CN105769968A - Traditional Chinese medicine for treating radiodermatitis - Google Patents

Traditional Chinese medicine for treating radiodermatitis Download PDF

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Publication number
CN105769968A
CN105769968A CN201610275188.XA CN201610275188A CN105769968A CN 105769968 A CN105769968 A CN 105769968A CN 201610275188 A CN201610275188 A CN 201610275188A CN 105769968 A CN105769968 A CN 105769968A
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fresh
chinese medicine
radiodermatitis
fresh herba
leaf
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李艳
季建伟
李民霞
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/36Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/31Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
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  • Medicinal Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention belongs to the technical field of traditional Chinese medicine and particularly relates to a traditional Chinese medicine for treating radiodermatitis. The traditional Chinese medicine for treating radiodermatitis is prepared from, by weight, 20%-40% of fresh dianthus chinensis, 20%-40% of fresh stem leaves of cirsium segetum and 20%-60% of fresh portulaca oleracea. The traditional Chinese medicine for treating radiodermatitis has efficacies of heat clearing, diuresis promoting, blood cooling, detoxifying, pain relieving and tissue regeneration promoting and is capable of reducing occurrence rate and occurrence degree of radiodermatitis.

Description

A kind of Chinese medicine for radiodermatitis
Technical field
The invention belongs to pharmaceutical technology field, be specifically related to a kind of Chinese medicine for radiodermatitis.
Background technology
Radiotherapy is one of essential therapeutic arsenals in malignant tumor patient, and the method can be effectively improved patients symptomatic, extends the survival of patients phase.But this Therapeutic Method normal tissue while treatment tumor also can produce certain damage, causes that patient there will be various acute and chronic skin injury, and severe patient will affect radiotherapy and be smoothed out.Radiodermatitis is modal complication in tumour radiotherapy process, incidence rate is 93.8%, serious radiodermatitis can cause pain, local infection, form cicatrix, force radiotherapy interruption or extended treatment time, thus reducing control rate and the cure rate of tumor, hence it is evident that reduce the quality of life of tumor patient.Therefore, take active and effective nursing intervention to strengthen its skin nursing during Patients Treated by Radiotherapy to have great importance.Radiodermatitis patient for making a definite diagnosis then should take active and effective Therapeutic Method, and conventional medicine is more based on efficacy of MEBO in treating, although the method can improve clinical efficacy, but patient treatment prognosis is poor.
Dianthus chinensis is called: Xingan's Dianthus chinensis, north Dianthus chinensis, brill leaf Dianthus chinensis, Mongolia's Dianthus chinensis, silk leaf Dianthus chinensis, high mountain Dianthus chinensis, east area of the Liao River, coextensive with eastern and southern Liaoning Province Dianthus chinensis, Dianthus longicalycinus (Maxim.0 Williams.), long bud Dianthus chinensis, wood pink, three stone-like pulse bamboos, Latin literary fame: DianthuschinensisL. is Caryophyllaceae Carnation perennial herb.Bitter in the mouth, cold in nature.GUIXIN, small intestine meridian.Dianthus chinensis can herb or root be used as medicine.Function cures mainly inducing diuresis for treating stranguria syndrome, and removing blood stasis stimulates the menstrual flow.Urinary tract infection, pyretic stranguria, hematuria, women's amenorrhea, sore, eczema.
Herba Cirsii another name field thistle, thorn dish, Qu Qucai, blue and green dish, Capsellabursa-pastoris(Linn.)Medic., thorn angle dish, Cold boiled chicken Fructus Gleditsia acupuncture, chicken Fructus Gleditsia acupuncture, calf tying, wild Flos Carthami, for Compositae field thistle platymiscium field thistle Cephalanoplossegetum(Bunge) dry aerial parts (wounded in the battle herb) of Kitam. [CirsiumsegetumBunge], root stock also can be used as medicine.Sweet in the mouth, hardship, cool in nature.GUIXIN, Liver Channel.Function stem and leaf cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, spit blood, hematuria, have blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Herba Portulacae another name Dens Equi dish, horse Amaranthus mangostanus L., pig mother's dish, edible kernel of melon seeds dish, Semen Benincasae dish, longevity greens/mustard green, horse Serpentis dish, for portulacaceous plant Herba Portulacae PortulacaoleraceaL., with all herbal medicine.Sour in the mouth, cold in nature.Enter large intestine, liver, spleen channel.Function clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For bacillary dysentery, acute gastroenteritis, acute appendicitis, mastitis, bleeding hemorrhoids, leucorrhea;Furuncle swelling toxin, eczema, herpes zoster are controlled in external.
Interact with fresh Dianthus chinensis, fresh Herba Cirsii stem and leaf and fresh Herba Portulacae at present, composition of prescription, prepare the medicine for the treatment of radiation dermatitis, there is not been reported.
Summary of the invention
It is an object of the invention to provide a kind of pure Chinese medicine for radiodermatitis, to meet the demand of extensive patients.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine for radiodermatitis, is made up of the raw material of Chinese medicine medicine of following percentage by weight: fresh Dianthus chinensis 20%~40%, fresh Herba Cirsii stem and leaf 20%~40%, fresh Herba Portulacae 20%~60%.
