CN103263527A - Chicken high fever disease prevention and treatment traditional Chinese medicine and preparation method thereof - Google Patents
Chicken high fever disease prevention and treatment traditional Chinese medicine and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese veterinary medicines, and discloses a chicken high fever disease prevention and treatment traditional Chinese medicine and a preparation method thereof. The chicken high fever disease prevention and treatment traditional Chinese medicine is prepared from the following raw materials: dandelion, Chinese thorowax root, rhizoma coptidis, rehmannia dride rhizome, milkvetch root, indigowoad root, hawthorn, gypsum and licorice root. The chicken high fever disease prevention and treatment traditional Chinese medicine can be blended with chicken feeding water or a feed to be used so as to improve high fever disease resistance ability of chicken and provide good treatment effects for chicken having the high fever disease.
Description
Technical field
The present invention relates to field of medicaments for animals, be specifically related to a kind of Chinese medicine of preventing and treating chicken high febrile disease and preparation method thereof.。
Background technology
Development along with modern farming, the inferior position of pulvis shows more and more obviously, is inconvenient to use, and especially occupies the very broiler aquaculture of great share in breed market, pulvis uses almost seldom, because what use mostly is pellet, no matter how good your medicine is, the raiser is exactly need not, if the effect the same with Western medicine, that just uses Western medicine, because it is easy to use, thereby has limited the development of herbal medicine.In China's veterinary drug allusion quotation 195 Chinese traditional patent formulation preparations are arranged at present, it is also many that enterprise declares, but dosage form is more single, be liquid preparations such as oral liquid, filling agent, injection less than 10% only, all the other 90% all are pulvises, and the herbal medicine of the disclosed control of prior art fowl poultry hyperpyrexia disease also major part is pulvis.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine of preventing and treating chicken high febrile disease and preparation method thereof.
The Chinese medicine oral liquid of control chicken high febrile disease of the present invention is to be formed by the feedstock production that comprises following weight portion:
Herba Taraxaci 25～45 Radix Bupleuri 25～50 Rhizoma Coptidis 25～50 Radix Rehmanniae 8～25
The Radix Astragali 10～30 Radix Isatidis 10～30 Fructus Crataegis 8～25 Gypsum Fibrosum 8～25
Radix Glycyrrhizae 10～35.
The Chinese medicine oral liquid of control chicken high febrile disease of the present invention, its preferred version are to be formed by the feedstock production that comprises following weight portion:
Herba Taraxaci 30～40 Radix Bupleuri 30～45 Rhizoma Coptidis 30～45 Radix Rehmanniae 10～20
The Radix Astragali 15～25 Radix Isatidis 15～25 Fructus Crataegis 10～20 Gypsum Fibrosum 10～20
Radix Glycyrrhizae 15～25.
The Chinese medicine oral liquid of control chicken high febrile disease of the present invention, its further preferred version is to be formed by the feedstock production that comprises following weight portion:
Herba Taraxaci 35 Radix Bupleuri 38 Rhizoma Coptidis 40 Radix Rehmanniae 18 Radixs Astragali 23
Radix Isatidis 20 Fructus Crataegis 16 Gypsum Fibrosum 18 Radix Glycyrrhizaes 20.
The Chinese medicine oral liquid of control chicken high febrile disease of the present invention, its preparation method is:
Get 8 flavor medical materials except Radix Bupleuri, decoct with water three times; The water that adds 10 times of amounts that are equivalent to 8 flavor medical material gross weights for the first time, decoct 1.5 h, second and third time adds the water of 8 times of amounts that are equivalent to 8 flavor medical material gross weights, and each decocted 1 hour, merge extractive liquid,, filter with 60 μ m filter membranes, be concentrated into relative density and be 1.20～1.23 extractum, add ethanol and make that to contain the alcohol amount be 65%, left standstill 24 hours, Separation and Recovery ethanol obtains supernatant A;
Get Radix Bupleuri, chopping adds the water logging bubble 12h that is equivalent to 8 times of Radix Bupleuri medical material weight, vapor distillation, and the distillation extraction time is 2h, collects volatile oil B and distillate C;
Merge supernatant A and distillate C, add 1% sorbic acid in heating, boil, cross 30 μ m filter membranes while hot, cooling adds volatile oil B mix homogeneously, and cold preservation adds water after leaving standstill 12 hours, stir evenly, and fill, sterilization, namely.
