CN104825824A - Anti-radiation traditional Chinese medicine gel for external application and method for manufacturing anti-radiation traditional Chinese medicine gel - Google Patents
Anti-radiation traditional Chinese medicine gel for external application and method for manufacturing anti-radiation traditional Chinese medicine gel Download PDFInfo
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Abstract
The invention discloses anti-radiation traditional Chinese medicine gel for external application. The anti-radiation traditional Chinese medicine gel comprises, by weight, 10-15% of traditional Chinese medicine extracts, 0.8-1.2% of thickeners, 10-20% of humectants, 0.4-0.6% of pH (potential of hydrogen) regulators, 0.3-0.6% of preservatives, 3-6% of solubilizers and the balance water. The traditional Chinese medicine extracts comprise, by weight, 10-20 parts of ginseng, 10-20 parts of centella asiatica, 10-20 parts of poria cocos, 5-15 parts of seaweeds, 5-15 parts of barbed skullcap herbs, 5-15 parts of cynomorium songaricum rupr, 5-15 parts of sea buckthorn, 5-15 parts of polygonum multiflorum, 5-15 parts of rhodiola rosea, 5-15 parts of polygonatum kingianum, 5-15 parts of ginkgo leaves and 5-15 parts of common bletilla pseudobulb. The invention further discloses a method for manufacturing the gel. The anti-radiation traditional Chinese medicine gel and the method have the advantages that the gel is made of traditional Chinese medicinal materials with anti-radiation functions and is reasonable in formula, main anti-radiation effects can be realized by the anti-radiation traditional Chinese medicine gel, and skin whitening and anti-aging effects and the like also can be realized by the anti-radiation traditional Chinese medicine gel.
Description
Technical field
The present invention relates to a kind of radiation-resistant Chinese medicine external gel and preparation method thereof, belong to technical field of traditional Chinese medicine preparation.
Background technology
The aging course of skin is mainly divided into endogenous old and feeble and extrinsic aging.Endogenous aging is that human body natural is old and feeble, be irreversible aging course, and is extrinsic agingly mainly caused by outside environmental elements, can slow down this aging course by certain preventive measure.The reason causing skin extrinsic aging is a lot, mainly comprises ultraviolet radiation and electromagnetic radiation etc.Skin, as the maximum organ of human body and extraneous contact, is the direct acting target organ of radiation.Contact excessive radiation and can cause skin tanning, erythema, photoaging, even a series of dermatosis such as skin carcinoma.Along with growth in the living standard, radiation has become one of principal element affecting health of people, has a strong impact on the quality of life of people.
The traditional Chinese medical science is thought, radiation is that a kind of external burning hot poison is evil, can invade human body, also directly may injure internal organs from the fur of human body, mouth and nose.The easy yin-damaging and Qi consuming of radiation damage, the function of interference human five internal organs, hinders the QI and blood of body biochemical, causes that healthy energy is weak, resistance against diseases is low.
Pre-radiation-resistant external preparation conventional is in the market sunscreen and sun screen, and sunscreen and sun screen can prevent skin to avoid radiation, but it has certain stimulation to skin, and life-time service easily blocks pore, increases the weight of scytitis.Therefore, develop a kind of natural external preparation with anti-radiation effect to have broad application prospects.
Summary of the invention
For the deficiency that above-mentioned prior art exists, the object of this invention is to provide a kind of radiation-resistant Chinese medicine external gel, adopt the Chinese crude drug with radiation proof function, carry out reasonable formula, make one based on radioprotective, have both whitening, the Chinese medicine external gel of the anti-ageing effect of waiting for a long time.
Another object of the present invention is to provide the preparation method of this radiation-resistant Chinese medicine external gel.
