CN103251721A - Radiation-proof skin-care gel and preparation method thereof - Google Patents
Radiation-proof skin-care gel and preparation method thereof Download PDFInfo
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- CN103251721A CN103251721A CN2013101661562A CN201310166156A CN103251721A CN 103251721 A CN103251721 A CN 103251721A CN 2013101661562 A CN2013101661562 A CN 2013101661562A CN 201310166156 A CN201310166156 A CN 201310166156A CN 103251721 A CN103251721 A CN 103251721A
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Abstract
The invention provides radiation-proof skin-care gel. The gel can be used for preventing and treating a radiation skin injury, and comprises the following crude medicines in parts by weight: 10-20 parts of American ginseng, 80-90 parts of radix angelicae, 20-40 parts of elecampane, 10-20 parts of sophora flower, 10-20 parts of scutellaria baicalensis, and 5-10 parts of fructus evodiae; and 80-120 parts of glycerol as a substrate material and 8-12 parts of Carbomer are added when the main crude medicines are prepared into gels. The skin-care gel disclosed by the invention can promote local tissue metabolism, plays a role of protecting the skin, prevents or reduces an injury caused by radiation on the skin tissue, and is good in curative effective, convenient to use and low in medicine cost.
Description
Technical field
The present invention relates to a kind of medicine, particularly, be used for the exterior-applied gel of prevention and radiotherapy skin injury when being a kind of radiotherapy.
Background technology
For malignant tumor patient, radiotherapy is a kind of important treatment means.Yet the radiotherapy meeting causes skin injury in various degree, cause radiotherapy to interrupt the course for the treatment of, skin can be because erythema appears in telangiectasis after patient's radiotherapy, and then microthrombusis in the pigmentation, little blood vessel appears, cause local anoxia and secondary cell injury, decortication, ulcer, hemorrhage, necrosis etc. occur.If the III degree occurs and above dermoreaction then need suspend radiotherapy, thereby delay treating time affects the treatment, and has increased patient's misery.
Summary of the invention
The purpose of this invention is to provide a kind of radioprotective skin-care gel, this gel can be used for prevention and radiotherapy skin injury.
For achieving the above object, the technical solution used in the present invention is:
A kind of radioprotective skin-care gel comprises following bulk drugs: Radix Panacis Quinquefolii 10-20 part, Radix Angelicae Dahuricae 80-90 part, Radix Aucklandiae 20-40 part, Flos Sophorae 10-20 part, Radix Scutellariae 10-20 part, Fructus Evodiae 5-10 part.
When preparing gel with above-mentioned primary raw material medicine, add glycerol 80-120 part and carbomer 8-12 part as the substrate adjuvant.
On above basis, preferential main material medicine and the weight portion proportioning of adjuvant are 15 parts of Radix Panacis Quinquefoliis, 85 parts of the Radixs Angelicae Dahuricae, 30 parts of the Radix Aucklandiae, 15 parts in Flos Sophorae, 15 parts of Radix Scutellariaes, 8 parts of Fructus Evodiaes, 100 parts of glycerol, 10 parts of carbomers.
In the present invention's prescription, Radix Panacis Quinquefolii can promote that serum albumin is synthetic, bone marrow protein is synthetic, organ albumen is synthetic, improves immunity of organisms, can reduce blood coagulation, suppresses platelet aggregation, promote the erythrocyte growth, increases hematochrome.We find that under study for action Radix Panacis Quinquefolii extract can significantly improve cytoactive, strengthen cellular metabolism, and the blood that improves local organization supplies and nutrition, promotes the reparation of local damaged cell.
The Radix Angelicae Dahuricae has following effect: 1, antiinflammatory action: the mouse stomach Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct (the suitable crude drug lg of lg) 4g/kg, can obviously suppress the inflammation of dimethylbenzene induced mice ear.2, antipyretic effect: with the high hot animal model that the peptone subcutaneous injection causes in the White Rabbit back, the 1g Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct 15g/kg have tangible refrigeration function.The mouse stomach Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct 8g/kg obviously reduce the mouse writhing number of times due to lumbar injection 1% acetic acid (0.l/kg), and effect is similar with aminophenazone 8mg/kg.Woolfe-Macdonald method test, the preceding threshold of pain of administration 30 minutes with interior person, irritate stomach and award the Radix Angelicae Dahuricae or Radix angelicae dahuricae 8g/kg, after the administration 60 minutes, the Radix Angelicae Dahuricae and the anti-Radix Angelicae Dahuricae obviously improved pain threshold.3, spasmolysis: contained bergapton, xanthotoxin, the isoimperatorin second of the Radix Angelicae Dahuricae has tangible spasmolysis to the rabbit ileum.Isoimperatorin can also increase the tonicity of contractility and the Lumbricus flesh of rabbit uterus.Scopoletin has spasmolysis at body or isolated rat hysterospasm due to estrogen or barium chloride, its ED50 is 0.09mg/kg.4, antibacterial action: Radix Angelicae Dahuricae decoct all has inhibitory action to escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, Bacillus tuberculosis etc.5, radiation resistance: Radix Angelicae Dahuricae methanolic extract 1g/kg is in preceding 5 minutes lumbar injections of roentgen radiation x, and infringement has protective action to mouse skin.
Radix Aucklandiae water extract, alcohol extract, volatile oil and total alkaloids can be to antihistamine and acetylcholine to tracheas and bronchially cause the convulsion effect.Lactone composition such as contained total lactone, constuslactone, dihydrocostulactone and the bronchoconstriction effect of going lactone volatile oil all can cause antihistamine, acetylcholine and barium chloride are wherein stronger with the dihydrocostulactone effect in the volatile oil.Myenteron spasm due to acetylcholine, histamine and the barium chloride there is antagonism.The contained volatile oil of the Radix Aucklandiae can suppress the growth of streptococcus, golden yellow and white grapes in 1:3000 concentration, and is faint to escherichia coli and diphtheria corynebacterium effect; Total alkaloids does not have antibiotic effect.Other has report, and decoct has inhibitory action to 10 kinds of funguses such as oidium schoenleinii and Mongolian mutation thereof.
Flos Sophorae can be converted into heat energy to the ultraviolet that skin absorbs and harmless light emission comes out, the glycoside that Radix Scutellariae is contained, has antiopxidant effect, can prevent UV-induced erythrocyte membrane oxidative damage, secretion that can the inflammation-inhibiting cytokine, can the restraint of tyrosinase activity, repair the damage of skin.The Fructus Evodiae ingredient can absorb ultraviolet, thus protection skin.
Above several drugs cooperatively interacts, and can promote the local organization metabolism, plays the effect of protection skin, prevents or alleviates the damage that radiation causes skin histology.
The preparation method of gel of the present invention is: with Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, and Radix Scutellariae, the Fructus Evodiae ethanol extraction adds glycerol in the extract and carbomer is made gel.
The invention provides a kind of preferred manufacturing procedure: with Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae is ground into coarse granule after Fructus Evodiae is mixed in proportion, and adds 75% ethanol of 5-7 times of quality, and is airtight, soaks after 6-8 days under the room temperature and takes out supernatant; 75% ethanol that adds 3-5 times of quality in the residue again soaks after 6-8 days under the room temperature and takes out supernatant; Merge extracted twice liquid, filter, add substrate adjuvant glycerol and carbomer under the stirring, make it dissolving, fill behind the homogenizing.
The using method of gel of the present invention: external, pick with cotton rod and to be applied to radiation position skin, be coated with 1-2 every day and smear 1-2 week after inferior to radiotherapy.
The present invention selects to have the promotion tissue repair based on China's Traditional Chinese medical theory, improves local blood circulation, alleviates radiation injury, and the Chinese medicine of anti-inflammatory analgetic function extracts active ingredient and makes gel, better efficacy, easy to use, and drug cost is low.
Below test the effect of provable medicine of the present invention.
(1) to patient with breast cancer's radioprotection
Physical data: it is sample that the 6O example breast carcinoma postoperative of accepting for medical treatment with mammary gland radiotherapy section of institute of Shanxi Province Tumor Hospital need be assisted the patient of radiotherapy, 36 years old～65 years old age, average out to 49 years old; Be the women.All auxiliary radiotherapy of capable postoperative of all patients.Patient's random number, odd numbers are observation group, and even numbers is matched group, every group of 30 examples.