The Chinese medicine of control chicken high febrile disease of the present invention, the preparation method of its granule is:
Get 8 flavor medical materials except Radix Bupleuri, decoct with water three times; The water that adds 10 times of amounts that are equivalent to 8 flavor medical material gross weights for the first time, decoct 1.5 h, second and third time adds the water of 8 times of amounts that are equivalent to 8 flavor medical material gross weights, and each decocted 1 hour, merge extractive liquid,, filter with 60 μ m filter membranes, be concentrated into relative density and be 1.20～1.23 extractum, add ethanol and make that to contain the alcohol amount be 65%, left standstill 24 hours, Separation and Recovery ethanol is concentrated into relative density and is 1.25～1.30 extractum, obtains extractum A;
Get Radix Bupleuri, chopping adds the water logging bubble 12h that is equivalent to 8 times of Radix Bupleuri gross weights, and vapor distillation is collected volatile oil B
Extractum A and sucrose is even according to the mixed of 1:7, and wet granulation sprays into volatile oil B, is drying to obtain.
The Chinese medicine oral liquid of control chicken high febrile disease provided by the present invention and the allotment of chicken drinking-water are used, and can improve the opposing hyperpyrexia disease of chicken and have the ability, and the chicken that has fallen ill is also had excellent curative, and have no side effect, and be safe and reliable.
The details of each medical material is as follows among the present invention:
Herba Taraxaci, feverfew Herba Taraxaci Toraxacum mongolicum Hand. Mazz., alkali ground Herba Taraxaci Toraxacum borealisinense Kitam. or belong to the dry herbs of several plants together, the flat sweet and slightly bitter taste of property has the effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
Radix Bupleuri, RootofChneseThorowax, samphire, the beginning is stated from Shennong's Herbal, is clearind deficient heat Chinese medicine, can be used for that cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus come off, menoxenia.
Rhizoma Coptidis, dicotyledon is called sheet lotus, JIZHUALIAN, takes off mountain tiger etc., and bitter in the mouth is cold in nature.The Main Ingredients and Appearance of itself is berberine, but heat clearing away is wet, and eliminating fire and detoxication can remove damp-heat in middle-JIAO, heart channel excess-heat etc.
The Radix Rehmanniae also is Radix Rehmanniae, the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch..The Radix Rehmanniae is cold in nature, and function is enriching yin and nourishing kidney.The Radix Rehmanniae is cold in nature, and function is enriching yin and nourishing kidney.Not only promoting the production of body fluid to quench thirst and heat clearing and blood cooling are also to metrorrhagia, have effect through uncomfortable, frequent fetal movement, constipation etc.
The Radix Astragali (Milkvetch Root) claims Radix Astragali or northern Millefolium again, also makes Radix Astragali or Radix astragali, and one of conventional Chinese medicine is the root of leguminous plant Radix Astagali or Radix Astragali.Main product in Inner Mongol of China, ground such as Shanxi, Heilungkiang.Mainly be to make decoction pieces, adjust in Chinese medicinal formulae.Modern times are also made industrial preparation with Radix Astragali extract, oral or intravenous drip.Radix Astragali sweet in the mouth, slightly warm in nature is returned liver, spleen, lung, kidney channel.There are benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.
Radix Isatidis, the dry root of cruciferae isatis Isatis indigotica Fort., another name: indigo-blue, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) root, Radix Clerodenri Cyrtophylli.Main product in the Hunan, ground such as Jiangxi, Guangxi, Guangdong.This product bitter in the mouth, cold in nature, heat clearing away is arranged, detoxifcation, removing heat from blood, the effect of sore-throat relieving cures mainly: maculae caused by violent heat pathogen; The hyperpyrexia headache; Major part pestilence; Crimson tongue is purple dark, diseases such as scarlet fever.
Fructus Crataegi, the dry mature fruit of rosaceous plant Fructus Pyri Pashiae Crataegus pinnatifida Bge. var. major N. E. Br. or Fructus Crataegi Crataegus pinnatifida Bge., slightly warm in nature, sweet in the mouth, acid.This product has invigorating the stomach and promoting digestion, the effect that invigorating blood circulation is tired.It is reported has the composition of relievining asthma and reducing phlegm, suppressing antibacterial, treating abdominal pain diarrhea in the Fructus Crataegi.