For achieving the above object, the present invention adopts following technical proposals:
A kind of radiation-resistant Chinese medicine external gel is made up of the raw material of following percentage by weight:
Chinese medicine extract 10-15%, thickening agent 0.8-1.2%, wetting agent 10-20%, pH adjusting agent 0.4-0.6%, antiseptic 0.3 ~ 0.6%, solubilizing agent 3% ~ 6%, surplus is water;
Described Chinese medicine extract is made up of the crude drug of following weight portion:
Radix Ginseng 10-20 part, Herba Centellae 10-20 part, Poria 10-20 part, Sargassum 5-15 part, Herba Scutellariae Barbatae 5-15 part, Herba Cynomorii 5-15 part, Fructus Hippophae 5-15 part, Radix Polygoni Multiflori 5-15 part, Radix Rhodiolae 5-15 part, Rhizoma Polygonati 5-15 part, Folium Ginkgo 5-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part;
Described thickening agent is the one or several arbitrarily in Acritamer 940, hydroxypropyl emthylcellulose, alginate, gelatin or starch;
Described wetting agent is glycerol or propylene glycol;
Described pH adjusting agent is sodium hydroxide or triethanolamine;
Described solubilizing agent is polyoxyethylene sorbitan monoleate or poloxamer;
Described antiseptic is chlorhexidine gluconate or ethyl hydroxybenzoate.
Preferably, this radiation-resistant Chinese medicine external gel is made up of the raw material of following percentage by weight:
Chinese medicine extract 13.5%, thickening agent 1.0%, wetting agent 15%, pH adjusting agent 0.4%, antiseptic 0.5%, solubilizing agent 5%, surplus is water;
Described Chinese medicine extract is made up of the crude drug of following weight portion:
Radix Ginseng 15 parts, Herba Centellae 15 parts, Poria 15 parts, Sargassum 10 parts, Herba Scutellariae Barbatae 10 parts, Herba Cynomorii 10 parts, Fructus Hippophae 10 parts, Radix Polygoni Multiflori 10 parts, Radix Rhodiolae 10 parts, Rhizoma Polygonati 10 parts, Folium Ginkgo 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts;
Described thickening agent is Acritamer 940;
Described wetting agent is propylene glycol;
Described pH adjusting agent is sodium hydroxide;
Described solubilizing agent is polyoxyethylene sorbitan monoleate;
Described antiseptic is ethyl hydroxybenzoate.
The preparation method of this radiation-resistant Chinese medicine external gel, the preparation process of the gel preparation of every 1000 grams is:
(1) by Radix Ginseng, Herba Centellae, Herba Cynomorii, Rhizoma Polygonati, Radix Rhodiolae, Poria 6 taste Chinese medicine, decoct with water 2 times, filter, filtrate merges, activated carbon decolorizing, and concentrating under reduced pressure is dry, for subsequent use;
(2) by Fructus Hippophae, Sargassum, Herba Scutellariae Barbatae, Radix Polygoni Multiflori, Folium Ginkgo 5 taste Chinese medicine, alcohol reflux 2 times, filters, and reclaims ethanol, activated carbon decolorizing, and concentrating under reduced pressure is dry, for subsequent use;
(3) Pseudobulbus Bletillae (Rhizoma Bletillae), decocts with water 2 times, and filter, merging filtrate, filtrate is concentrated into every 10ml and is equivalent to medical material 1g, and adding ethanol, to be adjusted to alcohol content be 65-75%, leaves standstill 24h, decompress filter, drying precipitate, for subsequent use;
(4) thickening agent gradation is spread on (1:50) on the water surface, treat surperficial complete wetting, fully stir, placement is spent the night, and makes it fully swelling, adds pH adjusting agent, stir, obtain Blank gel substrate;
(5) solubilizing agent added water make the solubilizer solution that mass fraction is 10%, by step (1), (2), (3) are extract obtained adds wherein, stirring and dissolving;
(6) wetting agent to be added etc. water gaging mixing, make wetting agent solution, antiseptic is added wherein, stirring and dissolving;
(7) step (5), (6) gained solution are joined in step (4) gained Blank gel substrate, stir, add water to 1000g, continue stirring 30 minutes, to obtain final product.
In step (1), decoct 8-10 times that the amount added water is medical material weight for the first time, decocting time is 2-3 hour; Decoct 6-8 times that the amount added water is medical material weight for the second time, decocting time is 1-2 hour.
