20至70%w/w),例如乙醇、丙酮或异丙醇。这些醇基爽肤水时皮肤可以是腐蚀性或刺激性的。其它爽肤水也使用高水平(例如,至少20至70%w/w)的二醇基成分(例如,乙二醇醚),其可能具有辛辣味。
虽然存在一些水基爽肤水,但是使用高量的水通常妨碍了可能有益于皮肤的其它成分(例如,增湿剂和皮肤活性剂)的加入。一种解决该问题的方法是使用大量的表面活性剂或乳化剂,令人遗憾地是其可以刺激皮肤。进一步,使用高量的水通常妨碍了使用可用于各种皮肤类型的标准基质。
发明简述
本申请人已经发现了与目前化妆爽肤水有关问题的解决办法。该解决方法是植物成分的组合,同时使用在潜在(underlying)化妆品载体中的成分的标准基质集合(base-set),所述植物成分可以用于制备对于特定皮肤类型(例如干性皮肤、中性皮肤、油性皮肤、混合性皮肤例如中性/干性、中性/油性、干性/油性)的调色制剂。进一步,考虑到植物成分的特定组合,可以调整在潜在化妆品载体中使用的成分的基质集合的量。
在一个宽泛的方面,公开了一种局部皮肤组合物,其包括植物提取物的组合和化妆品载体,所述提取物包括水飞蓟(Silybum marianum)果实提取物、罗汉果(Momordica grosvenori)果实提取物或向日葵(Helianthus annuus)籽提取物和柳珊瑚(Pseudopterogorgia elisabethae)提取物,所述化妆品载体包括至少80%重量的水(基于组合物的总重量计)。该组合可以用于所有皮肤类型(例如干性皮肤、中性皮肤、油性皮肤和混合性皮肤)。
发现向该组合中加入水解藻胶和亚麻(Linum usitatissimum)籽提取物对于于性皮肤的作用特别好,因为它可以恢复皮肤的天然pH平衡,同时使皮肤看起来更有光泽和更健康,以及使得皮肤感觉更柔软、更光滑和湿润。
发现分别加入白鸡蛋花(Plumeria alba)花提取物、油茶(Camelliaoleifera)叶提取物和蔬食埃塔棕(Euterpe oleracea)果提取物或加入白鸡蛋花花提取物和澳洲睡莲(Nymphaea gigantea)花提取物对中性皮肤的作用特别好,因为这些组合的每种都可以改善皮肤纹理,使其保持柔软的亚光面(mattefinish),同时还使得皮肤看起来更健康和感觉精神,且为局部施用保湿产品做好准备。
发现分别加入榆绣线菊(Spiraea ulmaria)提取物和番石榴(Psidiumguajava)果实提取物或加入卡奴卡树(Kunzea ericoides)叶提取物和番石榴果实提取物对油性皮肤的作用特别好,因为这些组合的每种都可以除去过量的油或皮脂,而不会使皮肤干燥,同时清洁毛孔和使毛孔的形态最小化,且改善皮肤透明度。
这些提取物在给定组合物中的量可以变化。在一个实例中,对于每种提取物,例如,发现下述范围/量作用良好:0.01至0.1%重量,或0.01、0.02、0.03、0.04、0.05、0.06、0.07、0.08、0.09或0.1%重量。在其它方面,范围为所述提取物重量的0.0001至0.001%或0.001到0.01%。然而,也预期所述植物性植物提取物(botanical plant extracts)的量可以低于或高于所述范围。在这方面,所述植物性植物提取物中任一种在给定组合物中的量的范围都可以为0.00001至10%、0.0001至5%、0.001至2%、0.01至1%、0.1至0.5%等。
在特定方面,且除了高量的水之外,化妆品载体也可以包括下述成分的任一种、任意组合或至少1、2、3、4、5或所有6种:甘油、丁二醇、Euxyll PE9010TM(参见实施例)、Glycacil 2000TM(参见实施例)、仙人果果实提取物、和消泡剂(例如Simethconel/C-T1101-Slicone AntifoamTM)。这些成分的范围可以为0.005至10%重量、或者其中任意范围(例如,0.05、0.5、1、2、3、4、5、6、7、8或9%重量)。而且,如之前指示的,本发明的组合物作为爽肤水例如清新剂作用良好。对此的原因之一是它们的重量轻和适度/温和的皮肤制剂特性。
在另一个方面,且除了高量的水之外,化妆品载体也可以包括下述成分的任一种、任意组合或至少1、2、3、4、5、6、7、8、9、10、11或所有12种:丁二醇;甘油;二偶氮烷基脲;尼泊金甲酯;EDTA二钠;西甲硅油(simethicone);PPG-26;PEG/PPG-22/23二甲硅油(dimethicone);柠檬酸;苯氧基乙醇;山梨酸钾;和/或苯甲酸钠。在特定方面,发现所有12种这些另外成分的组合可用作预期用于干性皮肤、中性皮肤、油性皮肤和混合性皮肤的产品的载体。这是一个独特的发现,因为为了提供不同的需要(例如,干性皮肤通常需要过度的保湿能力,而油性皮肤通常需要降低的保温能力等),对于特定皮肤类型的潜在载体倾向于不同。这些成分各自在载体中的一般范围/量可以为(基于组合物的总重量计):2至8%重量的丁二醇;1至5%重量的甘油;0.1至0.3%重量的二偶氮烷基脲;0.1至0.2%重量的尼泊金甲酯;0.05至0.1%重量的EDTA二钠;0.002至0.003%重量的西甲硅油;0.001至0.002%重量的PPG-26;0.001至0.002%重量的PEG/PPG-22/23二甲硅油;0.0002至0.002%重量的柠檬酸;0,00005至0.0008%重量的苯氧基乙醇;0.0001至0.0004%重量的山梨酸钾;和0.0001至0.0003%重量的苯甲酸钠。例如,在化妆品载体内的成分的含量或者也可以加入到化妆品载体中的赋形剂或其它成分的加入量改变载体的流变学特定性、改变了植物性植物提取物的组合、或者包括另外的皮肤益处。在一个特定实例中,发现下述载体对于干性皮肤作用良好((用量为基于组合物的总重量计):80至85%重量的水;6至8%重量的丁二醇;3至5%重量的甘油;0.1至0.3%重量的二偶氮烷基脲;0.1至0.2%重量的尼泊金甲酯;0.05至0.1%重量的EDTA二钠;0.002至0.003%重量的西甲硅油;0.001至0.002%重量的PPG-26;0.001至0.002%重量的PEG/PPG-22/23二甲硅油;0.001至0.002%重量的柠檬酸;0.0005至0.0007%重量的苯氧基乙醇;0.0002至0.0004%重量的山梨酸钾;和0.0001至0.0002%重量的苯甲酸钠。在另一个实例中,发现下述载体对于中性皮肤作用良好((用量为基于组合物的总重量计):85至90%重量的水;3至5%重量的丁二醇;3至5%重量的甘油;0.1至0.3%重量的二偶氮烷基脲;0.1至0.2%重量的尼泊金甲酯;0.05至0.1%重量的EDTA二钠;0.002至0.003%重量的西甲硅油;0.001至0.002%重量的PPG-26;0.001至0.002%重量的PEG/PPG-22/23二甲硅油;0.001至0.002%重量的柠檬酸;0.0007至0.0008%重量的苯氧基乙醇;0.0001至0.0002%重量的山梨酸钾;和0.0001至0.0002%重量的苯甲酸钠。在仍然另一个实例中,发现下述载体对于油性皮肤作用良好((用量为基于组合物的总重量计):94至96%重量的水;2至3%重量的丁二醇;0.5至2%重量的甘油;0.2至0.4%重量的二偶氮烷基脲;0.1至0.2%重量的尼泊金甲酯;0.01至0.2%重量的EDTA二钠;0.002至0.003%重量的西甲硅油;0.001至0.002%重量的PPG-26;0.001至0.002%重量的PEG/PPG-22/23二甲硅油;0.0002至0.0003%重量的柠檬酸;0.00004至0.00006%重量的苯氧基乙醇;0.0002至0.0004%重量的山梨酸钾;和0.0002至0.0003%重量的苯甲酸钠。所述组合物也可以包括其它植物性植物提取物,例如仙人果(Opuntia tuna)果实提取物,其是一种产地为北美和南美国家例如美国和墨西哥的肉质植物。仙人果果实提取物的量的范围可以为组合物重量的0.0004至0.0006%,或可以多于或少于如上对于其它植物性植物提取物所描述的。而且,如之前指示的,本发明的组合物作为爽肤水(例如清新剂)作用良好。对此的原因之一是它们的重量轻和适度/温和的皮肤制剂特性。
还公开了一种将任一种本发明的局部皮肤组合物施用于皮肤的方法。皮肤可以是脸部皮肤、身体皮肤(例如手臂、手、腿、足、颈、背部、胸部、腹部或头皮)。可以在通过清洁组合物(例如肥皂、清洁产品、湿巾(towellete)等)清洁皮肤之后的1、2、3、4、5、6、7、8、9或10分钟之内,将组合物施用于皮肤。进一步,可以在将任一种局部皮肤组合物施用于皮肤之后的1、2、3、4、5、6、7、8、9或10分针之内,将皮肤增湿剂产品施用于皮肤。在这种意义上,本发明的局部皮肤组合物可以以其它产品方案使用。例如,人们可以开始洗涤皮肤,接着向皮肤局部施用本发明的组合物,之后向皮肤局部施用增湿剂产品,并且在某些情况下,接着清洁皮肤来应用面膜(通常在晚上期间)。
在一个进一步的实施方案中,本发明人预期使用本发明的组合物治疗特定皮肤病症。所述皮肤病症可以为细纹或皱纹、肤色不均匀、皮肤松弛或下垂、皮肤红斑、皮肤过敏、干性皮肤、鳞片状皮肤、皮肤发痒、皮肤龟裂、瘙痒、蜘蛛状血管病、雀斑、老年斑(age spots)、老年性紫癜、角化病、黑斑病、大斑点、结节、日光损伤性皮肤、皮炎(包括,但不限于脂溢性皮炎、钱币状皮炎、接触性皮炎、特应性皮炎、剥脱性皮炎、口周皮炎和淤滞性皮炎)、银屑病、毛囊炎、酒糟鼻、痤疮、脓疱病、丹毒、红癣、湿疹、日光灼伤、皮肤烧伤、开放性创伤、和/或皮肤炎症性皮肤病症。
本发明的组合物可以采取喷雾剂、泡沫、爽肤水、乳膏、软膏、凝胶、或洗剂、乳剂、溶液的形式,可以为喷雾或粉未形式。组合物也可以配制用于局部皮肤应用,在使用期间,每天使用至少1、2、3、4、5、6、7次或更多次。在本发明的其它方面,组合物可以是贮存稳定的或颜色稳定的、或贮存稳定的和颜色稳定的。还预期可以选择组合物的粘度以获得期望的结果,例如根据期望组合物的类型,这样的组合物的粘度可以为约1cps至远超过1百万cps或其中可得出的任何范围或整数(例如,由使用TC转子的布鲁克菲尔德粘度计(Brookfield Viscometer)在25℃,2.5rpm下测定的,2cps、3、4、5、6、7、8、9、10、20、30、40、50、60、70、80、90、100、200、300、400、500、600、700、800、900、1000、2000、3000、4000、5000、6000、7000、8000、9000、10000、20000、30000、40000、50000、60000、70000、80000、90000、100000、200000、300000、400000、500000、600000、700000、800000、900000、1000000cps等)。在非限制性方面中,组合物可以具有约6至约9的pH。在其它方面中,pH可以为1、2、3、4、5、6、7、8、9、10、11、12、13或14。
