CN101700254B - Chinese medicine prescription granule flavoring agent, and preparation method and use method thereof - Google Patents
Chinese medicine prescription granule flavoring agent, and preparation method and use method thereof Download PDFInfo
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- CN101700254B CN101700254B CN2009102351088A CN200910235108A CN101700254B CN 101700254 B CN101700254 B CN 101700254B CN 2009102351088 A CN2009102351088 A CN 2009102351088A CN 200910235108 A CN200910235108 A CN 200910235108A CN 101700254 B CN101700254 B CN 101700254B
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Abstract
The invention relates to a Chinese medicine prescription granule flavoring agent, and a preparation method and a use method thereof. The Chinese medicine prescription granular flavoring agent is used for improving the mouthfeel of single-flavor or compound Chinese medicine prescription granules. The flavoring agent comprises the following raw materials in percentage by weight: 30-60% of mixture of carrageenin and konjac gum, 0.3-1.0% of trichloroesucrose, 0.5-0.8% of ethyl maltol, 1-4% of hydroxylated phospholipids, 35-60% of maltodextrin and 0.001-0.004% of fruit-flavor essence. The preparation method comprises the following steps: evenly mixing the carrageenin, the konjac gum, the trichloroesucrose, the ethyl maltol, the hydroxylated phospholipids, the maltodextrin and the fruit-flavor essence; making into wet granules by adding a proper amount of water as the adhesive; and drying at the temperature of 50-60 DEG C to obtain the Chinese medicine prescription granule flavoring agent. The use method comprises the following steps: pouring the Chinese medicine prescription granules to be taken and the flavoring agent into a container, adding hot water, stirring, and waiting until the mixture is frozen. The invention has the advantages of simple technique and convenient use, and has favorable flavor masking effect.
Description
(1) technical field
The present invention relates to a kind of Chinese medicinal granule correctives and preparation method thereof and using method.Be used to improve the mouthfeel of single or herbal mixture granule.Belong to field of traditional Chinese.
(2) background technology
Chinese medicinal granule is under Chinese medical theory instructs, through water extraction, concentrate, single granule that drying etc. is prepared from.With its steady quality, dosage accurately, advantages such as taking convenience, safety and sanitation are subjected to clinical patients and doctor's recognition and acceptance.Yet, because Chinese medicinal granule drug level height, mouthfeel are not good, often there are hardship, puckery, acid etc. allow the unhappy taste of people, make the patient cause sense of taste discomfort in use, even vomiting, especially the child patient compliance is relatively poor, often, the child takes delay treatment because of be unwilling to cooperating, limited its use in child patient, therefore be necessary to study the correctives of Chinese medicinal granule, to improve the compliance of child patient.
At present the common drug method to modify taste has film-coated technique, molecule inclusion technology, resin absorption technology, wax material technique for packing, Emulsion technique for packing, effervescent technology, uses sweeting agent or edible essence etc. merely.Wherein, film-coated technique is usually used in the taste masking of tablet, and for Chinese medicinal granule, because of particulate specific surface area is bigger, the required supplementary product consumption of coating is bigger, therefore the also taste masking of inapplicable Chinese medicinal granule; The molecule inclusion technology is pharmaceutical pack to be rolled in the cavity of host molecules such as cyclodextrin, can reduce contacting of medicine and taste bud, reach the purpose of flavoring, but because of large usage quantities such as cyclodextrin in the molecule inclusion technology, usually with the ratio of medicine more than 1: 1, so be not suitable for the flavoring of Chinese medicinal granule yet; The resin absorption technology, domestic research is less, and it is also less to can be used for medicinal ion exchange resin material; Wax material technique for packing, Emulsion technique for packing, effervescent technical matters complexity, operation are had relatively high expectations; Simple use sweeting agent or edible essence flavored action are limited, under the situation especially many in Chinese medicine compound constituent, that dosage is big, use certain sweeting agent or edible essence can't play good taste masking effect merely.
(3) summary of the invention
The objective of the invention is to overcome above-mentioned deficiency, provide a kind of taste masking of suitable Chinese medicinal granule, technology simple, the easy to use and Chinese medicinal granule correctives and preparation method thereof and the using method that can play good taste masking effect.
