CN103251721B - Radiation-proof skin-care gel and preparation method thereof - Google Patents
Radiation-proof skin-care gel and preparation method thereof Download PDFInfo
- Publication number
- CN103251721B CN103251721B CN201310166156.2A CN201310166156A CN103251721B CN 103251721 B CN103251721 B CN 103251721B CN 201310166156 A CN201310166156 A CN 201310166156A CN 103251721 B CN103251721 B CN 103251721B
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- skin
- angelicae dahuricae
- glycerol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides radiation-proof skin-care gel. The gel can be used for preventing and treating a radiation skin injury, and comprises the following crude medicines in parts by weight: 10-20 parts of American ginseng, 80-90 parts of radix angelicae, 20-40 parts of elecampane, 10-20 parts of sophora flower, 10-20 parts of scutellaria baicalensis, and 5-10 parts of fructus evodiae; and 80-120 parts of glycerol as a substrate material and 8-12 parts of Carbomer are added when the main crude medicines are prepared into gels. The skin-care gel disclosed by the invention can promote local tissue metabolism, plays a role of protecting the skin, prevents or reduces an injury caused by radiation on the skin tissue, and is good in curative effective, convenient to use and low in medicine cost.
Description
Technical field
The present invention relates to a kind of medicine, particularly, while being a kind of radiotherapy for preventing the exterior-applied gel with treating radioactive skin injury.
Background technology
For malignant tumor patient, radiotherapy is a kind of important treatment means.Yet radiotherapy meeting causes skin injury in various degree, cause radiotherapy to interrupt the course for the treatment of, after Patients Treated by Radiotherapy, skin can be because there is erythema in telangiectasis, and then there is microthrombusis in pigmentation, little blood vessel, cause local anoxia and secondary cell injury, occur decortication, ulcer, hemorrhage, downright bad etc.If occur, III degree and above dermoreaction need to suspend radiotherapy, thereby delay treating time affects the treatment, and it is painful to have increased patient.
Summary of the invention
The object of this invention is to provide a kind of radioprotective skin-care gel, this gel can be used for prevention and treating radioactive skin injury.
For achieving the above object, the technical solution used in the present invention is:
A radioprotective skin-care gel, comprises the crude drug of following weight portion: Radix Panacis Quinquefolii 10-20 part, Radix Angelicae Dahuricae 80-90 part, Radix Aucklandiae 20-40 part, Flos Sophorae 10-20 part, Radix Scutellariae 10-20 part, Fructus Evodiae 5-10 part.
While preparing gel with above-mentioned primary raw material medicine, add glycerol 80-120 part and carbomer 8-12 part as substrate adjuvant.
On above basis, preferential main material medicine and the weight portion proportioning of adjuvant are 15 parts of Radix Panacis Quinquefoliis, 85 parts of the Radixs Angelicae Dahuricae, 30 parts of the Radix Aucklandiae, 15 parts, Flos Sophorae, 15 parts of Radix Scutellariaes, 8 parts of Fructus Evodiaes, 100 parts of glycerol, 10 parts of carbomers.
In the present invention's formula, Radix Panacis Quinquefolii can promote that serum albumin is synthetic, bone marrow protein is synthetic, organ albumen is synthetic, improves immunity of organisms, can reduce blood coagulation, suppresses platelet aggregation, promote Growth of red blood cells, increases hematochrome.We find under study for action, and Radix Panacis Quinquefolii extract can significantly improve cytoactive, strengthen cellular metabolism, the blood that improves local organization for and nutrition, promote the reparation of Local Damaged cell.
The Radix Angelicae Dahuricae has following effect: 1, antiinflammatory action: the mouse stomach Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct (the suitable crude drug lg of lg) 4g/kg, can obviously suppress the inflammation of dimethylbenzene induced mice ear.2, antipyretic effect: the hot animal model of height causing in White Rabbit back with peptone subcutaneous injection, the 1g Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct 15g/kg, have obvious refrigeration function.The mouse stomach Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct 8g/kg, obviously reduce the mouse writhing number of times due to lumbar injection 1% acetic acid (0.l/kg), and effect is similar with aminophenazone 8mg/kg.Woolfe-Macdonald method test, the front threshold of pain of administration is at 30 minutes with interior person, and gavage awards the Radix Angelicae Dahuricae or Radix angelicae dahuricae 8g/kg, and after administration 60 minutes, the Radix Angelicae Dahuricae and the anti-Radix Angelicae Dahuricae obviously improved pain threshold.3, spasmolysis: contained bergapton, xanthotoxin, the isoimperatorin second of the Radix Angelicae Dahuricae has obvious spasmolysis to rabbit ileum.Isoimperatorin can also increase the tonicity of contractility and the Lumbricus flesh of rabbit uterus.Scopoletin has spasmolysis at body or isolated rat hysterospasm due to estrogen or barium chloride, and its ED50 is 0.09mg/kg.4, antibacterial action: Radix Angelicae Dahuricae decoct all has inhibitory action to escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, Bacillus tuberculosis etc.5, radiation resistance: Radix Angelicae Dahuricae methanolic extract 1g/kg is in first 5 minutes lumbar injections of roentgen radiation x, and infringement has protective action to mouse skin.
