CN107259635A - A kind of nicotine complex salt buccal tablets and preparation method thereof - Google Patents
A kind of nicotine complex salt buccal tablets and preparation method thereof Download PDFInfo
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- CN107259635A CN107259635A CN201710458893.8A CN201710458893A CN107259635A CN 107259635 A CN107259635 A CN 107259635A CN 201710458893 A CN201710458893 A CN 201710458893A CN 107259635 A CN107259635 A CN 107259635A
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- China
- Prior art keywords
- complex salt
- nicotine
- buccal tablets
- nicotine complex
- acid
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Classifications
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of nicotine complex salt buccal tablets.Material composition includes 0.01~1 part of 30~70 parts of sweetener, 5~10 parts of nicotine complex salt, 0.5~10 part of adhesive, 0.5~5 part of acid-base modifier, 0.5~5 part of flavoring essence, 0.5~5 part of flavor enhancement, 0.1~5 part of lubricant and antioxidant.Product is obtained using direct compression method after raw material is well mixed.The present invention substitutes the tobacco powder composition in traditional buccal tablets with nicotine complex salt, and nicotine complex salt, which can uniformly mix, to be fitted in buccal tablets, reduces the grains of sand mouthfeel of product, allows consumer preferably to enjoy the physiology satisfaction that nicotine is brought.Nicotine continues slow release, improves the faster negative impression of consumer's nicotine release during edible buccal tablets, and reduce to oral cavity and the excitant of stomach.
Description
Technical field
The invention belongs to smoke-free tobacco product technical field, be specifically related to it is a kind of using nicotine complex salt as mainly into
Divide the buccal tablets prepared.Meanwhile, the invention further relates to the preparation method of described buccal tablets.
Background technology
Improved constantly recently as people's living standard, health and environmental consciousness are stepped up.Smoking is asked with health
Topic is increasingly paid close attention to by masses.The material being detrimental to health in cigarette is largely produced from result of combustion of tobacco, makes non-
What the flow measurement flue gas that the second-hand-cigarette of smoker's puzzlement is also due to cigarette burning generation was caused.Therefore, smoke-free tobacco product had been both
The need for tobacco consumer being met, harm of the smoking to the public can be reduced again, and the research and development to such product seem even more important
With it is urgent.
The species of smoke-free tobacco product mainly has buccal cigarette (not chewing, there is residue), gum base type chewing tobacco (to chew, there is residual
Slag) and tobacco buccal tablets (not chewing, no residue).Buccal tablets has the characteristics of not producing second-hand-cigarette harm and hygienic environment-protecting, tool
There are good market prospects.But traditional tobacco buccal tablets is tabletted after tobacco fine powder is mixed with other compositions, is being disappeared
Exist during expense person's use coarse mouthfeel after buccal tablets dissolves in the oral cavity, free state nicotine release it is too fast, to oral cavity, throat
And intestines and stomach stimulation it is larger the problems such as.
The content of the invention
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide a kind of containing by main component of nicotine complex salt
Change piece.
The present invention also aims to provide a kind of method for preparing the buccal tablets.
The purpose of the present invention is achieved by the following technical programs.
Unless otherwise indicated, percentage of the present invention is mass percent.
A kind of nicotine complex salt buccal tablets, is made up of the raw material of following weight parts：30~70 parts of sweetener, nicotine complex salt
5~10 parts, 0.5~10 part of adhesive, 0.5~5 part of acid-base modifier, 0.5~5 part of flavoring essence, 0.5~5 part of flavor enhancement, profit
0.01~1 part of 0.1~5 part of lubrication prescription and antioxidant.
Described sweetener is xylitol, D-sorbite, honey, fructose, sucrose, glucose, maltose, licorice powder, sweet tea
One or more in sweet element, Aspartame, Sucralose, corn syrup.
Described nicotine complex salt is nicotine and malic acid, citric acid or salicylism reaction and obtained after freeze-dried
White powder.
Described adhesive be sodium alginate, xanthans, sodium cellulose glycolate, carboxy-propyl cellulose, Arabic gum or
One or more in maltodextrin.
Described acid-base modifier is sodium carbonate, sodium acid carbonate, potassium carbonate, saleratus, sodium citrate or potassium citrate
In one or more.
Described flavor enhancement is the one or more in mint extract, Fragaia ananassa Duchesne extract or blueberry extract.
Described lubricant is the one or more in magnesium stearate, talcum powder or silica.
Described antioxidant is the one or more in Tea Polyphenols, sodium benzoate, sorbic acid or potassium sorbate.