Observational technique: namely give the radioprotective skin-care gel after observation group's radiotherapy for the first time, medicine is spread upon irradiation field skin uniformly, and exceed the wild skin lcm of radiotherapy, and massaged gently 2-3 minute, to promote drug absorption, every day 2 times, wherein once after radiotherapy, be coated with, radiation period is in preceding 4 hours inactive radioprotective skin-care gels of radiotherapy, and cleans the residue ointment with dried cotton swab, finishes 14 days to radiotherapy.Matched group is skin nursing routinely, does not smear any medicine.Assess two groups of patients' irradiation field skin every day, time, degree and persistent period that the observed and recorded dermoreaction takes place.
Dermoreaction evaluation criterion: according to U.S. radiation oncology research center (RTOG) acute radiation skin injury grade scale [1]: 0 grade of no change; The I level is the dark red mottle of skin folliculus sample or alopecia or dryness decortication or perspires and reduce; The II level is skin tenderness or bright color erythema or the moist decortication of lamellar or intermediate edema; The III level is the moist decortication of amalgamation or the pitting edema at position beyond the skinfold; The IV level is ulcer or hemorrhage, downright bad.Carry out observed and recorded every day, finish until radiotherapy.
Statistical method: X 2 test is adopted in matched group and observation group's radiation skin injury incidence rate, occurrence degree analysis.
The result
The incidence rate of acute radiation skin injury: two groups of radiation skin injury incidence rates are 10O, I, II level, routine number takes place III level acute radiation skin injury and incidence rate specifically sees Table 1, the radiation skin injury degree alleviates after the medication, routine number takes place and obviously reduces in II level, III level acute radiation skin injury, the results are shown in Table 1.
Table 1 radioprotective skin-care gel is to patient with breast cancer's skin care effect
| Group | The example number | 0 grade | The I level | The II level | The III level | The IV level |
| Matched group | 30 | 0 | 4 | 16 | 10 | 0 |
| The treatment group | 30 | 0 | 14 | 11 | 5 | 0 |
(2) to the protective effect of tumor of head and neck patient radiation injury
Physical data: I 60 routine tumor of head and neck patients of institute's radiotherapy 1 lesion are divided into observation group and matched group at random, every group of 30 examples, all patients give the health education of skin care before radiotherapy.
Method: clean irradiation field skin with warm water during matched group radiotherapy, be not coated with any medicine; Use the radioprotective skin-care gel during observation group radiotherapy, radiotherapy begins namely to use, and uses earlier the warm water cleaning skin before each the use, then with radioprotective skin-care gel dab in the irradiation field skin surface, and forlement, every day 2-3 times.A situation arises for two groups of patient skins reactions of observation and comparison.Situation according to US and European radiation oncology treatment cooperative groups (RTOG/EORTC) acute radiation reaction standards of grading assess patient irradiation field skin.
Statistical method adopts SPSS12.0 software to carry out statistical analysis, and P＜0.05 is for having statistical significance.
Therapeutic outcome
Observation group and matched group acute radiation skin injury have significant difference (P＜0.05).A situation arises sees Table 2 for the damage of two groups of patient skins
Table 2 radioprotective skin-care gel is to the protective effect of tumor of head and neck patient skin
| Group | The example number | 0 grade | The I level | The II level | The III level | The IV level |
| Matched group | 30 | 0 | 8 | 15 | 7 | 0 |
| Observation group | 30 | 0 | 18 | 8 | 4 | 0 |
The specific embodiment
Embodiment 1
Prescription
Radix Panacis Quinquefolii 10 grams, the Radix Angelicae Dahuricae 80 grams, the Radix Aucklandiae 20 grams, Flos Sophorae 10 grams, Radix Scutellariae 10 grams, Fructus Evodiae 5 grams, glycerol 80 grams, carbomer 8 grams.
Preparation method
Be ground into coarse granule after Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae and Fructus Evodiae mixed by above-mentioned formula proportion, add 75% ethanol of 5 times of quality of above-mentioned five tastes principal agent, airtight, soak after 6 days under the room temperature and take out supernatant; 75% ethanol that adds 3 times of quality in the residue again soaks after 6 days under the room temperature and takes out supernatant; Merge extracted twice liquid, filter, adding glycerol stirs evenly, and adjusts amount of liquid medicine with 75% ethanol and reaches 1000ml, adds Acritamer 940 under the stirring, makes it dissolving, puts the homogenizer homogenizing, is filled in the bottle to get final product.