Radix Aucklandiae water extraction liquid, alcohol extract, volatile oil and total alkaloids can be to antihistamine and acetylcholine to trachea and bronchially cause convulsion effect.In volatile oil, the Ginkgolide Component such as contained total lactone, constuslactone, dihydrocostulactone and the bronchoconstriction effect of going lactone volatile oil all can cause antihistamine, acetylcholine and barium chloride, wherein stronger with dihydrocostulactone effect.Myenteron spasm due to acetylcholine, histamine and barium chloride is had to antagonism.The contained volatile oil of the Radix Aucklandiae can suppress the growth of streptococcus, golden yellow and white grapes in 1:3000 concentration, faint to escherichia coli and diphtheria corynebacterium effect; Total alkaloids is without antibacterial action.Separately have report, decoct has inhibitory action to 10 kinds of funguses such as oidium schoenleinii and Mongolian mutation thereof.
The ultraviolet that Flos Sophorae can absorb skin is converted into heat energy and harmless light radiates out, the glycoside that Radix Scutellariae is contained, there is antiopxidant effect, can prevent UV-induced erythrocyte membrane oxidative damage, secretion that can inflammation-inhibiting cytokine, can restraint of tyrosinase active, the damage of repairing skin.Fructus Evodiae ingredient can absorb ultraviolet, thus protection skin.
Above several drugs cooperatively interacts, and can promote local organization metabolism, plays the effect of protection skin, prevents or alleviate to radiate the damage that skin histology is caused.
The preparation method of gel of the present invention is: by Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, and Radix Scutellariae, Fructus Evodiae ethanol extraction, adds glycerol and carbomer to make gel in extract.
The invention provides a kind of preferred preparation method: by Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae, is ground into coarse granule after Fructus Evodiae is mixed in proportion, and adds 75% ethanol of 5-7 times of quality, airtight, soaks after 6-8 days and take out supernatant under room temperature; 75% ethanol that adds again 3-5 times of quality in residue, soaks under room temperature after 6-8 days and takes out supernatant; Merge extracted twice liquid, filter, under stirring, add substrate adjuvant glycerol and carbomer, make it to dissolve fill after homogenizing.
The using method of gel of the present invention: external, with swab stick, pick and be applied to radiation position skin, be coated with 1-2 every day and smear 1-2 week after inferior to radiotherapy.
The present invention be take China's Traditional Chinese medical theory as basis, selects to have promotion tissue repair, improves local blood circulation, alleviates radiation injury, and the Chinese medicine of anti-inflammatory analgetic function, extracts active ingredient and make gel, better efficacy, easy to use, and drug cost is low.
Below test the effect of provable medicine of the present invention.
(1) radioprotection to patient with breast cancer
Physical data: needing the patient of adjuvant radiotherapy after the 6O example breast cancer operation that institute of Shanxi Province Tumor Hospital mammary gland radiotherapy department of take is accepted for medical treatment is sample, 36 years old～65 years old age, average out to 49 years old; Be women.All patients are capable postoperative adjuvant radiotherapy all.Patient's random number, odd numbers is observation group, even numbers is matched group, every group of 30 examples.
Observational technique: give radioprotective skin-care gel after observation group's radiotherapy for the first time, medicine is spread upon to irradiation field skin uniformly, and exceed the wild skin lcm of radiotherapy, and massage gently 2-3 minute, and to promote drug absorption, every day 2 times, wherein once after radiotherapy, be coated with, radiation period is in first 4 hours inactive radioprotective skin-care gels of radiotherapy, and cleans residue ointment with dry cotton swab, finishes 14 days to radiotherapy.Matched group is skin nursing routinely, does not smear any medicine.Assess every day to two groups of patients' irradiation field skin, time, degree and persistent period that observed and recorded dermoreaction occurs.
