CN103181948A - Making method of eucommia leaf extract microcapsule and health care product made from the same - Google Patents
Making method of eucommia leaf extract microcapsule and health care product made from the same Download PDFInfo
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- CN103181948A CN103181948A CN2011104488186A CN201110448818A CN103181948A CN 103181948 A CN103181948 A CN 103181948A CN 2011104488186 A CN2011104488186 A CN 2011104488186A CN 201110448818 A CN201110448818 A CN 201110448818A CN 103181948 A CN103181948 A CN 103181948A
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- aucubin
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- chlorogenic acid
- folium eucommiae
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Abstract
The invention discloses a making method of an eucommia leaf extract microcapsule. The method has the beneficial effects that: a superfine grinding technology is employed to grind the raw material fine, the original physicochemical properties are maintained, the bioavailability is high, and a freshness retaining effect can be achieved; through high-speed centrifugal separation, loss of effective components can be prevented, active components of the eucommia leaves can be preserved, so that high purity eucommia leaf chlorogenic acid and aucubin crystals can be obtained; a microencapsulation treatment can be beneficial to long-term storage and acquisition of better antibacterial and antiviral effects; microencapsulated catechin-tea flavonoid crystals can play a better antibacterial and antiviral role; and silver ions are beneficial to achievement of a better adsorption effect, and simultaneously serve as a protective agent of microcapsulated eucommia leaf chlorogenic acid and aucubin crystals and microencapsulated catechin-tea flavonoid crystals.
Description
Technical field
[0001] the present invention relates to a kind of manufacture method of plant extract microcapsule and be the health product of raw material with this microcapsule, relate in particular to and a kind ofly from Folium Eucommiae, extract the method for high-purity chlorogenic acid and aucubin and be the health-care products of raw material with this high-purity chlorogenic acid and aucubin.
Background technology
[0002] medical value of the Cortex Eucommiae self and nutritive value are fully confirmed, Folium Eucommiae extract have sedation and analgesia effect, improve immunity, improve carbohydrate metabolism and the anti-ageing multiple action of waiting for a long time in the body, healthy significant to people.For this reason, at present each side is all strengthening the exploitation aspect the Cortex Eucommiae, and is no exception to Folium Eucommiae extract.But, make a general survey of the extracting method that at present Folium Eucommiae extract is adopted and mostly be traditional i.e. comprehensive extraction of extracting method, this traditional extracting method owing to fail to the abundant fragmentation of Folium Eucommiae material plant cell wall ubiquity that extractive content is low, purity is not enough, defective such as the active low and functional health effect of cost height, institute's extraction of substance life is outstanding.Be that the product of raw material also exists the cost height, degree of purification is low, biological activity is low and deficiency such as the anti-bacteria and anti-virus effect is limited with the Folium Eucommiae extract of traditional method for extracting.
At the problem of above-mentioned existence, the purpose of this invention is to provide a kind of extracting method of Folium Eucommiae, be beneficial to and obtain extractive content height, purity height, biological activity height and the remarkably productive extract of functional health; And be beneficial to simultaneously and reduce cost.
The objective of the invention is to be achieved through the following technical solutions:
A kind of manufacture method of folium cortex eucommiae extract microcapsules wherein, comprises the steps,
Step 1, micronizing Folium Eucommiae make superfine powder Folium Eucommiae powder body primary raw materials: be raw material with the Folium Eucommiae, through the micronizing unit, be subjected to the dither that the high speed impact of grating disk and shearing and eddy current produce and pulverized in pulverizing chamber, form powder body; Described powder body enters grading room and be subjected to air force and action of centrifugal force simultaneously under suction function, discharge after entering the pipeline that gathers materials thereafter, thereby obtain superfine powder Folium Eucommiae powder body primary raw materials;
Step 2 is made Folium Eucommiae chlorogenic acid and aucubin crystal raw material: the superfine powder Folium Eucommiae powder body primary raw materials that makes in the described step 1 is used the alcohol-pickled 1.5-3 of 70%-90% hour, obtain immersion thereby filter; Unsaturated common salt aqueous solution is poured in the gained immersion soak and soaked and desalting processing through salt in 1.5-3 hour, the elimination sediment obtains filtrate; Be 5.0-6.5 with gained filtrate pH value, under 55-85 ℃ of condition, carried out catalytic reaction 1.5-3 hour; Gained solution after the catalytic reaction is obtained extract with the ethyl acetate extraction of 1:1; Gained extract drying under vacuum condition is made Folium Eucommiae chlorogenic acid and aucubin crystal raw material;
Step 3, the high speed centrifugation separation makes Folium Eucommiae chlorogenic acid and aucubin crystal: the high speed centrifugation fan is installed in extracting tank body, described high speed centrifugation fan carries out the sedimentation processing with the rotating speed of 3000-50000 to Folium Eucommiae chlorogenic acid and the aucubin crystal raw material that makes in the described step 2, and then via hole diameter is that the micron-sized resin chromatographic column of the 20-120 branch caffeine of leaving away extracts and to make Folium Eucommiae chlorogenic acid and aucubin concentrated solution, makes Folium Eucommiae chlorogenic acid and aucubin crystal behind vacuum drying;
Step 4, preparation microencapsulation high ester catechin-tea flavone crystal: be core with the described Folium Eucommiae chlorogenic acid and the aucubin crystal that make in the described step 3, microencapsulation ester plastid is sheared for the wall material carries out emulsifying; Through atomization drying under the airtight vacuum situation, thereby obtain microencapsulation Folium Eucommiae chlorogenic acid and aucubin crystal.
