CN103180726B - 微型hplc设备 - Google Patents

微型hplc设备 Download PDF

Info

Publication number
CN103180726B
CN103180726B CN201180031388.6A CN201180031388A CN103180726B CN 103180726 B CN103180726 B CN 103180726B CN 201180031388 A CN201180031388 A CN 201180031388A CN 103180726 B CN103180726 B CN 103180726B
Authority
CN
China
Prior art keywords
liquid chromatography
chromatography device
liquid
column
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201180031388.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN103180726A (zh
Inventor
D·R·卡西
J·J·卡普林斯基
A·萨尔西-雷哈尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ip2ipo Innovations Ltd
Original Assignee
Imperial Innovations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Innovations Ltd filed Critical Imperial Innovations Ltd
Priority to CN201510312059.9A priority Critical patent/CN105004821A/zh
Publication of CN103180726A publication Critical patent/CN103180726A/zh
Application granted granted Critical
Publication of CN103180726B publication Critical patent/CN103180726B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/22—Injection in high pressure liquid systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/36—Control of physical parameters of the fluid carrier in high pressure liquid systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Fluid Mechanics (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CN201180031388.6A 2010-06-25 2011-06-27 微型hplc设备 Expired - Fee Related CN103180726B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510312059.9A CN105004821A (zh) 2010-06-25 2011-06-27 微型hplc设备

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1010737.3A GB201010737D0 (en) 2010-06-25 2010-06-25 Minature HPLC device
GB1010737.3 2010-06-25
PCT/GB2011/051217 WO2011161481A1 (en) 2010-06-25 2011-06-27 Miniature hplc device

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510312059.9A Division CN105004821A (zh) 2010-06-25 2011-06-27 微型hplc设备

Publications (2)

Publication Number Publication Date
CN103180726A CN103180726A (zh) 2013-06-26
CN103180726B true CN103180726B (zh) 2015-07-01

Family

ID=42583011

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201180031388.6A Expired - Fee Related CN103180726B (zh) 2010-06-25 2011-06-27 微型hplc设备
CN201510312059.9A Pending CN105004821A (zh) 2010-06-25 2011-06-27 微型hplc设备

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201510312059.9A Pending CN105004821A (zh) 2010-06-25 2011-06-27 微型hplc设备

Country Status (10)

Country Link
US (1) US9354209B2 (enExample)
EP (1) EP2585820A1 (enExample)
JP (1) JP6043715B2 (enExample)
CN (2) CN103180726B (enExample)
AU (1) AU2011268682B2 (enExample)
BR (1) BR112012032726A2 (enExample)
CA (1) CA2803962A1 (enExample)
GB (1) GB201010737D0 (enExample)
WO (1) WO2011161481A1 (enExample)
ZA (1) ZA201300607B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201213537D0 (en) * 2012-07-30 2012-09-12 Imp Innovations Ltd Self-limiting injection assembly for sample introduction in HPLC
WO2014055331A1 (en) * 2012-10-03 2014-04-10 Waters Technologies Corporation A chromatography column
CN103439309A (zh) * 2013-08-19 2013-12-11 南通大学 高灵敏度的co气体光谱传感器的制备方法
TWI579553B (zh) 2013-11-24 2017-04-21 中央研究院 以紫外光－可見光檢測之高效能液相層析設備及方法
WO2015110860A1 (en) * 2014-01-24 2015-07-30 Dh Technologies Development Pte. Ltd. Systems and methods for delivering liquid to an ion source
GB2534936B (en) * 2015-02-06 2021-09-08 Agilent Technologies Inc Liquid chromatography analysis unit
JP6704920B2 (ja) * 2015-10-14 2020-06-03 アルプスアルパイン株式会社 流路構造体および測定対象液体の測定装置
US9513220B1 (en) 2015-12-29 2016-12-06 International Business Machines Corporation On-chip molecule fluorescence detection
FR3055703B1 (fr) * 2016-09-05 2020-12-18 Elichens Procede d’analyse d’un gaz
JP6696578B2 (ja) * 2016-09-26 2020-05-20 株式会社島津製作所 切替バルブ、バイナリポンプ及びそのバイナリポンプを備えた液体クロマトグラフ
CN116183705A (zh) * 2017-03-30 2023-05-30 九零八图案公司 生物样品的微射流分析
EP3756002B1 (en) * 2018-02-23 2023-11-29 Silcotek Corp. Liquid chromatography technique
CN108593813B (zh) * 2018-07-17 2020-04-10 厦门大学 手持式一体化液相色谱仪
WO2022153571A1 (ja) * 2021-01-15 2022-07-21 エースバイオアナリシス株式会社 走査ユニット、システムおよび方法、ならびにマイクロカラム

