CN103182055A - Enteric-coated capsules comprising blue turmeric rhizome extract - Google Patents
Enteric-coated capsules comprising blue turmeric rhizome extract Download PDFInfo
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- CN103182055A CN103182055A CN2011104548100A CN201110454810A CN103182055A CN 103182055 A CN103182055 A CN 103182055A CN 2011104548100 A CN2011104548100 A CN 2011104548100A CN 201110454810 A CN201110454810 A CN 201110454810A CN 103182055 A CN103182055 A CN 103182055A
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- turmeric rhizome
- liposome
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Abstract
The invention discloses enteric-coated capsules comprising a blue turmeric rhizome extract. The capsules comprise microencapsulated liposome and ultrafine blue turmeric rhizome oil. Compared with prior arts, the capsules provided by the invention have the advantages that: with an ultrafine crushing process and a high-speed centrifugal separation method, blue turmeric rhizome raw material original physiochemical properties are maintained, bioavailability is high, and blue turmeric herb active components are preserved; ultrafine blue turmeric rhizome oil is subjected to microencapsulated liposome coating, such that blue turmeric rhizome oil volatility is controlled, blue turmeric rhizome oil content stability is maintained, and blue turmeric rhizome oil oxidation and deterioration are prevented; the liposome has high targeting property, such that blue turmeric rhizome oil anti-inflammatory and antibacterial functions are utilized and developed; microencapsulated catechin-tea flavonoid crystals are added, such that anti-inflammatory and antibacterial capacities of the product provided by the invention can be developed, and an antiviral effect can be provided; silver ions are added as an absorbent and disinfectant, such that catechin is prevented from being corroded, and catechin antibacterial and antiviral functions can be developed.
Description
Technical field
The present invention relates to a kind of capsule preparations that contains Chinese medicine extract, relate in particular to a kind of enteric coated capsule that contains Rhizoma Curcumae extract.
Background technology
Oleum Curcumae is a kind of volatile oil that extracts from the rhizome of zingiberaceous plant Rhizoma Curcumae, contains multiple active ingredients such as curcumenol, curzerenone and Gu Ma ketone, has effects such as antitumor, antiviral and antithrombotic.Oleum Curcumae has very high medical value, so be that the goods such as injection, suppository and ointment that raw material is made are widely used with the Oleum Curcumae.But mostly the Oleum Curcumae that contains at present in the goods of Oleum Curcumae is to take conventional method to extract, and Oleum Curcumae purity wherein is not high, and biological activity is low, and bioavailability is low; In addition, in leaching process, also to add other materials, thereby very easily cause the pollution of Oleum Curcumae itself to influence the value of Oleum Curcumae; Simultaneously, Oleum Curcumae is a kind of ethereal oil, and high volatility influences stability of formulation easily.
Summary of the invention
At the problem of above-mentioned existence, the purpose of this invention is to provide a kind of enteric coated capsule that contains Oleum Curcumae, Oleum Curcumae is handled through microencapsulation, utilizes control Rhizoma Curcumae oil volatility to keep the stable of its content; Oleum Curcumae is to extract through micronizing, high speed centrifugation, utilizes to keep high-purity, high biological activity and high bioavailability.
The objective of the invention is to be achieved through the following technical solutions:
A kind of enteric coated capsule that contains Rhizoma Curcumae extract, comprise the microencapsulation liposome, described microencapsulation liposome is made up of primary wall material and wall material, described primary wall material is made of soybean salad oil, Oleum Brassicae campestris or Camellia oil, described wall material is made of albumen NP and carbohydrate CA, CB, wherein, also comprises the ultra micro Oleum Curcumae, described ultra micro Oleum Curcumae is core, by the described microencapsulation liposome as the wall material, the percetage by weight of described microencapsulation Oleum Curcumae is 40%-60%.
Above-mentioned a kind of enteric coated capsule that contains Rhizoma Curcumae extract wherein, also comprises microencapsulation ester catechin-tea flavone crystal, and the percetage by weight of described microencapsulation ester catechin-tea flavone crystal is 40%-60%.