The manufacture method of above-mentioned a kind of folium cortex eucommiae extract microcapsules, wherein, the ethyl acetate extraction number of times with described 1:1 in the described step 2 is 3 times.
The microencapsulation Folium Eucommiae chlorogenic acid that the manufacture method of above-mentioned folium cortex eucommiae extract microcapsules makes and the health-care products of aucubin crystal, wherein, also comprise microencapsulation catechin-tea flavone crystal, the percentage by weight of described microencapsulation Folium Eucommiae chlorogenic acid and aucubin crystal is 50%-70%, and the percentage by weight of described microencapsulation catechin-tea flavone crystal is 30%-50%.
Above-mentioned a kind of health-care products that comprises microencapsulation Folium Eucommiae chlorogenic acid and aucubin crystal among its spy, also comprises silver ion, and the percentage by weight of described silver ion is 1%-10%.
Compared with the prior art, beneficial effect of the present invention is: by micronizing processes Folium Eucommiae raw material, make that the Folium Eucommiae raw material pulverizing is meticulous, even particle size distribution, crushing process does not produce heat, keeps original physicochemical property, the bioavailability height, the Folium Eucommiae raw material is had fresh-keeping function, and the ultrasound wave of crushing process generation simultaneously has certain sterilizing function; Make Folium Eucommiae chlorogenic acid and aucubin crystal by the high speed centrifugation separation, prevent loss of active ingredients effectively, preserve the active component of Folium Eucommiae to greatest extent, but shortened process also, energy-conservation and reduce cost, thus highly purified Folium Eucommiae chlorogenic acid and aucubin crystal obtained; Handle the highly purified Folium Eucommiae chlorogenic acid of gained and aucubin crystal by microencapsulation, be beneficial to long term storage and be beneficial to and obtain better anti-bacteria and anti-virus effect; Catechin-tea flavone the crystal that adds microencapsulation, the higher effect of bringing into play anti-bacteria and anti-virus better; Add silver ion; under equal conditions obtained better adsorption effect; the sterilization that more is conducive to the to bring into play catechin-tea flavone function of killing the virus also is the protective agent of microencapsulation Folium Eucommiae chlorogenic acid and aucubin crystal and microencapsulation catechin-tea flavone crystal simultaneously.
Description of drawings
Fig. 1 is the manufacturing approach craft schematic flow sheet of a kind of folium cortex eucommiae extract microcapsules of the present invention.
The specific embodiment
The invention will be further described below in conjunction with schematic diagram and concrete operations embodiment.
