CN103284318B - Sublingual cigarette and preparation method thereof - Google Patents
Sublingual cigarette and preparation method thereof Download PDFInfo
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- CN103284318B CN103284318B CN201310245741.1A CN201310245741A CN103284318B CN 103284318 B CN103284318 B CN 103284318B CN 201310245741 A CN201310245741 A CN 201310245741A CN 103284318 B CN103284318 B CN 103284318B
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Abstract
The invention discloses a sublingual cigarette and a preparation method of the sublingual cigarette and belongs to the field of novel tobacco products. The sublingual cigarette comprises, by mass, 0.01%-6% of nicotine, 3%-15% of non-carbonhydrate sweet substances, 5%-35% of sodium alginate, 45%-80% of green bean starch, 3%-8% of calcium sulphate, 0.5%-3% of licorzince, 0.2%-0.8% of vitamin and 0%-0.6 of menthol (or peppermint oil). Compared with existing novel tobacco products, the sublingual cigarette has the advantages that rapid sublingual dissolution can be achieved, onset is fast and no residue exists; the sweetness of the sweet substances is high, the dosage is small, and the cost is saved; the physiological needs of a consumer can be met, and the functions of decayed tooth prevention and oral ulcer can be achieved; elevated blood glucose can not be caused, and the sublingual cigarette is applicable to long-term use of the diabetic population.
Description
Technical field
The present invention relates to novel tobacco arts, specifically a kind of sublingual cigarette and preparation method thereof.
Background technology
Novel tobacco goods, owing to which overcoming the deficiency of conventional tobacco products (comprising cigarette, cigar), can not produce smog during use, the physiology of similar smoking can be provided again to experience simultaneously, therefore worldwide obtain the extensive accreditation of tobacco consumer.
" Si Nasi (Snus) " that Reynolds company of the U.S. popular on European & American Market at present produces is the pouch that the moist tobacco ground is housed, similar tea bag.Pouch can be placed between upper lip and gum by user, obtains the sensation the same with smoking.In India, Gutka is as the chewing tobacco of a kind of drying, portable non-traditional taste, and be subject to the favor of consumers in general, it meets the demand of modern's fast pace life style.
In recent years, domesticly many novel tobacco goods patents of invention are also in succession disclosed.As patent " a kind of buccal tobacco product " (publication number: CN101292776A) and " a kind of Novel buccal cigarette " (publication number: CN102715647A) etc.These inventions add China's novel tobacco goods category quantity, enrich the selection of consumer, but owing to the addition of the glucide of higher proportion in these inventions, as sucrose, honey, fructose, glucose etc., be not suitable for diabetic population Long-Time Service, simultaneously, existing product is buccal, long-term and the oral cavity of this kind of buccal cigarette and tooth close contact, both likely caused canker sore, and also can bring serious carious tooth side effect.
Summary of the invention
The present invention, just for the deficiency of existing novel tobacco goods, has developed a kind of sublingual cigarette.This sublingual cigarette is reformed occupation mode, changes existing buccal into sublingual use.Because human body is sublingual be distributed with more body of gland and blood vessel, thus bioavilability of the present invention is high, rapid-action, and successful is better than containing changing cigarette.Meanwhile, the formula that present invention improves over containing changing cigarette is formed, and with the addition of a certain proportion of non-carbohydrate sweet substance, licorzinc and multivitamin, Long-Time Service has effect of good caries prevention and canker sore.
The object of the invention is to be achieved through the following technical solutions: a kind of sublingual cigarette, it is characterized in that, its component and mass percentage thereof are: nicotine 0.01%-6%, non-carbohydrate sweet substance 3%-15%, sodium alginate 5%-35%, green starch 45%-80%, calcium sulfate 3%-8%, licorzinc 0.5%-3%, vitamin 0.2%-0.8%, menthol (or peppermint oil dementholized) 0-0.6%.
Optimum ratio is: nicotine 0.1%-1.5%, non-carbohydrate sweet substance 3%-15%, sodium alginate 5%-25%, green starch 60%-75%, calcium sulfate 3%-8%, licorzinc 0.5%-1.0%, vitamin 0.2%-0.8%, menthol (or peppermint oil dementholized) 0.3%-0.6%.