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0583003A1 (en) * 1992-08-13 1994-02-16 Perseptive Biosystems, Inc. Fluid metering, mixing and composition control system
US20040124085A1 (en) * 2002-06-26 2004-07-01 California Institute Of Technology Microfluidic devices and methods with electrochemically actuated sample processing
US20050142662A1 (en) * 2002-09-27 2005-06-30 Ulrich Bonne Phased micro analyzer VIII
CN1715910A (zh) * 2005-06-22 2006-01-04 夏之宁 一种微型化的液相色谱分离方法
CN1749750A (zh) * 2004-09-13 2006-03-22 聂智明 高效液相色谱仪
CN1755351A (zh) * 2004-09-30 2006-04-05 中国科学院大连化学物理研究所 发光二极管诱导荧光微型检测器
US20070068872A1 (en) * 2005-09-21 2007-03-29 Waters Investments Limited Nano-flow liquid chromatographic apparatus having robust capillary tubing
CN1963497A (zh) * 2006-11-08 2007-05-16 浙江大学 微分析芯片上的微液相色谱分离方法及其装置
CN101206205A (zh) * 2006-12-22 2008-06-25 中国科学院大连化学物理研究所 微流量液相色谱在线大体积进样的方法和专用装置
US20080277606A1 (en) * 2005-11-11 2008-11-13 Molecular Vision Limited Microfluidic Device
US20090153865A1 (en) * 2007-12-13 2009-06-18 Shimadzu Corporation Analysis system

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2389891B1 (enExample) * 1977-05-02 1981-07-03 Prolabo Sa
US5408326A (en) * 1993-04-28 1995-04-18 Shell Oil Company Dual-wavelength absorption detector adapted for continuous-flow detection
US6277257B1 (en) 1997-06-25 2001-08-21 Sandia Corporation Electrokinetic high pressure hydraulic system
JPH11287791A (ja) * 1998-04-01 1999-10-19 Naohiro Soga キャピラリーカラム
JP2003502655A (ja) * 1999-06-22 2003-01-21 アジレント・テクノロジーズ・インコーポレーテッド 微小流体デバイスの操作用装置
US20030223913A1 (en) * 2002-06-03 2003-12-04 Nanostream, Inc. Microfluidic separation devices and methods
US7700745B2 (en) * 2003-02-28 2010-04-20 Japan Science And Technology Agency Method for separating carbohydrate in glycoside-linkage-having compound, carbohydrate separating system, carbohydrate separating reagent kit, standard sample for carbohydrate separation, and evaluation system
JP4307221B2 (ja) * 2003-11-11 2009-08-05 株式会社日立ハイテクノロジーズ 進捗管理方法及び装置
JP2007163252A (ja) * 2005-12-13 2007-06-28 Sekisui Chem Co Ltd 液体クロマトグラフ用測定カートリッジ及び液体クロマトグラフ装置
WO2007112224A2 (en) 2006-03-24 2007-10-04 Waters Investments Limited Ceramic-based chromatography apparatus and methods for making same
US8268625B2 (en) 2006-03-24 2012-09-18 Arkray, Inc. Method of measuring glycated hemoglobin concentration and concentration measuring apparatus
US8696597B2 (en) 2006-04-03 2014-04-15 Nipro Diagnostics, Inc. Diagnostic meter
JP4253667B2 (ja) * 2006-06-02 2009-04-15 株式会社日立ハイテクノロジーズ 分離分析装置
JP4946647B2 (ja) * 2007-06-14 2012-06-06 株式会社島津製作所 試料前処理装置及び液体クロマトグラフ装置
KR100966590B1 (ko) 2007-12-11 2010-06-29 한국전자통신연구원 생체신호 측정 장치들의 상호 협업 방법 및 시스템

