CN105007895A - 用于敏感皮肤的组合物 - Google Patents
用于敏感皮肤的组合物 Download PDFInfo
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- CN105007895A CN105007895A CN201480003306.0A CN201480003306A CN105007895A CN 105007895 A CN105007895 A CN 105007895A CN 201480003306 A CN201480003306 A CN 201480003306A CN 105007895 A CN105007895 A CN 105007895A
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- skin
- sodium
- acid
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
本申请公开了包含水解藻胶、七叶皂苷、假叶树根提取物、甘草酸铵、积雪草提取物、水解酵母蛋白、和金盏花花提取物的组合的组合物及其使用方法。
Description
相关申请的交叉引用
本申请要求2013年11月22日提交的美国临时申请第61/907836号、2013年12月9日提交的美国临时申请第61/913551号和2013年12月30日提交的美国临时申请第61/921803号的权益,所述临时申请的内容通过引用并入到本申请中。
背景技术
A.技术领域
本发明涉及可以用于在具有敏感皮肤的人中处理或预防红斑(即,变红/发红的皮肤)的成分的组合。这种成分的组合可以被包含在宽范围的产品制剂中(例如,爽肤水、凝胶、面膜等)。
B.相关技术说明
敏感皮肤是其中在暴露于刺激如紫外光、热、冷、化学品或皮肤制剂中的活性成分等时皮肤具有发红、变红或脸红(即,红斑)趋势的状态。化妆品业中的问题之一是需要已知在敏感皮肤中可能引起红斑的活性成分来处理给定皮肤状态如细纹和皱纹、皮肤下垂、痤疮等。因此,具有敏感皮肤的人或者必须避免这种产品或者最终购买能够帮助缓解与敏感皮肤有关的上述症状的另外的产品。
发明内容
本发明提供上述问题的一种解决方案。该解决方案是在发现可以用于缓解甚至预防与敏感皮肤相关的症状(例如,红斑或皮肤炎症)的以下成分的组合的情况下做出的:水解藻胶、七叶皂苷、假叶树(Ruscusaculeatus)根提取物、甘草酸铵、积雪草(Centellaasiatica)提取物、水解酵母蛋白、和金盏花(Calendulaofficinalis)花提取物。成分的这种组合可以与已知在施用至敏感皮肤时引起红斑的其他皮肤活性成分一起用于各种产品制剂(例如,爽肤水、洁面乳、乳剂如乳液或面霜、面膜、凝胶等)。换言之,成分这种的组合可以与其他已知皮肤活性成分一起使用来处理给定皮肤状态(例如,与已知皮肤活性剂一起)和预防或减少与敏感皮肤相关的症状(例如,与前述的成分组合一起)。不希望拘泥于理论,据认为所发现的成分的组合提供强的抗氧化作用(参见实施例)和/或其干扰炎症过程/级联反应中的各个步骤,由此减少在敏感皮肤中通常可见的发红/脸红/变红。
在一个实例中,公开了包含水解藻胶、七叶皂苷、假叶树根提取物、甘草酸铵、积雪草提取物、水解酵母蛋白、和金盏花花提取物的组合的局部皮肤用组合物。或者,所述成分的一种或任意组合可以用于本发明的组合物。例如,七叶皂苷、假叶树根提取物、甘草酸铵、积雪草提取物、水解酵母蛋白、和金盏花花提取物的组合可以在需要抗氧化剂的皮肤上被用作抗氧化剂。所述组合物内成分的量可以改变(例如,量可以低至0.000001重量%到高至60重量%,或是其间的任意范围)。在一个实例中,组合物包含0.0001重量%至1重量%的七叶皂苷、0.0001重量%至1重量%的假叶树根提取物、0.0001重量%至1重量%的甘草酸铵、0.0001重量%至1重量%的积雪草提取物、0.0001重量%至1重量%的水解酵母蛋白、和0.0001重量%至1重量%的金盏花花提取物并且还可以包含计0.0001重量%至1重量%的水解藻胶。在一些方面,公开了施用本文中所公开的局部皮肤用组合物的任一种的方法,包括施用所述组合物至皮肤。在一些方面,将组合物施用至敏感皮肤。
在另一个方面,公开了配制为包含以下成分中的任一个、其任意组合、或其全部的爽肤水的局部皮肤用组合物:七叶皂苷、假叶树根提取物、甘草酸铵、积雪草提取物、水解酵母蛋白、金盏花花提取物、水、丁二醇、甘油、丙二醇、重氮烷基脲、PPG-5-鲸蜡醇聚醚-20、对羟基苯甲酸甲酯、柠檬酸钠、EDTA二钠、丁醇聚醚-3、对羟基苯甲酸丙酯、柠檬酸、苯并三唑基丁基苯酚磺酸钠、泛醇、水解藻胶、透明质酸钠、聚二甲硅烷、柠檬酸三丁酯、苯氧乙醇、环四硅氧烷、山梨酸钾、苯甲酸钠、环戊硅氧烷、环己硅氧烷、和仙人果(Opuntiatuna)果提取物。所述组合物内的成分的量可以改变(例如,量可以低达0.000001重量%到高达60重量%,或是其间的任意范围)。在一个实例中,组合物包含0.0001重量%至1重量%的七叶皂苷、0.0001%至1%的假叶树根提取物、0.0001重量%至1重量%的甘草酸铵、0.0001重量%至1重量%的积雪草提取物、0.0001重量%至1重量%水解酵母蛋白、0.0001重量%至1重量%的金盏花花提取物、70重量%至90重量%的水、5重量%至7重量%的丁二醇、3重量%至6重量%的甘油、0.1重量%至1.0重量%的丙二醇、0.1重量%至0.5重量%的重氮烷基脲、0.01重量%至0.3重量%的PPG-5-鲸蜡醇聚醚-20、0.05重量%至0.5重量%的对羟基苯甲酸甲酯、0.05重量%至0.5重量%的柠檬酸钠、0.05重量%至0.5重量%的EDTA二钠、0.005重量%至0.05重量%的丁醇聚醚-3、0.005重量%至0.05重量%的对羟基苯甲酸丙酯、0.005重量%至0.05重量%的柠檬酸、0.005重量%至0.05重量%的苯并三唑基丁基苯酚磺酸钠、0.005重量%至0.05重量%的泛醇、0.001重量%至0.01重量%的水解藻胶、0.001重量%至0.01重量%的透明质酸钠、0.0001重量%至0.001重量%的聚二甲硅烷、0.0001重量%至0.001重量%的柠檬酸三丁酯、0.0001重量%至0.001重量%的苯氧乙醇、0.0001重量%至0.001重量%的环四硅氧烷、0.0001重量%至0.001重量%的山梨酸钾、0.0001重量%至0.001重量%的苯甲酸钠、0.0001重量%至0.001重量%的环戊硅氧烷、0.0001重量%至0.001重量%的环己硅氧烷、和0.0001重量%至0.1重量%的仙人果果提取物。在一些方面,还公开了在已经用清洁组合物清洁皮肤后5分钟内施用所公开的组合物至皮肤的方法。在一些方面,在施用这些局部皮肤用组合物的任一种至皮肤后5分钟内将保湿剂施用至皮肤。
在另一个方面,公开了配制为包含以下成分中的任一个、其任意组合、或其全部的面膜的局部皮肤用组合物:七叶皂苷、假叶树根提取物、甘草酸铵、积雪草提取物、水解酵母蛋白、金盏花花提取物、水、戊二醇、聚硅氧烷-11、丙烯酸羟乙酯/丙烯酰基二甲基牛磺酸钠共聚物、二甲聚硅氧烷、角鲨烷、十一碳烯酸甘油酯、苯甲醇、二氧化硅、丁二醇、三乙醇胺、聚山梨醇酯60、丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物、羟丙基环糊精、异硬酯酸失水山梨醇酯、泛醇、水解藻胶、甘油、丁基氨甲酸碘代丙炔基酯、苯氧乙醇、柠檬酸钠、苯甲酸钠、柠檬酸、山梨酸钾、和仙人果果提取物。所述组合物内成分的量可以改变(例如,量可以低至0.000001重量%到高至60重量%,或是其间的任意范围)。在一个实例中,组合物包含0.0001重量%至1重量%的七叶皂苷、0.0001重量%至1重量%的假叶树根提取物、0.0001重量%至1重量%的甘草酸铵、0.0001重量%至1重量%的积雪草提取物、0.0001重量%至1重量%水解酵母蛋白、0.0001重量%至1重量%的金盏花花提取物、75重量%至95重量%的水、4重量%至6重量%的戊二醇、1重量%至4重量%的聚硅氧烷-11、1重量%至3重量%的丙烯酸羟乙酯/丙烯酰基二甲基牛磺酸钠共聚物、1重量%至3重量%的二甲聚硅氧烷、1重量%至3重量%的角鲨烷、0.5重量%至1.5重量%的十一碳烯酸甘油酯、0.5重量%至1.5重量%的苯甲醇、0.1重量%至1.0重量%的二氧化硅、0.1重量%至1.0重量%的丁二醇、0.1重量%至1.0重量%的三乙醇胺、0.1重量%至1.0重量%的聚山梨醇酯60、0.1重量%至1.0重量%的丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物、0.01重量%至0.1重量%的羟丙基环糊精、0.01重量%至0.1重量%的异硬酯酸失水山梨醇酯、0.01重量%至0.1重量%的泛醇、0.01重量%至0.1重量%的水解藻胶、0.01重量%至0.1重量%的甘油、0.001重量%至0.1重量%的丁基氨甲酸碘代丙炔基酯、0.001重量%至0.1重量%的苯氧乙醇、0.0001重量%至0.001重量%的柠檬酸钠、0.0001重量%至0.001重量%的苯甲酸钠、0.0001重量%至0.001重量%的柠檬酸、和0.0001重量%至0.001重量%的山梨酸钾。在一些方面,还公开了施用本文中所公开的局部皮肤用组合物的任一种至皮肤的方法,包括施用所述组合物至皮肤,其中所述组合物在皮肤上保留1至12小时。
