CN103251803A - Formula and process of health-assistant wine - Google Patents
Formula and process of health-assistant wine Download PDFInfo
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Abstract
The invention relates to a formula and process of a health-assistant wine which can be used for treating sub-health. The invention particularly relates to a traditional Chinese medicine medicated wine which uses Chinese herbal medicines as bulk drugs and is used for treating sub-health, and a preparation method of the traditional Chinese medicine medicated wine. According to the method, a feasible process route for extraction and preparation is reasonably optimized, and the results of corresponding pharmacodynamic experimental verifications show that the traditional Chinese medicine medicated wine is stable, effect and reliable in curative effect and has a unique curative effect on sub-healthy patients.
Description
Technical field
The present invention relates to a kind of health wine prescription and technology of helping, can be used for the treatment of subhealth state.Relating in particular to a kind of is the Chinese medicine medicated wine and preparation method thereof of the treatment subhealth state of crude drug with the Chinese herbal medicine.
Background technology
Along with the increase of operating pressure, daily life system is irregular, and modern youngster total quality descends.Often show as: the thinking logic confusion, language performance is incomplete, forgets after the preceding note, and body constitution is not good, lassitude etc., memory loss when serious, personality changes hot-tempered impermanence or dull mind, is in sub-health state, and the clinical onset rate has the trend of continuous rising in recent years.Modern medicine is at clinical a certain symptom treatment, often fall flat, can not find suitable Therapeutic Method, more existing health promoting wine, medical material content is low excessively, does not have health care's effect, and the health promoting wine Chinese crude drug too high levels that has, cause health promoting wine flavour of a drug overrich again, be difficult for accepting for people.In order to overcome above-mentioned defective, the present invention is based on the differential diagnosis of diseases and the dialectical principle that combines of Chinese traditional treatment subhealth state disease, treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, inside and outside logical accent, emergency is taken in concurrently, according to the theory of Chinese medical science prescription, is prepared from according to certain weight proportion.A kind of Chinese medicine medicated wine of evident in efficacy, with low cost, treatment subhealth state that toxic and side effects is minimum is provided.
Summary of the invention
Technical problem to be solved by this invention is to overcome above-described shortcoming, and a kind of Chinese medicine medicated wine for the treatment of subhealth state of evident in efficacy, with low cost, almost non-toxic side effect is provided, and has original effect at hypomnesis, dizziness and tinnitus.The prescription of specifically having introduced this Chinese medicine medicated wine forms and reasonably optimizing has gone out feasible extraction and preparation technique route, through corresponding pharmacodynamics test checking, the result show the stable curative effect of this Chinese medicine medicated wine, effectively, reliable.
The application is the technology by Fructus Rubi, Fructus Mori, Fructus Lycii, Rhizoma Polygonati four Chinese medicine material process science, the health promoting wine that obtains is better effects if aspect slow increase amount of blood supply raising immunity not only, effect is also very outstanding improving aspect the hypomnesis, is fit to very much subhealth state class crowd.
The present invention selects for use medical material as follows:
Fructus Rubi: the effect with kidney invigorating and YANG supporting.Raspberry seed oil belongs to unsaturated fatty acid, can promote the severe that of prostate secretion to cover.Effect: the liver and the kidney tonifying, the controlling nocturnal emission with astringent drugs reducing urination makes eye bright.
Fructus Mori: cure mainly weakness due to chronic disease, hepatic and renal YIN deficiency, soreness of the waist and knees, the dark tinnitus of order, articular instability, dryness of the intestine constipation, body fluid deficiency insufficiency of blood, hectic fever seminal emission, diabetes etc.
