JP2009533017A - 細胞脂肪を減少させるため、心毒性を予測するため、チロシンキナーゼ阻害剤による処置による組成物および方法 - Google Patents
細胞脂肪を減少させるため、心毒性を予測するため、チロシンキナーゼ阻害剤による処置による組成物および方法 Download PDFInfo
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Abstract
Description
Fabianら、「A small molecule-kinase interaction map for clinical kinase inhibitors」、Nature Biotechnology 23、329頁
Claims (18)
- チロシンキナーゼ阻害剤での処置に反応した毒性を予測するための方法であって、
チロシンキナーゼ阻害剤で処置される標的細胞集団を同定する段階と、
脂肪酸酸化障害が前記細胞に存在するかどうかを判定する段階とを含み、
それによって、前記細胞の脂肪酸酸化障害の存在により、チロシンキナーゼ阻害剤での細胞の処置が毒性である可能性が高いことが予測される、方法。 - 脂肪酸酸化障害が、チロシンキナーゼ阻害剤の存在下での脂肪酸酸化障害の無い細胞のグルコース吸収と比較した、チロシンキナーゼ阻害剤の存在下でのグルコース吸収のポジトロン放出断層撮影により判定される請求項1に記載の心毒性を予測する方法。
- チロシンキナーゼ阻害剤がerbB阻害剤である請求項1に記載の方法。
- チロシンキナーゼ阻害剤がヘルセプチンである請求項1に記載の方法。
- 脂肪酸酸化障害が、チロシンキナーゼ阻害剤での処置による脂肪酸酸化障害の無い細胞中の脂質含量の減少と比較して、チロシンキナーゼ阻害剤での処置による細胞の脂質含量の減少を測定することによって判定される請求項1に記載の方法。
- 脂肪酸酸化障害が、脂肪酸酸化障害の無い細胞と比較して、細胞中の脂肪酸酸化代謝経路における少なくとも1種の酵素活性の減少量を測定することによって判定される請求項1に記載の方法。
- 脂肪酸酸化障害が、脂肪酸酸化障害の無い細胞と比較して、細胞中の脂肪酸酸化代謝経路における少なくとも1種の酵素をコードするmRNAの減少量を測定することによって判定される請求項1に記載の方法。
- 脂肪酸酸化障害が、チロシンキナーゼ阻害剤での正常細胞の処置による細胞中の脂肪酸酸化代謝経路における少なくとも1種の酵素量を測定することによって判定される請求項1に記載の方法。
- 脂肪酸酸化障害が、チロシンキナーゼ阻害剤での正常細胞の処置によるATP量の減少を測定することによって判定される請求項1に記載の方法。
- 生体高分子がリン酸化AMP活性化キナーゼである請求項1に記載の方法。
- 生体高分子がサイトカインである請求項1に記載の方法。
- 生体高分子がTNFαである請求項1に記載の方法。
- 生体高分子がpNFκBである請求項1に記載の方法。
- 患者の生体高分子を分析する方法が、患者の組織から抽出物を得る段階と、前記抽出物をマイクロアレイアナライザーで分析する段階とを含む請求項1に記載の方法。
- 虚血のエピソードに罹った患者を処置するための方法であって、ある量のAMPKアクチベーターをほぼ虚血中または再灌流中の患者に投与する段階を含む方法。
- 心細胞または脳細胞を保護するために患者を処置するための方法であって、
心細胞または脳細胞に対する代謝ストレスを誘導すると思われる病態を診断する段階と、このような細胞を急性の障害から保護するのに十分な量のAMPKアクチベーターを投与する段階とを含む方法。 - 代謝ストレスを誘導すると思われる病態が、虚血、サイトカイン放出およびグルコース欠乏から選択される病態群から選択される請求項16に記載の方法。
- 移植用器官を保存する方法であって、
AMPKアクチベーターを含む保存溶液を調製する段階と、器官を前記保存液と接触させる段階とを含む方法。
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US77709606P | 2006-02-27 | 2006-02-27 | |
US60/777,096 | 2006-02-27 | ||
US82123006P | 2006-08-02 | 2006-08-02 | |
US60/821,230 | 2006-08-02 | ||
US82737206P | 2006-09-28 | 2006-09-28 | |
US60/827,372 | 2006-09-28 | ||
US82834506P | 2006-10-05 | 2006-10-05 | |
US60/828,345 | 2006-10-05 | ||
US86773606P | 2006-11-29 | 2006-11-29 | |
US60/867,736 | 2006-11-29 | ||
PCT/US2007/062871 WO2007101191A2 (en) | 2006-02-27 | 2007-02-27 | Compositions and methods for reducing cellular fat and for predicting cardiac toxicity and upon treatment with tyrosine kinase inhibitors |
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JP2012282502A Division JP2013063090A (ja) | 2006-02-27 | 2012-12-26 | 細胞脂肪を減少させるため、心毒性を予測するため、チロシンキナーゼ阻害剤による処置による組成物および方法 |
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JP2012282502A Pending JP2013063090A (ja) | 2006-02-27 | 2012-12-26 | 細胞脂肪を減少させるため、心毒性を予測するため、チロシンキナーゼ阻害剤による処置による組成物および方法 |
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JP2019017356A (ja) * | 2017-07-21 | 2019-02-07 | 公立大学法人福島県立医科大学 | 薬剤の心毒性評価方法及びそのための試薬又はキット |
