CN103191068B - A kind of catechin buccal tablet and manufacture method thereof - Google Patents
A kind of catechin buccal tablet and manufacture method thereof Download PDFInfo
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- CN103191068B CN103191068B CN201210003224.9A CN201210003224A CN103191068B CN 103191068 B CN103191068 B CN 103191068B CN 201210003224 A CN201210003224 A CN 201210003224A CN 103191068 B CN103191068 B CN 103191068B
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Abstract
The invention discloses a kind of catechin buccal tablet and manufacture method thereof, be conducive to by the method manufacture catechin buccal tablet the content obtaining high ester-type catechin-tea flavonoid in buccal tablet, be conducive to ensureing that in buccal tablet, high ester-type catechin-tea flavonoid has higher biological activity thus possesses good anti-bacteria and anti-virus ability.The high ester-type catechin-tea flavonoid that the catechin buccal tablet obtained by the method is mainly comprised microencapsulation ester plastid and wrapped up by microencapsulation ester plastid.Beneficial effect of the present invention is: utilize the manufacture method of described catechin buccal tablet to be beneficial to the catechin buccal tablet obtaining high ester-type catechin-tea flavonoid, the catechin be beneficial in buccal tablet is not oxidized, be beneficial to the long term storage of buccal tablet, be beneficial to the quality and curative effect that ensure buccal tablet; Utilize the catechin buccal tablet that said method is obtained, be beneficial to the quality and curative effect that have ensured, be beneficial to anti-bacteria and anti-virus, be beneficial to the biological activity that maintenance is higher.
Description
Technical field
The present invention relates to a kind of medicine buccal tablet, particularly relate to a kind of catechin buccal tablet containing catechin-tea flavone crystal.
Background technology
There are some researches show: high ester catechin has multidrug resistance, P glycoprotein, drug resistance inversion, anti-scale cancer, antioxidation, sterilization, antiviral, infection, antitumor, raising immunity and the specific ability of prevention of oral infections are strong; Have the tumor-inhibiting action of the cell toxicant enhanced sensitivity to people's multidrug resistance oral cancer, protection oral immunisation system, protects the health of one's teeth; Meanwhile, high ester catechin has the effects such as prevention and therapy periodontitis, anti-plaque.
Meanwhile, the existing buccal tablet macromole buccal tablet of taking traditional sugar-coat to wrap up on the market at present, the compositions be mainly made up of as excipient and general Chinese herbal medicine extract or polyphenol compound polysaccharide or amylase etc. more.Usually not containing catechin in existing buccal tablet, reason is catechin very easily in oxidation, loses the function affect of the antibacterial grade of antiviral; Even if containing catechin, even if neither high ester catechin containing catechin, the problem of anti-bacteria and anti-virus can not be solved.Existing buccal tablet usually to Chinese herbal medicine extract parcel imprecision, makes wrapped up Chinese herbal medicine extract be easy to oxidation even rotten, changes its molecular structure, lose medicinal function; And mostly there is the more toxic organic solvents of use and metal ion.
Summary of the invention
For above-mentioned Problems existing, the object of this invention is to provide the catechin buccal tablet containing tea flavone crystal of a kind of microencapsulation ester plastid parcel, be beneficial to and avoid catechin oxidized, be beneficial to long term storage and be beneficial to anti-bacteria and anti-virus, be beneficial to the quality and curative effect that ensure buccal tablet.
The object of the invention is to be achieved through the following technical solutions:
A manufacture method for catechin buccal tablet, wherein, comprises the steps:
Step one, superfine powder fannings raw material obtains catechin-tea flavone primary raw materials: catechin-tea flavone primary raw materials: with green tea or oolong tea for raw material, through micronizing unit, in pulverizing chamber, be subject to dither that the high speed impact of grating disk and shearing and eddy current produce and pulverized, forming powder body; Described powder body enters grading room and is subject to the effect of air force and centrifugal force simultaneously under suction function, discharges, thus obtain the elementary micro powder tea raw material of catechin-tea flavone after entering the pipeline that gathers materials thereafter;
Step 2, makes catechin-tea flavone crystal raw material: by catechin-alcohol-pickled 1.5-3 of tea flavone elementary micro powder tea raw material 70%-90% obtained in described step one hour, thus elimination tea grounds obtained immersion; Gained immersion is poured unsaturated common salt aqueous solution and soak 1.5-3 hour through salt leaching and desalting processing, elimination sediment obtains filtrate; Be 5.0-6.5 by gained filtrate pH value, under 55-85 DEG C of condition, carry out catalytic reaction 1.5-3 hour; The extraction into ethyl acetate of gained solution 1:1 after catalytic reaction is removed caffeine and is extracted liquid; By gained extract dry obtained catechin-tea flavone crystalline solid raw material under vacuum;
Step 3, high speed centrifugation is separated obtained high ester-type catechin-tea flavonoid crystal: in extraction tank body, install high speed centrifugation fan, described high speed centrifugation fan carries out settlement treatment with the rotating speed of 3000-50000 obtain catechin to catechin-tea flavone crystalline solid raw material obtained in described step 2--tea flavone liquid, and then via hole diameter is that the micron-sized resin chromatography post of 20-120 divides Carbonado Diamond of leaving away to obtain catechin--tea flavone concentrated solution, obtained catechin-tea flavone crystal after vacuum drying;
Step 4, prepares microencapsulation high ester-type catechin-tea flavonoid crystal: with described high ester-type catechin-tea flavonoid crystal obtained in described step 3 for core, microencapsulation ester plastid is that wall material carries out emulsifying shearing; Through atomization drying in airtight vacuum situation, thus obtain microencapsulation high ester-type catechin-tea flavonoid crystal.