Fructus Lycii: its sweet in the mouth, property are put down has the effect of the liver and the kidney tonifying, says in the Compendium of Material Medica that " obey hard muscles and bones for a long time, it is not old to make light of one's life by commiting suicide, cold-resistant summer-heat." traditional Chinese medical science commonly used it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, many tears of blurred vision, quench one's thirst, disease such as seminal emission.Modern pharmacology studies confirm that Fructus Lycii scalable body's immunity, can effectively suppress tumor growth and cell mutation, has slow down aging, the effect of anti-fatty liver, adjusting blood fat and aspects such as blood glucose, promotion hemopoietic function, and is applied to clinical.The Fructus Lycii taking convenience can be used as medicine, chews clothes, steep in wine.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
Rhizoma Polygonati: sweet, flat, return spleen, lung, kidney channel.Nourishing YIN and moistening the lung, invigorating the spleen and replenishing QI.Be used for lung-dryness syndrome due to deficiency of YIN, weakness of the spleen and stomach, the dizziness of deficiency of kidney essence, soreness of the waist and knees, early whitening of beard and hair and quench one's thirst etc.
Multiselect of the present invention is got medicine food homologous raw materials, takes for a long time to have no side effect, and is safe and reliable.Above-mentioned each raw material is with traditional Chinese medical science tonifying kidney, superintend and direct and promote blood circulation, replenishing QI to invigorate the spleen, nourish blood and transfer liver to be principle by force, and reasonably combined, the effect that can reach enhancing immunity, regains the strength of memory has unique curative effect to the subhealth state patient.
The technical problem of the desired solution of the present invention realizes by following technological approaches.
A kind of health Chinese medicine medicated wine of helping of the present invention, crude drug is made up of the component of following weight portion: 8～12 parts of Rhizoma Polygonatis, 4～8 parts of Fructus Rubies, 4～8 parts of Fructus Lycii, 8～12 parts in Fructus Mori.Be preferably: 9 parts of Rhizoma Polygonatis, 6 parts of Fructus Rubies, 6 parts of Fructus Lycii, 9 parts in Fructus Mori.Used its specification of herbal raw material medicine of the present invention meets the state-promulgated pharmacopoeia regulation.
The preparation method of Chinese medicine medicated wine is as follows: (1) gets Rhizoma Polygonati, Fructus Rubi, Fructus Lycii, the Fructus Mori of above-mentioned weight portion, add for the first time the water that pH value is 3.0-5.0, amount of water and medical material weight ratio are 6-10 times, behind supersound process 10-30min, heating extraction 1-2 hour, filter; Add for the second time the water that pH value is 5.5-7.0, amount of water and medical material weight ratio are 5-8 times, heating extraction 0.5-1.5 hour, filter; Add the water that pH value is 7.5-9.0 for the third time, amount of water is 5-8 times, heating extraction 0.5-1.5 hour, filter, the merging filtrate concentrating under reduced pressure adds a certain amount of ethanol, and left standstill 24 hours, filtering, it is that the clear paste of 1.10-1.25 is standby that filtrate recycling ethanol and 60 ℃ of concentrating under reduced pressure become relative density; (2) get above-mentioned clear paste, add the Chinese liquor of 15-25 times of clear paste weight, mixing filters, namely.
Above-mentioned Chinese liquor is the ancient well wine of 50 degree.
Preferred manufacturing procedure is as follows in the technical solution of the present invention:
(1) get Rhizoma Polygonati, Fructus Rubi, Fructus Lycii, the Fructus Mori of above-mentioned weight portion, add pH value for the first time and be 4.0 water, amount of water and medical material weight ratio are 8 times, behind supersound process 20min, and heating extraction 1.5 hours, filtration; Add for the second time pH value and be 6.0 water, amount of water and medical material weight ratio are 6 times, heating extraction 1.0 hours, filtration; Add pH value for the third time and be 8.0 water, amount of water is 6 times, heating extraction 0.5 hour, filter, the merging filtrate concentrating under reduced pressure adds a certain amount of ethanol and makes and contain the alcohol amount and reach 70%, and left standstill 24 hours, filtering, it is that 1.20 clear paste is standby that filtrate recycling ethanol and 60 ℃ of concentrating under reduced pressure become relative density; (2) get above-mentioned clear paste, add the Chinese liquor of 20 times of clear paste weight, mixing filters, namely.