In step (2), the process conditions of alcohol reflux are: the volumetric concentration of ethanol is 50%, and solid-liquid ratio is 1:20-30 (g/mL), and reflux temperature is 70-85 DEG C, and the time of each reflux, extract, is (2-3) hour.
In Chinese medicine extract, the pharmacological action of each crude drug is as follows
Radix Ginseng: sweet, micro-hardship, tepor.Return spleen, lung, the heart, kidney channel.Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid and nourish blood, Fructus Alpiniae Oxyphyllae of calming the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, deficiency of qi and blood, and prolonged illness void is won, palpitation with fear insomnia, sexual impotence cold womb.Clothes of a specified duration can life lengthening, and can physical strength reinforcing, the diseases such as the immunologic hypofunction that Therapeutic cancer patient causes because of radiation and chemotherapy; There is cold-and-heat resistent stress.There is the vigor strengthening human body surface cell simultaneously, suppress old and feeble and wait effect.
Herba Centellae: bitter, acrid, cold.Return liver,spleen,kidney warp.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, heatstroke is suffered from diarrhoea, stranguria caused by urinary stone stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.
Poria: sweet, light is flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Sargassum: bitter, salty, cold.Return liver, stomach, kidney channel.There is eliminating phlegm and softening indurated mass eliminating stagnation, effect of inducing diuresis to remove edema.
Herba Scutellariae Barbatae: pungent, bitter, cold.Return lung, liver, kidney channel.Heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, falls and flutters the pain of injury, edema, jaundice, snake bite and insect sting.
Herba Cynomorii: sweet, temperature.Return liver, kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.
Fructus Hippophae: sour, puckery, temperature.Return spleen, stomach, lung, heart channel.Strengthening the spleen to promote digestion, eliminating phlegm and stopping cough.Promoting blood circulation to remove blood stasis.For insufficiency of the spleen lack of appetite, abdominal pain due to retention of food, cough with copious phlegm, obstruction of qi in the chest and cardialgia, blood stasis amenorrhea, falls and flutters congestive edema
Radix Polygoni Multiflori: bitter, sweet, puckery, tepor.Return liver, the heart, kidney channel.Removing toxic substances, eliminating carbuncle, preventing the attack (or recurrence) of malaria, loosening bowel to relieve constipation.
Radix Rhodiolae: sweet, bitter is flat.Return lung, heart channel.Benefiting QI for activating blood circulation, promotes blood circulation and relievings asthma.For blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia is panted.
Rhizoma Polygonati: sweet is flat.Return spleen, lung, kidney channel.Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, chronic cough hemoptysis, asthenia of essence and blood, soreness of the waist and knees, early whitening of beard and hair, interior-heat is quenched one's thirst.
Folium Ginkgo: sweet, bitter, puckery is flat.GUIXIN, lung meridian.Blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, astringes the lung and relievings asthma, and changes turbid blood fat reducing.For obstruction of collaterals by blood stasis, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, cough and asthma due to lung deficiency, hyperlipemia.
Pseudobulbus Bletillae (Rhizoma Bletillae): bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Astringing to arrest bleeding, detumescence and promoting granulation.
Beneficial effect of the present invention:
In radiation-resistant Chinese medicine external gel preparation of the present invention, the rhodioloside in selected Radix Rhodiolae has protective effect to fibroblast by radiation-induced apoptosis; Radix Ginseng, Radix Polygoni Multiflori can strengthen the immunity of human body, have antidotal effect; Herba Centellae, Poria, Fructus Hippophae, Sargassum, Herba Scutellariae Barbatae, Rhizoma Polygonati, Folium Ginkgo then have the effect of beauty treatment, light speckle, defying age, benefiting QI for activating blood circulation, boosting qi and nourishing yin.Each taste Chinese medicine carries out composite by Chinese medicine external gel preparation of the present invention, and it can produce synergism each other, proves through animal experiment, and it has the effect of anti-electromagnetic-radiation.Chinese medicine external gel preparation of the present invention also has whitening, antidotal effect simultaneously.