本发明的组合物也可以包括下述另外成分的任一种、任意组合或全部:水、螯合剂、保湿剂、防腐剂、增稠剂、含聚硅氧烷的化合物、精油、结构化剂、维生素、药物成分、或抗氧剂、或这样的成分的任意组合或这样的成分的混合物。在某些方面,组合物可以包括在上述语句中确定的这些另外成分的至少两种、三种、四种、五种、六种、七种、八种、九种、十种或全部。这些另外成分的非限制性实例为在本说明书中确定的,且并入该部分作为参考。这样的成分的量的范围可以为组合物重量或体积的0.0001%至99.9%,或者如在本说明书其它部分中公开的任何整数或范围,将所述内容并入该段作为参考。
还预期包含本发明的组合物的试剂盒。在某些实施方案中,组合物包括在容器内。容器可以为瓶、分配器或包装。容器可以分配预定量的组合物。在某些方面,组合物以喷雾、团块(dollop)或液体的形式进行分配。容器可以包括在其表面上的标记。标记可以为文字、缩略语、图像或符号。
预期对于本发明的任何方法或组合物,可以实施在本说明书中讨论的任何实施方案,反之亦然。而且,本发明的组合物可用于实现本发明的方法。
在一个实施方案中,本发明的组合物可以是药用或化妆用优良的(elegant)或者可以具有舒适的触觉特性。“药用优良的”、“化妆用优良的”和/或“舒适的触觉特性”描述具有使皮肤感觉舒适的特别的触觉特性的组合物(例如,不是过于稀薄或油腻的组合物,具有丝绸般质感的组合物,非粘性或粘性的组合物等)。药用或化妆用优良的也可以涉及组合物的乳脂状特性或润滑特性,或者涉及组合物的保湿特性。
所述组合物及其使用方法可以“包括”本说明书中公开的任何成分、“基本上由其组成”或“由其组成”。对于基本上由其组成,意味着组合物中包含的另外成分不会实质上影响前述植物性植物提取物和化妆品载体组合的性质。一个这样的实例是包含了对于参与所述组合中确定的任一种成分具有不利作用(例如,降低功效或稳定性)的成分。
“痤疮”包括丘疹、黑头、白头、丘疹、结节、脓疱、炎性损伤或囊肿。
“局部施用”意味着向嘴唇或角质组织的表面施用或涂敷组合物。“局部皮肤组合物”包括适用于局部施用到嘴唇或角质组织的组合物。这样的组合物通常为皮肤学可接受的,当施用于嘴唇或皮肤时,其不会具有异常毒性、不相容性、不稳定性、过敏反应等。本发明的局部皮肤护理组合物可以具有选择的粘度,以避免在施用至皮肤之后的明显滴落或聚集。
“角质组织”包括作为哺乳动物的最外层保护层而排列的含角蛋白的层,并且包括但不限于嘴唇、皮肤、毛发和指(趾)甲。
如本领域普通技术人员所理解的,术语“约”或“接近”定义为接近于,在一个非限制性的实施方案中,该术语被定义为在10%之内、优选5%之内、更优选1%之内、且最优选0.5%之内。
如本领域普通技术人员所理解的,术语“基本上”及其变形定义为主要地但不一定全部是所指定的内容,并且在一个非限制性实施方案中,基本上是指在10%之内、5%之内、1%之内或0.5%之内的范围。
术语“抑制”或“降低”或“治疗”或这些术语的任意变形,当在权利要求书和/或说明书中使用时,其包括为了实现期望结果的任何可测量的减少或完全抑制。
当术语“有效的”用于说明书和/或权利要求书中时,该术语意味着足以实现期望的、预期的或计划的结果。
当单词“一个(种)”在权利要求和/或说明书中与术语“包含(包括)”联用时,该单词可能意味着“一个(种)”,但其也符合“一个或多个(一种或多种)”、“至少一个(至少一种)”和“一个或一个以上(一种或一种以上)”的含义。
如本说明书和权利要求书中使用的,单词“包括(comprising)”(及任何形式的包括,例如“含有(comprise和comprises)”)、“具有”(及任何形式的具有,例如“have”和has”)、“包括(inciuding)”(及任何形式的包括,例如“includes和include”)或“包含”(及任何形式的包含,例如“contains和con ta in”)是含端点值的或开放式的,并且不排除另外未列举出的要素或方法步骤。
根据如下详细说明,本发明的其它目的、特征和优点将变得显而易见。然而,应当理解,详细说明和实施例尽管指出了本发明的具体实施方案,但仅是通过例证方式给出的。另外,预期通过该详细说明,在本发明的精神和范围内的改变和修饰对于本领域技术人员是显而易见的。
具体实施方案
鉴于目前多种市售产品数量和众多不同的皮肤类型,人们经常对于鉴别用于合适的皮肤类型的合适产品存在困惑。
本发明的化妆爽肤水可用于保持和改善各种皮肤类型健康状态。例如,爽肤水提供了许多优点,包括:从皮肤除去不纯的成分例如皮脂;疏通皮肤毛孔;校正或平衡失常皮肤(upset skin)的pH水平;更新和再生皮肤;使皮肤毛孔平滑和紧致;和为皮肤做好随后应用皮肤增湿剂产品的准备。这些爽肤水利用独特的植物性成分的组合,其可用于制备特定皮肤类型(例如中性、干性、油性或混合性皮肤)的制剂,和用于化妆品载体的成分的潜在基质集合。
本发明的这些及其它非限定性方面进一步详细描述如下。
A.爽肤水
使用化妆品产品的人们通常在全天中使用各种不同的产品。这样的方案可以包括清洁皮肤,接着对皮肤调色,之后润湿皮肤。在某些情况下,人们将在晚上也使用化妆面膜,其可以是一种提供深度和长时的清洁、剥脱和/或增湿皮肤的较浓产品。
如名称表明的,清洁剂被设计为通过除去污垢、化妆产品和皮脂来清洁皮肤。清洁剂可以在皮肤上留下残余成分(例如,滑腻的膜)。进一步,由于其清洁性质,清洁剂可以改变皮肤表面的pH水平(其可以导致皮肤刺激或皮肤发红)。爽肤水,例如本发明人发现的爽肤水,可用于除去滑腻的残余物,恢复或平衡皮肤的pH水平,且平复和缓和清洁剂的皮肤腐蚀和刺激作用。进一步,爽肤水可以用于预处理皮肤表面以进一步应用皮肤保湿产品。
爽肤水通常分为三种亚型或种类的爽肤水,其包括清新剂(较温和,通常用于干性皮肤)、滋补剂(较强,通常用于中性、油性或中性/油性混合性皮肤)、和收敛剂(最强,通常用于油性皮肤)。本发明的爽肤水倾向于落入第一类,清新剂。特别独特的是本发明的爽肤水可以用于所有皮肤类型,而不限于特定皮肤类型。在这种意义上,虽然本发明的爽肤水可以归类为清新剂,但是它们可有效地用于干性皮肤、中性皮肤、油性皮肤或混合性皮肤。因此,本发明的爽肤水对于皮肤是温和的,然而可以有益于所有类型的皮肤。
本发明的爽肤水的温和性来源于潜在化妆品载体,而根据植物性植物确定皮肤类型。因此,两者的组合提供了具有广泛应用的独特的调色制剂。
B.确定皮肤类型
使用本发明爽肤水的第一步可以是确定使用者的皮肤类型。如上所述,存在三种主要的皮肤类型:(1)中性皮肤;(2)干性皮肤;和(3)油性皮肤。第四种皮肤类型仅仅是中性、干性或油性皮肤的任一种的组合(例如,中性/干性、中性/油性、油性/干性)。还存在确定个人皮肤类型的众所周知的方法。
例如,当具有光滑质感且没有油腻斑纹或鳞片状区域时,可以鉴定为中性皮肤。因此,可以使用保持其现有形式的皮肤润湿的产品来保持中性皮肤的外观。
至于干性皮肤,其具有低水平来自皮脂腺生成的皮脂,且易于刺激或产生红斑。干性皮肤的形态具有干焦的外观(parched look),这是由于皮肤不能保持润湿而引起。通常,其在洗涤之后感觉“紧致”和不舒服,且易于皴裂、剥落和裂开。干性皮肤可能会由于创伤、极端温度和空调而加重,所有这些都会引起皮肤剥落、皲裂和感觉紧致。干性皮肤通常具有暗淡的外观。因此,向干性皮肤递送合适的水合水分和恢复水分的产品可用于消除干性皮肤的效应。
关于油性皮肤,这样的皮肤是有光泽的、浓厚的和颜色暗淡的。由于来自皮脂腺和来自阻塞/闭塞毛孔的皮脂过量生成,皮肤感觉油滑,具有粗大毛孔和粉刺,及其它不美观的瑕疵。在这点上,油性皮肤通常具有活动过度的产油皮脂腺,并且产生比需要的更多的油。油渗出,赋予皮肤油腻的光泽。毛孔扩大,且皮肤具有毛糙的外观。因此,可以帮助控制皮肤表面油性,同时也能清洁堵塞毛孔的产品可用于消除油性皮肤的效应。
如上所述,混合性皮肤是油性、干性和/或中性皮肤中两者的组合(例如,中性/干性、油性/干性、中性/油性)。对于油性/干性皮肤,通常存在由鼻、前额和下巴组成的油腻性中央条带(center panel)(也称为个人面部的“T-区”)和由颊、口和眼睛周围区域组成的干性条带。因此,可以控制T-区皮脂腺产生的过量油、同时也能水合T-区之外的干性皮肤区域的产品可以用于这样的油性/干性皮肤。
一旦确定具体的皮肤类型,则人们可以因此选择矫正或保持该皮肤类型的合适的组合物。
C.植物组合
本发明人发现植物提取物的特定集合与潜在化妆品载体的组合对所有皮肤类型作用良好。这样的产品对于混合性皮肤或可能处于干性皮肤和中性皮肤、中性皮肤和油性皮肤、或干性皮肤和油性皮肤之间的皮肤特别有益。可用于所有皮肤类型的植物组合包括:水飞蓟果实提取物、罗汉果果实提取物、和柳珊瑚提取物中的任一种,或包含水飞蓟果实提取物、柳珊瑚提取物和向日葵籽提取物的组合。
水飞蓟(Silybum marianum)是一种产地为南部欧洲和亚洲的植物。其因产生红色至紫色花、具有白色叶脉的发亮的浅绿色叶子和果实而得名。本发明的水飞蓟提取物可以是水醇(水和变性乙醇(alcohol denat))提取物,其包括作为活性成分的水飞蓟素(水飞蓟素是一种二氢黄酮醇衍生物的混合物,所述二氢黄酮醇衍生物包括水飞蓟宾、水飞蓟丁(silicristine)、水飞蓟宁、isosolibine和isosilicristine)。水飞蓟的果实部分包括水飞蓟素。水飞蓟提取物可以从该植物的果实部分通过如下方法获得:浸软果浆,然后使浆料经受水和SD醇39-C(变性乙醇)的水醇溶液处理,以得到提取物。然后,可以将该提取物过滤且包装贮存或加入到本发明的组合物中。除了该提取工艺,水飞蓟提取物也可以以商品名PRONALEN SILYMARIN HSC或PRONALEN SILYMARIN SPE购自ProvitalS.A(SPAIN)。
Gorgonian提取物是一种来源于柳珊瑚(或Sea Whip)植物的海产提取物。柳珊瑚可以从大西洋采集。Gorgonian提取物可以通过将柳珊瑚植物浸软,然后用丁二醇或辛酸/癸酸甘油三酯或戊二醇处理浸软的植物。Gorgonian提取物的活性成分之一可以是伪蕨素(例如伪蕨素A)。除了该提取工艺之外,Gorgonian提取物可以以商品名GORGONIAN EXTRACT BG、GORGONIAN EXTRACT GC或GORGONIAN PTG购自Lipo Chemicals Inc.,Paterson,New Jersey(USA)。
罗汉果(Momordica grosvenori)是一种多年生藤本植物,其生长3-5米,具有窄的心形叶子和直径为5-7cm的绿色圆形果实。该植物的产地在中国南方。其果实已经在中国用作天然食品甜味剂数十年。本发明的罗汉果提取物可以通过如下方法从该植物的果实部分获得:将果浆浸软,然后使该浆料经受水、甘油和防腐剂的水甘醇(hydroglycolic)溶液处理,以得到提取物。然后,可以将该提取物过滤且包装贮存或加入到本发明的组合物中。除了该提物工艺之外,罗汉果果实提取物可以购自Carrubba Inc.,Milford,Connecticut(USA)。
