CA2643846A1 - Methods for predicting cellular toxicity upon treatment with tyrosine kinase inhibitors - Google Patents
Methods for predicting cellular toxicity upon treatment with tyrosine kinase inhibitors Download PDFInfo
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- CA2643846A1 CA2643846A1 CA002643846A CA2643846A CA2643846A1 CA 2643846 A1 CA2643846 A1 CA 2643846A1 CA 002643846 A CA002643846 A CA 002643846A CA 2643846 A CA2643846 A CA 2643846A CA 2643846 A1 CA2643846 A1 CA 2643846A1
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- cells
- fatty acid
- acid oxidation
- tyrosine kinase
- kinase inhibitor
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Classifications
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5061—Muscle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4703—Regulators; Modulating activity
- G01N2333/4706—Regulators; Modulating activity stimulating, promoting or activating activity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Tropical Medicine & Parasitology (AREA)
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Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
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| US77709606P | 2006-02-27 | 2006-02-27 | |
| US60/777,096 | 2006-02-27 | ||
| US82123006P | 2006-08-02 | 2006-08-02 | |
| US60/821,230 | 2006-08-02 | ||
| US82737206P | 2006-09-28 | 2006-09-28 | |
| US60/827,372 | 2006-09-28 | ||
| US82834506P | 2006-10-05 | 2006-10-05 | |
| US60/828,345 | 2006-10-05 | ||
| US86773606P | 2006-11-29 | 2006-11-29 | |
| US60/867,736 | 2006-11-29 | ||
| PCT/US2007/062871 WO2007101191A2 (en) | 2006-02-27 | 2007-02-27 | Compositions and methods for reducing cellular fat and for predicting cardiac toxicity and upon treatment with tyrosine kinase inhibitors |
Publications (1)
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| CA2643846A1 true CA2643846A1 (en) | 2007-09-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA002643846A Abandoned CA2643846A1 (en) | 2006-02-27 | 2007-02-27 | Methods for predicting cellular toxicity upon treatment with tyrosine kinase inhibitors |
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| Country | Link |
|---|---|
| US (2) | US8709738B2 (https=) |
| EP (1) | EP1996939B1 (https=) |
| JP (2) | JP5539653B2 (https=) |
| KR (1) | KR101390625B1 (https=) |
| CN (2) | CN101438155B (https=) |
| AU (1) | AU2007220094B2 (https=) |
| CA (1) | CA2643846A1 (https=) |
| ES (1) | ES2475162T3 (https=) |
| IL (1) | IL193715A (https=) |
| NZ (2) | NZ594178A (https=) |
| WO (1) | WO2007101191A2 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2010036910A1 (en) * | 2008-09-26 | 2010-04-01 | Yoshikazu Ohta | Heart protection by administering an amp-activated protein kinase activator |
| WO2015027171A1 (en) * | 2013-08-23 | 2015-02-26 | Quintiles Transnational Corporation | Methods for predicting toxicity in response to treatment with a drug by assessing activation of the sterol regulatory binding protein (srebp) pathway |
| EP3739041A1 (en) | 2014-03-27 | 2020-11-18 | The Salk Institute for Biological Studies | Compositions and methods for treating type 1 and type 2 diabetes and related disorders |
| AU2016225076B2 (en) | 2015-02-27 | 2018-09-13 | Salk Institute For Biological Studies | Reprogramming progenitor compositions and methods of use therefore |
| AU2017269364B2 (en) | 2016-05-25 | 2023-08-31 | Salk Institute For Biological Studies | Compositions and methods for organoid generation and disease modeling |
| JP7032723B2 (ja) * | 2017-07-21 | 2022-03-09 | 公立大学法人福島県立医科大学 | 薬剤の心毒性評価方法及びそのための試薬又はキット |
| WO2019084395A1 (en) * | 2017-10-27 | 2019-05-02 | University Of Virginia Patent Foundation | COMPOUNDS AND METHODS FOR REGULATING, LIMITING OR INHIBITING AVIL EXPRESSION |
| TWI711458B (zh) * | 2019-07-08 | 2020-12-01 | 大江生醫股份有限公司 | 植物發酵物及其製備方法與用於胃臟保健的用途 |
| KR102493664B1 (ko) | 2020-01-29 | 2023-02-01 | 한국화학연구원 | 심장 독성 예측 모델링 시스템 및 모델링 방법 |
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| GB9618420D0 (en) * | 1996-09-04 | 1996-10-16 | Scotia Holdings Plc | Fatty acid treatment |
| DE19932555A1 (de) * | 1999-07-13 | 2001-01-18 | Solvay Pharm Gmbh | Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen |
| US20020028826A1 (en) * | 2000-06-15 | 2002-03-07 | Robl Jeffrey A. | HMG-CoA reductase inhibitors and method |
| CA2459508A1 (en) * | 2001-09-24 | 2003-04-03 | Lipomics Technologies, Inc. | Methods of using quantitative lipid metabolome data |
| JP4611025B2 (ja) * | 2002-11-04 | 2011-01-12 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 体内のブドウ糖または脂肪酸の代謝に関する高処理量測定のための重水素化ブドウ糖または脂肪の耐性試験 |
| EP1980629A3 (en) | 2003-08-28 | 2008-12-17 | Ipsogen | Identification of an erbb2 gene expression signature in breast cancers |
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- 2007-02-27 JP JP2008556587A patent/JP5539653B2/ja not_active Expired - Fee Related
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- 2007-02-27 AU AU2007220094A patent/AU2007220094B2/en not_active Ceased
- 2007-02-27 US US12/280,893 patent/US8709738B2/en not_active Expired - Fee Related
- 2007-02-27 CA CA002643846A patent/CA2643846A1/en not_active Abandoned
- 2007-02-27 CN CN2013101368247A patent/CN103217520A/zh active Pending
- 2007-02-27 WO PCT/US2007/062871 patent/WO2007101191A2/en not_active Ceased
- 2007-02-27 NZ NZ571465A patent/NZ571465A/en not_active IP Right Cessation
- 2007-02-27 EP EP07757542.1A patent/EP1996939B1/en not_active Not-in-force
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- 2007-02-27 KR KR1020087023650A patent/KR101390625B1/ko not_active Expired - Fee Related
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2008
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2012
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2013
- 2013-04-05 US US13/857,591 patent/US20130288285A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20090008194A (ko) | 2009-01-21 |
| CN103217520A (zh) | 2013-07-24 |
| EP1996939A2 (en) | 2008-12-03 |
| NZ594178A (en) | 2013-02-22 |
| AU2007220094B2 (en) | 2013-12-05 |
| EP1996939A4 (en) | 2009-07-15 |
| JP5539653B2 (ja) | 2014-07-02 |
| IL193715A (en) | 2014-06-30 |
| KR101390625B1 (ko) | 2014-04-29 |
| WO2007101191A2 (en) | 2007-09-07 |
| NZ571465A (en) | 2011-09-30 |
| CN101438155A (zh) | 2009-05-20 |
| EP1996939B1 (en) | 2014-03-26 |
| WO2007101191A3 (en) | 2007-12-13 |
| JP2009533017A (ja) | 2009-09-17 |
| ES2475162T3 (es) | 2014-07-10 |
| US20090186910A1 (en) | 2009-07-23 |
| JP2013063090A (ja) | 2013-04-11 |
| CN101438155B (zh) | 2013-04-24 |
| US20130288285A1 (en) | 2013-10-31 |
| US8709738B2 (en) | 2014-04-29 |
| AU2007220094A1 (en) | 2007-09-07 |
| IL193715A0 (en) | 2009-05-04 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20170228 |