Detailed description of the invention
Below by instantiation, the present invention will be further elaborated, should be noted that following explanation is only to explain the present invention, not limiting its content.
Embodiment 1: the preparation of radiation-resistant Chinese medicine external gel
Formula: Chinese medicine extract 13.5%, thickening agent 1.0%, wetting agent 15%, pH adjusting agent 0.4%, antiseptic 0.5%, solubilizing agent 5%, surplus is water;
Chinese medicine extract is made up of the crude drug of following weight portion:
Radix Ginseng 15 parts, Herba Centellae 15 parts, Poria 15 parts, Sargassum 10 parts, Herba Scutellariae Barbatae 10 parts, Herba Cynomorii 10 parts, Fructus Hippophae 10 parts, Radix Polygoni Multiflori 10 parts, Radix Rhodiolae 10 parts, Rhizoma Polygonati 10 parts, Folium Ginkgo 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts.
Thickening agent is Acritamer 940; Wetting agent is propylene glycol; PH adjusting agent is sodium hydroxide; Antiseptic is ethyl hydroxybenzoate; Solubilizing agent is polyoxyethylene sorbitan monoleate.
Preparation method:
(1) by Radix Ginseng, Herba Centellae, Herba Cynomorii, Rhizoma Polygonati, Radix Rhodiolae, Poria 6 taste Chinese medicine, decoct with water 2 times, decoct 8 times that the amount added water is medical material weight for the first time, decocting time is 2 hours; Decoct 6 times that the amount added water is medical material weight for the second time, decocting time is 1 hour, filters, and filtrate merges, activated carbon decolorizing, and it is 1.3 (50 DEG C of surveys) that concentrating under reduced pressure is dried to relative density, for subsequent use;
(2) by Fructus Hippophae, Sargassum, Herba Scutellariae Barbatae, Radix Polygoni Multiflori, Folium Ginkgo 5 taste Chinese medicine, alcohol reflux 2 times, the volumetric concentration of ethanol is 50%, and solid-liquid ratio is 1:25 (g/mL), and reflux temperature is 75 DEG C, the time of each reflux, extract, is 2 hours, filter, reclaim ethanol, activated carbon decolorizing, it is 1.3 (50 DEG C of surveys) that concentrating under reduced pressure is dried to relative density, for subsequent use;
(3) Pseudobulbus Bletillae (Rhizoma Bletillae), decocts with water 2 times, and decoct 8 times that the amount added water is medical material weight for the first time, decocting time is 2 hours; Decoct 6 times that the amount added water is medical material weight for the second time, decocting time is 1 hour, and filter, merging filtrate, filtrate is concentrated into every 10ml and is equivalent to medical material 1g, and adding ethanol, to be adjusted to alcohol content be 70%, leaves standstill 24h, decompress filter, drying precipitate, for subsequent use;
(4) Acritamer 940 gradation is spread on (1:50, g/ml) on the water surface, treat surperficial complete wetting, fully stir, placement is spent the night, and makes it fully swelling, adds 10% sodium hydroxide solution, stir, obtain Blank gel substrate;
(5) polyoxyethylene sorbitan monoleate, adds water and makes 10% polyoxyethylene sorbitan monoleate solution, by step (1), (2), (3) are extract obtained adds wherein, stirring and dissolving;
(6) propylene glycol, the water gaging mixing such as to add, makes propylene glycol solution, added by ethyl hydroxybenzoate wherein, stirring and dissolving;
(7) step (5), (6) gained solution are joined in step (4) gained Blank gel substrate, stir, add water to 1000g, continue stirring 30 minutes, to obtain final product.
Embodiment 2: the preparation of radiation-resistant Chinese medicine external gel
Formula: Chinese medicine extract 10%, thickening agent 1.2%, wetting agent 10%, pH adjusting agent 0.6%, antiseptic 0.3%, solubilizing agent 5%, surplus is water;
Chinese medicine extract is made up of the crude drug of following weight portion:
Radix Ginseng 10 parts, Herba Centellae 20 parts, Poria 10 parts, Sargassum 15 parts, Herba Scutellariae Barbatae 5 parts, Herba Cynomorii 15 parts, Fructus Hippophae 5 parts, Radix Polygoni Multiflori 15 parts, Radix Rhodiolae 5 parts, Rhizoma Polygonati 15 parts, Folium Ginkgo 5 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts.