Step 5, tabletting forms catechin buccal tablet: the microencapsulation high ester-type catechin-tea flavonoid crystal basis obtained in described step 4 adds one or more in betacyclodextrin, Mentholum, sucrose, protein sugar and magnesium stearate as excipient, become catechin buccal tablet through tabletting punch press machine swaging.
The manufacture method of above-mentioned a kind of catechin buccal tablet, wherein, the described tea raw material in described step one is green tea or oolong tea.
The manufacture method of above-mentioned a kind of catechin buccal tablet wherein, is 3 times with the number of times of the extraction into ethyl acetate of described 1:1 in described step 4.
A kind of catechin buccal tablet that the manufacture method of above-mentioned a kind of catechin buccal tablet is obtained, wherein, comprise tea flavone crystal, microencapsulation ester plastid and excipient, described tea flavone crystal is encapsulated by described microencapsulation ester plastid, and described excipient is one or more in betacyclodextrin, Mentholum, sucrose, protein sugar and magnesium stearate.
A kind of catechin buccal tablet that the manufacture method of above-mentioned a kind of catechin buccal tablet is obtained, wherein, comprise tea flavone crystal, microencapsulation ester plastid and excipient, described high ester tea flavone crystal is encapsulated by described microencapsulation ester plastid, and described excipient is one or more in betacyclodextrin, Mentholum, sucrose, protein sugar and magnesium stearate.
Above-mentioned a kind of catechin buccal tablet, wherein, described microencapsulation ester plastid is made up of primary wall material and wall material, and described primary wall material is made up of soybean salad oil, Oleum Brassicae campestris or Camellia oil, and described wall material is made up of albumen NP and carbohydrate CA, CB.
Above-mentioned a kind of catechin buccal tablet, wherein, described microencapsulation ester plastid is made up of primary wall material and wall material, and described primary wall material is made up of soybean salad oil, Oleum Brassicae campestris or Camellia oil, and described wall material is made up of albumen NP and carbohydrate CA, CB.
Above-mentioned a kind of catechin buccal tablet, wherein, also comprises silver ion.
Above-mentioned a kind of catechin buccal tablet, wherein, described silver ion weight percent content is 1%-2%.
Above-mentioned a kind of catechin buccal tablet, wherein, the weight percent content of described high ester-type catechin-tea flavonoid is 85%-92%.
Compared with the prior art, beneficial effect of the present invention is: utilize the manufacture method of described catechin buccal tablet to be beneficial to the catechin buccal tablet obtaining high ester-type catechin-tea flavonoid, the catechin be beneficial in buccal tablet is not oxidized, is beneficial to the long term storage of buccal tablet, is beneficial to the quality and curative effect that ensure buccal tablet; Utilize the catechin buccal tablet that said method is obtained, be beneficial to the quality and curative effect that have ensured, be beneficial to anti-bacteria and anti-virus, be beneficial to the biological activity that maintenance is higher.
Accompanying drawing explanation
Fig. 1 is the manufacture method schematic flow sheet of a kind of catechin buccal tablet of the present invention.
Detailed description of the invention
Below in conjunction with schematic diagram and concrete operations embodiment, the invention will be further described.