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0583003A1 (en) * 1992-08-13 1994-02-16 Perseptive Biosystems, Inc. Fluid metering, mixing and composition control system
US20040124085A1 (en) * 2002-06-26 2004-07-01 California Institute Of Technology Microfluidic devices and methods with electrochemically actuated sample processing
US20050142662A1 (en) * 2002-09-27 2005-06-30 Ulrich Bonne Phased micro analyzer VIII
CN1749750A (zh) * 2004-09-13 2006-03-22 聂智明 高效液相色谱仪
CN1755351A (zh) * 2004-09-30 2006-04-05 中国科学院大连化学物理研究所 发光二极管诱导荧光微型检测器
CN1715910A (zh) * 2005-06-22 2006-01-04 夏之宁 一种微型化的液相色谱分离方法
US20070068872A1 (en) * 2005-09-21 2007-03-29 Waters Investments Limited Nano-flow liquid chromatographic apparatus having robust capillary tubing
US20080277606A1 (en) * 2005-11-11 2008-11-13 Molecular Vision Limited Microfluidic Device
CN1963497A (zh) * 2006-11-08 2007-05-16 浙江大学 微分析芯片上的微液相色谱分离方法及其装置
CN101206205A (zh) * 2006-12-22 2008-06-25 中国科学院大连化学物理研究所 微流量液相色谱在线大体积进样的方法和专用装置
US20090153865A1 (en) * 2007-12-13 2009-06-18 Shimadzu Corporation Analysis system

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D. ISHII et al.A STUDY OF MICRO-HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY:I. DEVELOPMENT OF TECHNIQUE FOR MINIATURIZATION OF HIGHPERFORMANCE LIQUID CHROMATOGRAPHY.《Journal of Chromatography A》.1977,第144卷(第2期), *
Miniaturized Cavity Ring-Down Detection in a Liquid Flow Cell;B. Bahnev et al;《Analytical Chemistry》;20050214;第77卷(第4期);第1188-1191页 *
Towards integrated microliquid handling systems;M Elwenspoek et al;《Journal of Micromechanics and Microengineering》;19941231;第4卷(第4期);第227-245页 *

Also Published As

Publication number Publication date
JP2013529780A (ja) 2013-07-22
GB201010737D0 (en) 2010-08-11
EP2585820A1 (en) 2013-05-01
US20130219999A1 (en) 2013-08-29
CN103180726A (zh) 2013-06-26
CA2803962A1 (en) 2011-12-29
ZA201300607B (en) 2014-05-26
AU2011268682A1 (en) 2013-01-10
AU2011268682B2 (en) 2015-01-29
CN105004821A (zh) 2015-10-28
JP6043715B2 (ja) 2016-12-14
US9354209B2 (en) 2016-05-31
BR112012032726A2 (pt) 2018-02-27
WO2011161481A1 (en) 2011-12-29

Similar Documents

Publication Publication Date Title
CN103180726B (zh) 微型hplc设备
Sharma et al. Hand-portable liquid chromatographic instrumentation
Foster et al. Portable capillary liquid chromatography for pharmaceutical and illicit drug analysis
Páscoa et al. Review on recent applications of the liquid waveguide capillary cell in flow based analysis techniques to enhance the sensitivity of spectroscopic detection methods
US20130206653A1 (en) Modular Multiple-Column Chromatography Cartridge
Hartwell et al. Flow injection/sequential injection chromatography: a review of recent developments in low pressure with high performance chemical separation
WO2010151440A1 (en) Chromatography apparatus having an integrated core
US20250321208A1 (en) Chromatography component
EP3523048B1 (en) Volumetric micro-injector for capillary electrophoresis
CN1749750A (zh) 高效液相色谱仪
AU2013298340B2 (en) Self-limiting injection assembly for sample introduction in HPLC
Yan et al. Capillary electrochromatography
Huang et al. Microfluidic chip-based valveless flow injection analysis system with gravity-driven flows
Lam Portable and modular liquid chromatography for pharmaceutical industry
De la Guardia et al. Downsizing the methods
US20230408457A1 (en) Column in a module with internal or external on-column or flow cell detectors with optional heating for liquid chromatography
CN120908338A (zh) 一种基于微芯片的便携式液相色谱仪、检测系统及方法
Sharma Hand-portable Capillary Liquid Chromatography Instrumentation

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150701

Termination date: 20180627

CF01 Termination of patent right due to non-payment of annual fee