CN103181971A - Heartleaf houttuynia herb oil enteric-coated capsules - Google Patents
Heartleaf houttuynia herb oil enteric-coated capsules Download PDFInfo
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- CN103181971A CN103181971A CN2011104548098A CN201110454809A CN103181971A CN 103181971 A CN103181971 A CN 103181971A CN 2011104548098 A CN2011104548098 A CN 2011104548098A CN 201110454809 A CN201110454809 A CN 201110454809A CN 103181971 A CN103181971 A CN 103181971A
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- herba houttuyniae
- heartleaf houttuynia
- oil
- houttuynia herb
- liposome
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Abstract
The invention discloses heartleaf houttuynia herb oil enteric-coated capsules comprising microencapsulated liposome and ultrafine heartleaf houttuynia herb oil. The capsules provided by the invention have the advantages that: the heartleaf houttuynia herb oil is obtained by ultrafine crushing and high-speed centrifugal separation, such that original physiochemical properties are maintained, bioavailability is high, and active components in heartleaf houttuynia herb are preserved to a great extent; the heartleaf houttuynia herb oil is adopted as a core material, and is coated by using liposome, such that heartleaf houttuynia herb oil oxidation and deterioration are prevented; also, liposome has high targeting performance, such that treatment and health-care effects of the product provided by the invention can be ensured; microencapsulated ester-type catechin-tea flavonoid crystals are added, such that the product can be used in breast cancer prevention and treatment, and antibacterial and antiviral capacities can be improved; silver ion are added as an absorbent and disinfectant, such that catechin is prevented from being corroded.
Description
Technical field
The present invention relates to a kind of enteric coated capsule that contains Chinese medicine extract, relate in particular to a kind of enteric coated capsule that contains Herba Houttuyniae extract.
Background technology
At present exist the multiple product that contains Herba Houttuyniae extract on the market, can be divided into following classification usually: a kind of is tablet, capsule or injection, and this series products mainly plays antibiotic effect; Another kind is that Herba Houttuyniae extract is made functional health product as raw material.Herba Houttuyniae extract in these products normally extracts with conventional method at present, and Herba Houttuyniae extract purity is not high, and biological activity is low, and bioavailability is low; In addition, in leaching process, also will add multiple other materials, the interpolation of this material very easily causes the pollution of Herba Houttuyniae extract.The present product that contains Herba Houttuyniae extract is not outstanding to treatment of diseases effects such as breast tumor.
Summary of the invention
At the problem of above-mentioned existence, the purpose of this invention is to provide and a kind ofly be beneficial to raising to the bioavailability of Herba Houttuyniae oil through micronizing, Herba Houttuyniae oil enteric coated capsule that biological activity is high, be beneficial to the therapeutic effect that improves enteric coated capsule of the present invention.
The objective of the invention is to be achieved through the following technical solutions:
A kind of Herba Houttuyniae oil enteric coated capsule, comprise the microencapsulation liposome, described microencapsulation liposome is made up of primary wall material and wall material, described primary wall material is made of soybean salad oil, Oleum Brassicae campestris or Camellia oil, described wall material is made of albumen NP and carbohydrate CA, CB, wherein, also comprises the ultra micro Herba Houttuyniae oil, described ultra micro Herba Houttuyniae oil is core, by the described microencapsulation liposome as the wall material.
Above-mentioned a kind of Herba Houttuyniae oil enteric coated capsule wherein, also comprises microencapsulation ester catechin-tea flavone crystal, and the percetage by weight of described microencapsulation ester catechin-tea flavone crystal is 30%-60%.
Above-mentioned a kind of Herba Houttuyniae oil enteric coated capsule wherein, also comprises silver ion, and the percetage by weight of described silver ion is 0.1%-0.5%.