The objective of the invention is to realize by following scheme:
A kind of Chinese medicinal granule correctives, described correctives is made up of the raw material of following percentage by weight composition:
Carrageenan and Konjac glucomannan mixture 30～60%
Sucralose 0.3～1.0%
Ethyl maltol 0.5～0.8%
Hydroxylated phosphatide 1～4%
Maltodextrin 35～60%
Fruity essence 0.001～0.004%
The percentage by weight summation of each component is 100%;
The weight ratio of described carrageenan and Konjac glucomannan is: carrageenan: Konjac glucomannan=1: 0.5～1: 3;
The preparation method of described Chinese medicinal granule correctives is as follows:
With carrageenan and Konjac glucomannan, sucralose, ethyl maltol, hydroxylated phosphatide, maltodextrin and fruity essence mix homogeneously, add suitable quantity of water and make binding agent, make wet granular, the Chinese medicinal granule correctives is made in 50～60 ℃ of oven dry.
The using method of described Chinese medicinal granule correctives is as follows:
Chinese medicinal granule that earlier will be to be taken and correctives are poured in the container, add hot water, and the weight ratio of correctives and water is 2: 100～2.5: 100, stir, and cooling is put to room temperature, or put into 2 ℃～6 ℃ environment and quicken cooling, treat can take after it freezes.
The present invention reaches ideal Chinese medicinal granule flavoring effect by multiple flavoring principle, specifically comprises:
1, adopt gellant carrageenan and Konjac glucomannan to form gel structure under certain condition, pharmaceutical pack is wrapped in wherein, can relax the taste of medicine, the control medicine is to the diffusion of taste bud, disturbs the sense of taste of taste bud and plays the effect of flavoring.
2, agent is used as plural gel for selected carrageenan and Konjac glucomannan, because single use carrageenan, form that gel fragility is big, elasticity is little, easy bleed, and single use Konjac glucomannan, form then that amount of gel is big, just plastic under the higher condition of pH value, and mouthfeel is not good enough, be out of favour, if with both compound according to a certain percentage uses, then have good synergism, can form the high elastic gel of gel strength, the scope of application is wide, after adding hot water dissolving, cooling with the Chinese medicinal granule of various physicochemical properties, has flavoring effect preferably.
3, selected sucralose is a kind of sweeting agent, sugariness is 600～650 times of sucrose, to puckery, wait bitterly for unpleasant taste and cover effect, its outstanding feature that is different from other sweeting agent is that calorific value and energy value are almost nil, in human body, do not participate in metabolism, be not absorbed, can not cause blood glucose fluctuation, be suitable for diabetes patient, obesity patient, cardiovascular disease patient use.
Because gel hardness, elasticity that the plural gel agent that above-mentioned carrageenan and Konjac glucomannan fit in forms after hot water dissolving, cooling are freezed are suitable, chewiness, better to eat is arranged when taking, but the taste of gel own is extremely light, if cooperate sucralose and fruit essence to use, on the one hand, gel can avoid Chinese medicine directly to contact with taste bud, on the other hand, the sweet taste of the good to eat cooperation sucralose of gel, the fragrance of fruit essence, the effect of fragrant, sweet, good to eat alternative Chinese medicine hardship, disagreeable taste such as puckery can be reached, the Chinese medicine disagreeable taste can be hidden preferably.
4, selected ethyl maltol is the synergist of a kind of perfume (or spice), sweet, delicate flavour, not only can strengthen the sweet taste effect of sucralose, and can strengthen the fragrance effects of fruit essence, can better cover tastes such as Chinese medicine hardship, acid, puckery, raw meat.
5, selected hydroxylated phosphatide can be by fighting for bitterness receptors with bitters competitively, stop the impression of bitterness receptors to bitterness, this is from weakening user self the impression degree of bitterness to be come flavoring, but use this flavoring mode separately, the effect of covering bitterness is not remarkable, must cooperate aforementioned plural gel agent, sucralose, fruit essence, ethyl maltol to use, just can reach flavoring effect preferably Chinese medicinal granule.