Preferably, the above-mentioned Chinese medicine for radiodermatitis, it is made up of the raw material of Chinese medicine medicine of following percentage by weight: fresh Dianthus chinensis 25%~35%, fresh Herba Cirsii stem and leaf 25%~35%, fresh Herba Portulacae 30%~50%.
It is furthermore preferred that the above-mentioned Chinese medicine for radiodermatitis, it is made up of the raw material of Chinese medicine medicine of following percentage by weight: fresh Dianthus chinensis 30%, fresh Herba Cirsii stem and leaf 30%, fresh Herba Portulacae 40%.
The above-mentioned Chinese medicine for radiodermatitis, its preparation method is: select totally dustless fresh Dianthus chinensis, fresh Herba Cirsii stem and leaf and fresh Herba Portulacae, do not wash, chopping, is placed in hermetic container, and room temperature is placed, allow fresh Dianthus chinensis, fresh Herba Cirsii stem and leaf and fresh Herba Portulacae natural fermentation, pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
Select totally dustless fresh Dianthus chinensis, fresh Herba Cirsii stem and leaf and fresh Herba Portulacae, do not wash, it is because inventor to find in substantial amounts of practice, fresh Dianthus chinensis, fresh Herba Cirsii stem and leaf and fresh Herba Portulacae ferment after washing storage again, quickly can rot after washed mouldy, easy wound causes infection, is not suitable for being used further to treatment and scalds.It addition, the fresh Dianthus chinensis do not cleaned, fresh Herba Cirsii stem and leaf and fresh Herba Portulacae fermentation after the holding time long.
The natural fermentation time can be 10 days-5 every year can, to be fermented into pureed or liquid to be as the criterion.
Above-mentioned hermetic container is airtight glass container, airtight ceramic vessel or airtight plastic containers.If adopt irony, steel, stainless steel, the canister such as copper, it is easy to cause the mouldy of this medicine to rot, it is impossible to use.
This product is applicable to prevention and treating radiation dermatitis.
Usage and dosage: radiotherapy gives the Chinese medicine for radiodermatitis of the present invention after starting, embrocates radiation open country, every day twice (sooner or later respectively once).Shot cycle adheres to using day off, terminates one week after to radiotherapy.All patients stop radiotherapy as there is serious skin lesion or accompanying infection.
Radiodermatitis is owing to skin accepts high-octane physics lonizing radiation, causes epiderm skin to entangle the degeneration that the occurrence degrees such as born of the same parents, sebaceous gland, hair follicle are different.Body is subject to after heavy dose of lonizing radiation irradiate, it may appear that local microcirculation obstacle, blood capillary early-age shrinkage, then expands, and permeability increases, and blood flow is slack-off, erythrocyte and platelet aggregation, small thrombosis, and blood viscosity increases.Along with adding up of exposure dose, dermal capillary dilatation and congestion, blood vessel and inflammatory cell infiltration around sebaceous gland, and then epidermis redness, vesicle, infection ulcer occur.The traditional Chinese medical science is thought, lonizing radiation are " burning hot poison are evil ", and radiation skin injury is owing to pyretic toxicity crosses Sheng, damp-heat accumulation, cause heat to accumulate the flesh natural fibre line of meat, coagulation of QI-blood, and cause the diseases such as desquamation, erythema, pruritus, ulcer, belong to Chinese medicine " fire abnormal pigmentary deposit on the skin skin ulcer ", " pellet ", " purpura wind " and " skin infection " category.Golden Mirror of Medicine is sayed, " carbuncle and cellulitis being originally caused by fire toxin, meridians intercept QI and blood and coagulate ".Visible, " pathogenic heat causes skin infection " is the Basic disease cause of radiodermatitis, and controlling should heat-clearing and toxic substances removing removing heat from blood.
In the Chinese medicine composition of the present invention, Dianthus chinensis, Herba Cirsii, Herba Portulacae all have effect of heat-clearing and toxic substances removing removing heat from blood.Wherein Herba Portulacae clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, Herba Cirsii cooling blood for hemostasis, removing blood stasis to reduce swelling, Dianthus chinensis heat clearing away removing blood stasis stimulates the menstrual flow, and three medicines share, and plays clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, effect of pain relieving granulation promoting altogether.The generation of radiodermatitis can be delayed, effectively alleviate wound pain, promote epithelial cell growth, accelerate wound repair, be the active drug of prevention and treating radioactive skin injury.
Dianthus chinensis, Herba Cirsii, Herba Portulacae are all the weeds in field that Shandong District is common, draw materials conveniently, have no side effect, cheap, simple to operate.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further described, in order to those skilled in the art knows more about the present invention, but does not limit the present invention with this.
Embodiment l:
Totally dustless fresh Herba Portulacae 400g, fresh Dianthus chinensis 300g, fresh Herba Cirsii stem and leaf 300g is selected not to wash, chopping, it is placed in closed glass jar, room temperature is placed, and allows fresh Dianthus chinensis, fresh Herba Cirsii stem and leaf and fresh Herba Portulacae natural fermentation, pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
Embodiment 2