As shown in Figure 1, the manufacture method of a kind of catechin buccal tablet of the present invention, mainly adopts microencapsulation ester plastid parcel tea flavone crystal.Obtain high ester-type catechin-tea flavonoid crystal, need with green tea or oolong tea for raw material, after then using the alcohol-pickled 1.5-3 of 70%-90% hour, elimination tea grounds obtains immersion; Then salt leaching and desalted water is carried out: unsaturated common salt aqueous solution 1.5-3 hour is poured in gained immersion, and elimination sediment obtains filtrate; Then gained filtrate pH value is adjusted to acidity, preferably controls between 1-6.5, and carry out catalytic reaction 1.5-3 hour at 35-85 DEG C; Thereafter by the extraction into ethyl acetate of reacted solution 1:1 to remove caffeine, the extraction into ethyl acetate 3 times of 1:1 can be selected; Then vacuum drying extract obtains high ester-type catechin-tea flavonoid crystal.When utilizing microencapsulation ester plastid to wrap up high ester-type catechin-tea flavonoid crystal, first with high ester-type catechin-tea flavonoid for core, soybean salad oil, Oleum Brassicae campestris or Camellia oil are primary wall material, to be wall material through emulsifying shear carries out spraying dry and obtain ester-type catechin-tea flavonoid crystal microcapsule for albumen NP and carbohydrate CA, CB, finally by adding one or more in betacyclodextrin, Mentholum, sucrose, protein sugar and magnesium stearate as excipient, become catechin buccal tablet through tabletting punch press machine swaging.Utilize the method to manufacture catechin buccal tablet, be conducive to the content obtaining high ester-type catechin-tea flavonoid in buccal tablet, the percentage by weight of high ester-type catechin-tea flavonoid is 85%-92%; Be conducive to ensureing that in buccal tablet, high ester-type catechin-tea flavonoid has higher biological activity thus possesses good anti-bacteria and anti-virus ability.
The catechin buccal tablet of said method manufacture is adopted mainly to comprise high ester-type catechin-tea flavonoid crystal, microencapsulation ester plastid and as one or more in the betacyclodextrin of excipient, Mentholum, sucrose, protein sugar and magnesium stearate, described high ester-type catechin-tea flavonoid crystal is encapsulated by described microencapsulation ester plastid, is beneficial to and ensures that in buccal tablet, high ester-type catechin-tea flavonoid has higher biological activity thus possesses good anti-bacteria and anti-virus ability.
Better wrap up effect for obtaining, the microencapsulation ester plastid for wrapping up high ester-type catechin-tea flavonoid can select soybean salad oil, Oleum Brassicae campestris or Camellia oil to form as primary wall material, and albumen NP and carbohydrate CA, CB make as wall material.
For ensureing the biological activity of catechin buccal tablet, improve that catechin is antibacterial, antiviral, raising immunity ability, in catechin buccal tablet, add the silver ion that percentage by weight is 1%-2%.
Be described in detail specific embodiments of the invention above, but the present invention is not restricted to specific embodiment described above, it is just as example.To those skilled in the art, any to this equivalent modifications of carrying out and substitute also all among category of the present invention.Therefore, equalization conversion done without departing from the spirit and scope of the invention and amendment, all should contain within the scope of the invention.
Claims (9)
1. a manufacture method for catechin buccal tablet, is characterized in that, comprises the steps:
Step one, micropowder fannings raw material obtains catechin-tea flavone primary raw materials: catechin-tea flavone primary raw materials: with green tea or oolong tea for raw material, through micronizing unit, in pulverizing chamber, be subject to dither that the high speed impact of grating disk and shearing and eddy current produce and pulverized, forming powder body; Described powder body enters grading room and is subject to the effect of air force and centrifugal force simultaneously under suction function, discharges, thus obtain the elementary micro powder tea raw material of catechin-tea flavone after entering the pipeline that gathers materials thereafter;
Step 2, makes catechin-tea flavone crystal raw material: by catechin-alcohol-pickled 1.5-3 of tea flavone elementary micro powder tea raw material 70%-90% obtained in described step one hour, thus elimination tea grounds obtained immersion; Gained immersion is poured unsaturated common salt aqueous solution and soak 1.5-3 hour through salt leaching and desalting processing, elimination sediment obtains filtrate; Gained filtrate pH value is 5.0-6.5, under 55-85 DEG C of condition, carry out catalytic reaction 1.5-3 hour; The extraction into ethyl acetate of gained solution 1:1 after catalytic reaction is removed caffeine and is extracted liquid; By gained extract dry obtained catechin-tea flavone crystalline solid raw material under vacuum;
Step 3, high speed centrifugation is separated obtained high ester-type catechin-tea flavonoid crystal: in extraction tank body, install high speed centrifugation fan, described high speed centrifugation fan carries out settlement treatment with the rotating speed of 3000-50000 to catechin-tea flavone crystalline solid raw material obtained in described step 2 and obtains catechin-tea flavone liquid, and then via hole diameter is that the micron-sized resin chromatography post of 20-120 divides Carbonado Diamond of leaving away to obtain catechin--tea flavone concentrated solution, obtained catechin-tea flavone crystal after vacuum drying;
Step 4, prepares microencapsulation high ester-type catechin-tea flavonoid crystal: with described high ester-type catechin-tea flavonoid crystal obtained in described step 3 for core, microencapsulation ester plastid is that wall material carries out emulsifying shearing; Through atomization drying in airtight vacuum situation, thus obtain microencapsulation high ester-type catechin-tea flavonoid crystal;
Step 5, tabletting forms catechin buccal tablet: the microencapsulation high ester-type catechin-tea flavonoid crystal basis obtained in described step 4 adds one or more in betacyclodextrin, Mentholum, sucrose, protein sugar and magnesium stearate as excipient, become catechin buccal tablet through tabletting punch press machine swaging;
Described microencapsulation ester plastid is made up of primary wall material and wall material, and described primary wall material is made up of soybean salad oil, Oleum Brassicae campestris or Camellia oil, and described wall material is made up of albumen NP and carbohydrate CA, CB.