Gypsum Fibrosum, main chemical compositions: CaSO
4NH
2O, heat clearing and fire purging medicine, acrid in the mouth, sweet is slightly cold, and attaches to the lung and stomach meridians.Clearly
The diarrhea of heat type fire, relieving restlessness is quenched the thirst, the convergence granulation promoting.Normal and Rhizoma Anemarrhenae mutual reinforcement between compatibility are for the syndrome of epidemic febrile disease edema caused by disorder of QI excess-heat.
Radix Glycyrrhizae: the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Feeble QI, it is sweet and special to distinguish the flavor of.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.
The specific embodiment
Embodiment 1
Take by weighing Herba Taraxaci 250g, Rhizoma Coptidis 250g, Radix Rehmanniae 80g, Radix Astragali 100g, Radix Isatidis 100g, Fructus Crataegi 80g, Gypsum Fibrosum 80g, Radix Glycyrrhizae 100g respectively, decoct with water three times; Add for the first time 10.4L water, decoct 1.5 h, second and third time adds the water of 8.32L, and each decocted 1 hour, merge extractive liquid,, filter with 60 μ m filter membranes, be concentrated into relative density and be 1.21 extractum, add ethanol and make that to contain the alcohol amount be 65%, left standstill 24 hours, Separation and Recovery ethanol obtains supernatant A;
Get Radix Bupleuri 250g, chopping adds 2L water logging bubble 12h, vapor distillation, and the distillation extraction time is 2h, collects volatile oil B and distillate C;
Merge supernatant A and distillate C, add 1% sorbic acid in heating, boil, cross 30 μ m filter membranes while hot, cooling adds volatile oil B mix homogeneously, and cold preservation adds water after leaving standstill 12 hours, stir evenly, and fill, sterilization, namely.
Embodiment 2
Get Herba Taraxaci 450g, Rhizoma Coptidis 500g, Radix Rehmanniae 250g, Radix Astragali 300g, Radix Isatidis 300g, Fructus Crataegi 250g, Gypsum Fibrosum 200g, Radix Glycyrrhizae 350g, decoct with water three times; For the first time add 26L water, decoct 1.5 h, second and third time adds 20.8L water, and each decocted 1 hour, merge extractive liquid, filters with 60 μ m filter membranes, is concentrated into relative density and is 1.21 extractum, adds ethanol and makes that to contain the alcohol amount be 65%, left standstill 24 hours, Separation and Recovery ethanol obtains supernatant A;
Get Radix Bupleuri 500g, chopping adds 4L water logging bubble 12h, vapor distillation, and the distillation extraction time is 2h, collects volatile oil B and distillate C;
Merge supernatant A and distillate C, in heating, add Gypsum Fibrosum decoction liquor D and 1% sorbic acid, boil, cross 30 μ m filter membranes while hot, cooling adds volatile oil B mix homogeneously, and cold preservation adds water after leaving standstill 15 hours, stir evenly, fill, sterilization namely gets Chinese medicine oral liquid of the present invention.
Embodiment 3
Get Herba Taraxaci 350g, Rhizoma Coptidis 380g, Radix Rehmanniae 180g, Radix Astragali 230g, Radix Isatidis 200g, Fructus Crataegi 160g, Gypsum Fibrosum 180g, Radix Glycyrrhizae 200g, decoct with water three times; For the first time add 18.8L water, decoct 1.5 h, second and third time adds 15L water, and each decocted 1 hour, merge extractive liquid, filters with 60 μ m filter membranes, is concentrated into relative density and is 1.23 extractum, adds ethanol and makes that to contain the alcohol amount be 65%, left standstill 24 hours, Separation and Recovery ethanol obtains supernatant A;
Get Radix Bupleuri 380g, chopping adds 3.04L and soaks 12h, vapor distillation, and the distillation extraction time is 2h, collects volatile oil B and distillate C;
Merge supernatant A and distillate C, in heating, add Gypsum Fibrosum decoction liquor D and 1% sorbic acid, boil, cross 30 μ m filter membranes while hot, cooling adds volatile oil B mix homogeneously, and cold preservation adds water after leaving standstill 15 hours, stir evenly, fill, sterilization namely gets Chinese medicine oral liquid of the present invention.