Embodiment 2
Prescription
Radix Panacis Quinquefolii 20 grams, the Radix Angelicae Dahuricae 90 grams, the Radix Aucklandiae 40 grams, Flos Sophorae 20 grams, Radix Scutellariae 20 grams, Fructus Evodiae 10 grams, glycerol 120 grams, carbomer 12 grams.
Preparation method
Be ground into coarse granule after Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae and Fructus Evodiae mixed by above-mentioned formula proportion, add 75% ethanol of 7 times of quality of above-mentioned five tastes principal agent, airtight, soak after 8 days under the room temperature and take out supernatant; 75% ethanol that adds 5 times of quality in the residue again soaks after 8 days under the room temperature and takes out supernatant; Merge extracted twice liquid, filter, adding glycerol stirs evenly, and adjusts amount of liquid medicine with 75% ethanol and reaches 1000ml, adds Acritamer 940 under the stirring, makes it dissolving, puts the homogenizer homogenizing, is filled in the bottle to get final product.
Embodiment 3
Prescription
Radix Panacis Quinquefolii 15 grams, the Radix Angelicae Dahuricae 85 grams, the Radix Aucklandiae 30 grams, Flos Sophorae 15 grams, Radix Scutellariae 15 grams, Fructus Evodiae 8 grams, glycerol 100 grams, carbomer 10 grams.
Preparation method
Be ground into coarse granule after Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae and Fructus Evodiae mixed by above-mentioned formula proportion, add 75% ethanol of 6 times of quality of above-mentioned five tastes principal agent, airtight, soak after 7 days under the room temperature and take out supernatant; 75% ethanol that adds 4 times of quality in the residue again soaks after 7 days under the room temperature and takes out supernatant; Merge extracted twice liquid, filter, adding glycerol stirs evenly, and adjusts amount of liquid medicine with 75% ethanol and reaches 1000ml, adds Acritamer 940 under the stirring, makes it dissolving, puts the homogenizer homogenizing, is filled in the bottle to get final product.
Embodiment 4
Prescription
Radix Panacis Quinquefolii 12 grams, the Radix Angelicae Dahuricae 86 grams, the Radix Aucklandiae 35 grams, Flos Sophorae 18 grams, Radix Scutellariae 12 grams, Fructus Evodiae 6 grams, glycerol 100 grams, carbomer 10 grams.
Preparation method
Be ground into coarse granule after Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae and Fructus Evodiae mixed by above-mentioned formula proportion, add 75% ethanol of 6 times of quality of above-mentioned five tastes principal agent, airtight, soak after 7 days under the room temperature and take out supernatant; 75% ethanol that adds 4 times of quality in the residue again soaks after 7 days under the room temperature and takes out supernatant; Merge extracted twice liquid, filter, adding glycerol stirs evenly, and adjusts amount of liquid medicine with 75% ethanol and reaches 1000ml, adds Acritamer 940 under the stirring, makes it dissolving, puts the homogenizer homogenizing, is filled in the bottle to get final product.
Embodiment 5
Prescription
Radix Panacis Quinquefolii 18 grams, the Radix Angelicae Dahuricae 82 grams, the Radix Aucklandiae 25 grams, Flos Sophorae 12 grams, Radix Scutellariae 17 grams, Fructus Evodiae 8 grams, glycerol 90 grams, carbomer 11 grams.
Preparation method
Be ground into coarse granule after Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae and Fructus Evodiae mixed by above-mentioned formula proportion, add 75% ethanol of 5 times of quality of above-mentioned five tastes principal agent, airtight, soak after 7 days under the room temperature and take out supernatant; 75% ethanol that adds 4 times of quality in the residue again soaks after 8 days under the room temperature and takes out supernatant; Merge extracted twice liquid, filter, adding glycerol stirs evenly, and adjusts amount of liquid medicine with 75% ethanol and reaches 1000ml, adds Acritamer 940 under the stirring, makes it dissolving, puts the homogenizer homogenizing, is filled in the bottle to get final product.