The method for preparing the nicotine complex salt buccal tablets, comprises the following steps：
(1) each raw material for standby is weighed by weight：30~70 parts of sweetener, 5~10 parts of nicotine complex salt, adhesive 0.5
~10 parts, 0.5~5 part of acid-base modifier, 0.5~5 part of flavoring essence, 0.5~5 part of flavor enhancement, 0.1~5 part of lubricant and anti-
0.01~1 part of oxidant；
(2) each raw material is well mixed, and control ph is 6~8, it is tabletted in tablet press machine；
(3) gained tabletting is dried 0.5 hour in an oven, it is 0.5~0.8% to control tabletting moisture, needed for producing
Nicotine complex salt buccal tablets.
Relative to prior art, the present invention has advantages below：
1st, the tobacco powder composition in traditional buccal tablets is substituted with nicotine complex salt, nicotine complex salt, which can uniformly mix, matches somebody with somebody
Into buccal tablets, the grains of sand mouthfeel of product is reduced.
2nd, nicotine complex salt has the effect for continuing slow release nicotine, improves consumer during edible buccal tablets
The faster negative impression of nicotine release, and reduce to oral cavity and the excitant of stomach.
3rd, the buccal tablets based on nicotine complex salt can be directly buccal, and nicotine progressively discharges during edible, to consumer
Bring physiology satisfaction；This process does not produce flue gas, can be used in various occasions.
Embodiment
The present invention is described in further detail by the following examples, but embodiment is not to the technology of the present invention side
The restriction of case.It is all based on present invention teach that made change or equivalent substitution, all should belong to protection scope of the present invention.
Embodiment 1
Take 5g sodium alginates and 2g mint extracts to dissolve in deionized water, binder solution is made, then by 40g sweet teas
Taste agent (5 parts of xylitols, 3 parts of glucose and 2 parts of Aspartames), 5g nicotine citrates, 2g flavoring essences, 2g magnesium stearates,
0.5g Tea Polyphenols is crossed after 100 mesh sieves and fully mixed with binder solution respectively, adds 0.5g sodium acid carbonates (acid-base modifier)
Control ph is 6-8, is subsequently poured into tablet press machine, and tabletting is carried out according to every 1.0g specification.Tablet is dried 0.5 in an oven
Hour, it is 0.5~0.8% to make pellet moisture control.Then packed, that is, obtain described nicotine complex salt buccal tablets.
Embodiment 2
Take 6g xanthans and 3g Fragaia ananassa Duchesne extracts to dissolve in deionized water, binder solution is made, then by 50g sweet tastes
Agent (5 parts of D-sorbites and 5 portions of sucrose), 6g nicotine malate, 2g flavoring essences, 2g talcum powder, 0.5g sodium benzoates difference
Cross after 100 mesh sieves and fully mixed with binder solution, add 0.5g saleratus (acid-base modifier) control ph for 6-8,
Tablet press machine is subsequently poured into, tabletting is carried out according to every 1.0g specification.Tablet is dried 0.5 hour in an oven, makes particle water
Sub-control is made as 0.5~0.8%.Then packed, that is, obtain described nicotine complex salt buccal tablets.
Embodiment 3
Take 7g Arabic gums and 5g blueberry extracts to dissolve in deionized water, binder solution is made, then by 60g sweet teas
Taste agent (5 parts of xylitols, 3 parts of fructose and 2 parts of honey elements), 6g nicotine salicylate, 2g flavoring essences, 2g silica, 0.5g
Potassium sorbate is crossed after 100 mesh sieves and fully mixed with binder solution respectively, adds 0.5g sodium acid carbonates (acid-base modifier) control
PH value processed is 6-8, is subsequently poured into tablet press machine, and tabletting is carried out according to every 1.0g specification.Tablet is dried to 0.5 in an oven small
When, it is 0.5~0.8% to make pellet moisture control.Then packed, that is, obtain described nicotine complex salt buccal tablets.
Claims (8)
1. a kind of nicotine complex salt buccal tablets, it is characterised in that be made up of the raw material of following weight parts：30~70 parts of sweetener, cigarette
5~10 parts of alkali complex salt, 0.5~10 part of adhesive, 0.5~5 part of acid-base modifier, 0.5~5 part of flavoring essence, flavor enhancement 0.5
~5 parts, 0.01~1 part of 0.1~5 part of lubricant and antioxidant.
2. nicotine complex salt buccal tablets according to claim 1, it is characterised in that：Described sweetener is xylitol, mountain
Pears sugar alcohol, honey, fructose, sucrose, glucose, maltose, licorice powder, honey element, Aspartame, Sucralose or corn syrup
In one or more.
3. nicotine complex salt buccal tablets according to claim 1, it is characterised in that：Described nicotine complex salt be nicotine with
Malic acid, citric acid or salicylism reaction and it is freeze-dried after obtained white powder.
4. nicotine complex salt buccal tablets according to claim 1, it is characterised in that：Described adhesive be sodium alginate,
One or more in xanthans, sodium cellulose glycolate, carboxy-propyl cellulose, Arabic gum or maltodextrin.
5. nicotine complex salt buccal tablets according to claim 1, it is characterised in that：Described acid-base modifier is carbonic acid
One or more in sodium, sodium acid carbonate, potassium carbonate, saleratus, sodium citrate or potassium citrate.
Described flavor enhancement is the one or more in mint extract, Fragaia ananassa Duchesne extract or blueberry extract.
6. nicotine complex salt buccal tablets according to claim 1, it is characterised in that：Described lubricant be magnesium stearate,
One or more in talcum powder or silica.
7. nicotine complex salt buccal tablets according to claim 1, it is characterised in that：Described antioxidant be Tea Polyphenols,
One or more in sodium benzoate, sorbic acid or potassium sorbate.
8. preparing the method for nicotine complex salt buccal tablets described in claim 1, comprise the following steps：
(1) each raw material for standby is weighed by weight：30~70 parts of sweetener, 5~10 parts of nicotine complex salt, adhesive 0.5~10
Part, 0.5~5 part of acid-base modifier, 0.5~5 part of flavoring essence, 0.5~5 part of flavor enhancement, 0.1~5 part of lubricant and anti-oxidant
0.01~1 part of agent；
(2) each raw material is well mixed, and control ph is 6~8, it is tabletted in tablet press machine；
(3) gained tabletting is dried 0.5 hour in an oven, it is 0.5~0.8% to control tabletting moisture, produces required nicotine
Complex salt buccal tablets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710458893.8A CN107259635A (en) | 2017-06-16 | 2017-06-16 | A kind of nicotine complex salt buccal tablets and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710458893.8A CN107259635A (en) | 2017-06-16 | 2017-06-16 | A kind of nicotine complex salt buccal tablets and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107259635A true CN107259635A (en) | 2017-10-20 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710458893.8A Pending CN107259635A (en) | 2017-06-16 | 2017-06-16 | A kind of nicotine complex salt buccal tablets and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2613211A (en) * | 2022-04-01 | 2023-05-31 | Amplicon Ab | Alkaline oral formulations |
| WO2023187223A1 (en) * | 2022-04-01 | 2023-10-05 | Amplicon Ab | Nicotine formulations |
| WO2023187224A1 (en) * | 2022-04-01 | 2023-10-05 | Amplicon Ab | Alkaline intraoral formulations |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012134380A1 (en) * | 2011-03-29 | 2012-10-04 | Chill Of Sweden Ab | Pouch containing nicotine in free salt form |
| CN105455190A (en) * | 2016-02-01 | 2016-04-06 | 湖北中烟工业有限责任公司 | Electronic cigarette liquid |
| CN105595404A (en) * | 2015-10-20 | 2016-05-25 | 贵州中烟工业有限责任公司 | Tobacco buccal tablet and preparation method thereof |
| CN105747267A (en) * | 2014-12-17 | 2016-07-13 | 贵州中烟工业有限责任公司 | Dissolvable smoke-free tobacco product and preparation method thereof |
| CN106456560A (en) * | 2014-04-08 | 2017-02-22 | 费尔廷制药公司 | Medical chewing gum |
-
2017
- 2017-06-16 CN CN201710458893.8A patent/CN107259635A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012134380A1 (en) * | 2011-03-29 | 2012-10-04 | Chill Of Sweden Ab | Pouch containing nicotine in free salt form |
| CN106456560A (en) * | 2014-04-08 | 2017-02-22 | 费尔廷制药公司 | Medical chewing gum |
| CN105747267A (en) * | 2014-12-17 | 2016-07-13 | 贵州中烟工业有限责任公司 | Dissolvable smoke-free tobacco product and preparation method thereof |
| CN105595404A (en) * | 2015-10-20 | 2016-05-25 | 贵州中烟工业有限责任公司 | Tobacco buccal tablet and preparation method thereof |
| CN105455190A (en) * | 2016-02-01 | 2016-04-06 | 湖北中烟工业有限责任公司 | Electronic cigarette liquid |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2613211A (en) * | 2022-04-01 | 2023-05-31 | Amplicon Ab | Alkaline oral formulations |
| WO2023187223A1 (en) * | 2022-04-01 | 2023-10-05 | Amplicon Ab | Nicotine formulations |
| WO2023187224A1 (en) * | 2022-04-01 | 2023-10-05 | Amplicon Ab | Alkaline intraoral formulations |
| GB2613211B (en) * | 2022-04-01 | 2023-12-27 | Amplicon Ab | Alkaline oral formulations |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171020 |
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