Embodiment 4
Get Herba Taraxaci 300g, Rhizoma Coptidis 300g, Radix Rehmanniae 100g, Radix Astragali 150g, Radix Isatidis 150g, Fructus Crataegi 100g, Gypsum Fibrosum 100g, Radix Glycyrrhizae 150g, decoct with water three times; For the first time add 13.5L water, decoct 1.5 h, second and third time adds 10.8L water, and each decocted 1 hour, merge extractive liquid, filters with 60 μ m filter membranes, is concentrated into relative density and is 1.22 extractum, adds ethanol and makes that to contain the alcohol amount be 65%, left standstill 24 hours, Separation and Recovery ethanol obtains supernatant A;
Get Radix Bupleuri 300g, chopping adds 2.4L water logging bubble 12h, vapor distillation, and the distillation extraction time is 2h, collects volatile oil B and distillate C;
Extractum A and sucrose is even according to the mixed of 1:7, and wet granulation sprays into volatile oil B, is drying to obtain.
Embodiment 5
Get Herba Taraxaci 400g, Rhizoma Coptidis 450g, Radix Rehmanniae 200g, Radix Astragali 250g, Radix Isatidis 250g, Fructus Crataegi 200g, Gypsum Fibrosum 200g, Radix Glycyrrhizae 250g, decoct with water three times; For the first time add 22L water, decoct 1.5 h, second and third time adds 17.6L water, and each decocted 1 hour, merge extractive liquid, filters with 60 μ m filter membranes, is concentrated into relative density and is 1.23 extractum, adds ethanol and makes that to contain the alcohol amount be 65%, left standstill 24 hours, Separation and Recovery ethanol obtains supernatant A;
Get Radix Bupleuri 450g, chopping adds 3.6L and soaks 12h, vapor distillation, and the distillation extraction time is 2h, collects volatile oil B and distillate C;
Extractum A and sucrose is even according to the mixed of 1:7, and wet granulation sprays into volatile oil B, is drying to obtain.
Embodiment 6
The clinical trial situation of the Chinese medicine oral liquid of control chicken high febrile disease of the present invention:
Enter summer in July, (1) 2012, and the area mostly is hot and humid weather in the osmanthus, is fowl poultry multiple season of hyperpyrexia disease.Choosing 200 chickens in chicken farm, Liujiang County, Liuzhou City is experiment sample, be divided into four groups, every group 50, the A group is matched group, B, C, D group Chinese medicine oral liquid and the drinking water of use-case 1, example 2, example 3 preparations are respectively allocated in the 1:50 ratio, five days is a course for the treatment of, feeds under identical management condition, observes the incidence of chicken.The result is as shown in table 1.As seen, Chinese medicine oral liquid of the present invention can reduce hyperpyrexia disease sickness rate 1.5%～3%, and wherein the product of example 3 preparations is the most obvious to prevention chicken high febrile disease effect.
25 days, 35 days, 45 days hyperpyrexia disease sickness rate of table 1
| ? | Feeding conditions | 25 days sequela rates (%) | 35 days sequela rates (%) | 45 days sequela rates (%) |
| Comparable group | Common feedstuffs+sterilization tap water | 1.0 | 2.5 | 5.5 |
| Test group A | Common feedstuffs+sterilization tap water+example 1 Chinese medicine oral liquid | 0.5 | 1.5 | 4.0 |
| Experiment group B | Common feedstuffs+sterilization tap water+example 2 Chinese medicine oral liquid | 0 | 2.0 | 3.5 |
| Test group C | Common feedstuffs+sterilization tap water+example 3 Chinese medicine oral liquid | 0 | 1.5 | 2.5 |
(2) Liucheng County, Liuzhou City raiser Zhang, supporting has 78 of chickens, and wherein, 3 are dead, 12 lethargy are arranged, be off one's feed, and are judged as colony's paralysis hyperpyrexia disease.Adopt the product of example of the present invention 4 preparations press 1:50 and feedstuff allotment, feeds after seven days, in 12 of the paralysis disease chickens, 11 are recovered normal, 1 death, and epidemic situation does not have further the diffusion in the chicken group.
