CN103217520A - 用于减少细胞脂肪和预测用酪氨酸激酶抑制剂治疗后的心脏毒性的组合物和方法 - Google Patents

用于减少细胞脂肪和预测用酪氨酸激酶抑制剂治疗后的心脏毒性的组合物和方法 Download PDF

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CN103217520A
CN103217520A CN2013101368247A CN201310136824A CN103217520A CN 103217520 A CN103217520 A CN 103217520A CN 2013101368247 A CN2013101368247 A CN 2013101368247A CN 201310136824 A CN201310136824 A CN 201310136824A CN 103217520 A CN103217520 A CN 103217520A
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cell
fatty acid
medicine
oxidation
tyrosine kinase
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S·S·巴克斯
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Targeted Molecular Diagnostics LLC
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
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    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5061Muscle cells
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    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/22Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
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    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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CN2013101368247A 2006-02-27 2007-02-27 用于减少细胞脂肪和预测用酪氨酸激酶抑制剂治疗后的心脏毒性的组合物和方法 Pending CN103217520A (zh)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US77709606P 2006-02-27 2006-02-27
US60/777,096 2006-02-27
US82123006P 2006-08-02 2006-08-02
US60/821,230 2006-08-02
US82737206P 2006-09-28 2006-09-28
US60/827,372 2006-09-28
US82834506P 2006-10-05 2006-10-05
US60/828,345 2006-10-05
US86773606P 2006-11-29 2006-11-29
US60/867,736 2006-11-29

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CN2007800136974A Division CN101438155B (zh) 2006-02-27 2007-02-27 一种预测使用酪氨酸激酶抑制剂的处理的心脏毒性的方法

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CN2007800136974A Expired - Fee Related CN101438155B (zh) 2006-02-27 2007-02-27 一种预测使用酪氨酸激酶抑制剂的处理的心脏毒性的方法

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US (2) US8709738B2 (https=)
EP (1) EP1996939B1 (https=)
JP (2) JP5539653B2 (https=)
KR (1) KR101390625B1 (https=)
CN (2) CN103217520A (https=)
AU (1) AU2007220094B2 (https=)
CA (1) CA2643846A1 (https=)
ES (1) ES2475162T3 (https=)
IL (1) IL193715A (https=)
NZ (2) NZ571465A (https=)
WO (1) WO2007101191A2 (https=)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
WO2010036910A1 (en) * 2008-09-26 2010-04-01 Yoshikazu Ohta Heart protection by administering an amp-activated protein kinase activator
WO2015027171A1 (en) * 2013-08-23 2015-02-26 Quintiles Transnational Corporation Methods for predicting toxicity in response to treatment with a drug by assessing activation of the sterol regulatory binding protein (srebp) pathway
EP3122872B1 (en) 2014-03-27 2019-07-03 The Salk Institute for Biological Studies Compositions and methods for treating type 1 and type 2 diabetes and related disorders
AU2016225076B2 (en) * 2015-02-27 2018-09-13 Salk Institute For Biological Studies Reprogramming progenitor compositions and methods of use therefore
US11760977B2 (en) 2016-05-25 2023-09-19 Salk Institute For Biological Studies Compositions and methods for organoid generation and disease modeling
JP7032723B2 (ja) * 2017-07-21 2022-03-09 公立大学法人福島県立医科大学 薬剤の心毒性評価方法及びそのための試薬又はキット
US11369608B2 (en) 2017-10-27 2022-06-28 University Of Virginia Patent Foundation Compounds and methods for regulating, limiting, or inhibiting AVIL expression
TWI711458B (zh) * 2019-07-08 2020-12-01 大江生醫股份有限公司 植物發酵物及其製備方法與用於胃臟保健的用途
KR102493664B1 (ko) 2020-01-29 2023-02-01 한국화학연구원 심장 독성 예측 모델링 시스템 및 모델링 방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1235542A (zh) * 1996-09-04 1999-11-17 斯科舍集团有限公司 脂肪酸治疗
CN1373666A (zh) * 1999-07-13 2002-10-09 索尔瓦药物有限公司 对氧化毒性物质,特别是对心脏毒性物质具有保护作用的药物
WO2003028271A2 (en) * 2001-09-24 2003-04-03 Lipomics Technologies, Inc. Methods of using quantitative lipid metabolome data
WO2004042360A3 (en) * 2002-11-04 2004-09-10 Univeristy Of California Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body
US20050089899A1 (en) * 2003-08-28 2005-04-28 Daniel Birnbaum Identification of an ERBB2 gene expression signature in breast cancers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020028826A1 (en) * 2000-06-15 2002-03-07 Robl Jeffrey A. HMG-CoA reductase inhibitors and method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1235542A (zh) * 1996-09-04 1999-11-17 斯科舍集团有限公司 脂肪酸治疗
CN1373666A (zh) * 1999-07-13 2002-10-09 索尔瓦药物有限公司 对氧化毒性物质,特别是对心脏毒性物质具有保护作用的药物
WO2003028271A2 (en) * 2001-09-24 2003-04-03 Lipomics Technologies, Inc. Methods of using quantitative lipid metabolome data
WO2004042360A3 (en) * 2002-11-04 2004-09-10 Univeristy Of California Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body
US20050089899A1 (en) * 2003-08-28 2005-04-28 Daniel Birnbaum Identification of an ERBB2 gene expression signature in breast cancers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DING AN: "The metabolic "switch" AMPK regulates cardiac heparin-releasable lipoprotein lipase", 《AMERICAN JOURNAL OF PHYSIOLOGY》 *
MALGORZATA TOKARSKA-SCHLATTNER ET AL.: "Acute toxicity of doxorubicin on isolated perfued heart- response of kinases regulating energy supply", 《AMERICAN JOURNAL OF PHYSILOLOGY》 *

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JP5539653B2 (ja) 2014-07-02
CN101438155A (zh) 2009-05-20
KR20090008194A (ko) 2009-01-21
CN101438155B (zh) 2013-04-24
KR101390625B1 (ko) 2014-04-29
NZ571465A (en) 2011-09-30
US20130288285A1 (en) 2013-10-31
EP1996939A2 (en) 2008-12-03
WO2007101191A2 (en) 2007-09-07
AU2007220094B2 (en) 2013-12-05
NZ594178A (en) 2013-02-22
EP1996939B1 (en) 2014-03-26
US20090186910A1 (en) 2009-07-23
US8709738B2 (en) 2014-04-29
IL193715A0 (en) 2009-05-04
JP2009533017A (ja) 2009-09-17
IL193715A (en) 2014-06-30
WO2007101191A3 (en) 2007-12-13
CA2643846A1 (en) 2007-09-07
AU2007220094A1 (en) 2007-09-07
EP1996939A4 (en) 2009-07-15
JP2013063090A (ja) 2013-04-11
ES2475162T3 (es) 2014-07-10

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Application publication date: 20130724