CN103251597A - 纳曲酮长效制剂和使用方法 - Google Patents

纳曲酮长效制剂和使用方法 Download PDF

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Publication number
CN103251597A
CN103251597A CN2013101596188A CN201310159618A CN103251597A CN 103251597 A CN103251597 A CN 103251597A CN 2013101596188 A CN2013101596188 A CN 2013101596188A CN 201310159618 A CN201310159618 A CN 201310159618A CN 103251597 A CN103251597 A CN 103251597A
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CN
China
Prior art keywords
naltrexone
durative action
action preparation
treatment
auc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2013101596188A
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English (en)
Chinese (zh)
Inventor
埃利奥特·埃瑞希
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Inc
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Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35187918&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN103251597(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alkermes Inc filed Critical Alkermes Inc
Publication of CN103251597A publication Critical patent/CN103251597A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Addiction (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN2013101596188A 2004-04-22 2005-03-18 纳曲酮长效制剂和使用方法 Pending CN103251597A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56454204P 2004-04-22 2004-04-22
US60/564,542 2004-04-22
US11/083,167 US7919499B2 (en) 2004-04-22 2005-03-17 Naltrexone long acting formulations and methods of use
US11/083,167 2005-03-17

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200580012712.4A Division CN1946353B (zh) 2004-04-22 2005-03-18 纳曲酮长效制剂和使用方法

Publications (1)

Publication Number Publication Date
CN103251597A true CN103251597A (zh) 2013-08-21

Family

ID=35187918

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2013101596188A Pending CN103251597A (zh) 2004-04-22 2005-03-18 纳曲酮长效制剂和使用方法

Country Status (10)

Country Link
US (5) US7919499B2 (https=)
EP (2) EP2386269A3 (https=)
JP (2) JP5426094B2 (https=)
KR (2) KR20070005722A (https=)
CN (1) CN103251597A (https=)
AU (1) AU2005239989B2 (https=)
CA (1) CA2563086C (https=)
NZ (1) NZ549976A (https=)
RU (1) RU2370257C2 (https=)
WO (1) WO2005107753A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113226288A (zh) * 2018-12-27 2021-08-06 昱展新药生技股份有限公司 纳曲酮注射型缓释制剂

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2818973B2 (ja) 1990-10-22 1998-10-30 株式会社藤井鉄工所 スキップ式水路用スクリーン除塵機
US20100196436A1 (en) * 2009-01-30 2010-08-05 Gooberman Lance L Implants containing disulfiram and an anti-inflammatory agent
US8791093B2 (en) * 2009-05-29 2014-07-29 Lance L. Gooberman Pharmaceutical delivery systems for treatment of substance abuse and other addictions
RU2471478C1 (ru) * 2011-12-08 2013-01-10 Станислав Анатольевич Кедик Фармацевтическая композиция для лечения алкоголизма, наркомании и токсикомании с улучшенным профилем высвобождения налтрексона
WO2016160715A1 (en) * 2015-03-27 2016-10-06 Markel Dan Method for treating addiction
AU2019362730B2 (en) 2018-10-15 2022-10-20 Chong Kun Dang Pharmaceutical Corp. Injectable long-acting naltrexone microparticle compositions
GR1009871B (el) * 2019-07-30 2020-11-12 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα που περιλαμβανει μικροσφαιριδια ναλτρεξονης και μεθοδος παρασκευης αυτου
US12343340B2 (en) 2020-12-31 2025-07-01 Soin Therapeutics Llc Methods of using low dose naltrexone to treat chronic pain
US11752143B2 (en) 2020-12-31 2023-09-12 Soin Therapeutics Llc Methods of using low dose naltrexone to treat chronic pain
US11197819B1 (en) 2021-04-09 2021-12-14 Drug Delivery Company, Llc Extended release bioabsorbable subcutaneous medicinal dosage delivery implant system
AU2022202053A1 (en) 2021-09-17 2023-04-06 Biocorrx, Inc. Biodegradable implant including naltrexone
WO2023114557A2 (en) * 2021-12-17 2023-06-22 Journey Colab Corp. METHODS OF TREATING SUBSTANCE USE DISORDERS USING 5-MeO-DMT
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882335A (en) * 1988-06-13 1989-11-21 Alko Limited Method for treating alcohol-drinking response
CN1354664A (zh) * 1999-04-09 2002-06-19 南方研究所 可注射的纳曲酮微球组合物及其在减少海洛因和酒精消耗中的用途
CN1415294A (zh) * 2002-11-07 2003-05-07 上海医药工业研究院 一种纳曲酮长效注射微球组合物及制备方法和应用