(3) Liucheng County, Liuzhou City raiser river, supporting has 106 of chickens, and paralysis is hyperpyrexia disease in various degree, and wherein 21 state of an illness are comparatively serious.Adopt the product of example 5 preparations of the present invention to press 1:50 and feedstuff allotment, feed after seven days, 99 are recovered normal, 7 death of failing to respond to any medical treatment, and cure rate reaches 93.4%.
Claims (5)
1. Chinese medicine of preventing and treating chicken high febrile disease is characterized in that it is to be formed by the feedstock production that comprises following weight portion:
Herba Taraxaci 25～45 Radix Bupleuri 25～50 Rhizoma Coptidis 25～50 Radix Rehmanniae 8～25
The Radix Astragali 10～30 Radix Isatidis 10～30 Fructus Crataegis 8～25 Gypsum Fibrosum 8～25
Radix Glycyrrhizae 10～35.
2. the Chinese medicine of control chicken high febrile disease as claimed in claim 1 is characterized in that it is to be formed by the feedstock production that comprises following weight portion:
Herba Taraxaci 30～40 Radix Bupleuri 30～45 Rhizoma Coptidis 30～45 Radix Rehmanniae 10～20
The Radix Astragali 15～25 Radix Isatidis 15～25 Fructus Crataegis 10～20 Gypsum Fibrosum 10～20
Radix Glycyrrhizae 15～25.
3. the Chinese medicine of control chicken high febrile disease as claimed in claim 2 is characterized in that it is to be formed by the feedstock production that comprises following weight portion:
Herba Taraxaci 35 Radix Bupleuri 38 Rhizoma Coptidis 40 Radix Rehmanniae 18 Radixs Astragali 23
Radix Isatidis 20 Fructus Crataegis 16 Gypsum Fibrosum 18 Radix Glycyrrhizaes 20.
4. as the Chinese medicine of any one described control chicken high febrile disease of claim 1～3, it is characterized in that the preparation method of its oral liquid is:
Get 8 flavor medical materials except Radix Bupleuri, decoct with water three times; The water that adds 10 times of amounts that are equivalent to 8 flavor medical material gross weights for the first time, decoct 1.5 h, second and third time adds the water of 8 times of amounts that are equivalent to 8 flavor medical material gross weights, and each decocted 1 hour, merge extractive liquid,, filter with 60 μ m filter membranes, be concentrated into relative density and be 1.20～1.23 extractum, add ethanol and make that to contain the alcohol amount be 65%, left standstill 24 hours, Separation and Recovery ethanol obtains supernatant A;
Get Radix Bupleuri, chopping adds the water logging bubble 12h that is equivalent to 8 times of Radix Bupleuri medical material weight, vapor distillation, and the distillation extraction time is 2h, collects volatile oil B and distillate C;
Merge supernatant A and distillate C, add 1% sorbic acid in heating, boil, cross 30 μ m filter membranes while hot, cooling adds volatile oil B mix homogeneously, and cold preservation adds water after leaving standstill 12 hours, stir evenly, and fill, sterilization, namely.
5. as the Chinese medicine of any one described control chicken high febrile disease of claim 1～3, it is characterized in that the preparation method of its granule is:
Get 8 flavor medical materials except Radix Bupleuri, decoct with water three times; The water that adds 10 times of amounts that are equivalent to 8 flavor medical material gross weights for the first time, decoct 1.5 h, second and third time adds the water of 8 times of amounts that are equivalent to 8 flavor medical material gross weights, and each decocted 1 hour, merge extractive liquid,, filter with 60 μ m filter membranes, be concentrated into relative density and be 1.20～1.23 extractum, add ethanol and make that to contain the alcohol amount be 65%, left standstill 24 hours, Separation and Recovery ethanol is concentrated into relative density and is 1.25～1.30 extractum, obtains extractum A;
Get Radix Bupleuri, chopping adds the water logging bubble 12h that is equivalent to 8 times of Radix Bupleuri gross weights, and vapor distillation is collected volatile oil B;
Extractum A and sucrose is even according to the mixed of 1:7, and wet granulation sprays into volatile oil B, is drying to obtain.
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