Compared with the prior art, beneficial effect of the present invention is: Herba Houttuyniae oil makes through micronizing and high speed centrifugation, has guaranteed original rational performance, bioavailability height, preserves the active ingredient in the Herba Houttuyniae dramatically; With the Herba Houttuyniae oil be core through liposome, be beneficial on the one hand and avoid Herba Houttuyniae oil oxidized rotten, because the liposome targeting is very strong, be beneficial to the treatment and the health-care effect that guarantee product of the present invention on the other hand; Add microencapsulation ester catechin-tea flavone crystal, be beneficial to product of the present invention to prevention and the treatment of breast carcinoma, improve the anti-bacteria and anti-virus ability simultaneously; Add silver ion as adsorbent and disinfectant, be beneficial to and avoid catechin to be etched, be beneficial to the anti-bacteria and anti-virus function of performance catechin simultaneously.
The specific embodiment
The invention will be further described below in conjunction with concrete operations embodiment.
A kind of Herba Houttuyniae oil enteric coated capsule of the present invention, comprise as the microencapsulation liposome of wall material with as the ultra micro Herba Houttuyniae oil of core, wherein, microencapsulation liposome as the wall material is made up of primary wall material and wall material, described primary wall material is made of soybean salad oil, Oleum Brassicae campestris or Camellia oil, and described wall material is made of albumen NP and carbohydrate CA, CB.The ultra micro Herba Houttuyniae oil can be made by following approach: at first, be raw material with the Herba Houttuyniae, adopt LF type micronizing unit to carry out micronizing, when the Herba Houttuyniae granule is sent in the pulverizing chamber through the charging aperture spiral, be subjected to high speed impact and the shearing of grating disk, the while also is subjected to the dither of eddy current generation and is pulverized.Powder body after the pulverizing is crossed the shunting tapered sleeve and is entered grading room under suction function.Because the high speed rotating of grading wheel, powder body is subjected to air force and action of centrifugal force simultaneously.When centrifugal force＞air force, illustrate that powder body is greater than predefined Cut size particle size, powder body is namely got rid of to be returned pulverizing chamber to tapered sleeve and continues to pulverize, and the qualified powder body of the pulverizing that meets the standard of setting in advance, this moment, air force＞centrifugal force was subjected to dynamic action, be discharged to subsidiary engine after entering the pipeline that gathers materials, become the Herba Houttuyniae ultrafine powder after the collection.Secondly, above-mentioned gained Herba Houttuyniae ultrafine powder after individual hour, is obtained immersion with the alcohol-pickled 1.5-3 of 70%-90%; Unsaturated common salt aqueous solution is poured in the gained immersion soak and soaked and desalting processing through salt in 1.5-3 hour, the elimination sediment obtains filtrate; Transfer pH value to be adjusted to acidity gained filtrate simultaneously, be approximately 1-6.5, under 55-85 ℃, carried out then catalytic reaction 1.5-3 hour; The ethyl acetate extraction of the back gained solution usefulness of reaction 1:1 repeatedly can preferably extract three times.The vacuum drying extract obtains Herba Houttuyniae crystalline solid raw material.Next, owing in extracting tank body, vertical shaft is installed, and the high speed centrifugation fan is installed on vertical shaft as required, under the transmission of vertical shaft, drive the high speed centrifugation fan like this and finish centrifugal operation; With the rotating speed of 3000-50000 prepared Herba Houttuyniae crystalline solid raw material being carried out sedimentation by described high speed centrifugation fan handles and obtains Herba Houttuyniae oil liquid, and then get the Herba Houttuyniae oil concentrated solution through large aperture resin chromatographic column, through making the ultra micro Herba Houttuyniae oil after the cooling rapidly; Be the wall material then with the liposome, be that core carries out emulsifying and shears and to make Herba Houttuyniae oil enteric coated capsule of the present invention with the ultra micro Herba Houttuyniae oil.
As improvement, for further increasing the effect of Herba Houttuyniae oil enteric coated capsule anti-bacteria and anti-virus of the present invention, also for avoiding the pollution of Herba Houttuyniae oil capsule of the present invention itself, can also add microencapsulation ester catechin-tea flavone crystal simultaneously.Studies confirm that: catechin-tea flavone crystal has very strong sterilizing ability, and the microencapsulation catechin of adding-tea flavone crystal is killing microorganisms and the ability that improves anti-bacteria and anti-virus effectively, can also play the effect of prevention and treatment breast carcinoma simultaneously.