向日葵(Helianthus annus)是一种生产金黄色向日葵的植物。种籽包含在花内。其产地为北美洲和南美洲。向日葵籽提取物是向日葵种籽的提取物,可以以商品名:ANTIGLYSKINTM、ASPERILIKE 2TM、BIOHAIRTM、MX023-COMMUCELLTM、GLYCALINETM、HELIOXINETM、MX016 SENSIKINTM或RETICALMINETM购自Silab(France)。
1.干性皮肤
发现加入亚麻籽提取物和水解藻胶对于干性皮肤作用良好。
亚麻籽(linum,usitatissimum(亚麻子))是一种可以达到3英尺高的一年生草本植物、两年生草本植物或多年生草本植物。其包括细长的杆、披针形叶子,且可以产生雪蓝色的花和油性褐色种子。该植物的产地在欧洲和亚洲。本发明的亚麻籽提取物可以通过如下方法从该植物的种子部分获得:将种子浸软,然后使该种子经受水和甘油的水甘醇溶液处理,以得到提取物。然后,可以将该提取物过滤且包装贮存或加入到本发明的组合物中。除了该提取工艺,亚麻籽提取物可以购自Carrubba Inc.,Milford,Connecticut(USA)。
水解藻胶可以从掌状海带(Laminaria digitata)获得,所述掌状海带是一种在水体的海岸带发现的褐藻。水解藻胶可以是低聚糖水溶液,所述低聚糖可以通过控制酶解聚来自掌状海带的膜多糖产生。所述低聚糖的结构是2糖醛酸链:甘露糖醛酸和古洛糖醛酸,其图示如下:
除了该制备方法之外,水解藻胶可以以商品名PHYKO AL-PF购自BarnetProducts Corp.,Englewood Cliffs,New Jersey(USA)。
2.中性皮肤
发现加入白鸡蛋花花提取物和澳洲睡莲花提取物或者白鸡蛋花花提取物、蔬食埃塔棕果提取物和山茶(Camellia sinensis)或油茶(oleifera)叶提取物的组合对中性皮肤作用良好。
白鸡蛋花(Frangipani)是一种大型常绿灌木,具有窄细长形叶子和具有黄色中心的大白花。其产地为中美洲和加勒比海。本发明的白鸡蛋花花提取物可以通过浸软花、然后使该花经受水提取过程从该植物的花部分获得。然后,可以将该提取物过滤,放入丁二醇溶液中,并且包装贮存或加入到本发明的组合物中。除了该提取工艺之外,白鸡蛋花花提取物可以以商品名ABACROSSFRANGIPANI FLOWER BG购自Southern Cross Botanicals,New South Wales(AUSTRALIA)。
澳洲睡莲(王莲)是一种热带植物,其产地为澳大利亚的热带和亚热带。该植物可以产生从水中出现的大(最大达25cm)的蓝-白色花和生长到直径最大为75cm的大的圆叶子。本发明的澳洲睡莲花提取物可以通过浸软花、然后使该花经受水提取过程从该植物的花部分获得。然后,可以将该提取物过滤,放入丁二醇溶液中,并且包装贮存或加入到本发明的组合物中。除了该提取工艺之外,白鸡蛋花花提取物可以以商品名ABACROSS WATER LILY BG购自Southern CrossBotanicals,New South Wales(AUSTRALIA)。
蔬食埃塔棕果(acai)是一种产地为巴西的植物。其产生暗紫色果实。来自acai果实的提取物可以以商品名ACAI FRUIT EXTRACTTM购自Southern CrossBotanicals Pty Ltd(NSW Australia),Amax NutraSource(USA),以商品名FRULIX TF ACAITM购自Assessa-Industria(Brazil),或者以商品名ACAI BERRYEXTRACTTM购自Centroflora Group Botucatu(Brazil)。
关于山茶油茶(Camellia sinensisor oleifera)叶提取物,山茶和油茶植物的产地都在中国。该提取物可以从整体植物或所述植物的一部分获得。在特别的实例中,其来自所述提取物的叶、根、花或种子,并且特别地,来自叶。在特别的实例中,山茶和油茶提取物可以包括多酚化合物,例如表没食子儿茶素没食子酸酯。山茶和油茶提取物,无论是来自整体植物或所述植物的一部分,都是从大量来源市售可获得的(参见,例如International Cosmetic IngredientDictionary and Handbook(“CTFA”),第12版,第1卷,第403-07页(2008),将其并入作为参考)。
3.油性皮肤
发现向水飞蓟果实提取物、柳珊瑚提取物和向日葵种子提取物组合中加入番石榴果实提取物、卡奴卡树叶提取物或榆绣线菊提取物对油性皮肤作用良好。
石榴或番石榴是一种可以高达6至25英尺的常绿树或灌木。其产生绿色叶子、芳香白花和果实。果实为梨形,且长度3至6cm。当成熟时,果实外皮具有桔红色。该植物的产地为跨越墨西哥至南美洲北部的地区。在本发明内容中使用石榴的果实部分以获得提取物。本发明的石榴果实提取物可以通过如下方法制备:将果浆浸软,然后使该浆料经受水和甘油的水甘醇溶液处理,以得到提取物。然后,将该提取物过滤,并包装贮存。除了该提取工艺之外,本发明的石榴果实提取物可以购自Carrubba Inc.,Milford,Connecticut(USA)。
卡奴卡(Kanuka)或卡奴卡树是一种可以达到最高达30米高的树。叶子为椭圆形,花为白色。该植物的产地为澳大利亚和新西兰。本发明的卡奴卡树叶提取物可以通过浸软叶子、然后使该叶子经受水提取过程从该植物的叶子部分获得。然后,可以将该提取物过滤,放入丁二醇溶液中,并且包装贮存或加入到本发明的组合物中。除了该提取工艺之外,卡奴卡叶浸出物可以以商品名为ABACROSS KANUKA BG购自Southern Cross Botanicals,New South Wales(AUSTRALIA)。
榆绣线菊(Spiraea ulmaria,绣线菊)是一种多年生草本植物,其产地遍及欧洲和西亚的大部分。得自叶子的提取物可以以商品名为CYTOBIO ULMAIRETM购自Gattefosse(Canada)。得自整体植物的榆绣线菊提取物可以以商品名ACBMEADOWSWEET EXTRACTTM、ACB MEADOWSWEET EXTRACT 20%(TM)购自ActiveConcepts(USA),以商品名DERMAPURTM、SEBONORMINETM和SEBOREGULTM购自Silab(France),或者以商品名COMPLEXE AMINCISSANT LP1TM、COMPLEXE AMINCISSANTSGLPTM、EXTRAIT d’ULMAIRE LP1TM和EXTRAIT d’ULMAIRE SGLPTM购自Phytocos(France)。得自花的榆绣线菊提取物可以以商品名SWEET SUPEXTRATTM购自Indena S.A.(France)或以商品名PHYTELENE COMPLEX EGX 250TM、PHYTELENE OFQUEEN MEADOW EG 213 LIQUIDTM和PHYTELENE OF ULMAIRE EG 213 LIQUIDTM和SLI删INGTM购自Greentech S.A.(France)。得自根的榆绣线菊提取物可以以如下商品名购自Active Organics(USA):ACTIPHYTE OF MEADOWSWEET PG50TM、COACTIPHYTE OF MEADOWSWEET AJTM、CO ACTIPHYTE OF MEADOWSWEET ALTM、COACTIPHYTE OF MEADOWSWEET GLTM、CO ACTIPHYTE OF MEADOWSWEET LIPO OTM、COACTIPHYTE OF MEADOWSWEET LIPO RSTM、CO ACTIPHYTE OF MEADOWSWEET LIPO STM和CO ACTIPHYTE OF MEADOWSWEET LIPO SUNTM。
D.化妆品载体
如上所述,本发明人发现可以使用两种单独的化妆品载体制备对于各种皮肤类型的爽肤水。即,所述载体可以用于对于干性皮肤、油性皮肤、中性皮肤和混合性皮肤设计的爽肤水中。所述载体包括水性爽肤水组合物的至少80%w/w。另外,其还包括甘油、丁二醇、EuxyllPE 9010、Glycacil 2000、仙人果果实提取物和Simethc//C-T1101-Slicone Antifom。在另一个方面,其也可以包括丁二醇、甘油、二偶氮烷基脲、尼泊金甲酯、EDTA二钠、西甲硅油、PPG-26、PEG/PPG-22/23二甲硅油、柠檬酸、苯氧基乙醇、山梨酸钾和苯甲酸钠。如在发明简述部分讨论的,所述成分在化妆品载体之内的量可以变化,以便确定期望的稠度或流变性质以及解释加入的另外植物性成分。
进一步,如果需要,所述载体甚至可以包括其它成分。每种这些成分的供应者都可以容易地获得(参见,例如(CTFA,第12版,第1-4卷(2008),将其相关部分并入作为参考)。
E.含量/浓度范围
除了之前讨论的之外,还预期本发明的组合物可以包括任何含量的在本说明书中描述的成分或另外的化妆品或药用成分。在该组合物内任何成分的浓度都可以变化。在非限制性实施方案中,例如,所述组合物在其最终形式中可以包括如下含量的至少一种在整个说明书或权利要求书中提及的成分、基本上由其组成或由其组成:所述含量例如至少约0.0001%、0.0002%、0.0003%、0.0004%、0.0005%、0.0006%、0.0007%、0.0008%、0.0009%、0.0010%、0.0011%、0.0012%、0.0013%、0.0014%、0.0015%、0.0016%、0.0017%、0.0018%、0.0019%、0.0020%、0.0021%、0.0022%、0.0023%、0.0024%、0.0025%、0.0026%、0.0027%、0.0028%、0,0029%、0.0030%、0.0031%、0.0032%、0.0033%、0.0034%、0.0035%、0.0036%、0.0037%、0.0038%、0.0039%、0.0040%、0.0041%、0.0042%、0.0043%、0.0044%、0.0045%、0.0046%、0.0047%、0.0048%、0.0049%、0.0050%、0.0051%、0.0052%、0.0053%、0.0054%、0.0055%、0.0056%、0.0057%、0.0058%、0.0059%、0.0060%、0.0061%、0.0062%、0.0063%、0.0064%、0.0065%、0.0066%、0.0067%、0.0068%、0.0069%、0.0070%、0.0071%、0.0072%、0.0073%、0.0074%、0.0075%、0.0076%、0.0077%、0.0078%、0.0079%、0.0080%、0.0081%、0.0082%、0.0083%、0.0084%、0.0085%、0.0086%、0.0087%、0.0088%、0.0089%、0.0090%、0.0091%、0.0092%、0.0093%、0.0094%、0.0095%、0.0096%、0.0097%、0.0098%、0.0099%、0.0100%、0.0200%、0.0250%、0.0275%