Dermoreaction evaluation criterion: according to U.S.'s radiation oncology research center (RTOG) acute radiation skin injury grade scale [1]: 0 grade unchanged; I level is the dark red mottle of skin folliculus sample or alopecia or dryness decortication or perspires and reduce; II level is skin tenderness or fresh color erythema or the moist decortication of lamellar or intermediate edema; III level is the moist decortication of amalgamation or the pitting edema at position beyond skinfold; IV level is ulcer or hemorrhage, downright bad.Carry out observed and recorded every day, until radiotherapy finishes.
Statistical method: matched group and observation group's radiation skin injury incidence rate, occurrence degree analysis adopt X 2 test.
Result
The incidence rate of acute radiation skin injury: two groups of radiation skin injury incidence rates are 10O, I, II level, III level acute radiation skin injury generation number of cases and incidence rate are specifically in Table 1, after medication, radiation skin injury degree alleviates, II level, III level acute radiation skin injury generation number of cases obviously reduce, and the results are shown in Table 1.
The skin care effect of table 1 radioprotective skin-care gel to patient with breast cancer
| Group | Number of cases | 0 grade | I level | II level | III level | IV level |
| Matched group | 30 | 0 | 4 | 16 | 10 | 0 |
| Treatment group | 30 | 0 | 14 | 11 | 5 | 0 |
(2) protective effect to tumor of head and neck patient radiation injury
Physical data: 60 routine tumor of head and neck patients of Jiang Wo institute radiotherapy 1 lesion are divided into observation group and matched group at random, every group of 30 examples, all patients give the health education of skin care before radiotherapy.
Method: clean irradiation field skin with warm water during matched group radiotherapy, be not coated with any medicine; Observation group applies radioprotective skin-care gel during radiotherapy, and radiotherapy starts to use, and before each use, first uses warm water cleaning skin, then by radioprotective skin-care gel dab in irradiation field skin surface, and forlement, every day 2-3 times.Observe and compare the reaction of two groups of patient skins a situation arises.According to the situation of US and European radiation oncology treatment cooperative groups (RTOG/EORTC) acute radiation reaction standards of grading assess patient irradiation field skin.
Statistical method adopts SPSS12.0 software to carry out statistical analysis, and P<0.05 is for having statistical significance.
Therapeutic outcome
Observation group and matched group acute radiation skin injury have significant difference (P <0.05).A situation arises in Table 2 in two groups of patient skin damages
The protective effect of table 2 radioprotective skin-care gel to tumor of head and neck patient skin
| Group | Number of cases | 0 grade | I level | II level | III level | IV level |
| Matched group | 30 | 0 | 8 | 15 | 7 | 0 |
| Observation group | 30 | 0 | 18 | 8 | 4 | 0 |
The specific embodiment
Embodiment 1
Formula
10 grams of Radix Panacis Quinquefoliis, 80 grams of the Radixs Angelicae Dahuricae, 20 grams of the Radix Aucklandiae, 10 grams, Flos Sophorae, 10 grams of Radix Scutellariaes, 5 grams of Fructus Evodiaes, 80 grams of glycerol, 8 grams of carbomers.
Preparation method
After Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae and Fructus Evodiae are mixed by above-mentioned formula proportion, be ground into coarse granule, add 75% ethanol of 5 times of quality of above-mentioned five tastes principal agent, airtight, under room temperature, soak after 6 days and take out supernatant; 75% ethanol that adds again 3 times of quality in residue, soaks under room temperature after 6 days and takes out supernatant; Merge extracted twice liquid, filter, add glycerol to stir evenly, with 75% ethanol, adjust amount of liquid medicine and reach 1000ml, under stirring, add Acritamer 940, make it to dissolve, put homogenizer homogenizing, be filled in bottle.
Embodiment 2
Formula
20 grams of Radix Panacis Quinquefoliis, 90 grams of the Radixs Angelicae Dahuricae, 40 grams of the Radix Aucklandiae, 20 grams, Flos Sophorae, 20 grams of Radix Scutellariaes, 10 grams of Fructus Evodiaes, 120 grams of glycerol, 12 grams of carbomers.
Preparation method
After Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae and Fructus Evodiae are mixed by above-mentioned formula proportion, be ground into coarse granule, add 75% ethanol of 7 times of quality of above-mentioned five tastes principal agent, airtight, under room temperature, soak after 8 days and take out supernatant; 75% ethanol that adds again 5 times of quality in residue, soaks under room temperature after 8 days and takes out supernatant; Merge extracted twice liquid, filter, add glycerol to stir evenly, with 75% ethanol, adjust amount of liquid medicine and reach 1000ml, under stirring, add Acritamer 940, make it to dissolve, put homogenizer homogenizing, be filled in bottle.