Above-mentioned a kind of enteric coated capsule that contains Rhizoma Curcumae extract wherein, also comprises silver ion, and the percetage by weight of described silver ion is 0.1%-0.5%.
Compared with the prior art, beneficial effect of the present invention is: by micronizing technology and high speed centrifugation separation method, utilize to keep the original physicochemical property of Rhizoma Curcumae raw material, the bioavailability height utilizes the active component of preserving in the Rhizoma Curcumae grass; The ultra micro Oleum Curcumae carries out the microencapsulation liposome, utilizes control Rhizoma Curcumae oil volatility, keeps the stability of oil of zedoary turmeric contents, avoids the Oleum Curcumae oxidation deterioration simultaneously; In addition, the liposome targeting is very strong, utilizes the anti-inflammatory, antibacterial function of performance Oleum Curcumae; Add microencapsulation ester catechin-tea flavone crystal, be beneficial to performance product antimicrobial antiphlogistic ability of the present invention, can play antivirus action simultaneously; Add silver ion as adsorbent and disinfectant, be beneficial to and avoid catechin to be etched, be beneficial to the anti-bacteria and anti-virus function of performance catechin simultaneously.
The specific embodiment
The invention will be further described below in conjunction with concrete operations embodiment.
A kind of enteric coated capsule that contains Rhizoma Curcumae extract of the present invention, comprise the microencapsulation liposome, described microencapsulation liposome is made up of primary wall material and wall material, described primary wall material is made of soybean salad oil, Oleum Brassicae campestris or Camellia oil, described wall material is made of albumen NP and carbohydrate CA, CB, wherein, also comprises the ultra micro Oleum Curcumae, described ultra micro Oleum Curcumae is core, by the described microencapsulation liposome as the wall material, the percetage by weight of described microencapsulation ultra micro Oleum Curcumae is 40%-60%.Wherein, the ultra micro Oleum Curcumae can make through following method: at first, be raw material with the Rhizoma Curcumae grass, adopt LF type micronizing unit to carry out micronizing, when the Rhizoma Curcumae grass particle is sent in the pulverizing chamber through the charging aperture spiral, be subjected to high speed impact and the shearing of grating disk, the while also is subjected to the dither of eddy current generation and is pulverized.Powder body after the pulverizing is crossed the shunting tapered sleeve and is entered grading room under suction function.Because the high speed rotating of grading wheel, powder body is subjected to air force and action of centrifugal force simultaneously.When centrifugal force＞air force, illustrate that powder body is greater than predefined Cut size particle size, powder body is namely got rid of to be returned pulverizing chamber to tapered sleeve and continues to pulverize, and the qualified powder body of the pulverizing that meets the standard of setting in advance, this moment, air force＞centrifugal force was subjected to dynamic action, be discharged to subsidiary engine after entering the pipeline that gathers materials, become Rhizoma Curcumae grass ultrafine powder after the collection.Secondly, above-mentioned gained Rhizoma Curcumae grass ultrafine powder after individual hour, is obtained immersion with the alcohol-pickled 1.5-3 of 70%-90%; Unsaturated common salt aqueous solution is poured in the gained immersion soak and soaked and desalting processing through salt in 1.5-3 hour, the elimination sediment obtains filtrate; Transfer pH value to be adjusted to acidity gained filtrate simultaneously, be approximately 1-6.5, under 55-85 ℃, carried out then catalytic reaction 1.5-3 hour; The ethyl acetate extraction of the back gained solution usefulness of reaction 1:1 repeatedly can preferably extract three times.The vacuum drying extract obtains Rhizoma Curcumae grass crystalline solid raw material.Next, owing in extracting tank body, vertical shaft is installed, and the high speed centrifugation fan is installed on vertical shaft as required, under the transmission of vertical shaft, drive the high speed centrifugation fan like this and finish centrifugal operation; With the rotating speed of 3000-50000 prepared Rhizoma Curcumae grass crystalline solid raw material is carried out sedimentation by described high speed centrifugation fan and handle and obtain Oleum Curcumae liquid, and then get cowherb oil concentrated solution through large aperture resin chromatographic column, after lowering the temperature rapidly, make Oleum Curcumae; Be the wall material then with the liposome, be that core carries out emulsifying and shears and to make a kind of enteric coated capsule that contains Rhizoma Curcumae extract of the present invention with the ultra micro Oleum Curcumae.