As shown in Figure 1, the manufacture method of a kind of folium cortex eucommiae extract microcapsules of the present invention, it at first is raw material with the Folium Eucommiae, adopt the micronizing unit to carry out micronizing, when the Folium Eucommiae plant granule is sent in the pulverizing chamber through the charging aperture spiral, be subjected to high speed impact and the shearing of grating disk, the while also is subjected to the dither of eddy current generation and is pulverized.Powder body after the pulverizing is crossed the shunting tapered sleeve and is entered grading room under suction function.Because the high speed rotating of grading wheel, powder body is subjected to air force and action of centrifugal force simultaneously.When centrifugal force＞air force, illustrate that powder body is greater than predefined Cut size particle size, powder body is namely got rid of to be returned pulverizing chamber to tapered sleeve and continues to pulverize, and the qualified powder body of the pulverizing that meets the standard of setting in advance, this moment, air force＞centrifugal force was subjected to dynamic action, be discharged to subsidiary engine after entering the pipeline that gathers materials, become superfine powder Folium Eucommiae powder body primary raw materials after the collection.Secondly, use the alcohol-pickled 1.5-3 of 70%-90% after individual hour above-mentioned gained gold superfine powder Folium Eucommiae powder body primary raw materials, the elimination tea grounds obtains immersion; Unsaturated common salt aqueous solution is poured in the gained immersion soak and soaked and desalting processing through salt in 1.5-3 hour, the elimination sediment obtains filtrate; Transfer pH value to be adjusted to acidity gained filtrate simultaneously, be approximately 5.0-6.5, under 55-85 ℃, carried out then catalytic reaction 1.5-3 hour; The reaction back gained solution ethyl acetate extraction of 1:1.Can preferably extract three times.The vacuum drying extract obtains Folium Eucommiae chlorogenic acid and aucubin crystal raw material.Next, owing in extracting tank body, vertical shaft is installed, and the high speed centrifugation fan is installed on vertical shaft as required, under the transmission of vertical shaft, drive the high speed centrifugation fan like this and finish centrifugal operation; The rotating speed of fanning with 3000-50000 by described high speed centrifugation carries out the sedimentation processing to prepared Folium Eucommiae chlorogenic acid and aucubin crystal raw material, and then get Folium Eucommiae chlorogenic acid and aucubin concentrated solution through large aperture resin chromatographic column, through rapidly making Folium Eucommiae chlorogenic acid and aucubin crystal after the cooling, make percentage by weight through above-mentioned steps and be not less than 90% Flos Lonicerae chlorogenic acid crystal; Be core with the described Folium Eucommiae chlorogenic acid that makes and aucubin crystal then, microencapsulation ester plastid is sheared for the wall material carries out emulsifying; Wherein can select soybean salad oil, Oleum Brassicae campestris or Camellia oil for use is the primary wall material, is that the wall material is as microencapsulation ester plastid with albumen NP and carbohydrate CA, CB; Through atomization drying under the airtight vacuum situation, thereby obtain microencapsulation Folium Eucommiae chlorogenic acid and aucubin crystal.
Be that the high ester catechin-tea flavone crystal of raw material and microencapsulation mixes with above-mentioned microencapsulation Folium Eucommiae chlorogenic acid and aucubin crystal, can make health product capsule or tablet.Wherein, microencapsulation Folium Eucommiae chlorogenic acid and aucubin crystal improve immunity well, improve carbohydrate metabolism and anti-ageing waiting for a long time in the human body; Add the high ester catechin of microencapsulation-tea flavone crystal and can play the effect of anti-bacteria and anti-virus.In order to reach effect better, can also add silver ion as adsorbent and protective agent.
More than specific embodiments of the invention are described in detail, but the present invention is not restricted to specific embodiment described above, it is just as example.To those skilled in the art, any to this equivalent modifications of carrying out and alternative also all among category of the present invention.Therefore, not breaking away from impartial conversion and the modification of having done under the spirit and scope of the present invention, all should contain within the scope of the invention.