在另一个方面,公开了配制为能够减少黑眼圈或眼部浮肿出现的面霜或凝胶的局部皮肤用组合物,其包含以下成分中的任一种、其任意组合、或其全部:七叶皂苷、假叶树根提取物、甘草酸铵、积雪草提取物、水解酵母蛋白、金盏花花提取物、水、甘油、戊二醇、甘油聚醚-26、丙二醇、三乙醇胺、丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物、重氮烷基脲、羟乙基纤维素、聚丙烯酸钠、对羟基苯甲酸甲酯、EDTA二钠、丁二醇、苯氧乙醇、辛二醇、对羟基苯甲酸丙酯、泛醇、和仙人果果提取物。所述组合物内成分的量可以改变(例如,量可以低至0.000001重量%到高至60重量%,或是其间的任意范围)。在一个实例中,组合物包含0.005重量%至0.05重量%的水解藻胶、0.0001重量%至1重量%的七叶皂苷、0.0001重量%至1重量%的假叶树根提取物、0.0001重量%至1重量%的甘草酸铵、0.0001重量%至1重量%的积雪草提取物、0.0001重量%至1重量%的水解酵母蛋白、0.0001重量%至1重量%的金盏花花提取物、75重量%至95重量%的水、3重量%至7重量%的甘油、3重量%至7重量%的戊二醇、1重量%至3重量%的甘油聚醚-26、0.3重量%至0.7重量%的丙二醇、0.3重量%至0.7重量%的三乙醇胺、0.1重量%至0.5重量%的丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物、0.1重量%至0.5重量%的重氮烷基脲、0.1重量%至0.5重量%的羟乙基纤维素、0.1重量%至0.5重量%的聚丙烯酸钠、0.1重量%至0.5重量%的对羟基苯甲酸甲酯、0.05重量%至0.5重量%的EDTA二钠、0.05重量%至0.1重量%的丁二醇、0.03重量%至0.07重量%的苯氧乙醇、0.03重量%至0.07重量%的辛二醇、0.01重量%至0.05重量%的对羟基苯甲酸丙酯、和0.01重量%至0.05重量%的泛醇。
在又一个方面,公开了配制为能够减少黑眼圈或眼部浮肿的出现的面霜或凝胶的局部皮肤用组合物,其包含以下成分中的任一种、任意组合或全部:七叶皂苷、假叶树根提取物、甘草酸铵、积雪草提取物、水解酵母蛋白、金盏花花提取物、水、甘油、戊二醇、甘油聚醚-26、苯甲醇、三乙醇胺、丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物、羟乙基纤维素、聚丙烯酸钠、EDTA二钠、羟丙基环糊精、丁二醇、苯氧乙醇、辛二醇、泛醇、丁基氨甲酸碘代丙炔基酯、水解藻胶、云母、二氧化钛、柠檬酸钠、山梨酸钾、苯甲酸钠、柠檬酸、和仙人果果提取物。所述组合物内成分的量可以改变(例如,量可以低至0.000001重量%到高至60重量%,或是其间的任意范围)。在一个实例中,组合物包含0.0001重量%至1重量%的七叶皂苷、0.0001重量%至1重量%的假叶树根提取物、0.0001重量%至1重量%的甘草酸铵、0.0001重量%至1重量%的积雪草提取物、0.0001重量%至1重量%水解酵母蛋白、0.0001重量%至1重量%的金盏花花提取物、75重量%至95重量%的水、3重量%至7重量%的甘油、2重量%至5重量%的戊二醇、1重量%至3重量%的甘油聚醚-26、0.3重量%至1.5重量%的苯甲醇、0.1重量%至1.5重量%的三乙醇胺、0.1重量%至0.7重量%的丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物、0.01重量%至1.0重量%的羟乙基纤维素、0.01重量%至1.0重量%的聚丙烯酸钠、0.01重量%至1.0重量%的EDTA二钠、0.01重量%至1.0重量%的羟丙基环糊精、0.01重量%至1.0重量%的丁二醇、0.01重量%至1.0重量%的苯氧乙醇、0.01重量%至0.1重量%的辛二醇、0.005重量%至0.1重量%的泛醇、0.001重量%至0.03重量%的丁基氨甲酸碘代丙炔基酯、0.001重量%至0.003重量%的水解藻胶、0.001重量%至0.03重量%的云母、0.001重量%至0.03重量%的二氧化钛、0.0001重量%至0.0003重量%的柠檬酸钠、0.0001重量%至0.0003重量%山梨酸钾、0.0001重量%至0.0003重量%苯甲酸钠、和0.0001重量%至0.0003重量%柠檬酸。
还预期处理红斑皮肤或红斑的方法,其包括局部地施用上述组合物中的任一种至已经或可能发展为红斑的皮肤。可能发展为红斑的皮肤包括具有敏感皮肤的人。红斑通常由至皮肤表面的血流增加引起。组合物也可以用来通过减少皮肤中的TNF-α、IL-6、IL-8、IL-10、IL-12p40、GM-CSF细胞因子产生、和/或CGRP产生来处理皮肤炎症。该组合物还可以被用作抗氧化剂来处理宽范围的皮肤状态,例如细纹、皱纹、皮肤下垂。例如,成分的组合的抗氧化作用可以用来阻止或减少活性氧自由基(ROS)的形成或可以阻止ROS与皮肤内的细胞机制相互作用。
本发明的组合物还可以包含以下附加成分中的任一种、任意组合或全部:水、螯合剂、保湿剂、防腐剂、增稠剂、含硅酮的化合物、精油、结构化剂、维生素、药物成分或抗氧化剂,或这类成分的任意组合或这类成分的混合物。在某些方面,组合物可以包含在之前句子中所列举的这些附加成分中的至少二、三、四、五、六、七、八、九、十种或全部。这些附加成分的非限制性实例在本说明书通篇列举并通过引用并入本部分。这类成分的量可以是以组合物的重量或体积计的0.0001%至99.9%,或者为本说明书其它部分中所公开的任意整数或范围,其通过引用并入本段。
在本发明的内容中还公开了实施例方案1至22。实施方案1是包含有效量的水解藻胶、七叶皂苷、假叶树根提取物、甘草酸铵、积雪草提取物、水解酵母蛋白、和金盏花花提取物的局部皮肤用组合物,其中该组合物能够减少皮肤细胞中的细胞因子产生并减少氧化性损伤。实施方案2是实施方案1的局部皮肤用组合物,其进一步包含80重量%至90重量%的水。实施方案3是实施方案2的局部皮肤用组合物,其包含0.005重量%至0.05重量%的水解藻胶。实施方案4是实施方案3的局部皮肤用组合物,其包含0.001重量%至0.05重量%的七叶皂苷、0.001重量%至0.01重量%的假叶树根提取物、0.001重量%至0.01重量%的甘草酸铵、0.0005重量%至0.005重量%的积雪草提取物、0.0003重量%至0.003重量%的水解酵母蛋白、和0.0003重量%至0.003重量%的金盏花花提取物。实施方案5是实施方案3的局部皮肤用组合物,其进一步包含仙人果果提取物。实施方案6是实施方案1-5中的任一个的局部皮肤用组合物,其中该组合物进一步包含丁二醇;甘油;丙二醇;重氮烷基脲;PPG-5-鲸蜡醇聚醚-20;对羟基苯甲酸甲酯;柠檬酸钠;EDTA二钠;丁醇聚醚-3;对羟基苯甲酸丙酯;柠檬酸;苯并三唑基丁基酚磺酸钠;和泛醇。实施方案7是实施方案6的局部皮肤用组合物,其中所述组合物包含:5重量%至7重量%的丁二醇;3重量%至5重量%的甘油;0.3重量%至0.7重量%的丙二醇;0.1重量%至0.5重量%重氮烷基脲;0.1重量%至0.5重量%的PPG-5-鲸蜡醇聚醚-20;0.1重量%至0.5重量%的对羟基苯甲酸甲酯;0.05重量%至0.1重量%的柠檬酸钠;0.03重量%至0.07重量%的EDTA二钠;0.03重量%至0.07重量%的丁醇聚醚-3;0.01重量%至0.05重量%的对羟基苯甲酸丙酯;0.01重量%至0.05重量%的柠檬酸;0.01重量%至0.05重量%的苯并三唑基丁基酚磺酸钠;和0.01重量%至0.05重量%的泛醇。实施方案8是实施方案1至5的任一个的局部皮肤用组合物,其中该组合物进一步包含:甘油;戊二醇;甘油聚醚-26;丙二醇;三乙醇胺;丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物;重氮烷基脲;羟乙基纤维素;聚丙烯酸钠;对羟基苯甲酸甲酯;EDTA二钠;丁二醇;苯氧乙醇;辛二醇;对羟基苯甲酸丙酯;和泛醇。实施方案9是实施方案8的局部皮肤用组合物,其中所述组合物包含:3重量%至7重量%的甘油;3重量%至7重量%的戊二醇;1重量%至3重量%的甘油聚醚-26;0.3重量%至0.7重量%的丙二醇;0.3重量%至0.7重量%的三乙醇胺;0.1重量%至0.5重量%的丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物;0.1重量%至0.5重量%的重氮烷基脲;0.1重量%至0.5重量%的羟乙基纤维素;0.1重量%至0.5重量%的聚丙烯酸钠;0.1重量%至0.5重量%的对羟基苯甲酸甲酯;0.05重量%至0.5重量%的EDTA二钠;0.05重量%至0.1重量%的丁二醇;0.03重量%至0.07重量%的苯氧乙醇;0.03重量%至0.07重量%的辛二醇;0.01重量%至0.05重量%的对羟基苯甲酸丙酯;和0.01重量%至0.05重量%的泛醇。实施方案10是实施方案1至5的任一个的局部皮肤用组合物,其中该组合物进一步包含:戊二醇;聚硅氧烷-11;丙烯酸羟乙酯/丙烯酰基二甲基牛磺酸钠共聚物;二甲聚硅氧烷;角鲨烷;十一碳烯酸甘油酯;二氧化硅;丁二醇;三乙醇胺;聚山梨醇酯60;丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物;羟丙基环糊精;异硬酯酸失水山梨醇酯;泛醇;和甘油。实施方案11是实施方案10的局部皮肤用组合物,其中所述组合物包含:3重量%至7重量%的戊二醇;1重量%至5重量%的聚硅氧烷-11;1重量%至5重量%的丙烯酸羟乙酯/丙烯酰基二甲基牛磺酸钠共聚物;1重量%至3重量%的二甲聚硅氧烷;1重量%至3重量%的角鲨烷;0.5重量%至2重量%的十一碳烯酸甘油酯;0.3重量%至0.7重量%的二氧化硅;0.1重量%至0.5重量%的丁二醇;0.1重量%至0.5重量%的三乙醇胺;0.1重量%至0.5重量%的聚山梨醇酯60;0.1重量%至0.5重量%的丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物;0.05重量%至0.1重量%的羟丙基环糊精;0.05重量%至0.1重量%的异硬酯酸失水山梨醇酯;0.03重量%至0.07重量%的泛醇;和0.03重量%至0.07重量%的甘油。