2. the manufacture method of a kind of catechin buccal tablet according to claim 1, is characterized in that, the described tea raw material in described step one is green tea or oolong tea.
3. the manufacture method of a kind of catechin buccal tablet according to claim 1, is characterized in that, is 3 times with the number of times of the extraction into ethyl acetate of described 1:1 in described step 2.
4. a kind of catechin buccal tablet that the manufacture method of a kind of catechin buccal tablet according to claim 1 is obtained, it is characterized in that, comprise tea flavone crystal, microencapsulation ester plastid and excipient, described tea flavone crystal is encapsulated by described microencapsulation ester plastid, and described excipient is one or more in betacyclodextrin, Mentholum, sucrose, protein sugar and magnesium stearate.
5. a kind of catechin buccal tablet that the manufacture method of a kind of catechin buccal tablet according to claim 2 is obtained, it is characterized in that, comprise tea flavone crystal, microencapsulation ester plastid and excipient, described high ester tea flavone crystal is encapsulated by described microencapsulation ester plastid, and described excipient is one or more in betacyclodextrin, Mentholum, sucrose, protein sugar and magnesium stearate.
6. a kind of catechin buccal tablet according to claim 4 or 5, is characterized in that, also comprise silver ion.
7. a kind of catechin buccal tablet according to claim 6, is characterized in that, described silver ion weight percent content is 1%-2%.
8. a kind of catechin buccal tablet according to claim 5, is characterized in that, the weight percent content of described tea flavone crystal is 85%-92%.
9. a kind of catechin buccal tablet according to claim 6, is characterized in that, the weight percent content of described tea flavone crystal is 85%-92%.
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| CN201210003224.9A CN103191068B (en) | 2012-01-08 | 2012-01-08 | A kind of catechin buccal tablet and manufacture method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299818A (en) * | 1999-07-23 | 2001-06-20 | 汪健 | Tea flavone as one flavone compound from tea |
| CN101926790A (en) * | 2009-06-26 | 2010-12-29 | 上海强圣医药科技有限公司 | (-)-epigallocatechin gallate composition and application |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299818A (en) * | 1999-07-23 | 2001-06-20 | 汪健 | Tea flavone as one flavone compound from tea |
| CN101926790A (en) * | 2009-06-26 | 2010-12-29 | 上海强圣医药科技有限公司 | (-)-epigallocatechin gallate composition and application |
Non-Patent Citations (1)
| Title |
|---|
| 喷雾干燥制备酯型儿茶素微胶囊;齐连祥等;《辽宁化工》;20060831;第35卷(第8期);第435-438页 * |
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Effective date of registration: 20170414 Address after: Wuhua District of Yunnan city in Kunming province 650000 Qianwang Street No. 82 Patentee after: Yunnan Tea Co.,Ltd. Address before: Tianhe District Tong East Road Guangzhou city Guangdong province 510665 B-101 No. 5, room B-118 Patentee before: GUANGDONG GAOHANG INTELLECTUAL PROPERTY OPERATION Co.,Ltd. Effective date of registration: 20170414 Address after: Tianhe District Tong East Road Guangzhou city Guangdong province 510665 B-101 No. 5, room B-118 Patentee after: GUANGDONG GAOHANG INTELLECTUAL PROPERTY OPERATION Co.,Ltd. Address before: 312500 Xinchang City, Shaoxing Province, Qixing street, Zhejiang, the Yangtze River Road, No. 1 Jiangnan tea market B3 building, 2011 Patentee before: Xinchang Guanyang Technology Development Co.,Ltd. |