The invention has the beneficial effects as follows:
1, supplementary product consumption is few, and technology is simple, and is easy to use, cheap.
2, used Sweetener Sucralose is a kind of novel sweetener, compares with other sweeting agent, and its outstanding characteristics are:
(1) sweet taste is pure, sweet sense presentation speed, maximum sweet taste experience intensity, sweet taste duration, aftertaste etc. all very near sucrose, be the very ideal intense sweetener of a kind of combination property.
(2) calorific value of sucralose and energy value are almost nil, do not participate in metabolism in human body, are not absorbed, and can not cause blood glucose fluctuation, are suitable for diabetes patient, obesity patient, cardiovascular disease patient use.
3, the taste masking technology behind employing carrageenan and the Konjac glucomannan formation gel in the correctives, and add other dissimilar correctives and comprise Sweetener Sucralose, fragrant and sweet flavor synergist ethyl maltol, odor mask hydroxylated phosphatide and fruity essence etc., synergism by multiple correctives, enlarge the scope of application of this correctives aspect the Chinese medicine flavoring, the result shows, this correctives has good flavoring effect to Chinese medicinal granule, can significantly improve the compliance of patient, especially child and dysphagia patients medication.
(4) specific embodiment
Embodiment 1:
Chinese medicinal granule correctives and preparation method thereof:
Consumption (1 bag)
Carrageenan and Konjac glucomannan (weight ratio is 1: 0.5) 0.8g
Sucralose 0.007g
Ethyl maltol 0.011g
Hydroxylated phosphatide 0.021g
Maltodextrin 1.17g
Lemon essence 0.04mg
With carrageenan and Konjac glucomannan, sucralose, ethyl maltol, hydroxylated phosphatide, maltodextrin and lemon essence mix homogeneously, add suitable quantity of water and make binding agent, make wet granular, the Chinese medicinal granule correctives is made in 50～60 ℃ of oven dry.
Get Rhizoma Coptidis Chinese medicinal granule 1 bag (0.5g) and correctives and pour in the container for 1 bag, add 100ml hot water, stir, put into 4 ℃ of environment cools, treat to take after it freezes, the result shows the bitterness that can obviously improve the Rhizoma Coptidis Chinese medicinal granule.
Embodiment 2:
Chinese medicinal granule correctives and preparation method thereof:
Consumption (1 bag)
Carrageenan and Konjac glucomannan (weight ratio is 1: 1) 1.0g
Sucralose 0.015g
Ethyl maltol 0.012g
Hydroxylated phosphatide 0.05g
Maltodextrin 1.10g
Honey peach flavor essence 0.08mg
With carrageenan and Konjac glucomannan, sucralose, ethyl maltol, hydroxylated phosphatide, maltodextrin and honey peach flavor essence mix homogeneously, add suitable quantity of water and make binding agent, make wet granular, the Chinese medicinal granule correctives is made in 50～60 ℃ of oven dry.
Get Rhizoma Coptidis Chinese medicinal granule 1 bag (0.5g) and correctives and pour in the container for 1 bag, add 100ml hot water, stir, put into 4 ℃ of environment cools, treat to take after it freezes, the result shows the bitterness that can obviously improve the Rhizoma Coptidis Chinese medicinal granule.
Embodiment 3:
Chinese medicinal granule correctives and preparation method thereof:
Consumption (1 bag)
Carrageenan and Konjac glucomannan (weight ratio is 1: 2) 1.2g
Sucralose 0.012g
Ethyl maltol 0.013g
Hydroxylated phosphatide 0.08g
Maltodextrin 0.75g
Fructus Fragariae Ananssae flavor essence 0.08mg
With carrageenan and Konjac glucomannan, sucralose, ethyl maltol, hydroxylated phosphatide, maltodextrin and honey peach flavor essence mix homogeneously, add suitable quantity of water and make binding agent, make wet granular, the Chinese medicinal granule correctives is made in 50～60 ℃ of oven dry.