Thickening agent is Acritamer 940; Wetting agent is glycerol; PH adjusting agent is sodium hydroxide; Antiseptic is ethyl hydroxybenzoate; Solubilizing agent is polyoxyethylene sorbitan monoleate.
Preparation method is with embodiment 1.
Embodiment 3: the preparation of radiation-resistant Chinese medicine external gel
Formula: Chinese medicine extract 15%, thickening agent 0.8%, wetting agent 20%, pH adjusting agent 0.4%, antiseptic 0.6%, solubilizing agent 6%, surplus is water;
Chinese medicine extract is made up of the crude drug of following weight portion:
Radix Ginseng 20 parts, Herba Centellae 10 parts, Poria 20 parts, Sargassum 5 parts, Herba Scutellariae Barbatae 15 parts, Herba Cynomorii 5 parts, Fructus Hippophae 15 parts, Radix Polygoni Multiflori 5 parts, Radix Rhodiolae 15 parts, Rhizoma Polygonati 5 parts, Folium Ginkgo 15 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts.
Thickening agent is Acritamer 940; Wetting agent is propylene glycol; PH adjusting agent is sodium hydroxide; Antiseptic is ethyl hydroxybenzoate; Solubilizing agent is polyoxyethylene sorbitan monoleate.
Preparation method is with embodiment 1.
Embodiment 4: zooblast is tested
Asepticly get 6-8 week Kunming mouse thymic tissue, preparation concentration is 5 × 10
6the thymocyte cell (thymocytes, T) of/mL, checks that cytoactive is greater than 95%, with the RPMI-1640 culture medium culturing cell containing 10% peptide Ox blood serum.Gel prepared by the embodiment 1 that experimental group adds whole mass concentration 1%, 5%, 10% respectively.Matched group adds the RPMI-1640 culture medium of equivalent respectively.At 37 DEG C, 5%CO
2cultivate 2h.(irradiation dose is 45mJ/cm to carry out UV-B irradiation
2).Then, then after continuing to cultivate 2h respectively, the activity of each group thymocyte cell after adopting mtt assay to detect uv b radiation damage.Result shows, gel of the present invention has significant protective effect to rat chest gland lymphocyte.
The above; be only the present invention's preferably detailed description of the invention; but protection scope of the present invention is not limited thereto; any those skilled in the art of being familiar with are in the technical scope that the present invention discloses; be equal to according to technical scheme of the present invention and inventive concept thereof and replace or change, all should be encompassed within protection scope of the present invention.
Claims (10)
1. a radiation-resistant Chinese medicine external gel, is characterized in that, is to be made up of the raw material of following percentage by weight:
Chinese medicine extract 10-15%, thickening agent 0.8-1.2%, wetting agent 10-20%, pH adjusting agent 0.4-0.6%, antiseptic 0.3 ~ 0.6%, solubilizing agent 3% ~ 6%, surplus is water;
Described Chinese medicine extract is made up of the crude drug of following weight portion:
Radix Ginseng 10-20 part, Herba Centellae 10-20 part, Poria 10-20 part, Sargassum 5-15 part, Herba Scutellariae Barbatae 5-15 part, Herba Cynomorii 5-15 part, Fructus Hippophae 5-15 part, Radix Polygoni Multiflori 5-15 part, Radix Rhodiolae 5-15 part, Rhizoma Polygonati 5-15 part, Folium Ginkgo 5-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part;
Described thickening agent is the one or several arbitrarily in Acritamer 940, hydroxypropyl emthylcellulose, alginate, gelatin or starch;
Described wetting agent is glycerol or propylene glycol;
Described pH adjusting agent is sodium hydroxide or triethanolamine;
Described solubilizing agent is polyoxyethylene sorbitan monoleate or poloxamer;
Described antiseptic is chlorhexidine gluconate or ethyl hydroxybenzoate.