、0.0300%、0.0325%、0.0350%、0.0375%、0.0400%、0.0425%、0.0450%、0.0475%、0.0500%、0.0525%、0.0550%、0.0575%、0.0600%、0.0625%、0.0650%、0.0675%、0.0700%、0.0725%、0.0750%、0.0775%、0.0800%、0.0825%、0.0850%、0.0875%、0.0900%、0.0925%、0.0950%、0.0975%、0.1000%、0.1250%、0.1500%、0.1750%、0.2000%、0.2250%、0.2500%、0.2750%、0.3000%、0.3250%、0.3500%、0.3750%、0.4000%、0.4250%、0.4500%、0.4750%、0.5000%、0.5250%、0.0550%、0.5750%、0.6000%、0.6250%、0.6500%、0.6750%、0.7000%、0.7250%、0.7500%、0.7750%、0.8000%、0.8250%、0.8500%、0.8750%、0,9000%、0.9250%、0.9500%、0.9750%、1.0%、1.1%、1.2%、1.3%、1.4%、1.5%、1.6%、1.7%、1.8%、1.9%、2.0%、2.1%、2.2%、2.3%、2.4%、2.5%、2.6%、2.7%、2.8%、2.9%、3.0%、3.1%、3.2%、3.3%、3.4%、3.5%、3.6%、3.7%、3.8%、3.9%、4.0%、4.1%、4.2%、4.3%、4.4%、4.5%、4.6%、4.7%、4.8%、4.9%、5.0%、5.1%、5.2%、5.3%、5.4%、5.5%、5.6%、5.7%、5.8%、5,9%、6.0%、6.1%、6.2%、6.3%、6.4%、6.5%、6.6%、6.7%、6.8%、6.9%、7.0%、7.1%、7.2%、7.3%、7.4%、7.5%、7.6%、7.7%、7.8%、7.9%、8.0%、8.1%、8.2%、8.3%、8.4%、8.5%、8.6%、8.7%、8.8%、8.9%、9.0%、9.1%、9.2%、9.3%、9.4%、9.5%、9.6%、9.7%、9.8%、9.9%、10%、11%、12%、13%、14%、15%、16%、17%、18%、19%、20%、21%、22%、23%、24%、25%、26%、27%、28%、29%、30%、35%、40%、45%、50%、60%、65%、70%、75%、80%、85%、90%、95%或99%或其中可衍生的任意范围。在非限制性方面,百分比可以以全部组合物的重量或体积计算。本领域普通技术人员应当理解,该浓度可以根据给定组合物中成分的添加、取代和/或减少而变化。
F.另外的成分
除了所述植物性提取物和化妆品载体成分之外,本发明的组合物可以包括另外的成分,例如化妆品成分和药用活性成分。这些另外的成分的非限制性实例描述在下述小节中。
1.化妆品成分
CTFA International Cosmetic Ingredient Dictionary and Handbook(2008)记载了大量可用于本发明上下文中的非限定性化妆品成分。这些成分种类的实例包括:香料(人工的和天然的)、染料和色彩成分(例如蓝1、蓝1色淀、红40、二氧化钛、D&C蓝第4号、D&C绿第5号、D&C橙第4号、D&C红第17号、D&C红第33号、D&C紫第2号、D&C黄第10号和D&C黄第11号)、吸附剂、润滑剂、溶剂、增湿剂(包括例如软化剂、润湿剂、成膜剂、闭塞剂和影响皮肤自然保湿机制的试剂)、避水剂(water-repel lant)、UV吸收剂(物理和化学吸收剂,例如对氨基苯甲酸(“PABA”)和相应的PABA衍生物、二氧化钛、氧化锌等)、精油、维生素(例如A、B、C、D、E和K)、痕量金属(例如锌、钙和硒)、抗刺激剂(例如甾体和非甾体抗炎剂)、植物提取物(例如真芦荟、春黄菊、黄瓜提取物、银杏(ginkgo biloba)、人渗和迷选香)、抗微生物剂、抗氧化剂(例如BHT和生育酚)、螯合剂(例如EDTA二钠和EDTA四钠)、防腐剂(例如尼泊金甲酯和尼泊金丙酯)、pH调节剂(例如氢氧化钠和柠檬酸)、吸收剂(例如淀粉辛烯基琥珀酸酯铝盐、高岭土、玉米淀粉、燕麦淀粉、环糊精、滑石和沸石)、皮肤漂白和亮白剂(例如氢醌和烟酰胺乳酸盐)、润湿剂(例如山梨醇、尿素和甘露醇)、角质剥落剂(exfoliants)、防水剂(例如氢氧化镁/铝硬脂酸盐)、皮肤调理剂(例如芦荟提取物、尿囊素、没药醇、神经酰胺、二甲硅油、透明质酸和甘草酸二钾)。某些这些成分的非限制实例提供在下述小节中。
a.UV吸收剂
可以与本发明组合物组合使用的UV吸收剂包括化学和物理防晒剂。可以使用的化学防晒剂的非限制性实例包括对氨基苯甲酸(PABA)、PABA酯(PABA甘油酯、二甲基PABA戊酯和二甲基PABA辛酯)、PABA丁酯、PABA乙酯、二羟丙基PABA乙酯、二苯甲酮类(羟苯甲酮、舒利苯酮、二苯甲酮和二苯甲酮-1至12)、肉桂酸酯(甲氧基肉桂酸辛酯、对甲氧基肉桂酸异戊酯、甲氧基肉桂酸辛酯(octylmethoxy cinnamate)、西诺沙酯、二异丙基肉桂酸甲酯、DEA-甲氧基肉桂酸酯、二异丙基肉桂酸乙酯、辛酸甘油酯(二甲氧基肉桂酸)酯和甲氧基肉桂酸乙酯)、肉桂酸酯、水杨酸酯(水杨酸高孟酯(homomethyl salicylate)、水杨酸苄酯、水杨酸羟乙酯、异丙苄醇水杨酸酯等)、邻氨基苯甲酸酯、尿刊酸乙酯、胡莫柳酯、辛水杨酯、二苯甲酰甲烷衍生物(例如阿伏苯宗)、氰双苯丙烯酸辛酯、辛基三嗪酮、二没食子酰三油酸酯(digalloy trioleate)、氨基苯甲酸甘油酯、含二羟基丙酮的散沫花素、乙基己基三嗪酮、二辛基丁酰氨基三嗪酮、丙二酸亚苄酯聚硅氧烷(benzylidene malonate polysiloxane)、对苯二亚甲基二樟脑磺酸、苯基二苯并咪唑四磺酸酯二钠、二乙氨基羟苯甲酰基苯甲酸己酯、双二乙氨基羟苯甲酰基苯甲酸酯(bis diethylamino hydroxybenzoylbenzoate)、双苯并噁唑基苯基乙基己基亚氨基三嗪(bis benzoxazoylphenylethylhexylimino triazine)、甲酚曲唑三硅氧烷(drometrizole trisiloxane)、亚甲基双-苯并三唑基四甲基丁基酚(methylene bis-benzotriazolyltetramethylbutyiphenol)和双乙基己基羟基酚甲氧基苯基三嗪(bis-ethylhexyloxyphenol methoxyphenyltriazine)、4-甲基苯亚甲基樟脑和4-甲氧基肉桂酸异戊酯。物理防晒剂的非限制性实例包括高岭土、滑石、矿脂和金属氧化物(例如二氧化钛和氧化锌)。
b.保湿剂
可以与本发明的组合物一起使用的保湿剂的非限制性实例包括氨基酸、硫酸软骨素、双甘油、赤藓醇、果糖、葡萄糖、甘油、甘油聚合物、乙二醇、1,2,6-己三醇、蜂蜜、透明质酸、氢化蜂蜜、氢化淀粉水解物、肌醇、拉克替醇、麦芽糖醇、麦芽糖、甘露醇、天然保湿因子、PEG-15丁二醇、聚甘油山梨醇、吡咯烷酮羧酸盐、PCA钾、丙二醇、葡醛酸钠、PCA钠、山梨醇、蔗糖、海藻糖、尿素和木糖醇。
其它实例包括乙酰化羊毛脂、乙酰化羊毛脂醇、丙氨酸、藻类提取物、翠绿芦荟(aloe barbadensis)、翠绿芦荟提取物、翠绿芦荟胶、药蜀葵(altheaofficinalis)提取物、杏(prunus armeniaca)仁油、精氨酸、精氨酸天冬氨酸、山金车(arnica montana)提取物、天冬氨酸、鳄梨(persea gratissima)油、屏障鞘脂(barrier sphingolipids)、丁醇、蜂蜡、山嵛醇、β-谷甾醇、白桦(betulaalba)树皮提取物、琉璃苣(borago officinalis)提取物、假叶树(ruscusaculeatus)提取物、丁二醇、金盏花(calendula officinalis)提取物、金盏花油、小烛树(euphorbia cerifera)蜡、芥花油(canola oil)、辛酸/癸酸甘油三酯、小豆蔻(elettaria cardamomum)油、巴西棕榈(copernicia cerifera)蜡、胡萝卜(daucus carota sativa)油、蓖麻(ricinus communis)油、神经酰胺、地蜡、鲸蜡硬脂醇聚醚-5、鲸蜡硬脂醇聚醚-12、鲸蜡硬脂醇聚醚-20、鲸蜡硬脂醇辛酸酯、鲸蜡醇聚醚-20、鲸蜡醇聚醚-24、乙酸鲸蜡基酯、辛酸鲸蜡基酯、棕榈酸鲸蜡基酯、白花黄春菊(anthemis nobilis)油、胆固醇、胆固醇酯、胆固醇羟基硬脂酸酯、柠檬酸、南欧丹参(salvia sclarea)油、可可(theobromacacao)脂、椰油醇辛酸酯/癸酸酯(coco-caprylate/caprate)、椰子(cocosnucifera)油、胶原蛋白、胶原蛋白氨基酸、玉米(zea mays)油、脂肪酸、油酸癸酯、聚二甲基硅氧烷共聚醇(dimethicone copolyol)、聚二甲基硅氧烷醇、己二酸二辛酯、琥珀酸二辛酯、二季戊四醇六辛酸酯/六癸酸酯、DNA、赤藓醇、乙氧基二甘醇、亚油酸乙酯、蓝桉树(eucalyptus globulus)油、月见草(oenothera biennis)油、脂肪酸、野生天竺葵(geranium maculatum)油、葡糖胺、葡糖谷氨酸酯、谷氨酸、甘油聚醚-26、甘油(glycerin)、甘油(glycerol)、二硬脂酸甘油酯、羟基硬脂酸甘油酯、月桂酸甘油酯、亚油酸甘油酯、肉豆蔻酸甘油酯、油酸甘油酯、硬脂酸甘油酯、硬脂酸甘油酯SE、甘氨酸、硬脂酸乙二醇酯、硬脂酸乙二醇酯SE、糖胺聚糖、葡萄(vitis vinifera)籽油、美洲榛(corylus americana)果油、欧洲榛(corylus avellana)果油、己二醇、透明质酸、杂红花(carthamus tinctorius)油、氢化蓖麻油、氢化可可甘油酯(hydrogenated coco-glycerides)、氢化椰子油、氢化羊毛酯、氢化卵磷脂、氢化棕榈酸甘油酯、氢化棕榈仁油、氢化大豆油、氢化牛脂酸甘油酯、氢化植物油、水解胶原蛋白、水解弹性蛋白、水解糖胺聚糖、水解角蛋白、水解大豆蛋白、羟基化羊毛脂、羟脯氨酸、硬脂酸异鲸蜡酯、硬脂酰基硬脂酸异鲸蜡酯、油酸异癸酯、异硬脂酸异丙酯、羊毛脂酸异丙酯、肉豆蔻酸异丙酯、棕榈酸异丙酯、硬脂酸异丙酯、异硬酰胺DEA、异硬脂酸、异硬脂醇乳酸酯、新戊酸异硬脂酯、茉莉(jasminum officinale)油、霍霍巴木(buxus chinensis)油、昆布、石栗(aleurites moluccana)果油、乳酰胺MEA、羊毛脂醇聚醚-16、羊毛脂醇聚醚-10乙酸酯、羊毛酯、羊毛酯酸、羊毛酯醇、羊毛酯油、羊毛脂蜡、薰衣草(lavandula angustifolia)油、卵磷脂、柠檬(citrus medica limonum)油、亚油酸、亚麻酸、澳洲坚果(macadamia