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US4719219A (en) 1982-03-30 1988-01-12 Per A. E. Carlsson Phenyl-azacycloalkanes and use thereof in treatment of central nervous system disorders
WO1990013361A1 (en) 1989-05-04 1990-11-15 Southern Research Institute Improved encapsulation process and products therefrom
US5512593A (en) 1993-03-02 1996-04-30 John S. Nagle Composition and method of treating depression using natoxone or naltrexone in combination with a serotonin reuptake inhibitor
CA2474701C (en) 1993-11-19 2009-01-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradeable microparticles containing a biologically active agent
US5922253A (en) 1995-05-18 1999-07-13 Alkermes Controlled Therapeutics, Inc. Production scale method of forming microparticles
JPH11505547A (ja) * 1996-03-13 1999-05-21 エール ユニバーシティ ナルトレキソン及び関連化合物を用いる禁煙処置
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US6143314A (en) * 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
RO121631B1 (ro) 1999-08-27 2008-01-30 Southern Research Institute Compoziţie cu buprenorfină şi utilizarea acesteia pentru reducerea consumului de heroină şi/sau alcool
WO2001043726A1 (en) 1999-12-16 2001-06-21 Trident Technologies, Llc System and method for extended delivery of a therapeutic agent with its receptor loading dose
US6264987B1 (en) 2000-05-19 2001-07-24 Alkermes Controlled Therapeutics Inc. Ii Method for preparing microparticles having a selected polymer molecular weight
NZ540318A (en) 2002-10-31 2007-09-28 Umd Inc Therapeutic compositions for drug delivery to and through covering epithelia
US7658998B2 (en) 2003-01-22 2010-02-09 Alkermes Controlled Therapeutics, Inc. Method of preparing sustained release microparticles
US7279579B2 (en) 2003-06-04 2007-10-09 Alkermes, Inc. Polymorphic forms of naltrexone

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US4882335A (en) * 1988-06-13 1989-11-21 Alko Limited Method for treating alcohol-drinking response
CN1354664A (zh) * 1999-04-09 2002-06-19 南方研究所 可注射的纳曲酮微球组合物及其在减少海洛因和酒精消耗中的用途
CN1415294A (zh) * 2002-11-07 2003-05-07 上海医药工业研究院 一种纳曲酮长效注射微球组合物及制备方法和应用

Non-Patent Citations (1)

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Title
RAYMOND T BARTUS ET AL.: "Vivitrex, an Injectable, Extended-Release Formulation ofNaltrexone, Provides Pharmacokinetic and PharmacodynamicEvidence of Efficacy for 1 Month in Rats", 《NEUROPSYCHOPHARMACOLOGY》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113226288A (zh) * 2018-12-27 2021-08-06 昱展新药生技股份有限公司 纳曲酮注射型缓释制剂
TWI827777B (zh) * 2018-12-27 2024-01-01 昱展新藥生技股份有限公司 納曲酮注射型緩釋製劑

Also Published As

Publication number Publication date
EP2386269A2 (en) 2011-11-16
JP2011225600A (ja) 2011-11-10
US20050245558A1 (en) 2005-11-03
KR20070005722A (ko) 2007-01-10
NZ549976A (en) 2009-11-27
US20140155424A1 (en) 2014-06-05
WO2005107753A3 (en) 2005-12-29
AU2005239989B2 (en) 2008-05-29
JP5426094B2 (ja) 2014-02-26
EP1740120A4 (en) 2008-06-25
CA2563086A1 (en) 2005-11-17
RU2006137349A (ru) 2009-04-20
WO2005107753A2 (en) 2005-11-17
JP2007533738A (ja) 2007-11-22
KR20090050111A (ko) 2009-05-19
US20110212985A1 (en) 2011-09-01
EP2386269A3 (en) 2012-04-25
AU2005239989A1 (en) 2005-11-17
US7919499B2 (en) 2011-04-05
CA2563086C (en) 2018-04-17
US20210244818A1 (en) 2021-08-12
RU2370257C2 (ru) 2009-10-20
US20180064814A1 (en) 2018-03-08
EP1740120A2 (en) 2007-01-10

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Application publication date: 20130821