Above-mentioned Chinese liquor is the ancient well wine of 50 degree.
Usage and dosage: every day 1-2 time, each 25-50ml.
The present invention mainly has following creationary useful technique effect:
One, the extraction of medical material and purification aspect:
The present invention's prescription is made up of Rhizoma Polygonati, Fructus Rubi, Fructus Lycii, Fructus Mori, and its prescription is simplified proper, and effect significantly.Our research is on the basis that prescription is determined, extraction and purification process to medical material is completely newly groped, factors such as medical material physical property, effective ingredient characteristic and production cost have been taken all factors into consideration, concrete improvement is mainly reflected in as follows: (1) four Chinese medicine material of the present invention, the effect characteristics of Chinese medicine preparation and in conjunction with modern biopharmaceutical new technique according to the present invention, we adopt semi-bionic extraction alcohol deposition method (being SBAE), creationary it is carried out the extraction purification, kept active component effectively.Semi-biomimetic method is a kind of Chinese medicine extraction new technique that the imitation oral drugs propose at the gastrointestinal transport process, and it adopts the acid water of selected pH value and alkaline water to extract continuously successively, its objective is to extract to contain index components high " active mixture ".This method is adhered to the viewpoint of " composition opinion being arranged; not only composition opinion; focus on the reaction of body pharmacodynamics " in the design of extraction process, do index with one or more effective ingredient, total extractives and opposed polarity part or main pharmacological, multifactorial evaluation, the theoretical principle of preferred extraction process can be given full play to the comprehensive function characteristics of mix ingredients like this, be conducive to again control the quality of the pharmaceutical preparations with monomer component, finally obtain being fit to the active ingredient of absorption of human body.In the present invention, we are through unremitting effort, by a large amount of experimentatioies, final also is to have obtained the technical scheme described in the present invention accidentally: namely extract 3 pH value and be respectively: 3.0～5.0,5.5～7.0,7.5～9.0, wherein pH value is preferably 4.0,6.0 and 8.0.We adopt the semi-bionic extraction alcohol deposition method to the active substance that extracts gained more then, finally reach the purpose of efficient medication.(2) will extract medical material and pass through ultrasonic pretreatment in advance after, its extraction ratio of effective constituents significantly improves, mainly be because by cavitation effect of ultrasonic waves, vibration effect and heating effect, can make the destruction of crude drug cell, thereby accelerate release and the stripping of effective ingredient, to be a very big saving to production cost and production capacity like this, finally be of value to the popularization of industrialization.
Two, pharmacodynamics aspect:
(1) the clinical observation on the therapeutic effect experiment of Chinese medicine medicated wine treatment hypomnesis of the present invention
1.1 the physical data of experimental subject: adopt Chinese medicine medicated wine of the present invention to treat 49 routine patients altogether, male 28 examples wherein, women 21 examples; The oldest person 79 years old, the age reckling has only 16 years old.
1.2 Therapeutic Method, usage and dosage: adopt the Chinese medicine medicated wine of the present invention's preparation, its usage and consumption are as follows: every day 1-2 time, each 25-50ml.The course for the treatment of: one month is a course for the treatment of, treats 4-6 the course for the treatment of altogether.
1.3 therapeutic evaluation standard
Cure: memory recovers normal, resourceful, clear thinking, and verbalization is complete, and is in high spirits, and diet and rest are normal, and mood is stable, and the patient does not have any bad sensation, and is happy, in high spirits.
Produce effects: memory significantly is restored, and thinking is comparatively quick, and thinking is more clear, and verbal expression skill strengthens, and is in high spirits, and diet and rest are normal, and mood is stable, and the patient does not have big bad sensation, and is happy, in high spirits.