Embodiment 3
Formula
15 grams of Radix Panacis Quinquefoliis, 85 grams of the Radixs Angelicae Dahuricae, 30 grams of the Radix Aucklandiae, 15 grams, Flos Sophorae, 15 grams of Radix Scutellariaes, 8 grams of Fructus Evodiaes, 100 grams of glycerol, 10 grams of carbomers.
Preparation method
After Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae and Fructus Evodiae are mixed by above-mentioned formula proportion, be ground into coarse granule, add 75% ethanol of 6 times of quality of above-mentioned five tastes principal agent, airtight, under room temperature, soak after 7 days and take out supernatant; 75% ethanol that adds again 4 times of quality in residue, soaks under room temperature after 7 days and takes out supernatant; Merge extracted twice liquid, filter, add glycerol to stir evenly, with 75% ethanol, adjust amount of liquid medicine and reach 1000ml, under stirring, add Acritamer 940, make it to dissolve, put homogenizer homogenizing, be filled in bottle.
Embodiment 4
Formula
12 grams of Radix Panacis Quinquefoliis, 86 grams of the Radixs Angelicae Dahuricae, 35 grams of the Radix Aucklandiae, 18 grams, Flos Sophorae, 12 grams of Radix Scutellariaes, 6 grams of Fructus Evodiaes, 100 grams of glycerol, 10 grams of carbomers.
Preparation method
After Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae and Fructus Evodiae are mixed by above-mentioned formula proportion, be ground into coarse granule, add 75% ethanol of 6 times of quality of above-mentioned five tastes principal agent, airtight, under room temperature, soak after 7 days and take out supernatant; 75% ethanol that adds again 4 times of quality in residue, soaks under room temperature after 7 days and takes out supernatant; Merge extracted twice liquid, filter, add glycerol to stir evenly, with 75% ethanol, adjust amount of liquid medicine and reach 1000ml, under stirring, add Acritamer 940, make it to dissolve, put homogenizer homogenizing, be filled in bottle.
Embodiment 5
Formula
18 grams of Radix Panacis Quinquefoliis, 82 grams of the Radixs Angelicae Dahuricae, 25 grams of the Radix Aucklandiae, 12 grams, Flos Sophorae, 17 grams of Radix Scutellariaes, 8 grams of Fructus Evodiaes, 90 grams of glycerol, 11 grams of carbomers.
Preparation method
After Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae and Fructus Evodiae are mixed by above-mentioned formula proportion, be ground into coarse granule, add 75% ethanol of 5 times of quality of above-mentioned five tastes principal agent, airtight, under room temperature, soak after 7 days and take out supernatant; 75% ethanol that adds again 4 times of quality in residue, soaks under room temperature after 8 days and takes out supernatant; Merge extracted twice liquid, filter, add glycerol to stir evenly, with 75% ethanol, adjust amount of liquid medicine and reach 1000ml, under stirring, add Acritamer 940, make it to dissolve, put homogenizer homogenizing, be filled in bottle.
Claims (4)
1. a radioprotective skin-care gel, is characterized in that being comprised of main material medicine and the substrate adjuvant of following weight portion: Radix Panacis Quinquefolii 10-20 part, Radix Angelicae Dahuricae 80-90 part, Radix Aucklandiae 20-40 part, Flos Sophorae 10-20 part, Radix Scutellariae 10-20 part, Fructus Evodiae 5-10 part, glycerol 80-120 part and carbomer 8-12 part.
2. radioprotective skin-care gel according to claim 1, the weight portion proportioning that it is characterized in that main material medicine and substrate adjuvant is 15 parts of Radix Panacis Quinquefoliis, 85 parts of the Radixs Angelicae Dahuricae, 30 parts of the Radix Aucklandiae, 15 parts, Flos Sophorae, 15 parts of Radix Scutellariaes, 8 parts of Fructus Evodiaes, 100 parts of glycerol, 10 parts of carbomers.
3. prepare the method for gel as claimed in claim 1 or 2, it is characterized in that: by Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae, Fructus Evodiae ethanol extraction, adds glycerol and carbomer to make gel in extract.