ternifolia)果油、麦芽糖醇、洋甘菊(chamomilla recutita)油、甲基葡糖倍半硬脂酸酯、甲基硅烷醇PCA、矿物油、貂油、被孢霉菌油、乳酸肉豆蔻酯、肉豆蔻酸肉豆蔻酯、丙酸肉豆蔻酯、新戊二醇二辛酸酯/二癸酸酯、辛基十二醇、肉豆蔻酸辛基十二醇酯、硬脂酰基硬脂酸辛基十二醇酯、羟基硬脂酸辛酸、棕榈酸辛酯、水杨酸辛酯、硬脂酸辛酯、油酸、橄榄(olea europaea)油、甜橙(citrus aurantium dulcis)油、棕榈(elaeisguineensis)油、棕榈酸、泛硫乙胺、泛醇、泛醇基乙基醚、石蜡、PCA、桃(prunuspersica)核油、花生(arachis hypogaea)油、PEG-8C12-18酯、PEG-15椰油胺、PEG-150二硬脂酸酯、PEG-60异硬脂酸甘油酯、PEG-5硬脂酸甘油酯、PEG-30硬脂酸甘油酯、PEG-7氢化蓖麻油、PEG-40氢化蓖麻油、PEG-60氢化蓖麻油、PEG-20甲基葡糖倍半硬脂酸酯、PEG40脱水山梨醇全油酸酯、PEG-5大豆甾醇、PEG-10大豆甾醇、PEG-2硬脂酸酯、PEG-8硬脂酸酯、PEG-20硬脂酸酯、PEG-32硬脂酸酯、PEG40硬脂酸酯、PEG-50硬脂酸酯、PEG-100硬脂酸酯、PEG-150硬脂酸酯、十五酸内酯、薄荷(mentha piperita)油、矿脂、磷脂、多氨基糖缩合物(polyamino sugar condensate)、聚甘油-3二异硬脂酸酯、聚季铵盐-24(polyquaternium-24)、聚山梨酯20、聚山梨酯40、聚山梨酯60、聚山梨酯80、聚山梨酯85、豆蔻酸钾、棕榈酸钾、丙二醇、丙二醇二辛酸酯/二癸酸酯、丙二醇二辛酸酯、丙二醇二壬酸酯、丙二醇月桂酸酯、丙二醇硬脂酸酯、丙二醇硬脂酸酯SE、PVP、吡哆醇二棕榈酸酯、视黄醇、棕榈酸视黄酯、大米(oryzasativa)糠油、RNA、迷迭香(rosmarinus officinalis)油、玫瑰油、红花(carthamus tinctorius)油、药鼠尾草(salvia officinalis)油、檀香(santalumalbum)油、丝氨酸、血清蛋白、芝麻(sesamum indicum)油、牛油树脂(butyrospermum parkii)、丝粉(silk powder)、硫酸软骨素钠、透明质酸钠、乳酸钠、棕榈酸钠、PCA钠、聚谷氨酸钠、可溶性胶原蛋白、脱水山梨醇月桂酸酯、脱水山梨醇油酸酯、脱水山梨醇棕榈酸酯、脱水山梨醇倍半油酸酯、脱水山梨醇硬脂酸酯、山梨醇、大豆(glycine soja)油、鞘脂类、角鲨烷、角鲨烯、硬脂酰胺MEA-硬脂酸酯、硬脂酸、硬脂氧基二甲聚硅氧烷、硬脂氧基三甲基硅烷、硬脂醇、硬脂基甘草亭酸酯、硬脂基庚酸酯、硬脂基硬脂酸酯、向日葵(helianthus annuus)籽油、甜杏仁(prunus amygdalus duicis)油、合成蜂蜡、生育酚、生育酚醋酸酯、生育酚亚油酸酯、二十二烷酸甘油三酯(tribehenin)、新戊酸十三烷酯、硬脂酸十三烷酯、三乙醇胺、三硬脂酸甘油酯、脲、植物油、水、蜡、小麦(trit icum vulgare)胚芽油和依兰(cananga odorata)油。
c.抗氧剂
可以与本发明的组合物一起使用的抗氧剂的非限制性实例包括乙酰半胱氨酸、抗坏血酸多肽、抗坏血酸二棕榈酸酯、抗坏血酸甲基硅烷醇果胶酸酯(ascorbyl methylsilanol pectinate)、抗坏血酸棕榈酸酯、抗坏血酸硬脂酸酯、BHA、BHT、叔丁基氢醌、半胱氨酸、半胱氨酸HCl、二戊基氢醌、二叔丁基氢醌、二鲸蜡醇硫代二丙酸酯、二油基生育酚甲基硅烷醇、抗坏血酸硫酸酯二钠、硫代二丙酸二硬脂酰酯、硫代二丙酸二(十三醇)酯、没食子酸十二酯、异抗坏血酸、抗坏血酸酯、阿魏酸乙酯、阿魏酸、没食子酸酯、氢醌、巯基乙醇酸异辛酯、曲酸、抗坏血酸镁、抗坏血酸磷酸镁、甲基硅烷醇抗坏血酸酯、天然植物抗氧化剂如绿茶提取物或葡萄籽提取物、去甲二氢愈创木酸、没食子酸辛酯、苯基巯基乙醇酸(phenylthioglycolic acid)、抗坏血酸生育酚磷酸钾、亚硫酸钾、没食子酸丙酯、醌、迷迭香酸、抗坏血酸钠、亚硫酸氢钠、异抗坏血酸钠、偏亚硫酸氢钠、亚硫酸钠、超氧化物歧化酶、巯基乙酸钠、山梨醇缩糠醛、硫二甘醇、亚硫基二乙酰胺(thiodiglycolamide)、亚硫基二乙酸(thiodiglycolic acid)、巯基乙酸、硫代乳酸、硫代水杨酸、生育酚聚醚-5、生育酚聚醚-10、生育酚聚醚-12、生育酚聚醚-18、生育酚聚醚-50、生育酚、水溶性维生素E(tocophersolan)、醋酸生育酚、生育酚亚油酸酯、生育酚烟酸酯、生育酚琥珀酸酯和三(壬基苯基)亚磷酸酯。
d.结构化剂
在其它非限制性的方面,本发明的组合物可以包含结构化剂。在某些方面,结构化剂协助向组合物提供流变学特性以改善组合物的稳定性。在其它方面,结构化剂也可以起到乳化剂或表面活性剂的作用。结构化剂的非限定性实例包括硬脂酸、棕榈酸、硬脂醇、鲸蜡醇、山嵛醇、硬脂酸、棕榈酸、具有平均约1个至约21个环氧乙烷单元的硬脂醇的聚乙二醇醚、具有平均约1个至约5个环氧乙烷单元的鲸蜡醇的聚乙二醇醚,及其混合物。
e.乳化剂
在本发明的某些方面,该组合物不包含乳化剂。然而,在其它方面,该组合物可包含一种或多种乳化剂。乳化剂可以降低各相之间的界面张力并改善乳液的配制和稳定性。乳化剂可以是非离子乳化剂、阳离子乳化剂、阴离子乳化剂和两性离子乳化剂(参见McCutcheon’s(1986);美国专利号5,011,681;4,421,769;3,755,560)。非限制性实例包括甘油酯、丙二醇酯、聚乙二醇脂肪酸酯、聚丙二醇脂肪酸酯、山梨醇酯、脱水山梨醇酸酐(sorbi tan anhydr ides)酯、羧酸共聚物、葡萄糖的酯和醚、乙氧基醚、乙氧基醇、磷酸烷基酯、聚氧乙烯脂肪醇醚磷酸酯、脂肪酸酰胺、酰基乳酸盐(acyll actylate)、皂、TEA硬脂酸酯、DEA油醇聚醚-3磷酸酯、聚乙二醇20脱水山梨醇单月桂酸酯(聚山梨酯20)、聚乙二醇5大豆甾醇、硬脂醇聚醚-2、硬脂醇聚醚-20、硬脂醇聚醚-21、鲸蜡硬脂醇聚醚-20、PPG-2甲基葡萄糖醚二硬脂酸酯、鲸蜡醇聚醚-10、聚山梨酯80、鲸蜡醇磷酸酯、鲸蜡醇磷酸钾、鲸蜡醇磷酸酯二乙醇胺、聚山梨酯60、硬脂酸甘油酯、PEG-100硬脂酸酯,及其混合物。
f.含聚硅氧烷的化合物
在非限制性方面,含聚硅氧烷的化合物包括任意聚合物产品家族的成员,该聚合物产品的分子骨架由交替的硅原子和氧原子构成,并具有与硅原子相连的侧基。通过改变-Si-O-的链长、侧基和交联,可以将聚硅氧烷合成为多种材料。它们可以具有从液体至凝胶至固体的不同稠度。
可用于本发明上下文中的含聚硅氧烷的化合物包括本说明书中记载的或本领域普通技术人员已知的化合物。非限制性实例包括硅油(例如挥发性油和非挥发性油)、凝胶和固体。在某些方面,含聚硅氧烷的化合物包括硅油,例如聚有机硅氧烷。聚有机硅氧烷的非限制性实例包括二甲硅油、环甲硅油、聚硅氧烷-11(polysilicone-11)、苯基三甲基聚硅氧烷(phenyl trimethicone)、三甲基硅烷氨基二甲聚硅氧烷(trimethylsilylamodimethicone)、硬脂氧基三甲基硅烷,或者这些材料和其它有机硅氧烷材料以任意给定比例的混合物,所述任意给定比例为了达到取决于预期用途(例如特定区域,如皮肤、毛发或眼睛)的期望的稠度以及使用特性。“挥发性硅油”包括具有低汽化热(即通常低于每克硅油约50cal)的硅油。挥发性硅油的非限制性实例包括:环甲硅油例如DowCorning 344 Fluid、Dow Corning 345 Fluid、Dow Corning 244 Fluid和DowCorning 245 Fluid、Volatile Silicon 7207(Union Carbide Corp.,Danbury,Conn.);低粘度二甲硅油,即粘度为约50cst或更低的二甲硅油类(例如,二甲硅油类例如Dow Corning 200-0.5cst Fluid)。Dow Corning Fluids可购自DowCorning Corporation,Midland,Michigan。在CTFA Cosmetic IngredientDictionary(并入作为参考)第三版中分别记载了作为环二甲基聚硅氧烷化合物和以三甲基硅氧基单元封端的全甲基化线性硅氧烷聚合物的环甲硅油和二甲硅油。可用于本发明上下文中的其它非限制性挥发性硅油包括购自GeneralElectric Co.,Silicone Products Div.,Waterford,N.Y.和SWS Silicones Div.of Stauffer Chemical Co.,Adrian,Michigan的硅油。
g.精油
精油包括源自草药、花、树和其它植物的油。这种油一般作为植物细胞之间的小液滴而存在,并且可通过本领域技术人员已知的多种方法提取(例如蒸汽蒸馏、吸香法(即通过使用脂肪提取)、浸渍、溶剂萃取或机械压榨)。当这些类型的油暴露在空气中时,其易于蒸发(即挥发油)。因此,虽然许多精油是无色的,但它们可能随时间而氧化并颜色变深。精油不溶于水,并且可溶于醇、醚、不挥发油(植物油)和其它有机溶剂。发现于精油的代表性物理性质包括:沸点范围为约160℃至240℃,并且密度范围为约0.759至约1.096。
精油一般由发现该油的植物命名。例如,玫瑰油或薄荷油分别源自致瑰或薄荷植物。可以用于本发明上下文中的精油的非限制性实例包括芝麻油、夏威夷果油、茶树油、月见草油、西班牙鼠尾草油、西班牙迷迭香油、芫荽油、百里香油、西班牙甘椒果油(pimento berries oil)、玫瑰油、茴香油、香脂油(balsam oil)、香柠檬油、玫瑰木油、雪松油、春黄菊油、鼠尾草油、香紫苏油(clary sage oil)、丁香油、柏油、桉树油、小茴香油、海茴香油(sea fenneloil)、乳香油、老鹳草油、姜油、葡萄柚油、茉莉油、杜松子油、薰衣草油、柠檬油、柠檬草油、白柠檬油、橘皮油、马郁兰油、没药油、橙花油、甜橙油、广藿香油、胡椒油、黑胡椒油、橙叶油、松油、奥图玫瑰油(rose otto oil)、迷迭香油、檀香油、留兰香油、甘松油、香根油、冬青油或依兰油。本领域技术人员已知的其它精油也可以用于本发明上下文中。
h.增稠剂
包括增稠剂(thickener)或胶凝剂在内的增稠剂(thickenlng agents)包含能够增加组合物粘度的物质。增稠剂包括可以在基本上不改变组合物中活性成分的功效的情况下增加组合物粘度的物质。增稠剂也可以提高本发明组合物的稳定性。在本发明的某些方面,增稠剂包括氢化聚异丁烯或三羟基硬脂精(trihydroxystearin),或二者的混合物。
