CN103181973A - Preparation method of cordate houttuynia oil - Google Patents
Preparation method of cordate houttuynia oil Download PDFInfo
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- CN103181973A CN103181973A CN2011104582737A CN201110458273A CN103181973A CN 103181973 A CN103181973 A CN 103181973A CN 2011104582737 A CN2011104582737 A CN 2011104582737A CN 201110458273 A CN201110458273 A CN 201110458273A CN 103181973 A CN103181973 A CN 103181973A
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Abstract
The invention discloses a preparation method of cordate houttuynia oil. The preparation method is characterized by comprising the following steps of 1. superfine grinding a cordate houttuynia raw material to prepare a cordate houttuynia primary raw material; 2. preparing a cordate houttuynia crystal raw material; and 3. separating by centrifugation at a high speed to obtain a high-ester cordate houttuynia oil crystal. The above method for preparing the cordate houttuynia oil has the beneficial effects that the cordate houttuynia raw material is processed by a superfine grinding process, so that the cordate houttuynia raw material is grinded finely, with uniform distributed particle size; the grinding process generates no heat; original physical and chemical properties of the cordate houttuynia raw material are retained; bioavailability is high; and the grinding process has a fresh-keeping function for the cordate houttuynia raw material. Besides, ultrasonic wave produced by the grinding process has a certain sterilization function. The cordate houttuynia oil is prepared by high-speed centrifugal separation, so that loss of effective ingredients of the cordate houttuynia raw material can be prevented; active ingredients in the cordate houttuynia can be retained maximally; a process flow is shortened; energy can be saved; cost is reduced; and the cordate houttuynia oil with high purity can be obtained.
Description
Technical field
The present invention relates to a kind of manufacture method of Chinese medicine extract, relate in particular to a kind of manufacture method of Herba Houttuyniae oil.
Background technology
The extracting mode of Herba Houttuyniae oil has a lot, but the Herba Houttuyniae oil purity that present conventional extracting method is obtained is not high, and biological activity is low, and bioavailability is low.In addition, in leaching process, also will add multiple other materials, the interpolation of this material very easily causes the pollution of Herba Houttuyniae oil.
Summary of the invention
At the problem of above-mentioned existence, the purpose of this invention is to provide a kind of manufacture method of Herba Houttuyniae oil, be beneficial to the purity that improves Herba Houttuyniae oil, be beneficial to the bioavailability that improves Herba Houttuyniae oil.
The objective of the invention is to be achieved through the following technical solutions:
A kind of manufacture method of Herba Houttuyniae oil is characterized in that, comprises the steps,
Step 1, micronizing Herba Houttuyniae raw material makes the Herba Houttuyniae primary raw materials: be raw material with the Herba Houttuyniae, through the micronizing unit, be subjected to the dither that the high speed impact of grating disk and shearing and eddy current produce and pulverized in pulverizing chamber, form powder body; Described powder body enters grading room and be subjected to air force and action of centrifugal force simultaneously under suction function, discharge after entering the pipeline that gathers materials thereafter, thereby obtain the Herba Houttuyniae ultrafine powder;
Step 2 is made the Herba Houttuyniae crystal raw material: the Herba Houttuyniae ultrafine powder that makes in the described step 1 is used the alcohol-pickled 1.5-3 of 70%-90% hour, thereby filter obtains immersion; Unsaturated common salt aqueous solution is poured in the gained immersion soak and soaked and desalting processing through salt in 1.5-3 hour, the elimination sediment obtains filtrate; Be 5.0-6.5 with gained filtrate pH value, under 55-85 ℃ of condition, carry out catalytic reaction 1.5-3 hour catalytic reaction solution; Catalytic reaction solution is removed caffeine with ethyl acetate extraction obtain extract; Gained extract drying under vacuum condition is made Herba Houttuyniae crystalline solid raw material;
Step 3, the high speed centrifugation separation makes high ester type Herba Houttuyniae oil: the high speed centrifugation fan is installed in extracting tank body, described high speed centrifugation fan carries out sedimentation with the rotating speed of 3000-50000 to the Herba Houttuyniae crystalline solid raw material that makes in the described step 2 to be handled and obtains Herba Houttuyniae oil liquid, and then via hole diameter is that the micron-sized resin chromatographic column of the 20-120 branch caffeine of leaving away extracts and to make the Herba Houttuyniae oil concentrated solution, makes Herba Houttuyniae oil behind vacuum drying;
The manufacture method of the high ester catechin of above-mentioned a kind of microencapsulation-tea flavone crystal, wherein, the number of times with the ethyl acetate extraction of described 1:1 in the described step 2 is 3 times.