4. method according to claim 3, is characterized in that comprising step: by Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae, after being mixed in proportion, Fructus Evodiae is ground into coarse granule, add 75% ethanol of 5-7 times of quality, airtight, under room temperature, soak after 6-8 days and take out supernatant; 75% ethanol that adds again 3-5 times of quality in residue, soaks under room temperature after 6-8 days and takes out supernatant; Merge extracted twice liquid, filter, under stirring, add substrate adjuvant glycerol and carbomer, make it to dissolve fill after homogenizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310166156.2A CN103251721B (en) | 2013-05-08 | 2013-05-08 | Radiation-proof skin-care gel and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310166156.2A CN103251721B (en) | 2013-05-08 | 2013-05-08 | Radiation-proof skin-care gel and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103251721A CN103251721A (en) | 2013-08-21 |
| CN103251721B true CN103251721B (en) | 2014-03-19 |
Family
ID=48956154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310166156.2A Expired - Fee Related CN103251721B (en) | 2013-05-08 | 2013-05-08 | Radiation-proof skin-care gel and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103251721B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825824A (en) * | 2015-05-25 | 2015-08-12 | 济南新斯诺生物技术有限公司 | Anti-radiation traditional Chinese medicine gel for external application and method for manufacturing anti-radiation traditional Chinese medicine gel |
| CN109381514B (en) * | 2017-08-04 | 2023-01-17 | 中国辐射防护研究院 | Scutellaria baicalensis extract, composition thereof and application of scutellaria baicalensis extract in radiation injury protection |
| CN110227084A (en) * | 2019-07-04 | 2019-09-13 | 华中科技大学同济医学院附属同济医院 | Medical anti-x-ray radiation disinfecting gel and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193738C (en) * | 2003-02-21 | 2005-03-23 | 郑延明 | Herbal skin care paste and its preparing process |
| CN102772355B (en) * | 2012-08-15 | 2013-09-04 | 天津科丝美特生物科技有限公司 | Skin care composition with light aging resisting effect |
-
2013
- 2013-05-08 CN CN201310166156.2A patent/CN103251721B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN103251721A (en) | 2013-08-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105943558A (en) | Application of periplaneta americana in preparation of drug for preventing and treating radiation-induced damage | |
| CN1289137C (en) | Medicine for treating mammary gland proliferation, its preparation method and application | |
| CN103611031B (en) | Be used for the treatment of the plaster of prostatic hyperplasia | |
| CN103251721B (en) | Radiation-proof skin-care gel and preparation method thereof | |
| CN105477129A (en) | External-use plaster for psoriasis and preparation method thereof | |
| CN105770669A (en) | Medicinal preparation for treating colour spots and application thereof | |
| CN101904932B (en) | External application Chinese ointment for preventing and curing skin injury caused by ionizing radiation | |
| KR20150144118A (en) | Microneedle coated by oriental medicine compositions and method for manufacturing thereof | |
| CN106511898A (en) | Traditional Chinese medicine composition, preparation method thereof and application of traditional Chinese medicine composition to treatment of breast cancer | |
| CN106727893A (en) | Pharmaceutical composition for radiation stomatitis and preparation method thereof | |
| CN105055800A (en) | Plant compound gel for treating chloasma and preparation method thereof | |
| CN110433284A (en) | A kind of composition that treating cervicitis, gelling agent and preparation method thereof | |
| CN104474405A (en) | Traditional Chinese medicine composition for treating chloasma | |
| CN106110218B (en) | A kind of anti-cancer pain pain relieving plaster and preparation method thereof | |
| CN105169143A (en) | Traditional Chinese medicinal composition for treating melanin and preparation method of traditional Chinese medicinal composition | |
| CN104189608B (en) | Traditional Chinese medicine preparation for recurrent oral ulcer and preparation method thereof | |
| CN115463182B (en) | Traditional Chinese medicine composition and gel preparation and application thereof in preventing and treating radiodermatitis | |
| CN107468787A (en) | A kind of medicine-filled pillow of protect liver hypotensive | |
| CN107468962A (en) | It is a kind of to be used to treat external medicine composition of milk cow mange and scab and preparation method thereof | |
| CN104906559A (en) | Traditional Chinese medicine composition for treating burns and scalds | |
| CN105797095A (en) | Traditional Chinese medicine external lotion for preventing and treating calf varicosity | |
| CN105769968A (en) | Traditional Chinese medicine for treating radiodermatitis | |
| CN105456956A (en) | Traditional Chinese medicine for treating myoma of uterus | |
| CN104771454B (en) | A kind of pharmaceutical composition for the treatment of of acute radiation oral mucositis | |
| CN109966384A (en) | A kind of mammary gland patch and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140319 Termination date: 20170508 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |