CN105770170A - Traditional Chinese medicine composition for treating radiodermatitis - Google Patents
Traditional Chinese medicine composition for treating radiodermatitis Download PDFInfo
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- CN105770170A CN105770170A CN201610275187.5A CN201610275187A CN105770170A CN 105770170 A CN105770170 A CN 105770170A CN 201610275187 A CN201610275187 A CN 201610275187A CN 105770170 A CN105770170 A CN 105770170A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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Abstract
The invention belongs to the technical field of traditional Chinese medicine compositions and particularly relates to a traditional Chinese medicine composition for treating radiodermatitis. The Chinese medicine composition for treating radiodermatitis is prepared from, by weight, 20%-40% of fresh plantain herb, 20%-40% of fresh solanum nigrum and 20%-60% of fresh portulaca oleracea. The traditional Chinese medicine composition for treating radiodermatitis has efficacies of heat clearing, diuresis promoting, blood cooling, detoxifying, pain relieving and tissue regeneration promoting and is an effective medicine for preventing and treating radioactive skin injuries.
Description
Technical field
The invention belongs to pharmaceutical technology field, be specifically related to a kind of Chinese medicine composition for radiodermatitis.
Background technology
Radiodermatitis is by all kinds ionizing radiation, is radiated at skin such as α, β, γ, X ray, electronics, proton etc., injury disease that mucosa causes, is complication common in malignant tumor radiotherapy.Acute radiodermatitis occurs at first, if treating not in time, there will be radiation-induced skin ulcer and even delaying and with the passing of time form chronic radiodermatitis, not only bring misery to patient, and the seriality for the treatment of can be affected, reduce life quality, find the method effectively preventing radiodermatitis significant.
Herba Plantaginis another name kohlrabi, horse formal shoe, Herba Plantaginis, blocking the way, mound formal shoe, Folium Fumicis Dentati, Rana limnocharis clothing, cattle are lost, victory formal shoe, wheel dish, victory formal shoe dish, clam ant grass, Rana limnocharis grass, Qian Guancao, cattle formal shoe, wild Radix Betae, Scabrous Elephantfoot Herb, Bai Guancao, pig Auricled Hedyotis Herb, meal spoon grass, Herba Lepisori Thunbergiani, five grass, yellow toad Testudinis grass, Bufo siccus grass, Gaster Sus domestica, ash pan are careless, squabble grass, wheel grass, Herba Saussureae amarae, cash strings grass, cattle Radix Betae, Huang toad leaf, Rhizoma Chiritae Eburneae.Herb for Plantaginaceae plant Herba Plantaginis PlantagoasiaticaL., Big Semen Plantaginis PlantagomajorL. and Plantago depressa Willd PlantagodepressaWilld.Feeble QI is fragrant, mildly bitter flavor.Sweet in the mouth；Cold in nature.Return liver；Kidney；Bladder warp.Function clearing away heat and promoting diuresis；Removing heat from blood；Removing toxic substances.Main accumulation of heat in the urinary bladder；Dysuria；Stranguria with turbid discharge leukorrhagia；Heat-damp in summer dysentery；Epistaxis；Hematuria；Liver-heat conjunctival congestion；Laryngopharynx swelling and pain；Carbuncle sore tumefacting virus.
Herba Solani Nigri another name Herba Solani Nigri, Herba Solani Surattensis, night sky, bitter certain herbaceous plants with big flowers, wild Fructus Capsici, black Fructus Solani melongenae, Radix vitis romanetii, for Solanaceae nightshade Herba Solani Nigri SolanumnigrumL., with all herbal medicine.Nature and flavor are bitter, cold.Function heat-clearing and toxic substances removing, inducing diuresis to remove edema.For cat fever, toothache, chronic bronchitis, dysentery, urinary system infection, mastitis, leucorrhea, cancer；Carbuncle furuncle furuncle, pemphigus, venom are controlled in external.
Herba Portulacae another name Dens Equi dish, horse Amaranthus mangostanus L., pig mother's dish, edible kernel of melon seeds dish, Semen Benincasae dish, longevity greens/mustard green, horse Serpentis dish, for portulacaceous plant Herba Portulacae PortulacaoleraceaL., with all herbal medicine.Sour in the mouth, cold in nature.Enter large intestine, liver, spleen channel.Function clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For bacillary dysentery, acute gastroenteritis, acute appendicitis, mastitis, bleeding hemorrhoids, leucorrhea；Furuncle swelling toxin, eczema, herpes zoster are controlled in external.
Interact with fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae at present, composition of prescription, prepare the medicine for the treatment of radiation dermatitis, there is not been reported.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for radiodermatitis, to meet the demand of extensive patients.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicine composition for radiodermatitis, is made up of the traditional Chinese medicinal composition raw materials of following percentage by weight: fresh Herba Plantaginis 20%～40%, fresh Herba Solani Nigri 20%～40%, fresh Herba Portulacae 20%～60%.
Preferably, the above-mentioned Chinese medicine composition for radiodermatitis, it is made up of the traditional Chinese medicinal composition raw materials of following percentage by weight: fresh Herba Plantaginis 25%～35%, fresh Herba Solani Nigri 25%～35%, fresh Herba Portulacae 30%～50%.
It is furthermore preferred that the above-mentioned Chinese medicine composition for radiodermatitis, it is made up of the traditional Chinese medicinal composition raw materials of following percentage by weight: fresh Herba Plantaginis 30%, fresh Herba Solani Nigri 30%, fresh Herba Portulacae 40%.
The above-mentioned Chinese medicine composition for radiodermatitis, its preparation method is: select totally dustless fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae, do not wash, chopping, is placed in hermetic container, and room temperature is placed, allow fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae natural fermentation, pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
Select totally dustless fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae, do not wash, being because inventor to find in substantial amounts of practice, fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae ferment after washing storage again, quickly can rot mouldy after washed, easy wound causes infection, is not suitable for being used further to treatment and scalds.It addition, the fresh Herba Plantaginis do not cleaned, fresh Herba Solani Nigri and fresh Herba Portulacae fermentation after the holding time long.
The natural fermentation time can be 10 days-5 every year can, to be fermented into pureed or liquid to be as the criterion.
Above-mentioned hermetic container is airtight glass container, airtight ceramic vessel or airtight plastic containers.If adopt irony, steel, stainless steel, the canister such as copper, it is easy to cause the mouldy of this medicine to rot, it is impossible to use.
This product is applicable to prevention and treating radiation dermatitis.
Usage and dosage: radiotherapy gives the Chinese medicine composition for radiodermatitis of the present invention after starting, embrocates radiation open country, every day twice (sooner or later respectively once).Shot cycle adheres to using day off, terminates one week after to radiotherapy.All patients stop radiotherapy as there is serious skin lesion or accompanying infection.
Radiodermatitis is owing to skin accepts high-octane physics lonizing radiation, causes epiderm skin to entangle the degeneration that the occurrence degrees such as born of the same parents, sebaceous gland, hair follicle are different.Body is subject to after heavy dose of lonizing radiation irradiate, it may appear that local microcirculation obstacle, blood capillary early-age shrinkage, then expands, and permeability increases, and blood flow is slack-off, erythrocyte and platelet aggregation, small thrombosis, and blood viscosity increases.Along with adding up of exposure dose, dermal capillary dilatation and congestion, blood vessel and inflammatory cell infiltration around sebaceous gland, and then epidermis redness, vesicle, infection ulcer occur.
In the Chinese medicine composition of the present invention, Herba Plantaginis, Herba Solani Nigri, Herba Portulacae all have effect of heat-clearing and toxic substances removing removing heat from blood.Wherein Herba Portulacae clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; stealthy biomembrane can be quickly formed at wound surface and patient part; good biocompatibility, safety non-toxic; this film plays the effect of protection wound surface, moisturizing skin mainly through resistance bacterium, resistance dirt; play barrier action; it is effectively reduced the radiation stimulation to skin, plays the effect preventing and treating radiodermatitis.Herba Plantaginis heat-clearing and toxic substances removing removing heat from blood, it is possible to reduce dermal capillary dilatation and congestion, blood vessel and inflammatory cell infiltration around sebaceous gland, thus prevention and minimizing epidermis redness, vesicle, infection ulcer.Herba Solani Nigri heat-clearing and toxic substances removing diuretic, reduces radiation position permeability, thus preventing epidermis redness, vesicle, infection ulcer.Three medicines share, and play clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, effect of pain relieving granulation promoting altogether.The generation of radiodermatitis can be delayed, effectively alleviate wound pain, promote epithelial cell growth, accelerate wound repair, be the active drug of prevention and treating radioactive skin injury.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further described, in order to those skilled in the art knows more about the present invention, but does not limit the present invention with this.
Embodiment l:
Totally dustless fresh Herba Plantaginis 300g, fresh Herba Solani Nigri 300g, fresh Herba Portulacae 400g is selected not to wash, chopping, it is placed in closed glass jar, room temperature is placed, and allows fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae natural fermentation, and pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
Embodiment 2
Totally dustless fresh Herba Plantaginis 250g, fresh Herba Solani Nigri 250g, fresh Herba Portulacae 500g is selected not to wash, chopping, it is placed in airtight terrine, room temperature is placed, and allows fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae natural fermentation, and pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
Embodiment 3
Totally dustless fresh Herba Plantaginis 350g, fresh Herba Solani Nigri 350g, fresh Herba Portulacae 300g is selected not to wash, chopping, it is placed in closed plastic bottle, room temperature is placed, and allows fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae natural fermentation, and pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
Embodiment 4
Totally dustless fresh Herba Plantaginis 400g, fresh Herba Solani Nigri 400g, fresh Herba Portulacae 200g is selected not to wash, chopping, it is placed in airtight terrine, room temperature is placed, and allows fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae natural fermentation, and pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
Embodiment 5
Totally dustless fresh Herba Plantaginis 200g, fresh Herba Solani Nigri 200g, fresh Herba Portulacae 600g is selected not to wash, chopping, it is placed in closed glass jar, room temperature is placed, and allows fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae natural fermentation, and pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
Reference examples 1
Totally dustless fresh Herba Plantaginis 1000g is selected not wash, chopping, it is placed in closed glass jar, room temperature is placed, and allows fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae natural fermentation, and pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
Reference examples 2
Totally dustless fresh Herba Solani Nigri 1000g is selected not wash, chopping, it is placed in closed glass jar, room temperature is placed, and allows fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae natural fermentation, and pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
Reference examples 3
Totally dustless fresh Herba Portulacae 1000g is selected not wash, chopping, it is placed in closed glass jar, room temperature is placed, and allows fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae natural fermentation, and pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
The Chinese medicine composition for radiodermatitis of the present invention has been carried out pharmacological testing, and Details as Follows:
1 material
Varian 600C electron linear accelerator (Varian Associates, Inc. (US) 611 Hansen Way, Palo Alto, California 94303, U.S.A., Paro Austria is many, California, the U.S.), radiation quality and energy: 6MeVX ray；SK_ III moisture of skin measuring instrument (Shenzhen Kai Er Electronics Factory)；Than sub-fragrant (this pharmaceutical factory of medik of France, lot number 20150708).
SD healthy adult rat, male and female half and half, weight 180 ~ 220g；Adult healthy kunming mice, male and female half and half, weight 18 ~ 22g.Shandong University's animal experimental center provides, and raises at Shandong University's animal experimental center, carries out experiment, temperature (25 ± 2) DEG C, humidity (60 ± 10), 12h illumination.
2 methods
2.1 radioresistance dermatitis test SD rats 60, are randomly divided into 6 groups, respectively normal saline radiation patterns group, embodiment 1 group, reference examples 1 group, reference examples 2 groups, reference examples 3 groups, than sub-fragrant group.Each group in pre-irradiation 30min in rat right hind leg uniform application relative medicine, every 1g, anesthesia is lower adopts 6Mev electric wire, and absorbed dose are 60Gy, and close rate is 600cGy min., the right hind once irradiating that rat is exposed, after irradiation, smear relative medicine every day once, successive administration 22d, freely drinks water during test and ingests.Within 22nd day, observe each group of dermatitis incidence rate, dermatitis scoring.Mark according to RTOG acute radiation injury grade scale.0 grade is chosen as 0 point: skin is unchanged；I level is chosen as 1 point: dark-coloured erythema；1 grade is chosen as 2 points: fresh color erythema, the moist decortication of lamellar；III grade is chosen as 3 points: moist decortication, pitting edema；IV level is chosen as 4 points: ulcer, hemorrhage, downright bad.
2.2 mice foot swelling test kunming mices 60, are randomly divided into 6 groups, often group 10.Group technology is ibid.30min before Yu Zhiyan, measures administration front foot volume, smears relative medicine respectively at mice right crus of diaphragm, and after every 0.5g, 30min, 10 Ovum Gallus domesticus album foot intradermal injection 0.1ml/ only cause inflammation, and after causing inflammation, 30,60min measure foot volume, calculate paw swelling.
Paw swelling (%)=(causing scorching metapedes volume unanimously scorching front foot volume)/cause scorching front foot volume × 100%.
2.3 statistical procedures adopt SPSS10.0 to carry out statistical analysis.Measurement data represents with x ± S, and result carries out t inspection.P < 0.05 has significance for difference.