可用于本发明上下文中的其它增稠剂的非限制性实例包括羧酸聚合物、交联聚丙烯酸酯聚合物、聚丙烯酰胺聚合物、多糖和树胶。羧酸聚合物的实例包括包含一个或多个衍生自丙烯酸、取代丙烯酸以及这些丙烯酸和取代丙烯酸的盐和酯的单体的交联化合物,其中交联剂包含两个或多个C-C双键,并且衍生自多元醇(参见美国专利号5,087,445;4,509,949;2,798,053;CTFAInternational Cosmetic Ingredient Dictionary,第四版,1991,第12和80页)。市售可获得的羧酸聚合物的实例包括卡波姆,其为与蔗糖或季戊四醇的烯丙基醚交联的丙烯酸的均聚物(例如购自B.F.Goodrich的CarbopolTM900系列)。
交联聚丙烯酸酯聚合物的非限制性实例包括阳离子聚合物和非离子聚合物。实例描述在美国专利号5,100,660;4,849,484;4,835,206;4,628,078;4,599,379)中。
聚丙烯酰胺聚合物的非限制性实例(包括包含取代的支链或无支链的聚合物的非离子聚丙烯酰胺聚合物)包括聚丙烯酰胺、异链烷烃和月桂醇聚醚-7、丙烯酰胺和取代丙烯酰胺与丙烯酸和取代丙烯酸的多嵌段共聚物。
多糖的非限制性实例包括纤维素、羧甲基羟乙基纤维素、乙酸丙酸羧酸纤维素、羟乙基纤维素、羟乙基乙基纤维素、羟丙基纤维素、羟丙基甲基纤维素、甲基羟乙基纤维素、微晶纤维素、纤维素硫酸钠、及其混合物。另外的实例为烷基取代的纤维素,其中纤维素聚合物的羟基被羟烷基化(优选羟乙基化或羟丙基化)以形成羟烷基化纤维素,然后其进一步被C10-C30直链或支链烷基通过醚键所改性。通常,这些聚合物是C10-C30直链或支链醇与羟烷基纤维素的醚。其它有用的多糖包括每三个单元包含直链(1-3)连接的葡萄糖单元与(1-6)连接的葡萄糖的硬葡聚糖。
可用于本发明的树胶的非限制性实例包括阿拉伯树胶、琼脂、藻胶、海藻酸、藻酸铵、支链淀粉、藻酸钙、角叉菜胶钙、肉碱、角叉菜胶、糊精、明胶、结冷胶、瓜尔胶、瓜尔胶羟丙基三甲基氯化铵(guar hydroxypropyltrimoniumchloride)、锂蒙脱石、透明质酸、水合二氧化硅(hydrated silica)、羟丙基壳聚糖、羟丙基瓜尔胶、刺梧桐树胶、海草、豆角胶(locust bean gum)、纳豆胶(natto gum)、海藻酸钾、角叉菜胶钾、海藻酸丙二醇酯、菌类植物胶、羧甲基葡聚糖钠、角叉菜胶钠、黄蓍胶、黄原胶及其混合物。
i.防腐剂
可用于本发明上下文中的防腐剂的非限制性实例包括季铵盐防腐剂,例如聚季铵盐-1和苯扎卤铵(benzalkonium halide)(例如,苯扎氯铵(“BAC”)和苯扎溴铵)、尼泊金类(例如尼泊金甲酯和尼泊金丙酯)、苯氧乙醇、苯甲醇、氯丁醇、苯酚、山梨酸、硫柳汞,或其组合。
2.药物成分
药物活性剂也预期用于本发明的组合物中。药物活性剂的非限制性实例包括抗痤疮剂、用于治疗酒渣鼻的药剂、镇痛剂、麻醉剂、肛门直肠剂(anorectals)、抗组胺剂、包括非甾体抗炎药在内的抗炎剂、抗生素、抗真菌剂、抗病毒剂、抗微生物剂、抗癌活性剂、杀疥螨药、灭虱药、抗肿瘤药、止汗剂、止痒剂、抗银屑病剂、抗皮脂溢剂、生物活性蛋白质和肽、烧伤治疗剂、烧灼剂(cauterizing agent)、褪色剂、脱毛剂、尿布疹治疗剂、酶、毛发生长刺激剂、包括DFMO及其盐和类似物在内的毛发生长阻滞剂、止血剂、角质层分离剂(kerotolytics)、复发性口溃疡治疗剂、冷疱治疗剂、口腔和牙周治疗剂、光敏化活性剂、皮肤防护剂/屏障剂、包括荷尔蒙和皮质类固醇在内的类固醇、晒伤治疗剂、防晒剂、经皮活性剂、鼻活性剂、阴道活性剂、疣治疗剂、创伤治疗剂、创伤愈合剂等。
G.试剂盒
还包括可用于本发明的某些方面的试剂盒。例如,本发明的组合物可包含在试剂盒内。试剂盒可包括容器。容器可包括瓶子、金属管、层压软管(laminatetube)、塑料管、分配器、压力容器、阻隔容器(barrier container)、包装物、隔室、唇膏容器、压缩容器(compact container)、可以容纳化妆品组合物的化妆盘,或者分散体或组合物或所需的瓶子、分配器或包装物被保存于其中的其它类型的容器,例如注射容器或吹塑塑制容器。试剂盒和/或容器可以在其表面包括标记。例如该标记可以是单词、短语、缩写、图片或符号。
容器能够分配预定量的组合物。在其它实施方案中,可以挤压容器(例如金属管、层压软管或塑料管)而分配期望量的组合物。可以将组合物分配为喷雾剂、气溶胶、液体、流体或半固体。该容器可具有喷雾、泵送或挤压机构。试剂盒也可以包括使用试剂盒组分以及使用容器中包含的任意其它组合物的说明书。该说明书可以包括对于如何施用、使用和保存该组合物的说明。
实施例
包括下述实施例以说明本发明的某些非限制性的方面。本领域技术人员应当理解,下述实施例中公开的技术代表本发明人发现的,在本发明的实践中作用良好的技术。然而,根据本发明公开的内容,本领域技术人员应当理解,可以在不背离本发明的精神和范围的情况下对所公开的具体实施方案做出多种改变,并且仍然获得相似或类似的结果。
实施例1
表1-8中的制剂各自为清新剂。表1和5的制剂为一般制剂,而表2-4和6-8的制剂为特定制剂。一般制剂可用于所有皮肤类型(干性、中性、油性、混合性)。表2和6的制剂设计用于干性皮肤。表3和7的制剂设计用于中性皮肤。表4和8的制剂设计用于油性皮肤。
表11
成分 | 浓度%(重量) |
水 | 适量(至少80%重量的水) |
丁二醇 | 2至8 |
甘油 | 1至5 |
EUXYL PE 90102 | 0.5至1 |
GLYCACIL 20003 | 0.1至0.2 |
仙人果果实提取物4 | 0.01至0.1 |
SIMETHC/D/C-TC101-SILICONE ANTIFOAM5 | 0.001至0.01 |
水飞蓟果实提取物6 | 0.01至0.1 |
罗汉果提取物7 | 0.01至0.1 |
柳珊瑚提取物8 | 0.01至0.1 |
赋形剂9 | 0.01至5 |
1可以通过在烧杯中将各组分在70-75℃加热下,混合直到均匀来制备制剂。接着,可以将该制剂冷却至静置室温(20-25℃)。进一步,且如果需要,例如,可以加入另外的组分,以改变组合物的流变学特性。2
2EUXYL PE 9010由Schulke & Mayr提供,是苯氧基乙醇(和)乙基己基甘油的组合。
3GLYCACIL 2000由Lonza Inc./Lonza Ltd.提供,是碘丙炔醇丁基氨甲酸酯。
4仙人果果实提取物由Vege-Tech以商品名Indian Fig Puree,VT-840和VT-853提供。
5SIMETHC/D/C TC101-SILICONE ANTIFOAM为Dow Corning销售的消泡剂。
6水飞蓟果实提取物是由Provital S.A(SPAIN)以商品名PRONALENSILYMARIN HSC提供。
7罗汉果提取物是从Carrubba Inc.,Milford,Connecticut(USA)获得。
8柳珊瑚提取物是从Lipo Chemicals Inc.,Paterson,New Jersey(USA)以商品名GORGONIAN EXTRACT BG获得。
9赋形剂例如防腐剂或增稠剂可用于保存该组合物以获得期望的粘度。
表21
成分 | 浓度%(重量) |
水 | 82 |
甘由 | 5 |
丁二醇 | 7.5 |
EUXYLPE90102 | 1 |
GLYCACIL 20003 | 0.2 |
仙人果果实提取物4 | 0.05 |
SIMETHC/D/C-TC 101-SILICONE ANTIFOAM5 | 0.005 |
水飞蓟果实提取物6 | 0.01 |
罗汉果提取物7 | 0.01 |
柳珊瑚提取物8 | 0.01 |
亚麻籽提取物9 | 0.05 |
PHYKO AI-PF10 | 0.05 |
赋形剂11 | 适量 |
1可以通过在烧杯中将各组分在70-75℃加热下,混合直到均匀来制备制剂。接着,可以将该制剂冷却至静置室温(20-25℃)。进一步,且如果需要,例如,可以加入另外的组分,以改变组合物的流变学特性。2
2EUXYL PE 9010由Schulke & Mayr提供,是苯氧基乙醇(和)乙基己基甘油的组合。
3GLYCACIL 2000由Lonza Inc./Lonza Ltd.提供,是碘丙炔醇丁基氨甲酸酯。
4仙人果果实提取物由Vege-Tech以商品名Indian Fig Puree,VT-840和VT-853提供。
5SIMETHC/D/C-TC101-SILICONE ANTIFOAM为由Dow Corning销售的消泡剂。
6水飞蓟果实提取物是由Provital S.A(SPAIN)以商品名PRONALENSILYMARIN HSC提供。
7罗汉果提取物是从Carrubba Inc.,Milford,Connecticut(USA)获得。
8柳珊瑚提取物是从Lipo Chemicals Inc.,Paterson,New Jersey(USA)以商品名GORGONIAN EXTRACT BG获得。
9亚麻籽提取物是从Carrubba Inc.,Milford,Connecticut(USA)获得。
10pHYKO AI-PF是水解藻胶,其从Barnet Products Corp.,Englewood Cliffs,New Jersey(USA)以商品名PHYKO AL-PF获得。
11赋形剂包括精氨酸、carbopol ultrez 10、EDTA二钠、泛醇、尿囊素、柠檬酸钠、柠檬酸和PEG-32。
表31
成分 | 浓度%(重量) |
水 | 86 |
甘油 | 4 |
丁二醇 | 4.5 |
EUXYL PE 90102 | 1 |
GLYCACIL 20003 | 0.2 |
仙人果果实提取物4 | 0.05 |
SIMETHC/D/C-TC 101-SILICONE ANTIFOAM5 | 0.005 |
水飞蓟果实提取物6 | 0.01 |
罗汉果提取物7 | 0.01 |
柳珊瑚提取物8 | 0.01 |
白鸡蛋花花提取物9 | 0.05 |
澳洲睡莲花花提取物10 | 0.05 |
赋形剂11 | 适量 |
1可以通过在烧杯中将各组分在70-75℃加热下,混合直到均匀来制备制剂。接着,可以将该制剂冷却至静置室温(20-25℃)。进一步,且如果需要,例如,可以加入另外的组分,以改变组合物的流变学特性。2
2EUXYL PE 9010由Schulke & Mayr提供,是苯氧基乙醇(和)乙基己基甘油的组合。
3GLYCACIL 2000由Lonza Inc./Lonza Ltd.提供,是碘丙炔醇丁基氨甲酸酯。
4仙人果果实提取物由Vege-Tech以商品名Indian Fig Puree,VT-840和VT-853提供。
5SIMETHC/D/C-TC101-SILICONE ANTIFOAM为由Dow Corning销售的消泡剂。
6水飞蓟果实提取物是由Provital S.A(SPAIN)以商品名PRONALENSILYMARIN HSC提供。
7罗汉果提取物是从Carrubba Inc.,Milford,Connecticut(USA)获得。
8柳珊瑚提取物是从Lipo Chemicals Inc.,Paterson,New Jersey(USA)以商品名GORGONIAN EXTRACT BG获得。