Claims (4)
1. the manufacture method of a folium cortex eucommiae extract microcapsules is characterized in that, comprise the steps,
Step 1, micronizing Folium Eucommiae make superfine powder Folium Eucommiae powder body primary raw materials: be raw material with the Folium Eucommiae, through the micronizing unit, be subjected to the dither that the high speed impact of grating disk and shearing and eddy current produce and pulverized in pulverizing chamber, form powder body; Described powder body enters grading room and be subjected to air force and action of centrifugal force simultaneously under suction function, discharge after entering the pipeline that gathers materials thereafter, thereby obtain superfine powder Folium Eucommiae powder body primary raw materials;
Step 2 is made Folium Eucommiae chlorogenic acid and aucubin crystal raw material: the superfine powder Folium Eucommiae powder body primary raw materials that makes in the described step 1 is used the alcohol-pickled 1.5-3 of 70%-90% hour, obtain immersion thereby filter; Unsaturated common salt aqueous solution is poured in the gained immersion soak and soaked and desalting processing through salt in 1.5-3 hour, the elimination sediment obtains filtrate; Be 5.0-6.5 with gained filtrate pH value, under 55-85 ℃ of condition, carried out catalytic reaction 1.5-3 hour; Gained solution after the catalytic reaction is obtained extract with the ethyl acetate extraction of 1:1; Gained extract drying under vacuum condition is made Folium Eucommiae chlorogenic acid and aucubin crystal raw material;
Step 3, the high speed centrifugation separation makes Folium Eucommiae chlorogenic acid and aucubin crystal: the high speed centrifugation fan is installed in extracting tank body, described high speed centrifugation fan carries out the sedimentation processing with the rotating speed of 3000-50000 to Folium Eucommiae chlorogenic acid and the aucubin crystal raw material that makes in the described step 2, and then via hole diameter is that the micron-sized resin chromatographic column of 20-120 separation and Extraction makes Folium Eucommiae chlorogenic acid and aucubin concentrated solution, makes Folium Eucommiae chlorogenic acid and aucubin crystal behind vacuum drying;
Step 4, preparation microencapsulation high ester catechin-tea flavone crystal: be core with the described Folium Eucommiae chlorogenic acid and the aucubin crystal that make in the described step 3, microencapsulation ester plastid is sheared for the wall material carries out emulsifying; Through atomization drying under the airtight vacuum situation, thereby obtain microencapsulation Folium Eucommiae chlorogenic acid and aucubin crystal.
2. the manufacture method of a kind of folium cortex eucommiae extract microcapsules according to claim 1 is characterized in that, the ethyl acetate extraction number of times with described 1:1 in the described step 2 is 3 times.
3. the microencapsulation Folium Eucommiae chlorogenic acid that makes of a manufacture method that comprises claim 1 or 2 described folium cortex eucommiae extract microcapsules and the health-care products of aucubin crystal, it is characterized in that, also comprise microencapsulation catechin-tea flavone crystal, the percentage by weight of described microencapsulation Folium Eucommiae chlorogenic acid and aucubin crystal is 50%-70%, and the percentage by weight of described microencapsulation catechin-tea flavone crystal is 30%-50%.
4. a kind of health-care products that comprises microencapsulation Folium Eucommiae chlorogenic acid and aucubin crystal according to claim 3 is characterized in that, also comprise silver ion, the percentage by weight of described silver ion is 1%-10%.
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| CN2011104488186A CN103181948A (en) | 2011-12-29 | 2011-12-29 | Making method of eucommia leaf extract microcapsule and health care product made from the same |
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| CN2011104488186A CN103181948A (en) | 2011-12-29 | 2011-12-29 | Making method of eucommia leaf extract microcapsule and health care product made from the same |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176376A (en) * | 2016-08-04 | 2016-12-07 | 广州悦创实业有限公司 | The microsphere of parcel Folium Camelliae sinensis extract complex and in the application of edible natural toothpaste |
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| CN1299818A (en) * | 1999-07-23 | 2001-06-20 | 汪健 | Tea flavone as one flavone compound from tea |
| CN101843651A (en) * | 2009-03-26 | 2010-09-29 | 刘青梅 | Method for preparing folium cortex eucommiae extract microcapsules |
| CN102240317A (en) * | 2010-05-10 | 2011-11-16 | 李太盛 | Extraction process for preparing total flavones and chlorogenic acid from traditional Chinese medicine eucommia leaf |
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- 2011-12-29 CN CN2011104488186A patent/CN103181948A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299818A (en) * | 1999-07-23 | 2001-06-20 | 汪健 | Tea flavone as one flavone compound from tea |
| CN101843651A (en) * | 2009-03-26 | 2010-09-29 | 刘青梅 | Method for preparing folium cortex eucommiae extract microcapsules |
| CN102240317A (en) * | 2010-05-10 | 2011-11-16 | 李太盛 | Extraction process for preparing total flavones and chlorogenic acid from traditional Chinese medicine eucommia leaf |
Non-Patent Citations (1)
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| 陈进，等。: "微囊的研究进展", 《安徽医药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176376A (en) * | 2016-08-04 | 2016-12-07 | 广州悦创实业有限公司 | The microsphere of parcel Folium Camelliae sinensis extract complex and in the application of edible natural toothpaste |
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Application publication date: 20130703 |