The manufacture method of above-mentioned a kind of Herba Houttuyniae oil is characterized in that, catalytic reaction solution described in the described step 2 and described ethyl acetate volume ratio are 1:1-1:2.
Compared with the prior art, beneficial effect of the present invention is: by micronizing processes Herba Houttuyniae raw material, make that pulverizing is meticulous, even particle size distribution, crushing process does not produce heat, the original physicochemical property of Herba Houttuyniae raw material, bioavailability height, the Herba Houttuyniae raw material is had fresh-keeping function, and the ultrasound wave of crushing process generation simultaneously has certain sterilizing function; Separate to make Herba Houttuyniae oil by high speed centrifugation, prevent loss of active ingredients in the Herba Houttuyniae raw material, preserve the active component in the Herba Houttuyniae to greatest extent, but shortened process also is energy-conservation and reduce cost, and obtains highly purified Herba Houttuyniae oil.
Description of drawings
Fig. 1 is the manufacturing approach craft schematic flow sheet of a kind of Herba Houttuyniae oil of the present invention.
The specific embodiment
The invention will be further described below in conjunction with schematic diagram and concrete operations embodiment.
As shown in Figure 1, the manufacture method of a kind of Herba Houttuyniae oil of the present invention, at first, be raw material with the Herba Houttuyniae, adopt LF type micronizing unit to carry out micronizing, send in the pulverizing chamber through the charging aperture spiral when the Herba Houttuyniae granule, be subjected to high speed impact and the shearing of grating disk, the while also is subjected to the dither of eddy current generation and is pulverized.Powder body after the pulverizing is crossed the shunting tapered sleeve and is entered grading room under suction function.Because the high speed rotating of grading wheel, powder body is subjected to air force and action of centrifugal force simultaneously.When centrifugal force＞air force, illustrate that powder body is greater than predefined Cut size particle size, powder body is namely got rid of to be returned pulverizing chamber to tapered sleeve and continues to pulverize, and the qualified powder body of the pulverizing that meets the standard of setting in advance, this moment, air force＞centrifugal force was subjected to dynamic action, be discharged to subsidiary engine after entering the pipeline that gathers materials, become the Herba Houttuyniae ultrafine powder after the collection.Secondly, above-mentioned gained Herba Houttuyniae ultrafine powder after individual hour, is obtained immersion with the alcohol-pickled 1.5-3 of 70%-90%; Unsaturated common salt aqueous solution is poured in the gained immersion soak and soaked and desalting processing through salt in 1.5-3 hour, the elimination sediment obtains filtrate; Transfer pH value to be adjusted to acidity gained filtrate simultaneously, be approximately 5.0-6.5, under 55-85 ℃, carried out then catalytic reaction 1.5-3 hour; The ethyl acetate extraction of the back gained solution usefulness of reaction 1:1 repeatedly can preferably extract three times.The vacuum drying extract obtains Herba Houttuyniae crystalline solid raw material.Next, owing in extracting tank body, vertical shaft is installed, and the high speed centrifugation fan is installed on vertical shaft as required, under the transmission of vertical shaft, drive the high speed centrifugation fan like this and finish centrifugal operation; With the rotating speed of 3000-50000 prepared Herba Houttuyniae crystalline solid raw material is carried out sedimentation by described high speed centrifugation fan and handle and obtain Herba Houttuyniae oil liquid, and then get the Herba Houttuyniae oil concentrated solution through large aperture resin chromatographic column, after lowering the temperature rapidly, make Herba Houttuyniae oil.
According to the Herba Houttuyniae oil that said method makes, life is active high, purity height, bioavailability height; The Herba Houttuyniae oil that makes with said method is raw material when making other products, more is conducive to the absorption of human body.
More than specific embodiments of the invention are described in detail, but the present invention is not restricted to specific embodiment described above, it is just as example.To those skilled in the art, any to this equivalent modifications of carrying out and alternative also all among category of the present invention.Therefore, not breaking away from impartial conversion and the modification of having done under the spirit and scope of the present invention, all should contain within the scope of the invention.