Effectively: memory is recovered to some extent, and thinking improves, and thinking is more preceding distinct, and verbalization improves, and spirit is better, and diet and rest are normal substantially, and mood is more stable, and it is better that the patient feels.
Invalid: sign does not have any change, and symptom such as preceding feels depressed, and lethargy is depressed.Product alleviating physical fatigue function test of the present invention
1.4 therapeutic outcome:
In the 49 routine cases of accepting for medical treatment, through treatment in 10 months, wherein cure 15 examples, produce effects 13 examples, effective 17 examples, invalid 4 examples, total effective rate reaches 91%.The result shows that Chinese medicine medicated wine of the present invention has extremely significant curative effect to the hypomnesis patient.
1.5 model case:
(1) Liu, man, 42 years old, driver.Before March, originally normal memory generation serious degradation behind the brain trauma surgery is all forgotten from sick 5 to 6 months thing before, have not a particle of impression, more seriously, present thing has not been remembered yet, and be that whole things are not a bit remembered, speak and always repeat those several.Took medicated wine of the present invention 15, subhealth state makes moderate progress, continue and obeyed Chinese medicine medicated wine of the present invention 1 month, thing at the moment can remember that mostly a former thing part can remember that memory before significantly improves, symptom is greatly taken on a new look, the clothes medicated wine of the present invention 3 months that continues, transference cure, memory recover as before.(2) Chen, woman, 73 years old, retired cadre.The patient engendered hypomnesis before 5 years, showed as forgetful, obvious with nearly hypomnesis especially.After hypomnesis far away gradually appears, bradykinesia, verbigeration.Sx over nearly 6 months, dystropy, apathetic expression, relatives all are not familiar with at one's side sometimes.Spirit is poor when examining, malaise, osteodynia discomfort, and night is heavy especially, and is unable to fall asleep whole night, the appetite extreme difference, apathetic expression, orientation force, memory, judgment, computing power obviously go down, and speech reduces.Took Chinese medicine medicated wine of the present invention 1 month, hypomnesis obviously improves, and cognitive competence improves, malaise, osteodynia are alleviated, and continue and obey Chinese medicine medicated wine of the present invention 2 months, and memory significantly promotes, diet increases, and spirit takes a turn for the better, and sleep is fragrant, cognitive competence improves, the whole body osteodynia disappears, and continues and obeys Chinese medicine medicated wine of the present invention 3 months, likes to speak with the people, initiatively greeting with the people exchanges, and the patient is conscious, and sign is better than ever.
(3) bent certain, man, 69 years old, professor.March, cause was gone to nonlocal lecture tour, runs to come and go, and the road fatigue, spirit is extremely tired.The back memory of going home obviously fails, and answers very not pertinent to the pointly, and chaos is unclear all day, speaking scarcely,taciturn, and it is poor to sleep, probably with other people speech, nearly 2 weeks increase the weight of, and apathetic expression occurs, and words are put upside down, bradykinesia, lustreless complexion, witless expression, white and thin fur, matter is light fat partially, deep,thready and forceless pulse.Took Chinese medicine medicated wine of the present invention 15 days, spirit makes moderate progress, and sleeps night and can sleep peacefully 5～7 hours, continues and obeys Chinese medicine medicated wine of the present invention 1 month, complexion is changeed profit, the consciousness reaction is normal, and memory makes moderate progress, and spirit is also shaken, answer and keep to the point, continue and obeyed Chinese medicine medicated wine of the present invention 3 months, various symptoms all disappear, and patient's mental attitude is taken on an entirely new look.