实施方案12是实施方案11的局部皮肤用组合物,其中所述组合物进一步包含苯甲醇。实施方案13是实施方案12的局部皮肤用组合物,其中所述组合物包含0.1重量%至1重量%的苯甲醇。实施方案14是实施方案1至5的任一个的局部皮肤用组合物,其中该组合物进一步包含:甘油;戊二醇;甘油聚醚-26;苯甲醇;三乙醇胺;丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物;羟乙基纤维素;聚丙烯酸钠;EDTA二钠;羟丙基环糊精;丁二醇;苯氧乙醇;辛二醇;和泛醇。实施方案15是实施方案14的局部皮肤用组合物,其中所述组合物包含:3重量%至7重量%的甘油;2重量%至5重量%的戊二醇;1重量%至3重量%的甘油聚醚-26;0.3重量%至1.5重量%的苯甲醇;0.1重量%至1.5重量%的三乙醇胺;0.1重量%至0.7重量%的丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物;0.01重量%至1.0重量%的羟乙基纤维素;0.01重量%至1.0重量%的聚丙烯酸钠;0.01重量%至1.0重量%的EDTA二钠;0.01重量%至1.0重量%的羟丙基环糊精;0.01重量%至1.0重量%的丁二醇;0.01重量%至1.0重量%的苯氧乙醇;0.01重量%至0.1重量%的辛二醇;和0.005重量%至0.1重量%的泛醇。实施方案16是减少皮肤细胞中促炎性细胞因子产生和保护皮肤免受来自自由基的氧化性损伤的方法,其包括局部地施用实施方案1至15的任一个的组合物至有此需要的皮肤,其中所述组合物减少皮肤细胞中促炎性细胞因子产生并保护皮肤免受来自自由基的氧化性损伤。实施方案17是实施方案16的方法,其中所述促炎性细胞因子是TNF-α;IL-6;IL-8;IL-10;IL-12p40;或GM-CSF;或其任意组合或全部。实施方案18是实施方案17的方法,其中将所述组合物施用至红斑的;敏感的或发炎的皮肤。实施方案19是实施方案17的方法,其中将所述组合物施用至干燥的;片状的或瘙痒的皮肤。实施方案20是减少皮肤细胞中CGRP产生和保护皮肤免受来自自由基的氧化性损伤的方法,其包括局部地施用实施方案1至15的任一个的组合物至有此需要的皮肤,其中所述组合物减少皮肤细胞中CGRP产生并保护皮肤免受来自自由基的氧化性损伤。实施方案21是实施方案20的方法,其中将所述组合物施用至红斑的;敏感的或发炎的皮肤。实施方案22是实施方案20的方法,其中将所述组合物施用至干燥的;片状的或瘙痒的皮肤。
还涉及包含本发明的组合物的试剂盒。在某些实施方案中,该组合物包含在容器中。该容器可以是瓶子、分配器或包装。该容器可以分配预定量的组合物。在某些方面,以喷雾、团块或流体分配组合物。容器可以在其表面上包含标记。该标记可以是单词、缩写、图片或符号。
还预期的是本说明书通篇所公开的所述组合物可以被用作保留型或洗去型组合物。举例来说,保留型组合物可以是被局部地施用至皮肤并在皮肤上保留一段时间(例如,至少5、6、7、8、9、10、20或30分钟,或至少1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23或24小时,或者整夜或整个白天)的组合物。或者,洗去型组合物可以是意在施用至皮肤,然后在一段时间如小于5、4、3、2或1分钟内从皮肤去除或洗去(比如用水)的产品。洗去型组合物的实例可以是皮肤清洁剂、洗发水、护发素或皂。保留型组合物的实例子可以是皮肤保湿剂、防晒剂、面膜、晚霜或日霜。
预期的是本说明书中所讨论的任何实施方案可以针对本发明的任何方法或组合物来实施,反之亦然。此外,本发明的组合物可以用于实现本发明的方法。
在一个实施方案中,本发明的组合物可以是可药用的或可化妆用的,或可以具有舒适的触觉性质。“可药用的”、“可化妆用的”和/或“舒适的触觉性质”描述具有令皮肤感觉舒适的特定触觉性质的组合物(例如,不是太水或太油的组合物、具有丝滑质地的组合物、非粘性或粘性的组合物等)。可药用的或可化妆用的还可以涉及组合物的乳脂状或润滑性能,或组合物的水分保留性能。
“局部施用”是指施用或涂布组合物到嘴唇或角质组织的表面上。“局部皮肤用组合物”包括适合在嘴唇或角质组织上局部施用的组合物。这类组合物一般为皮肤病学可接受的,这是因为当施用到嘴唇或皮肤时,其不具有异常毒性、不相容性、不稳定性、过敏反应等。本发明的局部护肤组合物可以具有选定的黏度以避免施用到皮肤后明显的滴落或淤积。
“角质组织”包括配置作为哺乳类最外保护层的含角质的层,并且包含但不限于嘴唇、皮肤、毛发和指甲。
术语“大约”或“约”定义为如本领域普通技术人员所理解的接近于,并且在一个非限制性实施方案中该术语定义为在10%以内,优选在5%以内,更优选在1%以内,最优选在0.5%以内。
术语“基本上”及其变体定义为如本领域普通技术人员所理解的大部分但不一定为所指定的全部,并且在一个非限定性实施方案中基本上指的是在10%以内、5%以内、1%以内或0.5%以内的范围。
术语“抑制”或“减少”或这些术语的任何变体包括实现期望结果的任何可测量的减少或完全的抑制。术语“促进”或“增加”或这些术语的任何变体包括实现期望结果的蛋白质或分子(例如,基质蛋白如纤连蛋白、层粘连蛋白、胶原蛋白或弹性蛋白,或者分子如透明质酸)的任何可测量的增加或产生。
作为本说明书和/或权利要求所使用的术语,术语“有效的”表示实现期望的、预期的或想要的结果而言是足够的。
当在权利要求和/或说明书中与术语“包含”一起使用时,单数名词可以表示“一个”,但是其也符合“一个或更多个”、“至少一个”和“一个或多于一个”的意思。
如本说明书和权利要求所使用的,单词“包含”(和任何形式的“包含”)、“具有”(和任何形式的“具有”)、“包括”(和任何形式的“包括”)或“含有”(和任何形式的“含有”)是包括性的或开放式的,并且不排除另外的、未列举的要素或方法步骤。
使用的组合物和方法可以“包含”本说明书通篇所公开的成分或步骤的任一个、“基本上由本说明书通篇所公开的成分或步骤的任一个组成”或“由本说明书通篇所公开的成分或步骤的任一个组成”。对于过渡性短语“基本上由……构成”,在一个非限制性方面,本说明书所公开组合物和方法的基本且新的特征包括组合物减少或预防与敏感性皮肤相关的症状(例如红斑)在使用者皮肤上出现的能力。
本发明的其它目的、特征和优点通过下面的详细描述会变得明显。然而,应理解详细的描述和实施例在表明本发明的具体实施方案时仅以举例说明的方式给出。另外,期望从该详细描述,本发明的精神和范围内的变化和修改对于本领域技术人员会变得明显。
具体实施方式
患有敏感皮肤的人容易受与市场上当前产品的皮肤反应的影响,所述产品包含针对特定皮肤状态如细纹和皱纹、失去弹性、色素沉着过度、黄褐斑、干燥皮肤、油性皮肤、痤疮等的活性成分。尽管特定皮肤状态的处理可以是有益的,但它也可以导致副作用,例如在具有敏感皮肤的人中产生变红的或发炎的皮肤。本发明通过提供可以在敏感皮肤上使用而不产生皮肤刺激反应如红斑/皮肤变红的成分的组合以提供该问题的解决方案。
在以下子部分提供本发明的这些和其它非限制性方面。
A.成分的组合
本发明是在发现可以用于缓解甚至预防与敏感皮肤相关的症状的以下成分的组合的情况下做出的:水解藻胶、七叶皂苷、假叶树根提取物、甘草酸铵、积雪草提取物、水解酵母蛋白、和金盏花花提取物。在下文中更详细地讨论这些成分。
水解藻胶是藻胶的水解产物。该成分可从多种来源(参见例如CTFA,第1卷,第1211页,其通过引用并入本文)商购获得。一种示例性来源可以从Barnet Products Corporation以商品名Phyko-Al-PF获得。已经发现该成分可以用于减少各种促炎性细胞因子的生成和CGRP生成(参见实施例1)。
七叶皂苷,也称为七叶素,是在七叶树(Aesculus hippocastanum)(马栗树)的种子中发现的皂苷的混合物。该活性成分可从各种不同来源商购得到(参见,例如国际化妆品成分词典和手册,2008年第12版(“CTFA”),第1卷,940页,其通过引用并入本文)。
假叶树根提取物是来自天门冬科(Asparagaceae)中的矮常绿欧亚灌木(Eurasian shrub)的根的提取物。它原产于北欧和欧亚国家。该提取物可从多种来源(参见例如CTFA,第2卷,第2405页,其通过引用并入本文)商购获得。在一些实施方案中,提取物可以为水提取物、醇提取物、或水-醇提取物。
甘草酸铵是甘草酸的铵盐,且可从多种来源(参见例如CTFA,第1卷,第154页,其通过引用并入本文)商购获得。
积雪草植物为一种原产于例如印度、斯里兰卡、澳大利亚、印度尼西亚、马来西亚、美拉尼西亚、巴布亚新几内亚和亚洲其它部分的国家的小型草本植物。来自该植物的提取物可从宽范围的来源(参见例如CTFA,第1卷,第458-60页,其通过引用并入本文)商购获得。在具体的实施方案中,可以使用全株提取物(参见CTFA的第458-59页)。可以从Bayer SanteFamiliale SAS(法国)以商品名TECA(积雪草的滴定提取物,TitratedExtract of Centella Asiatica)获得一种示例性来源,其包含积雪草苷、羟基积雪草酸和积雪草酸。在一些实施方案中,提取物可以为水提取物、醇提取物、或水-醇提取物。
水解酵母蛋白是酵母蛋白的水解产物。该活性成分可从多种来源(参见例如CTFA,第1卷,第1242页,其通过引用并入本文)商购获得。
金盏花花提取物是金盏花(Calendula officinalis)花的提取物。该植物原产于欧洲中部、东部和南部。其可从多种来源(参见例如CTFA,第1卷,第388-390页,其通过引用并入本文)商购获得。在一些实施方案中,提取物可以为水提取物、醇提取物、或水-醇提取物。