Claims (3)
1. the manufacture method of a Herba Houttuyniae oil is characterized in that, comprise the steps,
Step 1, micronizing Herba Houttuyniae raw material makes the Herba Houttuyniae primary raw materials: be raw material with the Herba Houttuyniae, through the micronizing unit, be subjected to the dither that the high speed impact of grating disk and shearing and eddy current produce and pulverized in pulverizing chamber, form powder body; Described powder body enters grading room and be subjected to air force and action of centrifugal force simultaneously under suction function, discharge after entering the pipeline that gathers materials thereafter, thereby obtain the Herba Houttuyniae ultrafine powder;
Step 2 is made the Herba Houttuyniae crystal raw material: the Herba Houttuyniae ultrafine powder that makes in the described step 1 is used the alcohol-pickled 1.5-3 of 70%-90% hour, thereby filter obtains immersion; Unsaturated common salt aqueous solution is poured in the gained immersion soak and soaked and desalting processing through salt in 1.5-3 hour, the elimination sediment obtains filtrate; Be 5.0-6.5 with gained filtrate pH value, under 55-85 ℃ of condition, carried out catalytic reaction 1.5-3 hour catalytic reaction solution; Catalytic reaction solution is obtained extract with ethyl acetate extraction; Gained extract drying under vacuum condition is made Herba Houttuyniae crystalline solid raw material;
Step 3, the high speed centrifugation separation makes high ester type Herba Houttuyniae oil: the high speed centrifugation fan is installed in extracting tank body, described high speed centrifugation fan carries out sedimentation with the rotating speed of 3000-50000 to the Herba Houttuyniae crystalline solid raw material that makes in the described step 2 to be handled and obtains Herba Houttuyniae oil liquid, and then via hole diameter is that the micron-sized resin chromatographic column of the 20-120 branch caffeine of leaving away extracts and to make the Herba Houttuyniae oil concentrated solution, makes Herba Houttuyniae oil behind vacuum drying.
2. the manufacture method of a kind of Herba Houttuyniae oil according to claim 1 is characterized in that, the number of times with described ethyl acetate extraction in the described step 2 is 3 times.
3. the manufacture method of a kind of Herba Houttuyniae oil according to claim 1 and 2 is characterized in that, catalytic reaction solution described in the described step 2 and described ethyl acetate volume ratio are 1:1-1:2.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110458273.7A CN103181973B (en) | 2011-12-31 | 2011-12-31 | A kind of manufacture method of Herba Houttuyniae oil |
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| CN201110458273.7A CN103181973B (en) | 2011-12-31 | 2011-12-31 | A kind of manufacture method of Herba Houttuyniae oil |
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| CN103181973A true CN103181973A (en) | 2013-07-03 |
| CN103181973B CN103181973B (en) | 2016-03-02 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878525A (en) * | 2014-12-15 | 2016-08-24 | 沈阳伟嘉牧业技术有限公司 | Method for preparing houttuynia cordata lyophilized superfine powder granules |
| CN106135545A (en) * | 2015-04-01 | 2016-11-23 | 周敬耀 | Tribute tea and preparation method thereof |
| CN108192735A (en) * | 2018-01-17 | 2018-06-22 | 刘勇 | Plant extraction oil, the leach extraction method of plant extraction oil and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085096A (en) * | 2007-06-04 | 2007-12-12 | 莫少凡 | Method for extracting cordate houttuynia |
| CN103181971A (en) * | 2011-12-30 | 2013-07-03 | 新昌县冠阳技术开发有限公司 | Heartleaf houttuynia herb oil enteric-coated capsules |
-
2011
- 2011-12-31 CN CN201110458273.7A patent/CN103181973B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085096A (en) * | 2007-06-04 | 2007-12-12 | 莫少凡 | Method for extracting cordate houttuynia |
| CN103181971A (en) * | 2011-12-30 | 2013-07-03 | 新昌县冠阳技术开发有限公司 | Heartleaf houttuynia herb oil enteric-coated capsules |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878525A (en) * | 2014-12-15 | 2016-08-24 | 沈阳伟嘉牧业技术有限公司 | Method for preparing houttuynia cordata lyophilized superfine powder granules |
| CN106135545A (en) * | 2015-04-01 | 2016-11-23 | 周敬耀 | Tribute tea and preparation method thereof |
| CN108192735A (en) * | 2018-01-17 | 2018-06-22 | 刘勇 | Plant extraction oil, the leach extraction method of plant extraction oil and application |
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| Publication number | Publication date |
|---|---|
| CN103181973B (en) | 2016-03-02 |
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Effective date of registration: 20191029 Address after: 314100 No.78 Huicheng Road, Huimin street, Jiashan County, Jiaxing City, Zhejiang Province Patentee after: Jiashan Haihong electronic component factory Address before: 312500, Zhejiang, Shaoxing province Xinchang County Star Street, 1 Titan Avenue, Jiangnan famous tea market B3 building 2011 Patentee before: Xinchang County Guanyang Technology Development Co., Ltd. |