(4) Lee, man, 67 years old, retired cadre.The patient over nearly 2 years memory obviously go down, apathetic expression, bradykinesia, it is unclear to tell word, sialorrhea is unsociable and eccentric, behavior is unusual sometimes.Examined preceding 10 days, insomnia appears in the patient, and excited language is many, speaking incoherently, and understanding, difficult judgment be can't take care of oneself, emotional fragility, memory obviously descends, and the body of the tongue purple is dim, greasy fur, deep and hesitant pulse.Took Chinese medicine medicated wine of the present invention 15 days, spirit makes moderate progress, and the sleep amelioration continues and obeyed Chinese medicine medicated wine of the present invention 1 month, the state of an illness takes a turn for the better gradually, be emotionally stable, memory, faculty of understanding, judgment improve, and life can be taken care of oneself, continue and obeyed Chinese medicine medicated wine of the present invention 3 months, all recover as before, follow up a case by regular visits to 1 year surplus, do not see recurrence.
(5) Gong, woman, 57 years old, peasant.Told forgetful 2 years, subhealth state, absent minded, timid susceptible to fright, vexed uneasiness, it is disintoxicated to sleep night, sticks with paste when clear during mind, and the sight anxiety is given an irrelevant answer, computing power forfeiture, thirst and drinking, constipation, the dizzy soreness of waist, emaciated physique.Red tongue, tongue is few, thready pulse.Took Chinese medicine medicated wine of the present invention 2 months, memory increases, and mind is clear, god's peace of sleeping surely, can answer simple problem, the dizzy soreness of waist subtracts, thirstyly removes, and is convenient to both as usual, recover the units computing power, continue and obeyed Chinese medicine medicated wine of the present invention 3 months, the state of an illness takes a turn for the better gradually, is emotionally stable, memory, faculty of understanding, judgment significantly improve, and life can be taken care of oneself, and the clothes Chinese medicine medicated wine of the present invention that continues is surplus March, mind is more preceding more clear, and is in high spirits, has rosy cheeks, the food of sleeping is all good, and question and answer are kept to the point, and life is normal.
(2) increase the oxygen-supplying amount experiment
1, test material:
Kunming mouse, body weight 20 ± 2 grams, male and female half and half, totally 48.The Chinese medicine medicated wine that embodiment 1 prepares.Sodica calx, vaseline, stopwatch, 250ml wide mouthed bottle.
2, method and result:
2.1 the influence to the ligation bilateral common carotid arteries time-to-live
Get 24 male and female half and half of mice, be divided into 2 groups at random, 12 every group.The blank group is irritated stomach and is given distilled water, and Chinese medicine medicated wine group is irritated stomach and is subjected to reagent liquid 11.33g/kg, 20ml/kg.Once a day, successive administration 5 days, the last administration with the separation of mice bilateral common carotid arteries and together with the vagus nerve ligation, was observed its death time after 1 hour.The results are shown in Table 1, visible Chinese medicine medicated wine can obviously prolong the time-to-live of mice ligation bilateral common carotid arteries.
The table 1 mice ligation bilateral common carotid arteries time-to-live
Annotate: compare * P＜0.05 with matched group
2.2 the influence to the normal pressure anoxia enduring
The mice group administration is all with 2.1.After the last administration 1 hour, put into the 250ml wide mouthed bottle that fills the 5g sodica calx, bottleneck is coated with vaseline to increase sealing.The observed and recorded mice dying time.The results are shown in Table 2, visible Chinese medicine medicated wine can obviously prolong the time-to-live of anoxia under the mice normal pressure.
The table 2 mice normal pressure anoxia enduring time-to-live
Annotate: compare * P＜0.05 with matched group
3, conclusion:
Experimental result shows that Chinese medicine medicated wine can increase the cerebral blood flow of mice, improves cerebral ischemia, improves hypoxia-bearing capability, helps to improve the symptom of subhealth state patient's dizziness and tinnitus.
The treatment that the present invention is directed to the subhealth state patient is very effective, various crude drug are coordinated mutually, at utmost bring into play drug effect, extractive technique by the advanced person obtains effective ingredient in the medical material, can effectively improve the self-coordination ability of patient's body, significantly improve function and clinical subjective symptoms, can reach enhancing immunity, improve the effect of renal function, have advantage such as have no side effect, expense is lower in addition.