3 results
3.1 on irradiation rat radiodermatitis occurrence rate and dermatitis degree to affect result visible, after irradiation the 22nd day, normal saline radiation patterns group matched group dermatitis incidence rate is 100%, 1 group of dermatitis incidence rate of reference examples is 78.2%, 2 groups of dermatitis incidence rates of reference examples are 72.5%, 3 groups of dermatitis incidence rates of reference examples are 68.7%, are 50.0% than sub-fragrant group dermatitis incidence rate, and the present invention is only 10.8% for 1 group of dermatitis incidence rate of embodiment of the Chinese medicine composition of radiodermatitis.Compared with normal saline negative control group, all groups of dermatitis degree that all can significantly reduce after irradiation, wherein the present invention is the most obvious for 1 group of reduction effect of Chinese medicine composition embodiment of radiodermatitis, and its inflammatory score is only the 4.5% of negative control group.Compared with other groups, the present invention significantly reduces for 1 group of inflammatory score of Chinese medicine composition embodiment of radiodermatitis, points out its radioresistance dermatitis curative effect to be better than alone Herba Plantaginis, Herba Solani Nigri, Herba Portulacae and Bi Ya fragrant, and result is in Table 1.
The table 1 impact (x ± s) on irradiation rat radiodermatitis occurrence rate and dermatitis degree
| Group | Dermatitis incidence rate (%) | Dermatitis degree is marked |
| Normal saline radiation patterns group | 100 | 2.68±0.52 |
| Embodiment 1 group | 10.8 | 0.12±0.19bcdef |
| Reference examples 1 group | 78.2 | 1.75±0.45a |
| Reference examples 2 groups | 72.5 | 1.56±0.26a |
| Reference examples 3 groups | 68.7 | 1.42±0.36a |
| Than sub-fragrant group | 50.0 | 1.24±0.46a |
Note: compared with normal saline radiation patterns group,aP < 0.05,bP<0.05；Compared with reference examples 1,cP<0.05；Compared with reference examples 2,dP<0.05；Compared with reference examples 3,eP<0.05；With compared with sub-sweet smell,fP<0.05。
3.2 mice Ovum Gallus domesticus album caused scorching paw swelling to affect result visible, compared with normal saline negative control group, reference examples 1 group, reference examples 2 groups, reference examples 3 groups and than sub-sweet smell group, mice group swelling is had no significant effect；The present invention is used for the Chinese medicine composition embodiment 1 group of radiodermatitis in time causing scorching 10min, 60min, and paw swelling is respectively lower than negative control group 53.4%, 72.4%, and difference has pole significance (P < 0.01), and result is in Table 2.
Mice Ovum Gallus domesticus album is caused the impact (x ± s) of scorching paw swelling by table 2
Note: compared with normal saline radiation patterns group,aP < 0.05,bP<0.01；Compared with reference examples 1,cP<0.05；Compared with reference examples 2,dP<0.05；Compared with reference examples 3,eP<0.05；With compared with sub-sweet smell,fP<0.05。
Claims (4)
1., for a Chinese medicine composition for radiodermatitis, it is made up of the traditional Chinese medicinal composition raw materials of following percentage by weight: fresh Herba Plantaginis 20%～40%, fresh Herba Solani Nigri 20%～40%, fresh Herba Portulacae 20%～60%.
2. the Chinese medicine composition for radiodermatitis according to claim 1, it is characterised in that be made up of the traditional Chinese medicinal composition raw materials of following percentage by weight: fresh Herba Plantaginis 25%～35%, fresh Herba Solani Nigri 25%～35%, fresh Herba Portulacae 30%～50%.
3. the Chinese medicine composition for radiodermatitis according to claim 1 and 2, it is characterised in that be made up of the traditional Chinese medicinal composition raw materials of following percentage by weight: fresh Herba Plantaginis 30%, fresh Herba Solani Nigri 30%, fresh Herba Portulacae 40%.
4. the preparation method for the Chinese medicine composition of radiodermatitis described in claim 1 or 2 or 3 is: select totally dustless fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae, do not wash, chopping, it is placed in hermetic container, room temperature is placed, and allows fresh Herba Plantaginis, fresh Herba Solani Nigri and fresh Herba Portulacae natural fermentation, pureed to be fermented into or liquid, filtration is removed slag, and to obtain final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106138590A (en) * | 2016-07-29 | 2016-11-23 | 时学军 | The Chinese medicine preparation of a kind for the treatment of radioactive skin injury and preparation method |
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