另外,七叶皂苷、假叶树根提取物、甘草酸铵、积雪草提取物、水解酵母蛋白、和金盏花花提取物的混合物可以从BASF Care Creations以商品名BiphytexTMLS 9832购买。已经发现该混合物可以被用作抗氧化剂(参见实施例1)。该混合物可以以0.01重量%至2重量%的量使用。
B.成分的量
预期本发明所述组合物可以包含任意量的本说明书所讨论的成分。该组合物还可包含在本说明书通篇中所描述的附加成分的任意数目的组合(例如,颜料或附加的化妆品或药物成分)。在该组合物中任意成分的浓度可以改变。例如,在非限制性实施方案中,该组合物在其最终形式中可以包含、主要由以下组分组成或由以下组分组成:例如至少大约0.0001%、0.0002%、0.0003%、0.0004%、0.0005%、0.0006%、0.0007%、0.0008%、0.0009%、0.0010%、0.0011%、0.0012%、0.0013%、0.0014%、0.0015%、0.0016%、0.0017%、0.0018%、0.0019%、0.0020%、0.0021%、0.0022%、0.0023%、0.0024%、0.0025%、0.0026%、0.0027%、0.0028%、0.0029%、0.0030%、0.0031%、0.0032%、0.0033%、0.0034%、0.0035%、0.0036%、0.0037%、0.0038%、0.0039%、0.0040%、0.0041%、0.0042%、0.0043%、0.0044%、0.0045%、0.0046%、0.0047%、0.0048%、0.0049%、0.0050%、0.0051%、0.0052%、0.0053%、0.0054%、0.0055%、0.0056%、0.0057%、0.0058%、0.0059%、0.0060%、0.0061%、0.0062%、0.0063%、0.0064%、0.0065%、0.0066%、0.0067%、0.0068%、0.0069%、0.0070%、0.0071%、0.0072%、0.0073%、0.0074%、0.0075%、0.0076%、0.0077%、0.0078%、0.0079%、0.0080%、0.0081%、0.0082%、0.0083%、0.0084%、0.0085%、0.0086%、0.0087%、0.0088%、0.0089%、0.0090%、0.0091%、0.0092%、0.0093%、0.0094%、0.0095%、0.0096%、0.0097%、0.0098%、0.0099%、0.0100%、0.0200%、0.0250%、0.0275%、0.0300%、0.0325%、0.0350%、0.0375%、0.0400%、0.0425%、0.0450%、0.0475%、0.0500%、0.0525%、0.0550%、0.0575%、0.0600%、0.0625%、0.0650%、0.0675%、0.0700%、0.0725%、0.0750%、0.0775%、0.0800%、0.0825%、0.0850%、0.0875%、0.0900%、0.0925%、0.0950%、0.0975%、0.1000%、0.1250%、0.1500%、0.1750%、0.2000%、0.2250%、0.2500%、0.2750%、0.3000%、0.3250%、0.3500%、0.3750%、0.4000%、0.4250%、0.4500%、0.4750%、0.5000%、0.5250%、0.0550%、0.5750%、0.6000%、0.6250%、0.6500%、0.6750%、0.7000%、0.7250%、0.7500%、0.7750%、0.8000%、0.8250%、0.8500%、0.8750%、0.9000%、0.9250%、0.9500%、0.9750%、1.0%、1.1%、1.2%、1.3%、1.4%、1.5%、1.6%、1.7%、1.8%、1.9%、2.0%、2.1%、2.2%、2.3%、2.4%、2.5%、2.6%、2.7%、2.8%、2.9%、3.0%、3.1%、3.2%、3.3%、3.4%、3.5%、3.6%、3.7%、3.8%、3.9%、4.0%、4.1%、4.2%、4.3%、4.4%、4.5%、4.6%、4.7%、4.8%、4.9%、5.0%、5.1%、5.2%、5.3%、5.4%、5.5%、5.6%、5.7%、5.8%、5.9%、6.0%、6.1%、6.2%、6.3%、6.4%、6.5%、6.6%、6.7%、6.8%、6.9%、7.0%、7.1%、7.2%、7.3%、7.4%、7.5%、7.6%、7.7%、7.8%、7.9%、8.0%、8.1%、8.2%、8.3%、8.4%、8.5%、8.6%、8.7%、8.8%、8.9%、9.0%、9.1%、9.2%、9.3%、9.4%、9.5%、9.6%、9.7%、9.8%、9.9%、10%、11%、12%、13%、14%、15%、16%、17%、18%、19%、20%、21%、22%、23%、24%、25%、26%、27%、28%、29%、30%、35%、40%、45%、50%、60%、65%、70%、75%、80%、85%、90%、95%或99%或其中可得到的任何范围的至少一种在本说明书和权利要求通篇所提及的成分。在非限制性方面,该百分比可以按整个组合物的重量或体积进行计算。本领域普通技术人员会理解,在给定组合物中浓度可以根据成分的添加、替换和/或减少而改变。
C.载体
本发明的组合物可以并入到所有类型的载体中。非限制性实例包括乳剂(例如,油包水、水包油包水、水包油、水包硅胶、硅胶包水、油包水包油、硅胶包水包油的乳剂)、面霜、乳液、溶液(水的和水-乙醇的两者)、无水基质(例如口红和粉末)、凝胶和软膏。变体和其它合适的载体对于熟练的技术人员是明显的,并且适用于本发明。在某些方面,重要的是,化合物、成分和试剂的浓度和组合可以选择为使得该组合是化学相容的并且不形成从最终产物中沉淀出来的络合物。
D.额外成分
除了本发明所公开成分的组合之外,组合物还可以包含附加成分,例如化妆品成分和药物活性成分。这些附加成分的非限制性实例在以下子章节中进行描述。
1.化妆品成分
CTFA国际化妆品成分词典和手册(2004和2008)描述了多种可以在本发明的上下文中使用的非限制性化妆品成分。这些成分种类的实例包括:芳香剂(人造的和天然的)、染料和着色成分(例如蓝色1号、蓝色1号色淀、红色40号、二氧化钛、D&C蓝色4号、D&C绿色5号、D&C橙色4号、D&C红色17号、D&C红色33号、D&C紫色2号、D&C黄色10号和D&C黄色11号)、吸附剂、润滑剂、溶剂、保湿剂(包括例如润肤剂、湿润剂、成膜剂、封闭剂和影响皮肤天然保湿机制的试剂)、拒水剂、紫外吸收剂(物理和化学吸收剂,例如对氨基苯甲酸(“PABA”)和相应的PABA衍生物、二氧化钛、氧化锌等)、精油、维生素(例如A、B、C、D、E和K)、微量金属(例如锌、钙和硒)、抗刺激物(例如类固醇和非固醇类抗炎药)、植物提取物(例如芦荟、甘菊、黄瓜提取物、银杏、人参和迷迭香)、抗菌剂、抗氧化剂(例如BHT和生育酚)、螯合剂(例如EDTA二钠和EDTA四钠)、防腐剂(例如对羟基苯甲酸甲酯和对羟基苯甲酸丙酯)、pH调节剂(例如氢氧化钠和柠檬酸)、吸收剂(例如淀粉辛烯琥珀酸铝、高岭土、玉米淀粉、燕麦淀粉、环糊精、滑石和沸石)、皮肤漂白和光亮剂(例如氢醌和烟酰胺乳酸酯)、湿润剂(例如山梨醇、尿素和甘露醇)、磨砂剂、防水剂(例如氢氧化镁/氢氧化铝硬脂酸盐)、皮肤调节剂(例如芦荟提取物、尿囊素、没药醇、神经酰胺、二甲聚硅氧烷、透明质酸和甘草酸二钾)。这些附加成分中一部分的非限制性实例在以下子章节中提供。
a.紫外吸收剂
可以与本发明的组合物组合使用的紫外吸收剂包括化学和物理防晒物质。可以使用的化学防晒物质的非限制性实例包括对氨基苯甲酸(PABA)、PABA酯(PABA甘油酯、戊基二甲醇PABA酯和辛基二甲醇PABA酯)、PABA丁酯、PABA乙酯、乙基二羟基丙醇PABA酯、二苯甲酮(氧苯酮、磺异苯酮、二苯甲酮和二苯甲酮-1至12)、肉桂酸盐/酯(甲氧基肉桂酸辛酯、对甲氧基肉桂酸异戊酯、辛基甲氧基肉桂酸酯、西诺沙酯、二异丙基肉桂酸甲酯、甲氧基肉桂酸DEA盐、二异丙基肉桂酸乙酯、甘油辛酸酯二甲氧基肉桂酸酯和甲氧基肉桂酸乙酯)、肉桂酸酯、水杨酸酯(胡莫柳酯、水杨酸苄酯、乙二醇水杨酸酯、异丙基苄醇水杨酸酯等)、邻氨基苯甲酸盐/酯、尿刊酸乙酯、胡莫柳酯、水杨酸辛酯、二苯甲酰基甲烷衍生物(例如阿伏苯宗)、奥克立林、辛基三嗪酮、棓酰棓酸三油酸酯、氨基苯甲酸甘油酯、散沫花素和二羟基丙酮、乙基己基三嗪酮、二辛基丁酰胺基三嗪酮、苯亚甲基丙二酸酯聚硅氧烷、对苯二亚甲基二莰酮磺酸、苯基二苯并咪唑四磺酸酯二钠、二乙氨基羟基苯甲酰基苯甲酸己酯、双二乙氨基羟基苯甲酰基苯甲酸酯、双苯并噁唑基苯基乙基己基亚氨基三嗪、甲酚曲唑三硅氧烷、亚甲基双苯并三唑基四甲基丁基苯酚和双乙基己基氧苯酚甲氧苯基三嗪、4-甲基苯亚甲基莰酮和4-甲氧基肉桂酸异戊酯。物理防晒物质的非限制性实例包括高岭土、滑石、凡士林和金属氧化物(例如二氧化钛和氧化锌)。
b.保湿剂
可以与本发明的组合物一起使用的保湿剂的非限制性实例包括氨基酸、硫酸软骨素、双甘油、赤藓糖醇、果糖、葡萄糖、甘油、甘油聚合物、乙二醇、1,2,6-己三醇、蜂蜜、透明质酸、氢化蜂蜜、氢化淀粉水解物、肌醇、乳糖醇、麦芽糖醇、麦芽糖、甘露醇、天然保湿因子、PEG-15丁二醇、聚甘油山梨醇、吡咯烷酮羧酸的盐、PCA钾、丙二醇、葡糖醛酸钠、PCA钠、山梨醇、蔗糖、海藻糖、尿素和木糖醇。