2. radiation-resistant Chinese medicine external gel as claimed in claim 1, is characterized in that, is be made up of the raw material of following percentage by weight:
Chinese medicine extract 13.5%, thickening agent 1.0%, wetting agent 15%, pH adjusting agent 0.4%, antiseptic 0.5%, solubilizing agent 5%, surplus is water.
3. radiation-resistant Chinese medicine external gel as claimed in claim 2, is characterized in that, described Chinese medicine extract is made up of the crude drug of following weight portion:
Radix Ginseng 15 parts, Herba Centellae 15 parts, Poria 15 parts, Sargassum 10 parts, Herba Scutellariae Barbatae 10 parts, Herba Cynomorii 10 parts, Fructus Hippophae 10 parts, Radix Polygoni Multiflori 10 parts, Radix Rhodiolae 10 parts, Rhizoma Polygonati 10 parts, Folium Ginkgo 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts.
4. radiation-resistant Chinese medicine external gel as claimed in claim 2, is characterized in that, described thickening agent is Acritamer 940.
5. radiation-resistant Chinese medicine external gel as claimed in claim 2, is characterized in that, described wetting agent is propylene glycol.
6. radiation-resistant Chinese medicine external gel as claimed in claim 2, is characterized in that, described pH adjusting agent is sodium hydroxide.
7. radiation-resistant Chinese medicine external gel as claimed in claim 2, is characterized in that, described antiseptic is ethyl hydroxybenzoate.
8. radiation-resistant Chinese medicine external gel as claimed in claim 2, is characterized in that, described solubilizing agent is polyoxyethylene sorbitan monoleate.
9. the preparation method of the radiation-resistant Chinese medicine external gel described in any one of claim 1 to 8, is characterized in that, the preparation process of the gel of every 1000 grams is:
(1) by Radix Ginseng, Herba Centellae, Herba Cynomorii, Rhizoma Polygonati, Radix Rhodiolae, Poria 6 taste Chinese medicine, decoct with water 2 times, filter, filtrate merges, activated carbon decolorizing, and concentrating under reduced pressure is dry, for subsequent use;
(2) by Fructus Hippophae, Sargassum, Herba Scutellariae Barbatae, Radix Polygoni Multiflori, Folium Ginkgo 5 taste Chinese medicine, alcohol reflux 2 times, filters, and reclaims ethanol, activated carbon decolorizing, and concentrating under reduced pressure is dry, for subsequent use;
(3) Pseudobulbus Bletillae (Rhizoma Bletillae), decocts with water 2 times, and filter, merging filtrate, filtrate is concentrated into every 10ml and is equivalent to medical material 1g, and adding ethanol, to be adjusted to alcohol content be 65-75%, leaves standstill 24h, decompress filter, drying precipitate, for subsequent use;
(4) thickening agent gradation is spread on (1:50) on the water surface, treat surperficial complete wetting, fully stir, placement is spent the night, and makes it fully swelling, adds pH adjusting agent, stir, obtain Blank gel substrate;
(5) solubilizing agent added water make the solubilizer solution that mass fraction is 10%, by step (1), (2), (3) are extract obtained adds wherein, stirring and dissolving;
(6) wetting agent to be added etc. water gaging mixing, make wetting agent solution, antiseptic is added wherein, stirring and dissolving;
(7) step (5), (6) gained solution are joined in step (4) gained Blank gel substrate, stir, add water to 1000g, continue stirring 30 minutes, to obtain final product.
10. preparation method as claimed in claim 9, is characterized in that, in step (1), decoct 8-10 times that the amount added water is medical material weight for the first time, decocting time is 2-3 hour; Decoct 6-8 times that the amount added water is medical material weight for the second time, decocting time is 1-2 hour; In step (2), the process conditions of alcohol reflux are: the volumetric concentration of ethanol is 50%, and solid-liquid ratio is 1:20-30, and reflux temperature is 70-85 DEG C, and the time of each reflux, extract, is 2-3 hour.
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