Also can add a certain amount of silver ion on the basis of the above as adsorbent and disinfectant, can play synergism to the anti-bacteria and anti-virus of Herba Houttuyniae oil and catechin, better effects if like this.
More than specific embodiments of the invention are described in detail, but the present invention is not restricted to specific embodiment described above, it is just as example.To those skilled in the art, any to this equivalent modifications of carrying out and alternative also all among category of the present invention.Therefore, not breaking away from impartial conversion and the modification of having done under the spirit and scope of the present invention, all should contain within the scope of the invention.
Claims (3)
1. Herba Houttuyniae oil enteric coated capsule, comprise the microencapsulation liposome, described microencapsulation liposome is made up of primary wall material and wall material, described primary wall material is made of soybean salad oil, Oleum Brassicae campestris or Camellia oil, described wall material is made of albumen NP and carbohydrate CA, CB, it is characterized in that, also comprises the ultra micro Herba Houttuyniae oil, described ultra micro Herba Houttuyniae oil is core, by the described microencapsulation liposome as the wall material.
2. a kind of Herba Houttuyniae oil enteric coated capsule according to claim 1 is characterized in that, also comprises microencapsulation ester catechin-tea flavone crystal, and the percetage by weight of described microencapsulation ester catechin-tea flavone crystal is 30%-60%.
3. a kind of Herba Houttuyniae oil enteric coated capsule according to claim 1 and 2 is characterized in that, also comprises silver ion, and the percetage by weight of described silver ion is 0.1%-0.5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104548098A CN103181971A (en) | 2011-12-30 | 2011-12-30 | Heartleaf houttuynia herb oil enteric-coated capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104548098A CN103181971A (en) | 2011-12-30 | 2011-12-30 | Heartleaf houttuynia herb oil enteric-coated capsules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103181971A true CN103181971A (en) | 2013-07-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN2011104548098A Pending CN103181971A (en) | 2011-12-30 | 2011-12-30 | Heartleaf houttuynia herb oil enteric-coated capsules |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103181973A (en) * | 2011-12-31 | 2013-07-03 | 新昌县冠阳技术开发有限公司 | Preparation method of cordate houttuynia oil |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583047A (en) * | 2004-06-11 | 2005-02-23 | 成都厚发科技开发有限公司 | Anti-virus houttuynia cordate medicine and its preparation |
| CN1772272A (en) * | 2004-11-08 | 2006-05-17 | 北京铁草科技有限公司 | Food antibiotic and its prepn |
| CN101305798A (en) * | 2007-05-15 | 2008-11-19 | 唐晨光 | Cailv capsules |
-
2011
- 2011-12-30 CN CN2011104548098A patent/CN103181971A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583047A (en) * | 2004-06-11 | 2005-02-23 | 成都厚发科技开发有限公司 | Anti-virus houttuynia cordate medicine and its preparation |
| CN1772272A (en) * | 2004-11-08 | 2006-05-17 | 北京铁草科技有限公司 | Food antibiotic and its prepn |
| CN101305798A (en) * | 2007-05-15 | 2008-11-19 | 唐晨光 | Cailv capsules |
Non-Patent Citations (3)
| Title |
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| 吴广通等: "改善中药挥发油稳定性的制剂学研究进展", 《药学服务与研究》 * |
| 张美玉等: "鱼腥草及其制剂研究进展", 《中药药理与临床》 * |
| 齐连祥等: "喷雾干燥制备酯型儿茶素微胶囊", 《辽宁化工》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103181973A (en) * | 2011-12-31 | 2013-07-03 | 新昌县冠阳技术开发有限公司 | Preparation method of cordate houttuynia oil |
| CN103181973B (en) * | 2011-12-31 | 2016-03-02 | 新昌县冠阳技术开发有限公司 | A kind of manufacture method of Herba Houttuyniae oil |
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Application publication date: 20130703 |