其它实例包括乙酰化羊毛脂、乙酰化羊毛脂醇、丙氨酸、藻类提取物、翠叶芦荟、翠叶芦荟提取物、翠叶芦荟凝胶、药蜀葵提取物、杏(prunusarmeniaca)仁油、精氨酸、精氨酸天冬氨酸盐/酯、山金车提取物、天冬氨酸、鳄梨(persea gratissima)油、屏障鞘脂、丁醇、蜂蜡、山萮醇、β-谷甾醇、桦树(betula alba)树皮提取物、琉璃苣(Borago officinalis)提取物、假叶树提取物、丁二醇、金盏花提取物、金盏花油、小烛树(euphorbiacerifera)蜡、菜籽油、辛酸/癸酸甘油三酯、豆蔻(elettaria cardamomum)油、巴西棕榈(copernicia erifera)蜡、胡萝卜(daucus carota sativa)油、蓖麻(ricinus communis)油、神经酰胺、地蜡、鲸蜡硬脂醇聚醚-5、鲸蜡硬脂醇聚醚-12、鲸蜡硬脂醇聚醚-20、鲸蜡硬脂醇辛酸酯、鲸蜡醇聚醚-20、鲸蜡醇聚醚-24、鲸蜡醇乙酸酯、鲸蜡醇辛酸酯、鲸蜡醇棕榈酸酯、洋甘菊(anthemis nobilis)油、胆固醇、胆固醇酯、胆甾醇羟基硬脂酸酯、柠檬酸、鼠尾草(salvia sclarea)油、可可(theobroma cacao)脂、椰油醇-辛酸酯/癸酸酯、椰子(cocos nucifera)油、胶原蛋白、胶原蛋白氨基酸、玉米(zeamays)油、脂肪酸、癸基油酸酯、二甲聚硅氧烷共聚醇、二甲聚硅氧烷醇、己二酸二辛酯、琥珀酸二辛酯、二聚季戊四醇六辛酸酯/六癸酸酯、DNA、赤藓糖醇、乙氧基二乙二醇、亚油酸乙酯、蓝桉油、月见草(oenothera biennis)油、脂肪酸、斑点老鹳草油、葡萄糖胺、葡糖谷氨酸酯、谷氨酸、甘油聚醚-26、甘油、丙三醇、二硬脂酸甘油酯、羟基硬脂酸甘油酯、月桂酸甘油酯、亚油酸甘油酯、豆蔻酸甘油酯、油酸甘油酯、硬脂酸甘油酯、硬脂酸甘油酯SE、甘氨酸、乙二醇硬酯酸酯、乙二醇硬酯酸酯SE、葡糖氨基葡聚糖、葡萄(vitis vinifera)籽油、美洲榛(corylus americana)坚果油、欧洲榛(corylus avellana)坚果油、己二醇、透明质酸、混合红花(carthamustinctorius)油、氢化蓖麻油、氢化椰油酸甘油酯、氢化椰子油、氢化羊毛脂、氢化卵磷脂、氢化棕榈油甘油酯、氢化棕榈仁油、氢化大豆油、氢化牛脂酸甘油酯、氢化植物油、水解胶原蛋白、水解弹性蛋白、水解葡糖氨基葡聚糖、水解角蛋白、水解大豆蛋白、羟基化羊毛脂、羟基脯氨酸、硬脂酸异鲸蜡醇酯、异鲸蜡醇硬脂酰基硬脂酸酯、油酸异癸酯、异硬脂酸异丙酯、羊毛脂酸异丙酯、肉豆蔻酸异丙酯、棕榈酸异丙酯、硬脂酸异丙酯、异硬脂酰胺DEA、异硬脂酸、异硬脂醇乳酸酯、异硬脂醇新戊酸酯、茉莉(jasminum officinale)油、霍霍巴(buxus chinensis)油、巨藻、石栗(aleuritesmoluccana)坚果油、乳酰胺MEA、羊毛脂醇聚醚-16、羊毛脂醇聚醚-10乙酸酯、羊毛脂、羊毛脂酸、羊毛脂醇、羊毛脂油、羊毛脂蜡、薰衣草(lavandula angustifolia)油、卵磷脂、柠檬(citrus medica limonum)油、亚油酸、亚麻酸、澳洲坚果油、麦芽糖醇、洋甘菊(chamomilla recutita)油、甲基葡糖倍半硬脂酸酯、甲基硅烷醇PCA、矿物油、貂油、被孢霉油、肉豆蔻醇乳酸酯、肉豆蔻醇肉豆蔻酸酯、肉豆蔻醇丙酸酯、新戊二醇二辛酸酯/二癸酸酯、辛基月桂醇、辛基月桂醇肉豆蔻酸酯、辛基月桂醇硬脂酰基硬脂酸酯、羟基硬脂酸辛酯、棕榈酸辛酯、水杨酸辛酯、硬脂酸辛酯、油酸、橄榄(olea europaea)油、橙(citrus aurantium dulcis)油、棕榈(elaeisguineensis)油、棕榈酸、泛硫乙胺、泛醇、泛醇基乙基醚、石蜡、PCA、桃(prunus persica)仁油、花生(arachis hypogaea)油、PEG-8C12-18酯、PEG-15椰油烷基胺、PEG-150二硬脂酸酯、PEG-60甘油异硬脂酸酯、PEG-5甘油硬脂酸酯、PEG-30甘油硬脂酸酯、PEG-7氢化蓖麻油、PEG-40氢化蓖麻油、PEG-60氢化蓖麻油、PEG-20甲基葡糖倍半硬脂酸酯、PEG40失水山梨醇全油酸酯、PEG-5大豆甾醇、PEG-10大豆甾醇、PEG-2硬脂酸酯、PEG-8硬脂酸酯、PEG-20硬脂酸酯、PEG-32硬脂酸酯、PEG-40硬脂酸酯、PEG-50硬脂酸酯、PEG-100硬脂酸酯、PEG-150硬脂酸酯、十五酸内酯、薄荷(mentha piperita)油、凡士林、磷脂、多氨基酸多糖缩合物、聚甘油-3-二异硬脂酸酯、聚季铵盐-24、聚山梨醇酯20、聚山梨醇酯40、聚山梨醇酯60、聚山梨醇酯80、聚山梨醇酯85、肉豆蔻酸钾、棕榈酸钾、丙二醇、丙二醇二辛酸酯/二癸酸酯、丙二醇二辛酸酯、丙二醇二壬酸酯、丙二醇月桂酸酯、丙二醇硬脂酸酯、丙二醇硬脂酸酯SE、PVP、吡哆醇二棕榈酸酯、视黄醇、视黄醇棕榈酸酯、米(oryza sativa)糠油、RNA、迷迭香(rosmarinusofficinalis)油、玫瑰油、红花(carthamus tinctorius)油、鼠尾草(salviaofficinalis)油、檀香(santalum album)油、丝氨酸、血清蛋白、芝麻(sesamumindicum)油、牛油果(butyrospermum parkii)脂、蚕丝粉、软骨素硫酸钠、透明质酸钠、乳酸钠、棕榈酸钠、PCA钠、聚谷氨酸钠、可溶胶原、月桂酸失水山梨醇酯、油酸失水山梨醇酯、棕榈酸失水山梨醇酯、倍半油酸失水山梨醇酯、硬脂酸失水山梨醇酯、山梨醇、大豆(glycine soja)油、鞘脂、角鲨烷、角鲨烯、硬脂酰胺MEA-硬脂酸酯、硬脂酸、硬脂氧基二甲聚硅氧烷、硬脂氧基三甲基硅烷、硬脂醇、甘草亭酸硬脂醇酯、庚酸硬脂醇酯、硬脂酸硬脂醇酯、向日葵(helianthus annuus)籽油、甜杏仁(prunus amygdalusdulcis)油、合成蜂蜡、生育酚、乙酸生育酚酯、油酸生育酚亚酯、三山嵛精、新戊酸十三烷醇酯、硬脂酸十三烷醇酯、三乙醇胺、三硬脂酸精、尿素、植物油、水、蜡、小麦(triticum vulgare)胚芽油和依兰(cananga odorata)油。
c.抗氧化剂
可以与本发明的组合物一起使用的抗氧化剂的非限制性实例包括乙酰半胱氨酸、抗坏血酸多肽、抗坏血酸二棕榈酸酯、抗坏血酸甲基硅烷醇果胶酸酯、抗坏血酸棕榈酸酯、抗坏血酸硬脂酸酯、BHA、BHT、叔丁基氢醌、半胱氨酸、半胱氨酸HCI、二戊基氢醌、二叔丁基氢醌、硫代二丙酸二鲸蜡醇酯、二油基生育酚甲基硅烷醇、抗坏血酸硫酸酯二钠、硫代二丙酸二硬脂醇酯、硫代二丙酸双十三烷醇酯、没食子酸月桂酯、异抗坏血酸、抗坏血酸酯、阿魏酸乙酯、阿魏酸、没食子酸酯、氢醌、巯基乙酸异辛酯、曲酸、抗坏血酸镁、抗坏血酸磷酸酯镁、甲基硅烷醇抗坏血酸酯、天然植物抗氧化剂例如绿茶或葡萄籽提取物、去甲二氢愈创木酸、没食子酸辛酯、苯巯基乙酸、磷酸抗坏血酸酯生育酚酯钾、亚硫酸钾、没食子酸丙酯、醌、迷迭香酸、抗坏血酸钠、亚硫酸氢钠、异抗坏血酸钠、偏亚硫酸氢钠、亚硫酸钠、超氧化物歧化酶、巯基乙酸钠、山梨醇缩糠醛、硫二甘醇、亚硫基二乙酰胺、硫二乙酸、巯基乙酸、硫代乳酸、硫代水杨酸、生育酚聚醚-5、生育酚聚醚-10、生育酚聚醚-12、生育酚聚醚-18、生育酚聚醚-50、生育酚、托可索伦、乙酸生育酚酯、生育酚亚油酸酯、生育酚烟酸酯、生育酚琥珀酸酯和三(壬基酚)亚磷酸酯。
d.结构化剂
在其它非限制性方面,本发明的组合物可以包含结构化剂。在特定的方面,结构化剂帮助为组合物提供流变学特征以有助于组合物的稳定性。在其它方面,结构化剂还可以起乳化剂或表面活性剂的作用。结构化剂的非限制性实例包括硬脂酸、棕榈酸、硬脂醇、鲸蜡醇、山嵛醇、硬脂酸、棕榈酸、具有平均约1到约21个亚乙基氧单元的硬脂醇的聚乙二醇醚、具有平均约1到约5个亚乙基氧单元的鲸蜡醇的聚乙二醇醚及其混合物。
e.乳化剂
在本发明的特定方面,组合物不包含乳化剂。然而,在其它方面,组合物可以包含一种或更多种乳化剂。乳化剂可以降低相间的表面张力并改善乳剂的剂型和稳定性。乳化剂可以是非离子的、阳离子的、阴离子的和两性离子的乳化剂(参见McCutcheon's(1986);美国专利5011681号;4421769号;3755560号)。非限制性实例包括甘油酯、丙二醇酯、丙二醇的脂肪酸酯、聚丙二醇的脂肪酸酯、山梨醇的酯、失水山梨醇酐酯、羧酸共聚物、葡萄糖的酯和醚、乙氧基化的酯、乙氧基化的醇、磷酸烷基酯、聚氧乙烯脂肪醚磷酸酯、脂肪酸酰胺、酰基乳酸酯、脂肪酸盐、TEA硬脂酸酯、DEA油醇聚氧乙烯-3-醚磷酸酯、聚乙二醇20失水山梨醇单月桂酸酯(聚山梨醇酯20)、聚乙二醇5大豆甾醇、硬脂醇聚醚-2、硬脂醇聚醚-20、硬脂醇聚醚-21、鲸蜡硬脂醇聚醚-20、PPG-2甲基葡萄糖醚二硬脂酸酯、鲸蜡醇聚醚-10、聚山梨醇酯80、鲸蜡醇磷酸酯、鲸蜡醇磷酸酯钾、二乙醇胺鲸蜡醇磷酸酯、聚山梨醇酯60、硬脂酸甘油酯、PEG-100硬脂酸酯及其混合物。
f.含有硅酮的化合物
在非限制性方面,含硅酮的化合物包括分子主链由侧基连接至硅原子的交替的硅和氧原子组成的聚合产物家族中的任何成员。通过改变-Si-O-链的长度、侧基和交联,硅酮可以合成为各种各样的材料。它们的稠度可以从液体到凝胶到固体变化。
可以在本发明的上下文中使用的含硅酮的化合物包括在本说明书中所描述的那些或本领域普通技术人员已知的那些。非限制性实例包括硅油(例如挥发性和非挥发性油)、凝胶和固体。在特定的方面,含硅酮的化合物包括硅油,例如聚有机硅氧烷。聚有机硅氧烷的非限制性实例包括二甲聚硅氧烷、环聚二甲基硅氧烷、聚硅酮-11、苯基聚三甲基硅氧烷、聚三甲基硅氨基二甲聚硅氧烷、硬脂氧基三甲基硅烷或它们的混合物和其它任何给定比例的有机硅氧烷材料,以根据预期的应用(例如,对特定区域如皮肤、毛发或眼睛)达到期望的稠度和应用特征。“挥发性硅油”包括具有低气化热的硅油,即通常低于约50卡每克硅油。挥发性硅油的非限制性实例包括:环聚二甲基硅氧烷,例如道康宁344流体、道康宁345流体、道康宁244流体和道康宁245流体、挥发性硅7207(Union Carbide Corp.,Danbury,康涅狄格州);低粘度二甲聚硅氧烷,即粘度大约为50cst或更低的二甲聚硅氧烷(举例来说,二甲聚硅氧烷,例如道康宁200-0.5cst流体)。道康宁流体可以从密歇根州米德兰的Dow Corning Corporation购得。在CTFA化妆品成分词典的第三版中(通过引用并入本文),环聚二甲基硅氧烷和二甲聚硅氧烷分别被描述为环状二甲基聚硅氧烷化合物和用三甲基硅氧基单元封端的完全甲基化的线性硅氧烷混合物。可以在本发明的上下文中使用的其它非限制性挥发性硅油包括从纽约州沃特福德的通用电气公司有机硅产品分部和密歇根州艾德里安的Stauffer Chemical Co.的SWS有机硅分部购得的那些。