The specific embodiment
Embodiment 1
(1) get Rhizoma Polygonati, Fructus Rubi, Fructus Lycii, the Fructus Mori of above-mentioned weight portion, add pH value for the first time and be 4.0 water, amount of water and medical material weight ratio are 8 times, behind supersound process 20min, and heating extraction 1.5 hours, filtration; Add for the second time pH value and be 6.0 water, amount of water and medical material weight ratio are 6 times, heating extraction 1.0 hours, filtration; Add pH value for the third time and be 8.0 water, amount of water is 6 times, heating extraction 0.5 hour, filter, the merging filtrate concentrating under reduced pressure adds a certain amount of ethanol and makes and contain the alcohol amount and reach 70%, and left standstill 24 hours, filtering, it is that 1.20 clear paste is standby that filtrate recycling ethanol and 60 ℃ of concentrating under reduced pressure become relative density; (2) get above-mentioned clear paste, add the Chinese liquor of 20 times of clear paste weight, mixing filters, namely.Above-mentioned Chinese liquor is the ancient well wine of 50 degree.
Embodiment 2
(1) get Rhizoma Polygonati, Fructus Rubi, Fructus Lycii, the Fructus Mori of above-mentioned weight portion, add pH value for the first time and be 3.0 water, amount of water and medical material weight ratio are 6 times, behind supersound process 10min, and heating extraction 1 hour, filtration; Add for the second time pH value and be 5.5 water, amount of water and medical material weight ratio are 5 times, heating extraction 0.5 hour, filtration; Add pH value for the third time and be 7.5 water, amount of water is 5 times, heating extraction 0.5 hour, filter, the merging filtrate concentrating under reduced pressure adds a certain amount of ethanol and makes and contain the alcohol amount and reach 70%, and left standstill 24 hours, filtering, it is that 1.10 clear paste is standby that filtrate recycling ethanol and 60 ℃ of concentrating under reduced pressure become relative density; (2) get above-mentioned clear paste, add the Chinese liquor of 15 times of clear paste weight, mixing filters, namely.Above-mentioned Chinese liquor is the ancient well wine of 50 degree.
Embodiment 3
(1) get Rhizoma Polygonati, Fructus Rubi, Fructus Lycii, the Fructus Mori of above-mentioned weight portion, add pH value for the first time and be 5.0 water, amount of water and medical material weight ratio are 10 times, behind supersound process 30min, and heating extraction 2 hours, filtration; Add for the second time pH value and be 7.0 water, amount of water and medical material weight ratio are 8 times, heating extraction 1.5 hours, filtration; Add pH value for the third time and be 9.0 water, amount of water is 8 times, heating extraction 1.5 hours, filter, the merging filtrate concentrating under reduced pressure adds a certain amount of ethanol and makes and contain the alcohol amount and reach 70%, and left standstill 24 hours, filtering, it is that 1.25 clear paste is standby that filtrate recycling ethanol and 60 ℃ of concentrating under reduced pressure become relative density; (2) get above-mentioned clear paste, add the Chinese liquor of 25 times of clear paste weight, mixing filters, namely.Above-mentioned Chinese liquor is the ancient well wine of 50 degree.