As improvement, for further increasing a kind of effect that contains Rhizoma Curcumae extract enteric coated capsule anti-bacteria and anti-virus of the present invention, also for avoiding the pollution of enteric coated capsule of the present invention itself, can also add microencapsulation ester catechin-tea flavone crystal simultaneously.Studies confirm that: catechin-tea flavone crystal has very strong sterilizing ability, and the microencapsulation catechin of adding-tea flavone crystal is killing microorganisms and the ability that improves anti-bacteria and anti-virus effectively.
Also can add a certain amount of silver ion on the basis of the above as adsorbent and disinfectant, like this can curcuma zedoary oil and the anti-bacteria and anti-virus of catechin play synergism, better effects if.
More than specific embodiments of the invention are described in detail, but the present invention is not restricted to specific embodiment described above, it is just as example.To those skilled in the art, any to this equivalent modifications of carrying out and alternative also all among category of the present invention.Therefore, not breaking away from impartial conversion and the modification of having done under the spirit and scope of the present invention, all should contain within the scope of the invention.
Claims (3)
1. enteric coated capsule that contains Rhizoma Curcumae extract, comprise the microencapsulation liposome, described microencapsulation liposome is made up of primary wall material and wall material, described primary wall material is made of soybean salad oil, Oleum Brassicae campestris or Camellia oil, described wall material is made of albumen NP and carbohydrate CA, CB, it is characterized in that, also comprises the ultra micro Oleum Curcumae, described ultra micro Oleum Curcumae is core, by the described microencapsulation liposome as the wall material, the percetage by weight of described microencapsulation ultra micro Oleum Curcumae is 40%-60%.
2. a kind of enteric coated capsule that contains Rhizoma Curcumae extract according to claim 1 is characterized in that, also comprises microencapsulation ester catechin-tea flavone crystal, and the percetage by weight of described microencapsulation ester catechin-tea flavone crystal is 40%-60%.
3. a kind of enteric coated capsule that contains Rhizoma Curcumae extract according to claim 1 and 2 is characterized in that, also comprises silver ion, and the percetage by weight of described silver ion is 0.1%-0.5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104548100A CN103182055A (en) | 2011-12-30 | 2011-12-30 | Enteric-coated capsules comprising blue turmeric rhizome extract |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104548100A CN103182055A (en) | 2011-12-30 | 2011-12-30 | Enteric-coated capsules comprising blue turmeric rhizome extract |
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| CN103182055A true CN103182055A (en) | 2013-07-03 |
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| CN2011104548100A Pending CN103182055A (en) | 2011-12-30 | 2011-12-30 | Enteric-coated capsules comprising blue turmeric rhizome extract |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103182056A (en) * | 2011-12-31 | 2013-07-03 | 新昌县冠阳技术开发有限公司 | Preparation method of zedoary oil |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1994455A (en) * | 2006-12-22 | 2007-07-11 | 北京亚东生物制药有限公司 | Enteric coated Chinese medicinal capsule for treating cancer and preparation method thereof |
| CN101850091A (en) * | 2010-06-04 | 2010-10-06 | 重庆市中医院 | Chinese medicament for treating colorectal polypus and preparation method thereof |
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2011
- 2011-12-30 CN CN2011104548100A patent/CN103182055A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1994455A (en) * | 2006-12-22 | 2007-07-11 | 北京亚东生物制药有限公司 | Enteric coated Chinese medicinal capsule for treating cancer and preparation method thereof |
| CN101850091A (en) * | 2010-06-04 | 2010-10-06 | 重庆市中医院 | Chinese medicament for treating colorectal polypus and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103182056A (en) * | 2011-12-31 | 2013-07-03 | 新昌县冠阳技术开发有限公司 | Preparation method of zedoary oil |
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Application publication date: 20130703 |