g.精油
精油包括来自药草、花、树木和其它植物的油。这类油一般在植物细胞间以微小的液滴存在,并可以用本领域技术人员已知的几种方法进行提取(例如,蒸气蒸馏、花香提取(即使用脂肪提取)、浸渍、溶剂提取或机械压榨)。当这些类型的油暴露于空气时,其趋于挥发(即挥发性油)。因此,虽然许多精油是无色的,但是随着时间它们可以被氧化并且颜色变得更深。精油不溶于水,但溶于醇、醚、固定油(植物的)和其它有机溶剂。在精油中发现的一般物理特征包括从约160℃到240℃变化的沸点和从约0.759到约1.096的密度。
精油一般通过油被发现的来源植物命名。例如,玫瑰油或薄荷油分别来自玫瑰或薄荷植物。可以在本发明的上下文中使用的精油的非限制性实例包括芝麻油、澳洲坚果油、茶树油、月见草油、西班牙鼠尾草油、西班牙迷迭香油、芫荽油、百里香油、众香果油、玫瑰油、大茴香油、凤仙花油、香柠檬油、玫瑰木油、香柏油、甘菊油、鼠尾草油、香紫苏油、丁香油、柏木油、桉油、茴香油、海茴香油、乳香油、香叶油、姜油、葡萄柚油、茉莉油、杜松子油、薰衣草油、柠檬油、柠檬草油、梨莓油、橘子油、甘牛至油、没药油、苦橙花油、橙油、绿叶油、胡椒油、黑胡椒油、苦橙叶油、松油、奥图玫瑰油、迷迭香油、檀香油、绿薄荷油、甘松油、香根草油、冬青油、依兰依兰。还预期本领域技术人员已知的其它精油在本发明的上下文中是有用的。
h.增稠剂
包括增稠剂或凝胶剂在内的增稠剂,包括可以增加组合物黏度的物质。增稠剂包括可以增加组合物黏度而基本上不改变组合物内活性成分功效的那些。增稠剂还可以增加本发明的组合物的稳定性。在本发明的特定方面,增稠剂包括氢化聚异丁烯或三羟基硬脂酸甘油酯,或两者的混合物。
可以在本发明的上下文中使用的另外的增稠剂的非限制性实例包括羧酸聚合物、交联的聚丙烯酸酯聚合物、聚丙烯酰胺聚合物、多糖和胶。羧酸聚合物的实例包括含有一种或更多种衍生自丙烯酸、取代的丙烯酸和这些丙烯酸和取代的丙烯酸的盐和酯的单体的交联化合物,其中所述交联剂含有两个或更多个碳-碳双键,并衍生自多元醇(参见美国专利5,087,445号;4,509,949号;2,798,053号;CTFA国际化妆品成分词典,第四版,1991,第12和80页)。市售羧酸聚合物的实例包括卡波姆,其为与蔗糖或季戊四醇的烯丙基醚交联的丙烯酸的均聚物(例如,购自B.F.Goodrich的CarbopolTM900系列)。
交联的聚丙烯酸酯聚合物的非限制性实例包括阳离子型和非离子型聚合物。在美国专利第5100660号;4849484号;4835206号;4628078号;4599379号中描述了实例。
聚丙烯酰胺聚合物(包括非离子的聚丙烯酰胺聚合物,其包括取代的支链的或无支链的聚合物)的非限制性实例包括聚丙烯酰胺、异构烷烃和月桂醇聚氧乙烯(7)醚、丙烯酰胺与被丙烯酸和经取代的丙烯酸取代的丙烯酰胺的多嵌段共聚物。
多糖的非限制性实例包括纤维素、羧甲基羟乙基纤维素、乙酸丙酸羧酸纤维素、羟乙基纤维素、羟乙基乙基纤维素、羟丙基纤维素、羟丙基甲基纤维素、甲基羟乙基纤维素、微晶纤维素、纤维素硫酸钠及其混合物。另一个实例为烷基取代的纤维素,其中纤维素聚合物的羟基被羟烷基化(优选地羟乙基化或羟丙基化)以形成羟烷基化的纤维素,得到的羟烷基化的纤维素然后用C10-C30直链或支链烷基基团通过醚键进行进一步修饰。一般这些聚合物为C10-C30直链或支链醇与羟烷基纤维素的醚。其它有用的多糖包括硬葡聚糖类,其包含每三个单元具有一个(1-6)连接的葡萄糖的(1-3)连接的葡萄糖单元的直链。
本发明可以使用的胶的非限制性实例包括阿拉伯树胶、琼脂、藻胶、藻酸、藻酸铵、支化淀粉、藻酸钙、角叉菜胶钙、肉毒碱、角叉菜胶、糊精、明胶、结冷胶、瓜尔豆胶、瓜尔胶羟丙基三甲基氯化铵、锂蒙脱石、透明质酸、水合二氧化硅、羟丙基壳聚糖、羟丙基瓜尔胶、卡拉亚胶、巨藻、角豆胶、纳豆胶、藻酸钾、角叉菜胶钾、藻酸丙二醇酯、菌核胶、羧甲基葡聚糖钠、角叉菜胶钠、黄蓍胶、黄原胶及其混合物。
i.防腐剂
在本发明的上下文中可以使用的防腐剂的非限制性实例包括季铵盐防腐剂如聚季铵盐-1和苄烷铵卤化物(例如苯扎氯铵(“BAC”)和苯扎溴铵)、对羟基苯甲酸酯类(例如对羟基苯甲酸甲酯和对羟基苯甲酸丙酯)、苯氧乙醇、苄醇、氯丁醇、苯酚、山梨酸、硫汞撒或其组合。
2.药物成分
还预期药物活性成分对本发明的组合物是有用的。药物活性剂的非限制性实例包括抗粉刺剂、用于处理酒渣鼻的试剂、止痛剂、麻醉剂、肛门直肠的、抗组胺药、包括非甾族消炎药在内的消炎剂、抗生素、抗真菌剂、抗病毒剂、抗微生物剂、抗癌活性物、抗疥螨剂、灭虱剂、抗肿瘤药、防汗药、止痒剂、抗牛皮癣剂、抗脂溢剂、生物活性蛋白质和多肽、烧伤处理剂、烧灼剂、脱色剂、脱毛剂、尿布疹处理剂、酶、毛发生长刺激剂、包括DFMO及其盐和类似物在内的毛发生长抑制剂、止血剂、角质分离剂、口疮处理剂、唇疱疹处理剂、牙科或牙周处理剂、光敏感活性物、皮肤保护剂/屏障剂、包括激素和皮质类固醇的类固醇、晒伤处理剂、遮光剂、经皮活性物、鼻活性物、阴道活性物、疣处理剂、创伤处理剂、创伤愈合剂等。
E.试剂盒
还预期试剂盒用于本发明的特定方面。例如,本发明的组合物可以包含在试剂盒内。试剂盒可以包括容器。容器可以包括瓶子、金属管、层压管、塑料管、分配器、加压容器、阻隔容器、包装、隔室、口红容器、压缩容器、能够保存化妆品组合物的化妆品盘或其它类型的容器如注射或吹塑成型的塑料容器,向其中保存分散体或组合物或期望的瓶子、分配器或包装。试剂盒和/或容器在其表面可包含标记。举例来说,标记可以是单词、短语、缩写、图片或符号。
所述容器可以分配预定量的组合物。在其他实施方案中,可以挤压容器(例如金属管、层压管或塑料管)以分配期望量的组合物。组合物可以作为喷雾、气溶胶、液体、流体或半固体来分配。容器可以具有喷雾、抽吸或挤压机构。试剂盒还可以包含使用试剂盒组分以及使用包含于容器内的任何其他组合物的说明书。说明书可以包含如何施用、使用和保存组合物的解释。
实施例
列出以下实施例以说明本发明的一些非限制性方面。本领域技术人员应理解,以下实施例中所公开的技术代表本发明人发现的在本发明的实践中发挥良好作用的技术。然而,根据本公开,本领域技术人员应理解,在所公开的具体实施方案中可以做出许多改变,并仍然获得相同或相似的结果,而不脱离本发明的精神和范围。
实施例1
(成分的功效)
促炎性细胞因子的抑制
利用MesoScale Discovery SECTOR成像仪2400发现水解藻胶在主要的成年人角质细胞(Cascade#C-005-5C)中抑制各种促炎性细胞因子的生成。使用成像仪2400检测并计算在样品中存在的选定的促炎性细胞因子的量。表1是这些数据的汇总。
表1*
促炎性细胞因子 | 与对照相比的变化%** |
TNF-α | -37 |
IL-6 | -70 |
IL-8 | -33 |
IL-10 | -40 |
IL-12 p40 | -32 |
GM-CSF | -28 |
*使用了1%水解藻胶并且其是从Barnet Products Corporation以商品名Phyko-Al-PF获得。
**所使用的对照是0.5%DMSO。与对照相比的变化%=促炎性细胞因子%-对照的促炎性细胞因子%。因此,负值(-)表明黑色素生成的抑制。
用于获得表1数据的程序包括以下步骤:
细胞培养–HEKa:在3xT75组织培养瓶中(37℃,5%CO2)使HEKa细胞从冷冻瓶中生长至亚融合(subconfluence)。用HBSS洗涤融合的T75s(P1-P3),然后在37℃用1.5ml胰蛋白酶消化约4分钟。将细胞收集在4ml TNS中,然后在15ml锥形管中离心并重悬于Epilife培养基,再接种在6孔板中。将测试化合物在培养基+10ng/ml PMA中稀释至1%和0.1%。达到85%融合后,洗涤细胞并用2ml经稀释的测试化合物代替培养基4至6小时(37℃,5%CO2)。从每个孔收集2ml培养基,分装,并在-80℃冷冻直至用前胶原肽试剂盒(PIP)分析。从细胞去除所有培养基,并将1mL经稀释的MTS试剂添加至每个孔,孵育15至30分钟(37℃,5%CO2),在490nm读板。
步骤1:在用于分析之前样品可以不需要稀释。使合适的稀释液和板达到室温并在冰上解冻细胞因子校准品。在4℃下储存检测抗体混合物,避光。准备校准品溶液和校准曲线(如果适用的话)。使用1μg/mL校准品原液来制备10000pg/mL、2500pg/mL、625pg/mL、156pg/mL、39pg/mL、9.8pg/mL、2.4pg/mL、和0pg/mL的8点校准曲线。必要时可以修改校准曲线以满足具体的分析要求。通过将检测抗体在3.0mLHSC.抗体稀释液(每板)(血清/血浆样品)或抗体稀释液(组织培养样品)中稀释至1μg/mL来制备检测抗体溶液。在黑暗中保存该试剂。通过用去离子水以1:2稀释4倍的读数缓冲液T来制备25mL的2倍读数缓冲液T。使用以下合适的方案继续分析。
步骤2:对于利用IFN-γ的MULTI-SPOT分析,以150μL/孔分配1%封闭剂B溶液。对于利用IL-12p40的MULTI-SPOT分析,以150μL/孔分配0.1%封闭剂B溶液。在剧烈摇晃(300-1000rpm)下于室温孵育1小时。用PBS或其他标准缓冲液洗涤板3次。以25μL/孔分配校准品或样品。在剧烈摇晃(300-1000rpm)下于室温孵育1至2小时。
步骤3:以25μL/孔分配1μg/mL的检测抗体溶液。在剧烈摇晃(300-1000rpm)下于室温孵育1至2小时。
步骤4:用PBS-0.05%吐温-20洗涤板3次。以150μL/孔分配2倍读数缓冲液T。在SECTOR成像仪2400上分析板。
CGRP生成的抑制
发现水解藻胶抑制人类表皮角质细胞的CGRP生成。该分析的终点是通过Meso Scale Discovery系统SECTOR 2400成像仪分析的直接检测阵列。使用成像仪2400检测并计算在样品中存在的CGRP的量。使用与上述促炎性细胞因子的抑制分析中所使用的相似的程序发现1%水解藻胶混合物抑制在主要的成年人角质细胞(Cascade#C-005-5C)中CGRP的生成。可见比对照高65.70%的平均抑制。
抗氧化性质
利用氧自由基吸收能力(ORAC)分析(Zen-Bio ORAC抗氧化分析试剂盒(#AOX-2))发现七叶皂苷、假叶树根提取物、积雪草提取物、水解酵母蛋白、金盏花花提取物、和甘草酸铵的混合物具有抗氧化性质。该分析测量了由于通过AAPH(2,2'-偶氮二-2-甲基丙基咪二盐酸盐)分解而形成过氧化氢-自由基的随时间的荧光素荧光的损失。Trolox是一种水溶性维生素E类似物,用作阳性对照,其以剂量依赖的方式抑制荧光素衰减。表2是这些数据的汇总。
表2*
混合物量 | 好于100μM Trolox的% | 好于未处理的% |
0.1% | 201.31 | 276.21 |
0.01% | 48.69 | 136.31 |
0.001% | -73.80 | 24.02 |
*所使用的七叶皂苷、假叶树根提取物、积雪草提取物、水解酵母蛋白、金盏花花提取物、和甘草酸铵的混合物是BiophytexTMLS 9832,其可以从BASF Care Creations获得。
用于获得表2中的数据的程序包括以下步骤:
步骤1:将酶标仪孵育室加温至37℃。设置酶标仪以执行以1分钟间隔的动态读取30分钟。激发=480nm;发射=520nm。
步骤2:从通过转移16.8ml分析缓冲液至空试管(未提供)并添加1.2ml储存荧光素溶液所提供的储液制备荧光素工作溶液。混合并避光。
步骤3:按以下步骤制备Trolox标准品:在解冻后短暂旋转下1.5mMTrolox标准品试管的内容物。用移液器移取580μl分析缓冲液到所提供的1.5mM Trolox标准品试管中并通过涡旋充分混合。这产生50M经稀释的储存Trolox标准品。用移液器移取50μl分析缓冲液到6个管中。使用新稀释的储存Trolox溶液,制备稀释液系列。在进行下一步骤前充分混合每个新的稀释液。50M储存稀释液用作最高的标准品,而分析缓冲液用作零标准品。
步骤4:将150μl工作荧光素溶液添加至所提供分析板的每个孔。
步骤5:将25μl样品或Trolox标准品添加至所提供分析板的单个孔,添加25μl分析缓冲液至单个孔作为阴性对照。将板在37℃放置至少5分钟。
步骤6:在将分析板平衡至37℃时,通过添加2.7ml分析缓冲液至所提供的管并温和颠倒来制备AAPH工作溶液。将工作溶液放置在冰上直至需要时。如果保存在冰上,AAPH溶液在8小时是有效的。
步骤7:为了开始分析,将25μl的AAPH工作溶液添加至来自步骤5的每一个含有标准品和样品的孔。将分析板放置在酶标仪中并开始动态荧光读取。
实施例2
(制剂)
将具有来自实施例1的成分的制剂制备为爽肤水/化妆水(表3)、面膜(表4)和凝胶(表5和表6)。
表3*
成分 | %浓度(以重量计) |
水 | 88 |
丁二醇 | 6 |
甘油 | 4.5 |
丙二醇 | 0.56 |
重氮烷基脲 | 0.3 |
PPG-5-鲸蜡醇聚醚-20 | 0.17 |
对羟基苯甲酸甲酯 | 0.11 |
柠檬酸钠 | 0.07 |
乙二胺四乙酸二钠 | 0.05 |
丁醇聚醚-3 | 0.04 |
对羟基苯甲酸丙酯 | 0.03 |
柠檬酸 | 0.02 |
苯并三唑基丁基酚磺酸钠 | 0.02 |
泛醇 | 0.01 |
水解藻胶 | 0.007 |
七叶皂苷 | 0.003 |
假叶树根提取物 | 0.0015 |
甘草酸铵 | 0.001 |
积雪草提取物 | 0.00065 |
水解酵母蛋白 | 0.0004 |
金盏花花提取物 | 0.00035 |
赋形剂** | 适量 |
*制剂可以通过在70至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到长期的室温(20至25℃)。
**添加赋形剂以改变组合物的流变性能。或者,可以改变水的量,只要组合物中水的量为至少80重量%,优选80重量%至重量90%。
表4*
成分 | %浓度(以重量计) |
水 | 84 |
戊二醇 | 5 |
聚硅氧烷-11 | 2.9 |
丙烯酸羟乙酯/丙烯酰基二甲基牛磺酸钠共聚物 | 1.9 |
二甲聚硅氧烷 | 1.4 |
角鲨烷 | 1.3 |
十一碳烯酸甘油酯 | 1 |
二氧化硅 | 0.5 |
丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物 | 0.45 |
丁二醇 | 0.35 |
三乙醇胺 | 0.35 |
聚山梨醇酯60 | 0.28 |
羟丙基环糊精 | 0.08 |
异硬脂酸失水山梨醇酯 | 0.08 |
泛醇 | 0.05 |
水解藻胶 | 0.035 |
甘油 | 0.03 |
七叶皂苷 | 0.015 |
假叶树根提取物 | 0.0075 |
甘草酸铵 | 0.005 |
积雪草提取物 | 0.00325 |
水解酵母蛋白 | 0.002 |
金盏花花提取物 | 0.00175 |
赋形剂** | 适量 |
*制剂可以通过在70至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到长期的室温(20至25℃)。
**添加赋形剂以改变组合物的流变性能。或者,可以改变水的量,只要组合物中水的量为至少80重量%,优选80重量%至90重量%。
表5*
成分 | %浓度(以重量计) |
水 | 86 |
甘油 | 5.4 |
戊二醇 | 4 |
甘油聚醚-26 | 2 |
丙二醇 | 0.56 |
三乙醇胺 | 0.55 |
丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物 | 0.3 |
重氮烷基脲 | 0.3 |
羟乙基纤维素 | 0.2 |
聚丙烯酸钠 | 0.15 |
对羟基苯甲酸甲酯 | 0.11 |
乙二胺四乙酸二钠 | 0.1 |
丁二醇 | 0.07 |
苯氧乙醇 | 0.05 |
辛二醇 | 0.05 |
对羟基苯甲酸丙酯 | 0.03 |
泛醇 | 0.01 |
水解藻胶 | 0.007 |
七叶皂苷 | 0.003 |
假叶树根提取物 | 0.0015 |
甘草酸铵 | 0.001 |
积雪草提取物 | 0.00065 |
水解酵母蛋白 | 0.0004 |
金盏花花提取物 | 0.00035 |
赋形剂** | 适量 |
*制剂可以通过在70至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到长期的室温(20至25℃)。
**添加赋形剂以改变组合物的流变性能。或者,可以改变水的量,只要组合物中水的量为至少80重量%,优选80重量%至90重量%。
表6*
成分 | %浓度(以重量计) |
水 | 86 |
甘油 | 5.4 |
戊二醇 | 4 |
甘油聚醚-26 | 2 |
苯甲醇 | 0.9 |
三乙醇胺 | 0.55 |
丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物 | 0.3 |
羟乙基纤维素 | 0.2 |
聚丙烯酸钠 | 0.15 |
乙二胺四乙酸二钠 | 0.1 |
羟丙基环糊精 | 0.08 |
丁二醇 | 0.07 |
苯氧乙醇 | 0.05 |
辛二醇 | 0.05 |
泛醇 | 0.01 |
水解藻胶 | 0.007 |
七叶皂苷 | 0.003 |
假叶树根提取物 | 0.0015 |
甘草酸铵 | 0.001 |
积雪草提取物 | 0.00065 |
水解酵母蛋白 | 0.0004 |
金盏花花提取物 | 0.00035 |
赋形剂** | 适量 |
*制剂可以通过在70至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到长期的室温(20至25℃)。
**添加赋形剂以改变组合物的流变性能。或者,可以改变水的量,只要组合物中水的量为至少80重量%,优选80重量%至90重量%。
本说明书中所公开和要求保护的所有皮肤活性成分、组合物或方法根据本公开不需要过度的实验即可实现和执行。尽管已经以具体实施方案的方式描述了本发明的皮肤活性成分、组合物或方法,但是对于本领域技术人员明显的是,在不脱离本发明的概念、精神和范围情况下,可以对所述皮肤活性成分、组合物或方法以及在本文所描述方法的步骤或步骤的顺序中实施变化。
Claims (22)
1.一种包含有效量的水解藻胶、七叶皂苷、假叶树根提取物、甘草酸铵、积雪草提取物、水解酵母蛋白、和金盏花花提取物的局部皮肤用组合物,其中所述组合物能够减少皮肤细胞中的细胞因子生成和减少皮肤细胞中的氧化性损伤。
2.权利要求1所述的局部皮肤用组合物,其还包含80重量%至90重量%的水。
3.权利要求2所述的局部皮肤用组合物,其包含0.005重量%至0.05重量%的水解藻胶。
4.权利要求3所述的局部皮肤用组合物,其包含0.001重量%至0.05重量%的七叶皂苷、0.001重量%至0.01重量%的假叶树根提取物、0.001重量%至0.01重量%的甘草酸铵、0.0005重量%至0.005重量%的积雪草提取物、0.0003重量%至0.003重量%的水解酵母蛋白、和0.0003重量%至0.003重量%的金盏花花提取物。
5.权利要求3所述的局部皮肤用组合物,其还包含仙人果果提取物。
6.权利要求1所述的局部皮肤用组合物,其中所述组合物还包含:
丁二醇;
甘油;
丙二醇;
重氮烷基脲;
PPG-5-鲸蜡醇聚醚-20;
对羟基苯甲酸甲酯;
柠檬酸钠;
EDTA二钠;
丁醇聚醚-3;
对羟基苯甲酸丙酯;
柠檬酸;
苯并三唑基丁基酚磺酸钠;和
泛醇。
7.权利要求6所述的局部皮肤用组合物,其中所述组合物包含:
5重量%至7重量%的丁二醇;
3重量%至5重量%的甘油;
0.3重量%至0.7重量%的丙二醇;
0.1重量%至0.5重量%的重氮烷基脲;
0.1重量%至0.5重量%的PPG-5-鲸蜡醇聚醚-20;
0.1重量%至0.5重量%的对羟基苯甲酸甲酯;
0.05重量%至0.1重量%的柠檬酸钠;
0.03重量%至0.07重量%的EDTA二钠;
0.03重量%至0.07重量%的丁醇聚醚-3;
0.01重量%至0.05重量%的对羟基苯甲酸丙酯;
0.01重量%至0.05重量%的柠檬酸;
0.01重量%至0.05重量%的苯并三唑基丁基酚磺酸钠;和
0.01重量%至0.05重量%的泛醇。
8.权利要求1所述的局部皮肤用组合物,其中所述组合物还包含:
甘油;
戊二醇;
甘油聚醚-26;
丙二醇;
三乙醇胺;
丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物;
重氮烷基脲;
羟乙基纤维素;
聚丙烯酸钠;
对羟基苯甲酸甲酯;
EDTA二钠;
丁二醇;
苯氧乙醇;
辛二醇;
对羟基苯甲酸丙酯;和
泛醇。
9.权利要求8所述的局部皮肤用组合物,其中所述组合物包含:
3重量%至7重量%的甘油;
3重量%至7重量%的戊二醇;
1重量%至3重量%的甘油聚醚-26;
0.3重量%至0.7重量%的丙二醇;
0.3重量%至0.7重量%的三乙醇胺;
0.1重量%至0.5重量%的丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物;
0.1重量%至0.5重量%的重氮烷基脲;
0.1重量%至0.5重量%的羟乙基纤维素;
0.1重量%至0.5重量%的聚丙烯酸钠;
0.1重量%至0.5重量%的对羟基苯甲酸甲酯;
0.05重量%至0.5重量%的EDTA二钠;
0.05重量%至0.1重量%的丁二醇;
0.03重量%至0.07重量%的苯氧乙醇;
0.03重量%至0.07重量%的辛二醇;
0.01重量%至0.05重量%的对羟基苯甲酸丙酯;和
0.01重量%至0.05重量%的泛醇。
10.权利要求1所述的局部皮肤用组合物,其中所述组合物还包含:
戊二醇;
聚硅氧烷-11;
丙烯酸羟乙酯/丙烯酰基二甲基牛磺酸钠共聚物;
二甲聚硅氧烷;
角鲨烷;
十一碳烯酸甘油酯;
二氧化硅;
丁二醇;
三乙醇胺;
聚山梨醇酯60;
丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物;
羟丙基环糊精;
异硬脂酸失水山梨醇酯;
泛醇;和
甘油。
11.权利要求10所述的局部皮肤用组合物,其中所述组合物包含:
3重量%至7重量%的戊二醇;
1重量%至5重量%的聚硅氧烷-11;
1重量%至5重量%的丙烯酸羟乙酯/丙烯酰基二甲基牛磺酸钠共聚物;
1重量%至3重量%的二甲聚硅氧烷;
1重量%至3重量%的角鲨烷;
0.5重量%至2重量%的十一碳烯酸甘油酯;
0.3重量%至0.7重量%的二氧化硅;
0.1重量%至0.5重量%的丁二醇;
0.1重量%至0.5重量%的三乙醇胺;
0.1重量%至0.5重量%的聚山梨醇酯60;
0.1重量%至0.5重量%的丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物;
0.05重量%至0.1重量%的羟丙基环糊精;
0.05重量%至0.1重量%的异硬酯酸失水山梨醇酯;
0.03重量%至0.07重量%的泛醇;和
0.03重量%至0.07重量%的甘油。
12.权利要求11所述的局部皮肤用组合物,其中所述组合物还包含苯甲醇。
13.权利要求12所述的局部皮肤用组合物,其中所述组合物包含0.1重量%至1重量%的苯甲醇。
14.权利要求1所述的局部皮肤用组合物,其中所述组合物还包含:
甘油;
戊二醇;
甘油聚醚-26;
苯甲醇;
三乙醇胺;
丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物;
羟乙基纤维素;
聚丙烯酸钠;
EDTA二钠;
羟丙基环糊精;
丁二醇;
苯氧乙醇;
辛二醇;和
泛醇。
15.权利要求14所述的局部皮肤用组合物,其中所述组合物包含:
3重量%至7重量%的甘油;
2重量%至5重量%的戊二醇;
1重量%至3重量%的甘油聚醚-26;
0.3重量%至1.5重量%的苯甲醇;
0.1重量%至1.5重量%的三乙醇胺;
0.1重量%至0.7重量%的丙烯酸酯/C10-30烷醇丙烯酸酯交联聚合物;
0.01重量%至1.0重量%的羟乙基纤维素;
0.01重量%至1.0重量%的聚丙烯酸钠;
0.01重量%至1.0重量%的EDTA二钠;
0.01重量%至1.0重量%的羟丙基环糊精;
0.01重量%至1.0重量%的丁二醇;
0.01重量%至1.0重量%的苯氧乙醇;
0.01重量%至0.1重量%的辛二醇;和
0.005重量%至0.1重量%的泛醇。
16.一种减少皮肤细胞中的促炎性细胞因子生成和保护皮肤免受来自自由基的氧化性损伤的方法,其包括将权利要求1所述的组合物局部地施用至有此需要的皮肤,其中所述组合物减少皮肤细胞中的促炎性细胞因子生成并保护皮肤免受来自自由基的氧化性损伤。
17.权利要求16所述的方法,其中所述促炎性细胞因子是TNF-α、IL-6、IL-8、IL-10、IL-12p40、或GM-CSF、或其任意组合或全部。
18.权利要求17所述的方法,其中将所述组合物施用于红斑的、敏感的、或发炎的皮肤。
19.权利要求17所述的方法,其中将所述组合物施用至干燥的、片状的或瘙痒的皮肤。
20.一种减少皮肤细胞中的CGRP生成和保护皮肤免受来自自由基的氧化性损伤的方法,其包括将权利要求1所述的组合物局部地施用至有此需要的皮肤,其中所述组合物减少皮肤细胞中的CGRP生成并保护皮肤免受来自自由基的氧化性损伤。
21.权利要求20所述的方法,其中将所述组合物施用于红斑的、敏感的、或发炎的皮肤。
22.权利要求20所述的方法,其中将所述组合物施用至干燥的、片状的或瘙痒的皮肤。
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CN107184411A (zh) * | 2017-04-21 | 2017-09-22 | 韩后化妆品股份有限公司 | 一种复合水嫩因子、化妆品及化妆品的制备方法 |
CN107157884A (zh) * | 2017-06-04 | 2017-09-15 | 广州珈源日化用品有限公司 | 一种含多种植物提取精华有祛黑眼圈功效的熬夜洁面乳 |
CN107157817A (zh) * | 2017-06-17 | 2017-09-15 | 严贇华 | 一种酵母水 |
CN107998020A (zh) * | 2017-12-18 | 2018-05-08 | 福建省海乐威生物工程有限公司 | 一种具有抗过敏功效的护肤霜 |
CN108853468A (zh) * | 2018-08-10 | 2018-11-23 | 昆明贝泰妮生物科技有限公司 | 一种辅助治疗银屑病的复方制剂及其制备方法 |
CN108853468B (zh) * | 2018-08-10 | 2022-04-26 | 云南贝泰妮生物科技集团股份有限公司 | 一种辅助治疗银屑病的复方制剂及其制备方法 |
CN110721102A (zh) * | 2019-10-29 | 2020-01-24 | 佛山科学技术学院 | 一种具有保湿抗皱抗氧化作用的眼膜 |
CN110623898A (zh) * | 2019-11-01 | 2019-12-31 | 苏州东方之宝生物药业有限公司 | 一种舒敏霜 |
CN115245469A (zh) * | 2021-10-09 | 2022-10-28 | 浙江东印化妆品有限公司 | 一种修复肌肤屏障的组合物及其制备方法 |
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KR101681857B1 (ko) | 2016-12-01 |
US20200330373A1 (en) | 2020-10-22 |
HK1210704A1 (zh) | 2016-05-06 |
US10245282B2 (en) | 2019-04-02 |
US11559480B2 (en) | 2023-01-24 |
US20150147357A1 (en) | 2015-05-28 |
CN105007895B (zh) | 2017-11-17 |
KR20160061902A (ko) | 2016-06-01 |
US20230330007A1 (en) | 2023-10-19 |
US20180085393A1 (en) | 2018-03-29 |
US10736837B2 (en) | 2020-08-11 |
US20190183786A1 (en) | 2019-06-20 |
US11865204B2 (en) | 2024-01-09 |
WO2015077618A1 (en) | 2015-05-28 |
US9801900B2 (en) | 2017-10-31 |
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