JP2019107026A (ja) * | 2015-02-27 | 2019-07-04 | ソーク インスティチュート フォー バイオロジカル スタディーズ | リプログラミング前駆体組成物およびその使用方法 |
US11685901B2 (en) | 2016-05-25 | 2023-06-27 | Salk Institute For Biological Studies | Compositions and methods for organoid generation and disease modeling |
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WO2010036910A1 (en) * | 2008-09-26 | 2010-04-01 | Yoshikazu Ohta | Heart protection by administering an amp-activated protein kinase activator |
WO2015027171A1 (en) * | 2013-08-23 | 2015-02-26 | Quintiles Transnational Corporation | Methods for predicting toxicity in response to treatment with a drug by assessing activation of the sterol regulatory binding protein (srebp) pathway |
EP3710001A4 (en) | 2017-10-27 | 2021-07-14 | University Of Virginia Patent Foundation | COMPOUNDS AND PROCEDURES FOR REGULATING, LIMITING OR INHIBITING AVIL EXPRESSION |
TWI711458B (zh) * | 2019-07-08 | 2020-12-01 | 大江生醫股份有限公司 | 植物發酵物及其製備方法與用於胃臟保健的用途 |
KR102493664B1 (ko) | 2020-01-29 | 2023-02-01 | 한국화학연구원 | 심장 독성 예측 모델링 시스템 및 모델링 방법 |
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2019107026A (ja) * | 2015-02-27 | 2019-07-04 | ソーク インスティチュート フォー バイオロジカル スタディーズ | リプログラミング前駆体組成物およびその使用方法 |
US10920199B2 (en) | 2015-02-27 | 2021-02-16 | Salk Institute For Biological Studies | Reprogramming progenitor compositions and methods of use therefore |
JP7449648B2 (ja) | 2015-02-27 | 2024-03-14 | ソーク インスティチュート フォー バイオロジカル スタディーズ | リプログラミング前駆体組成物およびその使用方法 |
US11981931B2 (en) | 2015-02-27 | 2024-05-14 | Salk Institute For Biological Studies | Reprogramming progenitor compositions and methods of use thereof |
US11685901B2 (en) | 2016-05-25 | 2023-06-27 | Salk Institute For Biological Studies | Compositions and methods for organoid generation and disease modeling |
US11760977B2 (en) | 2016-05-25 | 2023-09-19 | Salk Institute For Biological Studies | Compositions and methods for organoid generation and disease modeling |
JP2019017356A (ja) * | 2017-07-21 | 2019-02-07 | 公立大学法人福島県立医科大学 | 薬剤の心毒性評価方法及びそのための試薬又はキット |
JP7032723B2 (ja) | 2017-07-21 | 2022-03-09 | 公立大学法人福島県立医科大学 | 薬剤の心毒性評価方法及びそのための試薬又はキット |
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CA2643846A1 (en) | 2007-09-07 |
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US20130288285A1 (en) | 2013-10-31 |
EP1996939A4 (en) | 2009-07-15 |
JP2013063090A (ja) | 2013-04-11 |
KR20090008194A (ko) | 2009-01-21 |
IL193715A (en) | 2014-06-30 |
JP5539653B2 (ja) | 2014-07-02 |
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EP1996939B1 (en) | 2014-03-26 |
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US8709738B2 (en) | 2014-04-29 |
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AU2007220094B2 (en) | 2013-12-05 |
WO2007101191A3 (en) | 2007-12-13 |
US20090186910A1 (en) | 2009-07-23 |
CN101438155B (zh) | 2013-04-24 |
KR101390625B1 (ko) | 2014-04-29 |
ES2475162T3 (es) | 2014-07-10 |
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