Claims (6)
1. help health Chinese medicine medicated wine for one kind, crude drug is made up of the component of following weight portion: 8～12 parts of Rhizoma Polygonatis, 4～8 parts of Fructus Rubies, 4～8 parts of Fructus Lycii, 8～12 parts in Fructus Mori, its preparation method is: (1) gets Rhizoma Polygonati, Fructus Rubi, Fructus Lycii, the Fructus Mori of above-mentioned weight portion, add for the first time the water that pH value is 3.0-5.0, amount of water and medical material weight ratio are 6-10 times, behind supersound process 10-30min, heating extraction 1-2 hour, filter; Add for the second time the water that pH value is 5.5-7.0, amount of water and medical material weight ratio are 5-8 times, heating extraction 0.5-1.5 hour, filter; Add the water that pH value is 7.5-9.0 for the third time, amount of water is 5-8 times, heating extraction 0.5-1.5 hour, filter, the merging filtrate concentrating under reduced pressure adds a certain amount of ethanol, and left standstill 24 hours, filtering, it is that the clear paste of 1.10-1.25 is standby that filtrate recycling ethanol and 60 ℃ of concentrating under reduced pressure become relative density; (2) get above-mentioned clear paste, add the Chinese liquor of 15-25 times of clear paste weight, mixing filters, namely.
2. Chinese medicine medicated wine according to claim 1, crude drug is made up of the component of following weight portion: 9 parts of Rhizoma Polygonatis, 6 parts of Fructus Rubies, 6 parts of Fructus Lycii, 9 parts in Fructus Mori.
3. Chinese medicine medicated wine according to claim 1 and 2 is characterized in that: Chinese liquor is the ancient well wine of 50 degree.
4. the preparation method of Chinese medicine medicated wine according to claim 1 and 2, it is characterized in that: (1) gets Rhizoma Polygonati, Fructus Rubi, Fructus Lycii, the Fructus Mori of above-mentioned weight portion, add for the first time the water that pH value is 3.0-5.0, amount of water and medical material weight ratio are 6-10 times, behind supersound process 10-30min, heating extraction 1-2 hour, filter; Add for the second time the water that pH value is 5.5-7.0, amount of water and medical material weight ratio are 5-8 times, heating extraction 0.5-1.5 hour, filter; Add the water that pH value is 7.5-9.0 for the third time, amount of water is 5-8 times, heating extraction 0.5-1.5 hour, filter, the merging filtrate concentrating under reduced pressure adds a certain amount of ethanol, and left standstill 24 hours, filtering, it is that the clear paste of 1.10-1.25 is standby that filtrate recycling ethanol and 60 ℃ of concentrating under reduced pressure become relative density; (2) get above-mentioned clear paste, add the Chinese liquor of 15-25 times of clear paste weight, mixing filters, namely.
5. the preparation method of Chinese medicine medicated wine according to claim 4: it is characterized in that: (1) gets Rhizoma Polygonati, Fructus Rubi, Fructus Lycii, the Fructus Mori of above-mentioned weight portion, add for the first time pH value and be 4.0 water, amount of water and medical material weight ratio are 8 times, behind supersound process 20min, heating extraction 1.5 hours filters; Add for the second time pH value and be 6.0 water, amount of water and medical material weight ratio are 6 times, heating extraction 1.0 hours, filtration; Add pH value for the third time and be 8.0 water, amount of water is 6 times, heating extraction 0.5 hour, filter, the merging filtrate concentrating under reduced pressure adds a certain amount of ethanol and makes and contain the alcohol amount and reach 70%, and left standstill 24 hours, filtering, it is that 1.20 clear paste is standby that filtrate recycling ethanol and 60 ℃ of concentrating under reduced pressure become relative density; (2) get above-mentioned clear paste, add the Chinese liquor of 20 times of clear paste weight, mixing filters, namely.
6. according to the preparation method of claim 4 or 5 described Chinese medicine medicated wine, it is characterized in that: Chinese liquor is the ancient well wine of 50 degree.
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| 赵余庆: "《中药及天然产物提取制备关键技术》", 31 January 2012, 中国医药科技出版社 * |
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| CN108117961A (en) * | 2018-01-26 | 2018-06-05 | 贵州理工学院 | A kind of minuent health preserving wine and preparation method thereof |
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| CN108618128A (en) * | 2018-05-08 | 2018-10-09 | 广州莱可福生物科技有限公司 | Adjust the composition and its preparation method and application of immunity |
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