Totally dustless fresh Herba Portulacae 500g, fresh Dianthus chinensis 250g, fresh Herba Cirsii stem and leaf 250g is selected not to wash, chopping, it is placed in airtight terrine, room temperature is placed, and allows fresh Dianthus chinensis, fresh Herba Cirsii stem and leaf and fresh Herba Portulacae natural fermentation, pureed to be fermented into or liquid, and filtration is removed slag, and to obtain final product.
Embodiment 3
Totally dustless fresh Herba Portulacae 300g, fresh Dianthus chinensis 350g, fresh Herba Cirsii stem and leaf 350g is selected not to wash, chopping, it is placed in closed plastic bottle, room temperature is placed, and allows fresh Dianthus chinensis, fresh Herba Cirsii stem and leaf and fresh Herba Portulacae natural fermentation, pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
Embodiment 4
Totally dustless fresh Herba Portulacae 200g, fresh Dianthus chinensis 400g, fresh Herba Cirsii stem and leaf 400g is selected not to wash, chopping, it is placed in airtight terrine, room temperature is placed, and allows fresh Dianthus chinensis, fresh Herba Cirsii stem and leaf and fresh Herba Portulacae natural fermentation, pureed to be fermented into or liquid, and filtration is removed slag, and to obtain final product.
Embodiment 5
Totally dustless fresh Herba Portulacae 600g, fresh Dianthus chinensis 200g, fresh Herba Cirsii stem and leaf 200g is selected not to wash, chopping, it is placed in closed glass jar, room temperature is placed, and allows fresh Dianthus chinensis, fresh Herba Cirsii stem and leaf and fresh Herba Portulacae natural fermentation, pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
The Chinese medicine for radiodermatitis of the embodiment of the present invention 1 has been carried out clinical trial, and Details as Follows:
Clinical data
1 data and method
It is malignant tumor that 1.1 physical data 100 example radiotherapy patients are through pathological diagnosis, is and accepts radiotherapy first.KarnofskyPerformanceStatus (KPS) marks > 70 points.Estimate that life cycle was more than 3 months, be resistant to omnidistance radiotherapy.Wherein male 68 examples, female 32 example, age 17-80 year, 60.2 years old mean age, tumor of head and neck 52 example, 22 Cases of Patients with Lung-cancer, esophageal carcinoma 8 example, mammary cancer 10 example, other malignant tumor 8 examples.It is randomly divided into treatment group 50 example, matched group 50 example.2 groups all comparing difference in age, sex, irradiation number of times, exposure dose, disease degree etc. without significant (P > 0.05), there is comparability.
1.2 methods
1.2.1 all patients all adopt 6MVX line to irradiate, dosage 1.8~2.0Gy/d, 5 times/week, irradiate accumulated dose 50~75Cy.
1.2.3 prevention and nursing intervention
Advise during skin nursing radiotherapy and play softness, loose, pure cotton underwear;Keep irradiation field skin clean, dry.Avoid friction, illumination, be stained with gently with warm water and fur towel and wash, disable the zest disinfectant solution such as soap, iodine tincture, ethanol alcohol;Not with the oiliness articles for use such as adhesive plaster, protective skin cream, it is to avoid caloric stimulation, not scratching, desquamation is avulsion not.Patient's irradiation field skin conditions is observed in timing, supervises execution matters needing attention.
1.2.4, after dosage regimen treatment group gives the cleaning of normal saline local after radiotherapy starts, radiation wild every day twice (sooner or later respectively once) is embrocated in the Chinese medicine local taking the embodiment of the present invention 1.After matched group gives the cleaning of normal saline local, radiation wild every day twice (sooner or later respectively once) is embrocated in normal saline local.Shot cycle adheres to using day off, terminates one week after to radiotherapy.All patients stop radiotherapy as there is serious skin lesion or accompanying infection.
1.2.5 evaluation methodology skin injury grade scale is with reference to nineteen ninety-five U.S.'s radiation oncology cooperative groups RTOG grade scale: 0 grade substantially unchanged, I level dermatitis: light red speckle, alopecia, dryness is peeled, perspire and reduce: II grade of dermatitis: skin is touched a tender spot, hence it is evident that erythema, the moist decortication of lamellar, intermediate edema: III grade of dermatitis: allowance for bark the moist decortication of the amalgamation outside skin fold place, severe edema;IV grade of dermatitis: ulcer, downright bad, hemorrhage.The evaluation of skin lesion degree, using calibration when skin lesion degree is the most serious between radiotherapy as the calibration of its skin lesion degree.Compare incidence rate and the skin lesion degree of 2 groups of patient radiation's property dermatitis.
1.2.6 statistical analysis adopts SPSS16.0 to carry out statistical analysis, and enumeration data adopts χ2Inspection, measurement data adopts t inspection, with P < 0.05 for Variant statistical meaning.
2. result
The comparison of 2 groups of patient radiation's property dermatitis incidence rates, in Table l.
The comparative example (%) of 12 groups of patient radiation's property dermatitis incidence rates of table
The comparison of the radiodermatitis occurrence degree of 2.22 groups of patients, result is in Table 2.
The comparison (example) of 22 groups of patient radiation's property dermatitis occurrence degrees of table
Group Number of cases 0 grade I level II grade III grade
Treatment group 50 1 40 9 0
Matched group 50 9 11 25 5
Table 1 and table 2 it is shown that the Chinese medicine for radiodermatitis of the present invention, it is possible to reduce incidence rate and the occurrence degree of radiodermatitis, and more than II degree radiodermatitis relatively matched group significantly reduce.

Claims (4)

1., for a Chinese medicine for radiodermatitis, it is made up of the raw material of Chinese medicine medicine of following percentage by weight: fresh Dianthus chinensis 20%~40%, fresh Herba Cirsii stem and leaf 20%~40%, fresh Herba Portulacae 20%~60%.
2. the Chinese medicine for radiodermatitis according to claim 1, it is characterised in that be made up of the raw material of Chinese medicine medicine of following percentage by weight: fresh Dianthus chinensis 25%~35%, fresh Herba Cirsii stem and leaf 25%~35%, fresh Herba Portulacae 30%~50%.
3. the Chinese medicine for radiodermatitis according to claim 1 and 2, it is characterised in that be made up of the raw material of Chinese medicine medicine of following percentage by weight: fresh Dianthus chinensis 30%, fresh Herba Cirsii stem and leaf 30%, fresh Herba Portulacae 40%.
4. the preparation method for the Chinese medicine of radiodermatitis described in claim 1 or 2 or 3 is: select totally dustless fresh Dianthus chinensis, fresh Herba Cirsii stem and leaf and fresh Herba Portulacae, do not wash, chopping, it is placed in hermetic container, room temperature is placed, and allows fresh Dianthus chinensis, fresh Herba Cirsii stem and leaf and fresh Herba Portulacae natural fermentation, pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
CN201610275188.XA 2016-04-28 2016-04-28 Traditional Chinese medicine for treating radiodermatitis Pending CN105769968A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110755547A (en) * 2019-12-04 2020-02-07 王小龙 Externally applied traditional Chinese medicine for treating radiodermatitis and preparation method thereof

Citations (2)

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Publication number Priority date Publication date Assignee Title
CN104706970A (en) * 2015-01-19 2015-06-17 滨州医学院附属医院 Traditional Chinese medicine for preventing radiodermatitis caused by nasopharyngeal carcinoma radiotherapy
CN105327032A (en) * 2015-11-26 2016-02-17 王辉 Traditional Chinese medicine composition for treating solar dermatitis, preparation method and use method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104706970A (en) * 2015-01-19 2015-06-17 滨州医学院附属医院 Traditional Chinese medicine for preventing radiodermatitis caused by nasopharyngeal carcinoma radiotherapy
CN105327032A (en) * 2015-11-26 2016-02-17 王辉 Traditional Chinese medicine composition for treating solar dermatitis, preparation method and use method thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110755547A (en) * 2019-12-04 2020-02-07 王小龙 Externally applied traditional Chinese medicine for treating radiodermatitis and preparation method thereof

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Application publication date: 20160720