Getting respectively 1 bag of Pericarpium Citri Reticulatae, Flos Lonicerae, Fructus Forsythiae Chinese medicinal granule (3.5g altogether) and correctives pours in the container for 1 bag, add 100ml hot water, stir, cooling is put to room temperature, treat to take after it freezes, the result shows can obviously improve Pericarpium Citri Reticulatae, Flos Lonicerae, the hardship of Fructus Forsythiae Chinese medicinal granule, astringent taste.
Claims (3)
1. Chinese medicinal granule correctives is characterized in that described correctives is made up of the raw material of following percentage by weight composition:
Carrageenan and Konjac glucomannan mixture 30～60%
Sucralose 0.3～1.0%
Ethyl maltol 0.5～0.8%
Hydroxylated phosphatide 1～4%
Maltodextrin 35～60%
Fruity essence 0.001～0.004%
The percentage by weight summation of each component is 100%;
The weight ratio of described carrageenan and Konjac glucomannan is: carrageenan: Konjac glucomannan=1: 0.5～1: 3.
2. the preparation method of a Chinese medicinal granule correctives as claimed in claim 1, it is characterized in that described preparation method comprises following technical process: with carrageenan and Konjac glucomannan, sucralose, ethyl maltol, hydroxylated phosphatide, maltodextrin and fruity essence mix homogeneously, add suitable quantity of water and make binding agent, make wet granular, the Chinese medicinal granule correctives is made in 50～60 ℃ of oven dry.
3. the using method of a Chinese medicinal granule correctives as claimed in claim 1, it is characterized in that described using method comprises following process: Chinese medicinal granule that earlier will be to be taken and correctives are poured in the container, add hot water, the weight ratio of correctives and water is 2: 100～2.5: 100, stir, cooling is put to room temperature, or puts into 2 ℃～6 ℃ environment and quicken cooling, treats can take after it freezes.
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| CN2009102351088A CN101700254B (en) | 2009-10-30 | 2009-10-30 | Chinese medicine prescription granule flavoring agent, and preparation method and use method thereof |
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| CN2009102351088A CN101700254B (en) | 2009-10-30 | 2009-10-30 | Chinese medicine prescription granule flavoring agent, and preparation method and use method thereof |
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| CN101700254A CN101700254A (en) | 2010-05-05 |
| CN101700254B true CN101700254B (en) | 2011-08-17 |
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| CN110585119A (en) * | 2019-09-30 | 2019-12-20 | 河南中医药大学第一附属医院 | Jelly type traditional Chinese medicine mate |
| CN114452328B (en) * | 2020-11-04 | 2023-02-28 | 沈阳清宫药业集团有限公司 | Sihuang heart-fire-clearing pill and preparation method thereof |
| CN114632124B (en) * | 2022-04-07 | 2024-02-02 | 武汉贝参药业股份有限公司 | Compound radix pseudostellariae cough relieving qi tonifying powder and flavor correcting preparation and preparation method thereof |
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| CN1706366A (en) * | 2005-04-28 | 2005-12-14 | 美晨集团股份有限公司 | Breath freshening tablet |
| CN1840167A (en) * | 2006-01-18 | 2006-10-04 | 张静 | Method for preparing anti-diarrhea Chinese medicinal oral gel for infant |
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2009
- 2009-10-30 CN CN2009102351088A patent/CN101700254B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1706366A (en) * | 2005-04-28 | 2005-12-14 | 美晨集团股份有限公司 | Breath freshening tablet |
| CN1840167A (en) * | 2006-01-18 | 2006-10-04 | 张静 | Method for preparing anti-diarrhea Chinese medicinal oral gel for infant |
Non-Patent Citations (3)
| Title |
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| 吕正检等.新型矫味剂在药物口服制剂中的应用.《第二届药用辅料（国际）学术研讨会暨口服固体制剂辅料的研究与应用论文集》.2005,25-28. * |
| 林少雯.多糖胶质的国际发展趋势.《中国食品添加剂》.1998,27-38. * |
| 穆旻.麦芽酚和乙基麦芽酚的合成及其在食品工业中的应用.《中国食品学报》.2006,第6卷(第1期),407-410. * |
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