9白鸡蛋花花提取物是从Southern Cross Botanicals,New South Wales(AUSTRALIA)以商品名ABACROSS FRANGIPANI FLOWER BG获得。
10澳洲睡莲花花提取物是从Southern Cross Botanicals,New South Wales(AUSTRALIA)以商品名ABACROSS WATER LILY BG获得。
11赋形剂包括EDTA二钠、泛醇、尿囊素、柠檬酸钠、柠檬酸和PEG-32。
表41
成分 | 浓度%(重量) |
水 | 94 |
甘油 | 1 |
丁二醇 | 2.5 |
EUXyL PE 90102 | 1 |
GLYCACIL 20003 | 0.2 |
仙人果果实提取物4 | 0.05 |
SIMETHC/D/C-TC 101-SILICONE ANTIFOAM5 | 0.005 |
水飞蓟果实提取物6 | 0.1 |
罗汉果提取物7 | 0.1 |
柳珊瑚提取物8 | 0.1 |
番石榴果实提取物9 | 0.05 |
卡奴卡树叶提取物10 | 0.05 |
赋形剂11 | 适量 |
1可以通过在烧杯中将各组分在70-75℃加热下,混合直到均匀来制备制剂。接着,可以将该制剂冷却至静置室温(20-25℃)。进一步,且如果需要,例如,可以加入另外的组分,以改变组合物的流变学特性。2
2EUXYL PE 9010由Schulke & Mayr提供,是苯氧基乙醇(和)乙基己基甘油的组合。
3GLYCACIL 2000由Lonza Inc./Lonza Ltd.提供,是碘丙炔醇丁基氨甲酸酯。
4仙人果果实提取物由Vege-Tech以商品名Indian Fig Puree,VT-840和VT-853提供。
5SIMETHC/D/C-TC101-SILICONE ANTIFOAM为由Dow Corning销售的消泡剂。
6水飞蓟果实提取物是由Provital S.A(SPAIN)以商品名PRONALENSILYMARIN HSC提供。
7罗汉果提取物是从Carrubba Inc.,Milford,Connecticut(USA)获得。
8柳珊瑚提取物是从Lipo Chemicals Inc.,Paterson,New Jersey(USA)以商品名GORGONIAN EXTRACT BG获得。
9番石榴果实提取物是从Carrubba Inc.,Milford,Connecticut(USA)获得。
10卡奴卡树叶提取物是从Southern Cross Botanicals,New South Wales(AUSTRALIA)以商品名ABACROSS KANUKA BG.获得。
11赋形剂包括精氨酸、carbopol ultrez 10、EDTA二钠、泛醇、尿囊素、柠檬酸钠、柠檬酸和PEG-32。
表5*
成分 | 浓度%(重量) |
水 | 适量(至少80%重量的水) |
丁二醇 | 2至8 |
甘油 | 1至5 |
二偶氮烷基脲 | 0.1至0.3 |
尼泊金甲酯 | 0.1至0.2 |
EDTA二钠 | 0.05至0.1 |
西甲硅油 | 0.002至0.003 |
PPG-26 | 0.001至0.002 |
PEG/PPG-22/23二甲硅油 | 0.001至0.002 |
柠檬酸 | 0.0002至0.002 |
苯氧基乙醇 | 0.00005至0.0008 |
山梨酸钾 | 0.0001至0.0004 |
苯甲酸钠 | 0.0001至0.0003 |
水飞蓟果实提取物 | 0.0003至0.0005 |
向日葵籽提取物 | 0.0003至0.0005 |
柳珊瑚提取物 | 0.0003至0.0005 |
*可以通过在烧杯中将各组分在70-75℃加热下,混合直到均匀来制备制剂。接着,可以将该制剂冷却至静置室温(20-25℃)。进一步,且如果需要,例如,可以加入另外的组分,以改变组合物的流变学特性。
表6*
成分 | 浓度%(重量) |
水 | 83 |
丁二醇 | 7.5 |
甘油 | 5 |
二偶氮烷基脲 | 0.2 |
尼泊金甲酯 | 0.15 |
EDTA二钠 | 0.05 |
西甲硅油 | 0.0025 |
PPG-26 | 0.00125 |
PEG/PPG-22/23二甲硅油 | 0.00125 |
柠檬酸 | 0.01225 |
苯氧基乙醇 | 0.000675 |
山梨酸钾 | 0.000325 |
苯甲酸钠 | 0.00015 |
水飞蓟果实提取物 | 0.00035 |
向日葵籽提取物 | 0.000335 |
柳珊瑚提取物 | 0.0004 |
水解藻胶 | 0.0035 |
亚麻籽提取物 | 0.0005 |
*可以通过在烧杯中将各组分在70-75℃加热下,混合直到均匀来制备制剂。接着,可以将该制剂冷却至静置室温(20-25℃)。进一步,且如果需要,例如,可以加入另外的组分,以改变组合物的流变学特性。
表7*
成分 | 浓度%(重量) |
水 | 87 |
丁二醇 | 4.6 |
甘油 | 4 |
二偶氮烷基脲 | 0.2 |
尼泊金甲酯 | 0.15 |
EDTA二钠 | 0.05 |
西甲硅油 | 0.0025 |
PPG-26 | 0.00125 |
PEG/PPG-22/23二甲硅油 | 0.00125 |
柠檬酸 | 0.001125 |
苯氧基乙醇 | 0.000715 |
山梨酸钾 | 0.00015 |
苯甲酸钠 | 0.00015 |
水飞蓟果实提取物 | 0.00035 |
向日葵籽提取物 | 0.000335 |
柳珊瑚提取物 | 0.0004 |
白鸡蛋花花提取物 | 0.01 |
油茶叶提取物 | 0.01 |
蔬食埃塔棕果提取物 | 0.0005 |
*可以通过在烧杯中将各组分在70-75℃加热下,混合,直到均匀来制备制剂。接着,可以将该制剂冷却至静置室温(20-25℃)。进一步,且如果需要,例如,可以加入另外的组分,以改变组合物的流变学特性。
表8*
成分 | 浓度%(重量) |
水 | 95 |
丁二醇 | 2.5 |
甘油 | 1 |
二偶氮烷基脲 | 0.3 |
尼泊金甲酯 | 0.11 |
EDTA二钠 | 0.1 |
西甲硅油 | 0.0025 |
PPG-26 | 0.00125 |
PEG/PPG-22/23二甲硅抽 | 0.00125 |
柠檬酸 | 0.00025 |
苯氧基乙醇 | 0.00005 |
山梨酸钾 | 0.000275 |
苯甲酸钠 | 0.000275 |
水飞蓟果实提取物 | 0.00035 |
向日葵籽提取物 | 0.000335 |
柳珊瑚提取物 | 0.0004 |
绣线菊提取物 | 0.00095 |
番石榴果实提取物 | 0.0005 |
*可以通过在烧杯中将各组分在70-75℃加热下,混合直到均匀来制备制剂。接着,可以将该制剂冷却至静置室温(20-25℃)。进一步,且如果需要,例如,可以加入另外的组分,以改变组合物的流变学特性。
将具有表2和6中制剂的特性的制剂用于还包括清洁剂、增湿剂和面膜产品的方案中。表2和6的制剂有助于恢复皮肤的天然pH平衡,同时也使得皮肤看起来更有光泽和更健康。所述制剂也能平复和缓和皮肤。在局部施用至皮肤之后,也能感知到到皮肤的触感柔软、光滑和水合化。数据是从一周独立的消费者研究获得。
将具有表3和7中制剂的特性的制剂用于还包括清洁剂、增湿剂和面膜产品的方案中。表3和6的制剂有助于改善皮肤的纹理,使其保持柔软的亚光面。感知到皮肤似乎更健康、恢复活力,且为局部施用增湿剂做好准备。数据是从一周的独立消费者研究获得。
将具有表4和8中制剂的特性的制剂用于还包括清洁剂、增湿剂和面膜产品的方案中。表4和8的制剂有助于从皮肤除去过量的油,同时也能清洁毛孔和最小化毛孔的形态。也感知到所述制剂使皮肤透明。数据是从一周的独立消费者研究获得。
实施例2(另外的测定)
可以通过本领域普通技术人员已知的方法进行用于测定本说明书和权利要求书中公开的任一种组合物的功效的另外的测定。下述为在本发明上下文中可使用的非限制性测定。应当认识到可以使用其它测试方法,包括例如客观方法和主观方法。
控油测定:可以通过使用本领域普通技术人员已知的标准技术进行用于测量来自皮脂腺的皮脂分泌减少和/或来自皮脂腺的皮脂生成减少的测定。在一个实例中,可以使用前额。可以将本发明的组合物应用于前额的一部分,每日一次或两次,应用一个规定的天数(例如1、2、3、4、5、6、7、8、9、10、11、12、13、14天或更多天),而前额的另一部分没有用该组合物处理。然后,在规定的天数期满之后,可以通过向处理的和未处理的前额皮肤应用细吸油纸来测定皮脂分泌。这可以通过首先用湿布和干布从处理的和未处理的区域除去任何皮脂来进行。然后,可以将吸油纸应用于前额的处理和为未处理区域,并可以将弹性带放置在前额周围,以将该吸油纸轻轻地压在皮肤上。在2小时之后,可以除去吸油纸,使其干燥,然后透照。吸油纸越暗与皮脂分泌越多有关,或者吸油纸越亮与皮脂分泌减少有关。
红斑测定:可以使用Minolta比色计评价用于测量皮肤发红减少的测定。可以通过向受试者的前臂上应用0.2%十二烷基硫酸钠溶液诱导皮肤红斑。通过封闭贴剂保护该区域24小时。在24小时之后,除去贴剂,使用Minolta ChromaMeter的a*值评价刺激-诱导的发红。a*值测量红色区域的皮肤颜色变化。在读取之后,立即用本发明的组合物处理该区域。规则性间隔进行重复测量,以确定该制剂减少发红和刺激的能力。
皮肤保湿/水化测定:可以通过使用Nova Dermal Phase Meter进行阻抗测量来测量皮肤保湿/水化益处。阻抗计测量皮肤的含水量的变化。皮肤的外层具有独特的电特性。当皮肤干燥时,其导电性非常差。当其变得更为湿润时,引起导电率增加。因此,皮肤阻抗的变化(与电导率有关)可用于评价皮肤水化的变化。可以在每个测试日,根据仪器说明书校准元件。还可以制作温度和相对湿度的标记。可以按照如下操作评价受试者:在测量之前,他们可以在具有确定湿度(例如30-50%)和温度(例如68-72℃)的房间内进行平衡。可以在脸部的每侧取三个单独的阻抗读数,记录,并取平均值。可以对阻抗计使用T5设定(T5setting),其对每5秒钟脸部施用的阻抗值取平均值。可以由统计方差和统计显著性记录变化。
皮肤透明度和雀斑与老年斑的减少测定:可以使用Minolta Chromometer来评价皮肤透明度以及雀斑与老年斑的减少。可以使用Minolta Chroma Meter的a*值来评价皮肤颜色的变化以测定由产品处理引起的潜在刺激性。a*值测量在红色区域中皮肤颜色的变化。这用于确定组合物是否诱发刺激。可以在脸部的每侧进行测量,并将其平均为左脸和右脸的值。还可以使用Minolta Meter测量皮肤透明度。测量结果是Minolta Meter的a*、b和L值的结合,并与皮肤亮度相关,与皮肤光滑度和水化密切相关。如上取皮肤读数。在一个非限制性的方面,可以将皮肤透明度称作L/C,其中C为色度,并被定义为(a2+b2)1/2。