Claims (5)
1. radioprotective skin-care gel is characterized in that comprising the main material medicine of following weight portion: Radix Panacis Quinquefolii 10-20 part, Radix Angelicae Dahuricae 80-90 part, Radix Aucklandiae 20-40 part, Flos Sophorae 10-20 part, Radix Scutellariae 10-20 part, Fructus Evodiae 5-10 part.
2. radioprotective skin-care gel according to claim 1 is characterized in that: comprise glycerol 80-120 part and carbomer 8-12 part as the substrate adjuvant.
3. radioprotective skin-care gel according to claim 2, the weight portion proportioning that it is characterized in that main material medicine and substrate adjuvant is 15 parts of Radix Panacis Quinquefoliis, 85 parts of the Radixs Angelicae Dahuricae, 30 parts of the Radix Aucklandiae, 15 parts in Flos Sophorae, 15 parts of Radix Scutellariaes, 8 parts of Fructus Evodiaes, 100 parts of glycerol, 10 parts of carbomers.
4. preparation is characterized in that as the method for claim 1 or 2 or 3 described gels: with Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, and Radix Scutellariae, the Fructus Evodiae ethanol extraction adds glycerol in the extract and carbomer is made gel.
5. method according to claim 4 is characterized in that comprising step: with Radix Panacis Quinquefolii, the Radix Angelicae Dahuricae, the Radix Aucklandiae, Flos Sophorae, Radix Scutellariae, after being mixed in proportion, Fructus Evodiae is ground into coarse granule, add 75% ethanol of 5-7 times of quality, airtight, soak after 6-8 days under the room temperature and take out supernatant; 75% ethanol that adds 3-5 times of quality in the residue again soaks after 6-8 days under the room temperature and takes out supernatant; Merge extracted twice liquid, filter, add substrate adjuvant glycerol and carbomer under the stirring, make it dissolving, fill behind the homogenizing.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825824A (en) * | 2015-05-25 | 2015-08-12 | 济南新斯诺生物技术有限公司 | Anti-radiation traditional Chinese medicine gel for external application and method for manufacturing anti-radiation traditional Chinese medicine gel |
| CN109381514A (en) * | 2017-08-04 | 2019-02-26 | 中国辐射防护研究院 | A kind of Baical Skullcap root P.E and combinations thereof and purposes for radiation injury protection |
| CN110227084A (en) * | 2019-07-04 | 2019-09-13 | 华中科技大学同济医学院附属同济医院 | Medical anti-x-ray radiation disinfecting gel and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193738C (en) * | 2003-02-21 | 2005-03-23 | 郑延明 | Herbal skin care paste and its preparing process |
| CN102772355A (en) * | 2012-08-15 | 2012-11-14 | 天津科丝美特生物科技有限公司 | Skin care composition with light aging resisting effect |
-
2013
- 2013-05-08 CN CN201310166156.2A patent/CN103251721B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193738C (en) * | 2003-02-21 | 2005-03-23 | 郑延明 | Herbal skin care paste and its preparing process |
| CN102772355A (en) * | 2012-08-15 | 2012-11-14 | 天津科丝美特生物科技有限公司 | Skin care composition with light aging resisting effect |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825824A (en) * | 2015-05-25 | 2015-08-12 | 济南新斯诺生物技术有限公司 | Anti-radiation traditional Chinese medicine gel for external application and method for manufacturing anti-radiation traditional Chinese medicine gel |
| CN109381514A (en) * | 2017-08-04 | 2019-02-26 | 中国辐射防护研究院 | A kind of Baical Skullcap root P.E and combinations thereof and purposes for radiation injury protection |
| CN109381514B (en) * | 2017-08-04 | 2023-01-17 | 中国辐射防护研究院 | Scutellaria baicalensis extract, composition thereof and application of scutellaria baicalensis extract in radiation injury protection |
| CN110227084A (en) * | 2019-07-04 | 2019-09-13 | 华中科技大学同济医学院附属同济医院 | Medical anti-x-ray radiation disinfecting gel and preparation method thereof |
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| CN103251721B (en) | 2014-03-19 |
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