Preparation method one: non-carbohydrate sweet substance, sodium alginate, green starch, calcium sulfate, licorzinc and vitamin are mixed, spraying adds water, open mixer granulator and prepare particle, after drying, cross 20 mesh sieves, the enable particle by 20 mesh sieves accounts for 1/3 of total amount, and without the fine powder by 100 mesh sieves; After nicotine and menthol (or peppermint oil dementholized) are dissolved with the ethanol water of 45wt%, be evenly sprayed on the particle for preparing, stir and evenly mix, airtight placements 2-5h, active ingredient is permeated even, use stamping machine tabletted, to obtain final product.
Preparation method two: add water by sodium alginate, add thermal agitation, sodium alginate is dissolved and forms sodium alginate rubber cement; Non-carbohydrate sweet substance, green starch, calcium sulfate, licorzinc and vitamin are mixed, adds sodium alginate rubber cement and make softwood, extrude particle with 14 mesh sieves, use the whole grain of 12 mesh sieve for subsequent use after drying again; After nicotine, menthol (or peppermint oil dementholized) are dissolved with the ethanol water of 70wt%, be evenly sprayed on the particle for preparing, stir and evenly mix, airtight placements 2-5h, active ingredient is permeated even, use stamping machine tabletted, to obtain final product.
Nicotine of the present invention is by commercial acquisition, and its purity requirement is >=98.5%.
Sweet substance of the present invention includes but not limited to stevioside, xylitol, mabinlin, Momordia grosvenori aglycone, glycyrrhizin, trifloroside, perillaldehyde, or their combination.These sweet substances are all the products extracted from natural plants, and sugariness is high, except xylitol sugariness and sucrose quite except, other sugarinesses are generally more than 200 times of sucrose, can cover preferably nicotine produce excitant taste, improve mouthfeel during sublingual administration.Meanwhile, compared with sucrose, honey, glucose, fructose, can not blood sugar level be improved, also there is effect of caries prevention.
The object of sodium alginate of the present invention be make that material fine powder is fully wetting, bonding is so that prepare particle and compressing tablet.Sodium alginate, also known as algin, is a kind of natural polysaccharide, has the stability needed for pharmaceutical adjunct, dissolubility, viscosity and security.Its this characteristic is conducive to material binding forming and improves tablet quality, rapidly dissolvable during consumer's sublingual administration, release nicotine, sweet substance and the composition such as trace element, vitamin.
Green starch Main Function of the present invention increases the weight of tablet and volume is beneficial to its shaping and divided dose.Green starch has higher chemical stability, does not react, do not affect the treatment with main component, harmless, and source is wide, and cost is low.Compared with wheaten starch, farina, after consumption, the speed that the hydrolysis of its carbohydrate digestion forms monose is slow, has the effect controlling blood sugar preferably for green starch, is applicable to diabetic population and uses.
The calcium sulfate that the present invention uses is white, tasteless, odorless powder, and stable in properties, has good moisture resistance, good absorption adhesive ability is had to nicotine, volatile oil, the tablet surface made is bright and clean attractive in appearance, and hardness and disintegration are all good, ideal with the use of effect with green starch.
Licorzinc of the present invention is from the root of Radix Glycyrrhizae, extract the product that the active ingredient that obtains is combined with zinc, in sepia, and slightly sweet taste, good stability.Animal experiment proves, licorzinc has certain protection and the effect of Promotive union to canker sore, and Long-Time Service can not cause the change of major organs trace element in body, also can not cause the accumulation of zinc.
Vitamin of the present invention is Cobastab, folic acid, Cobastab
12, one in vitamin C or its combination.Medical research confirms, as the vitamin of needed by human, the shortage of these vitamins can cause the generation of canker sore.
The invention solves following several respects technical problem: one is improve occupation mode.Existing product is buccal, and the present invention is sublingual use, and successful is better than existing product.Because human body is sublingual be distributed with more body of gland and blood vessel, thus bioavilability of the present invention is high, rapid-action.Two is selections of sweet substance.For reaching the good flavoring effect of tobacco material, existing product with the addition of the glucide of higher proportion, and present invention uses the sweet substance extracted from natural plants, sugariness is high, mouthfeel is good, and blood sugar can not be caused to raise, and is particularly suitable for diabetic population and uses.Three is effects that the present invention has caries prevention.Existing product employs more glucide, for intraoral acetic bacterial such as the Bacillus acidi lactici etc. that causes provides sufficient nutriment, the decalcification of Long-Time Service Hui Shi dental hard tissue, thus formation carious tooth, the sweet substance that the present invention uses can not be caused acetic bacterial metabolism as nutriment and be utilized, and thus has the effect of good caries prevention.Four is effects that the present invention has preventing canker sore.Massive epidemiology statistical confirmation, existing buccal cigarette due to excitant large, Long-Time Service easily causes canker sore, and then brings out the disease such as carcinoma of mouth, cancer of the esophagus.Present invention uses licorzinc and multivitamin, can provide trace element zinc and the vitamin of needed by human body, Long-Time Service has effect of good preventing canker sore.The present invention agrees with modern society public common concern life style and healthy fashion trend, is a kind of novel tobacco goods of applicable all tobacco consumer.
The present invention is compared with existing novel tobacco goods, and its major advantage is: 1) the rapid stripping of sublingual administration, rapid-action, without residue; 2) sweet substance sugariness is high, and consumption is few, saves cost; 3) while meeting consumer's psychological need, there is the effect of caries prevention and canker sore; 4) blood sugar can not be caused to raise, be applicable to diabetic population Long-Time Service.
Detailed description of the invention
The present invention is further described below in conjunction with embodiment, but does not limit the present invention.Except as otherwise noted, be all weight percentage in the embodiment of the present invention.
Embodiment 1:
Composition of raw materials: nicotine 0.3%, green starch 65%, calcium sulfate 5%, sodium alginate 15%, xylitol 10%, stevioside 3%, licorzinc 0.8%, vitamin C 0.3%, menthol 0.6%.
Preparation method: by adding the water of its quality 3 times in sodium alginate, add thermal agitation, makes sodium alginate dissolve formation 25% sodium alginate rubber cement; Green starch, calcium sulfate, xylitol, stevioside, licorzinc and vitamin C are mixed, adds 25% sodium alginate rubber cement and make softwood, extrude particle with 14 mesh sieves, 70-80 DEG C of dry 2h, then use the whole grain of 12 mesh sieve for subsequent use.After nicotine, menthol are dissolved with 70% ethanol, be evenly sprayed on the particle for preparing.Stir and evenly mix, airtight placement 3h, make active ingredient permeate evenly, to prevent from producing sliver phenomenon during compressing tablet.Use stamping machine tabletted, to obtain final product.The every sheet weight of this sublingual cigarette is 280mg.
This sublingual cigarette appearance white, taste is sweet, comfortable taste, and sublingual administration dissolution time is about 3-4min, and can produce rapidly the excitation of similar smoking, strength is moderate, has refrigerant sense.
Embodiment 2:
Composition of raw materials: nicotine 0.4%, green starch 70%, calcium sulfate 4.8%, sodium alginate 10%, xylitol 12%, perillaldehyde 2%, licorzinc 0.5%, Cobastab 0.2%, vitamin C 0.1%.
Preparation method: by green starch, calcium sulfate, sodium alginate, xylitol, perillaldehyde, licorzinc and Cobastab, vitamin C mixing; spraying adds suitable quantity of water; open mixer granulator and prepare particle; granule materials 60 DEG C of dry 2h; cross 20 mesh sieves; the enable particle by 20 mesh sieves accounts for 1/3 of total amount, and without the fine powder by 100 mesh sieves.After nicotine is dissolved with 45% ethanol, be evenly sprayed on the particle for preparing.Stir and evenly mix, airtight placement 3h, active ingredient is permeated evenly, uses stamping machine tabletted, to obtain final product.The every sheet weight of this sublingual cigarette is 270mg.
This sublingual cigarette outward appearance is white, and taste is sweet, comfortable taste, and sublingual administration dissolution time is about 4-5min, and can produce rapidly nicotine excitation, strength is strong.
Embodiment 3:
Composition of raw materials: nicotine 0.2%, green starch 75%, calcium sulfate 4.5%, sodium alginate 10%, Momordia grosvenori aglycone 5%, trifloroside 3%, licorzinc 0.7%, folic acid 0.6%, peppermint oil dementholized 1%.
Preparation method: by adding the water of its quality 3 times in sodium alginate, add thermal agitation, makes sodium alginate dissolve formation 25% sodium alginate rubber cement; Green starch, calcium sulfate, Momordia grosvenori aglycone, trifloroside, licorzinc and folic acid are mixed, adds 25% sodium alginate rubber cement and make softwood, extrude particle with 14 mesh sieves, 70-80 DEG C of dry 2h, then use the whole grain of 12 mesh sieve for subsequent use.After nicotine, peppermint oil dementholized are dissolved with 70% ethanol, be evenly sprayed on the particle for preparing.Stir and evenly mix, airtight placement 3h, active ingredient is permeated evenly.Use stamping machine tabletted, to obtain final product.The every sheet weight of this sublingual cigarette is 300mg.
This sublingual cigarette appearance white, sweet taste is dense, comfortable taste, and sublingual administration dissolution time is about 3-4min, and can produce rapidly the excitation of similar smoking, strength is soft, has refrigerant sense.
Embodiment 4:
Composition of raw materials: nicotine 0.5%, green starch 70%, calcium sulfate 5.5%, sodium alginate 15%, glycyrrhizin 5%, mabinlin 2.5%, licorzinc 0.8%, Cobastab
120.5%, folic acid 0.2%.
Preparation method: by green starch, calcium sulfate, sodium alginate, glycyrrhizin, mabinlin, licorzinc and Cobastab
12, folic acid mixing, spraying adds suitable quantity of water, and open mixer granulator and prepare particle, granule materials 60 DEG C of dry 2h, cross 20 mesh sieves, the enable particle by 20 mesh sieves accounts for 1/3 of total amount, and without by the fine powder of 100 mesh sieves.After nicotine is dissolved with 45% ethanol, be evenly sprayed on the particle for preparing.Stir and evenly mix, airtight placement 3h, active ingredient is permeated evenly, uses stamping machine tabletted, to obtain final product.The every sheet weight of this sublingual cigarette is 230mg.
This sublingual cigarette outward appearance is white, and sweet taste is dense, comfortable taste, and sublingual administration dissolution time is about 4-5min, and can produce rapidly nicotine excitation, strength is strong.
Claims (4)
1. prepare a method for sublingual cigarette, it is characterized in that,
Component and the mass percentage thereof of described sublingual cigarette are: nicotine 0.01%-6%, non-carbohydrate sweet substance 3%-15%, sodium alginate 5%-35%, green starch 45%-80%, calcium sulfate 3%-8%, licorzinc 0.5%-3%, vitamin 0.2%-0.8%, menthol or peppermint oil dementholized 0-0.6%;
Non-carbohydrate sweet substance, sodium alginate, green starch, calcium sulfate, licorzinc and vitamin are mixed, spraying adds water, opens mixer granulator and prepares particle, after drying, cross 20 mesh sieves, the enable particle by 20 mesh sieves accounts for 1/3 of total amount, and without the fine powder by 100 mesh sieves; After being dissolved by the ethanol water of nicotine and menthol or peppermint oil dementholized 45wt%, be evenly sprayed on the particle for preparing, stir and evenly mix, airtight placement 2-5h, uses stamping machine tabletted, to obtain final product.
2. a kind of method preparing sublingual cigarette as claimed in claim 1, is characterized in that,
Component and the mass percentage thereof of described sublingual cigarette are: nicotine 0.1%-1.5%, non-carbohydrate sweet substance 3%-15%, sodium alginate 5%-25%, green starch 60%-75%, calcium sulfate 3%-8%, licorzinc 0.5%-1.0%, vitamin 0.2%-0.8%, menthol or peppermint oil dementholized 0.3%-0.6%.
3. prepare a method for sublingual cigarette, it is characterized in that,
Component and the mass percentage thereof of described sublingual cigarette are: nicotine 0.01%-6%, non-carbohydrate sweet substance 3%-15%, sodium alginate 5%-35%, green starch 45%-80%, calcium sulfate 3%-8%, licorzinc 0.5%-3%, vitamin 0.2%-0.8%, menthol or peppermint oil dementholized 0-0.6%;
Add water by sodium alginate, add thermal agitation, sodium alginate is dissolved and forms sodium alginate rubber cement; Non-carbohydrate sweet substance, green starch, calcium sulfate, licorzinc and vitamin are mixed, adds sodium alginate rubber cement and make softwood, extrude particle with 14 mesh sieves, use the whole grain of 12 mesh sieve for subsequent use after drying again; After being dissolved by the ethanol water of nicotine, menthol or peppermint oil dementholized 70wt%, be evenly sprayed on the particle for preparing, stir and evenly mix, airtight placement 2-5h, uses stamping machine tabletted, to obtain final product.
4. a kind of method preparing sublingual cigarette as claimed in claim 3, is characterized in that,
Component and the mass percentage thereof of described sublingual cigarette are: nicotine 0.1%-1.5%, non-carbohydrate sweet substance 3%-15%, sodium alginate 5%-25%, green starch 60%-75%, calcium sulfate 3%-8%, licorzinc 0.5%-1.0%, vitamin 0.2%-0.8%, menthol or peppermint oil dementholized 0.3%-0.6%.
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| CN201310245741.1A CN103284318B (en) | 2013-06-20 | 2013-06-20 | Sublingual cigarette and preparation method thereof |
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| CN103284318B true CN103284318B (en) | 2015-03-11 |
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| CN103549649B (en) * | 2013-11-07 | 2015-05-06 | 中国烟草总公司山东省公司 | Health-care gum cigarette |
| CN103549648B (en) * | 2013-11-11 | 2016-08-17 | 云南烟草科学研究院 | A kind of Novel pressure flap-type smokeless tobacco articles and preparation method thereof |
| CN103708109A (en) * | 2013-12-04 | 2014-04-09 | 红塔烟草(集团)有限责任公司 | Mouth-holding smokeless tobacco product packing bag |
| CN103815540A (en) * | 2014-03-14 | 2014-05-28 | 红塔烟草(集团)有限责任公司 | Smokeless tobacco product with areca-nut flavor and manufacturing method thereof |
| US10568852B2 (en) | 2015-05-22 | 2020-02-25 | Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Combination compositions and their use in methods for treating obesity and obesity-related disorders |
| CN110279739B (en) * | 2019-06-25 | 2022-07-01 | 云南中烟工业有限责任公司 | Application of wild chrysanthemum extract in preparation of medicine or health-care product for preventing and treating oral epithelial cell death caused by mouth tobacco |
| CN110123893B (en) * | 2019-06-25 | 2022-07-01 | 云南中烟工业有限责任公司 | Application of dark plum extract in preparation of medicine or health-care product for preventing and treating oral epithelial cell death caused by mouth tobacco |
| CN114304712A (en) * | 2021-12-17 | 2022-04-12 | 深圳市元雾科技有限公司 | Liquid high-load nicotine buccal product particles and preparation method thereof |
| WO2023187223A1 (en) * | 2022-04-01 | 2023-10-05 | Amplicon Ab | Nicotine formulations |
| WO2023187224A1 (en) * | 2022-04-01 | 2023-10-05 | Amplicon Ab | Alkaline intraoral formulations |
| CN115969898A (en) * | 2023-02-09 | 2023-04-18 | 东莞市吉纯生物技术有限公司 | Buccal cigarette lozenge for preventing and treating dental ulcer and preparation method thereof |
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