皮肤干燥度、表面细纹、皮肤光滑度和肤色测定:可以使用临床分级技术(clinical grading techniques)评价皮肤干燥度、表面细纹、皮肤光滑度和肤色。例如,可通过五点标准Kligman量表(five point standard Kligman Scale)来测定皮肤干燥度的临麻分级:(0)皮肤柔软并湿润;(1)皮肤看起来正常,无明显干爆(2)触碰皮肤感觉轻微干燥,无可见皮屑;(3)皮肤感觉干燥,硬,且具有白色外观,略带鳞屑;和(4)皮肤感觉非常干燥,粗糙,且具有白色外观,有鳞屑。可以由两个临床医师独立完成评价,并取平均值。
肤色的临床分级测定:可以经由十点模拟数字量表(ten point analognumerical scale)进行肤色的临床分级:(10)均匀的粉褐色的平滑皮肤。用手持放大镜检查时,无黑斑、红斑或鳞状斑。触摸时皮肤的微观纹理非常均匀;(7)无放大的观察下肤色均匀。无鳞状区域,但由于色素沉着或红斑导至轻度变色。没有直径大于1cm的变色;(4)皮肤变色和不均匀的纹理容易注意到。轻微起屑。触摸某些区域时皮肤粗糙;和(1)肤色和纹理不均匀。多个区域起屑和变色,包括脱色斑、红斑或黑斑。肤色不均匀的大面积大于直径1cm。可以由两个临床医师独立完成评价,并取平均值。
皮肤光滑度的临床分级测定:可以通过十点模拟数字量表分析此肤光滑度的临床分级:(10)光滑,皮肤湿润并反光,且手指拖过表面时没有阻力;(7)比较光滑,轻微阻力;(4)粗糙,可见的改变,摩擦时有摩擦力;和(1)粗糙,鳞状,不均匀表面。可以由两个临床医师独立完成评价,并取平均值。
使用Packman等人(1978)公开的方法进行皮肤光滑度和皱纹减少测定:还可以通过使用Packman等人(1978)公开的方法视觉评价皮肤光滑度和皱纹减少。例如,在每位受试者就诊中,可以对每位受试者的深度、浅度和面部浅表皱纹(SFLs)的总数进行仔细评分并记录。通过将数量因子乘以深度/宽度/长度因子而获得数字评分。获得对于眼部区域和嘴部区域(左右两侧)的评分,并相加得到总的皱纹评分。
使用Hargens ballistometer进行皮肤紧致度(firmness)测定:可以使用Hargens ballistometer来测量皮肤紧致度,Hargens ballistometer是一种通过向皮肤上落下小物体并记录其前两个反弹峰来评价皮肤弹性和紧致度的装置。所述baLlistometry是小而轻的探针,并使用相对钝的尖(4平方毫米接触区域)。该探针轻微刺入皮肤,并给出取决于皮肤外层(包括角质层和外表皮以及某些真皮层)的性质的测试结果。
使用载气电测力计(Gas Bearing Electrodynamometer)进行皮肤柔软度/柔度(softness/suppleness)测定:可以使用载气电测力计来评价皮肤柔软度/柔度,载气电测力计是一种测量皮肤的应力/应变性质(stress/strain properties)的仪器。皮肤的粘弹性质与皮肤的湿润程度有关。可以通过用双面胶将探头粘附到皮肤表面来在脸颊区域的预定部位获得测量结果。可以向皮肤表面平行施加约3.5gm的力,并精确测量皮肤的位移。然后,可以计算皮肤的柔度(suppleness),并表示为DSR(动态弹簧刚性(Dynamic Spring Rate),以gm/mm表示)。
使用复制品(replicas)进行细纹和皱纹出现的测定:可以使用复制品来评价皮肤上细纹和皱纹的出现,该复制品是皮肤表面的印模。可以使用硅酮橡胶类材料。可以通过图像分析来分析复制品。可以经由以下操作客观量化细纹和皱纹可见性的改变:从受试者的脸部取硅复制品,并使用计算机图像分析系统来分析该复制品图像。可以从眼部区域和颈部区域取复制品,并用数码相机以低采光入射角拍摄。可以通过图像处理程序分析数字图像,并确定被皱纹和细纹覆盖的复制品区域。
使用面型测定器/记录笔(Stylus)法进行皮肤表面轮廓的测定:可以使用面型测定器/记录笔法来测量皮肤的表面轮廓。该方法包括在复制品表面闪光或将记录笔拖拽过复制品表面。可以经由远程传感器将记录笔的垂直位移输入电脑,在扫描复制品的固定长度之后,以二维曲线生成皮肤轮廓的截面分析。可沿着固定轴重复这种扫描任意次,以产生皮肤的模拟3-D图像。可以获得使用记录笔技术的复制品的10个任意部分,并结合以生成平均值。感兴趣的值包括Ra,其是通过积分相对于平均轮廓高度的轮廓高度而计算的所有粗糙度(高度)值的算术平均值。Rt是最高峰和最低谷的最大垂直距离,而Rz是平均峰振幅减去平均峰高。作为以mm为单位的校准值给出数值。应当在每次使用之前,通过扫描已知值的金属标准而校准设备。可以通过以下等式计算Ra值:Ra=标准化粗糙度;lm=横向(扫描)长度;以及y=相对于平均轮廓高度(x-轴)的轮廓位置的绝对值。
MELANODERMTM测定:在其它非限制性方面,可以通过使用皮肤类似物,比如例如MELANODERMTM来评价本发明组合物的功效。当黑素细胞(皮肤类似物中的一种细胞)暴露在L-二羟苯基丙氨酸(L-DOPA,一种黑色素前体)中时,其染色阳性。可以用包含本发明组合物和增白剂的多种基质处理皮肤类似物MELANODERMTM,或者单独用基质处理作为对照。可选地,可以使用皮肤类似物的未处理的样品作为对照。
依据本发明公开的内容,在无需过度实验的情况下,本说明书中公开和要求保护的所有皮肤-活性成分、组合物和/或方法均可制备和实施。尽管已经以具体实施方案的方式描述了本发明的皮肤-活性成分、组合物或方法,但是对本领域技术人员而言显而易见的是,可以在不背离本发明的原理、精神和范围的情况下,在方法的步骤或步骤顺序方面对所述的皮肤-活性成分、组合物和/或方法进行变化。
Claims (11)
1.一种用作爽肤水或清新剂的局部皮肤组合物,其包括:(a)80至95%重量的水;(b)水飞蓟果实提取物;(c)罗汉果果实提取物;和(d)柳珊瑚提取物。
2.权利要求1的局部皮肤组合物,其进一步包括:
(e)亚麻籽提取物;和(f)水解藻胶。
3.权利要求2的局部皮肤组合物,其中所述组合物配制用于干性皮肤。
4.权利要求1的局部皮肤组合物,其进一步包括:
(e)白鸡蛋花花提取物;和(f)澳洲睡莲花提取物。
5.权利要求4的局部皮肤组合物,其中所述组合物配制用于中性皮肤。
6.权利要求1的局部皮肤组合物,其进一步包括:(e)番石榴果实提取物;和
(f)卡奴卡树叶提取物。
7.权利要求6的局部皮肤组合物,其中所述组合物配制用于油性皮肤。
8.权利要求1-7中任一项的局部皮肤组合物,其进一步包括:
-甘油;
-丁二醇;-苯氧基乙醇和乙基己基甘油的组合;-碘丙炔醇丁基氨甲酸酯;
-仙人果果实提取物;和-消泡剂。
9.一种向皮肤施用权利要求1-8中任一项的局部皮肤组合物的方法,其包括将所述组合物施用于皮肤。
10.权利要求9的方法,其中在通过清洁组合物清洁皮肤之后5分钟之内,将权利要求1-8中任一项的局部皮肤组合物施用于皮肤。
11.权利要求10的方法,其中在将权利要求1-8中任一项的局部皮肤组合物施用于皮肤之后的5分钟之内,将增湿剂施用于皮肤。
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CN104739715A (zh) * | 2015-03-04 | 2015-07-01 | 上海应用技术学院 | 一种含亚麻籽胶提取液的面膜液及其制备方法 |
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WO2024055536A1 (zh) * | 2022-09-16 | 2024-03-21 | 上海优萃生物科技有限公司 | 一种具有抗氧化活性的半胱天冬酶-1活性抑制剂及其应用 |
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CN103458872A (zh) * | 2010-12-30 | 2013-12-18 | 玫琳凯有限公司 | 多功能化妆品组合物 |
CN103284897B (zh) * | 2012-01-27 | 2018-02-09 | 玫琳凯有限公司 | 化妆品制剂 |
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KR20220004112A (ko) * | 2019-04-25 | 2022-01-11 | 젤리스트 인코퍼레이티드 | 케라틴-고함유 기질의 재성형 및 부착성 유연 막의 형성을 위한 조성물 및 방법 |
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CN104288019B (zh) * | 2014-09-25 | 2016-10-26 | 江苏奇力康皮肤药业有限公司 | 一种保湿芦荟胶及其制备方法 |
CN104188887A (zh) * | 2014-09-29 | 2014-12-10 | 广东真丽斯化妆品有限公司 | 一种美白组合物及其应用 |
CN104739715A (zh) * | 2015-03-04 | 2015-07-01 | 上海应用技术学院 | 一种含亚麻籽胶提取液的面膜液及其制备方法 |
CN111182906A (zh) * | 2017-08-07 | 2020-05-19 | 玫琳凯有限公司 | 处理红斑或皮肤炎症的局部皮肤用组合物 |
CN109820802A (zh) * | 2019-04-11 | 2019-05-31 | 冯江 | 一种亮颜润肤精华液及其制备方法 |
US11786451B2 (en) | 2019-06-28 | 2023-10-17 | The Procter & Gamble Company | Skin care composition |
CN111317707A (zh) * | 2020-04-28 | 2020-06-23 | 厦门羸利康实业有限公司 | 一种柳珊瑚补水保湿面膜及其制备方法 |
WO2024055536A1 (zh) * | 2022-09-16 | 2024-03-21 | 上海优萃生物科技有限公司 | 一种具有抗氧化活性的半胱天冬酶-1活性抑制剂及其应用 |
Also Published As
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US20130192624A1 (en) | 2013-08-01 |
US20150099017A1 (en) | 2015-04-09 |
CN103284897B (zh) | 2018-02-09 |
US10588851B2 (en) | 2020-03-17 |
US20200170927A1 (en) | 2020-06-04 |
US20220287955A1 (en) | 2022-09-15 |
US20160136086A1 (en) | 2016-05-19 |
US11376210B2 (en) | 2022-07-05 |
US9278061B2 (en) | 2016-03-08 |
US8828455B2 (en) | 2014-09-09 |
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