CN103156867B - 预防或治疗淀粉样β肽相关疾病或状况的医药组合物 - Google Patents

预防或治疗淀粉样β肽相关疾病或状况的医药组合物 Download PDF

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CN103156867B
CN103156867B CN201210548516.0A CN201210548516A CN103156867B CN 103156867 B CN103156867 B CN 103156867B CN 201210548516 A CN201210548516 A CN 201210548516A CN 103156867 B CN103156867 B CN 103156867B
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solvent
polar solvent
water
isoacteoside
benzyl carbinol
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CN103156867A (zh
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林汉钦
苏慕寰
黄永名
唐静静
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Sinphar Tian Li Pharmaceutical Co Ltd
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Sinphar Tian Li Pharmaceutical Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23GCOCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00Chewing gum
    • A23G4/06Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/10Chewing gum characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52Adding ingredients
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/64Orobanchaceae (Broom-rape family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Nutrition Science (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201210548516.0A 2011-12-16 2012-12-17 预防或治疗淀粉样β肽相关疾病或状况的医药组合物 Active CN103156867B (zh)

Applications Claiming Priority (2)

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US201161576367P 2011-12-16 2011-12-16
US61/576367 2011-12-16

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CN103156867A CN103156867A (zh) 2013-06-19
CN103156867B true CN103156867B (zh) 2019-04-30

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US (1) US20150087606A1 (https=)
EP (1) EP2792361B1 (https=)
JP (1) JP6134331B2 (https=)
KR (1) KR102048289B1 (https=)
CN (1) CN103156867B (https=)
AU (1) AU2012350437B2 (https=)
CA (1) CA2859227C (https=)
MY (1) MY171048A (https=)
SG (1) SG11201403265VA (https=)
TW (1) TWI488630B (https=)
WO (1) WO2013087042A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015154721A1 (zh) * 2014-04-10 2015-10-15 杏辉天力(杭州)药业有限公司 异类叶升麻苷衍生物及其制造方法与用途
TWI650131B (zh) 2014-07-03 2019-02-11 杏輝藥品工業股份有限公司 管花肉蓯蓉萃取物之用於製備保護眼部細胞之藥品或食品用途
CN104922137B (zh) * 2015-06-04 2018-07-31 苏州大学 苯乙醇苷类化合物Torenoside B的新用途
KR102018085B1 (ko) * 2017-12-06 2019-09-04 김좌진 악테오사이드를 함유하는 뇌종양 치료 및 전이 억제용 약학 조성물
KR102135148B1 (ko) * 2019-08-28 2020-07-20 김좌진 악테오사이드를 함유하는 뇌종양 치료 및 전이 억제용 약학 조성물
CN110812375A (zh) * 2019-12-12 2020-02-21 中国海洋大学 一种老鼠簕中苯乙醇苷类提取物及其制备方法与作为抗肝损伤药物的应用
CN111632058A (zh) * 2020-06-24 2020-09-08 新疆医科大学 毛蕊花糖苷在制备预防和治疗神经退行性疾病药物中的应用
CN112225766A (zh) * 2020-10-27 2021-01-15 杏辉天力(杭州)药业有限公司 一种由肉苁蓉萃取物中富集及分离苯乙醇苷类化合物的方法

Citations (6)

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CN1526400A (zh) * 2003-03-04 2004-09-08 杭州天力药业有限公司 来源于管花肉苁蓉的含有苯乙醇苷的制剂及其制备方法和用途
CN1721425A (zh) * 2004-07-16 2006-01-18 北京华医神农医药科技有限公司 一种从肉苁蓉药材中提取、分离松果菊苷的方法
CN101411753A (zh) * 2008-12-04 2009-04-22 闫明 列当提取物、列当总苷和列当多糖及其制备方法和用途
CN101797307A (zh) * 2010-04-09 2010-08-11 广州中医药大学 一种含苯乙醇苷的枇杷叶紫珠提取物及其制备方法
EP2397144A1 (en) * 2010-06-16 2011-12-21 Sinphar Tian-li Pharmaceutical Co., Ltd. (Hangzhou) Use of Isoacteoside in Preventing or Treating Amyloid Beta Peptide-Associated Diseases or Conditions, and Method for Inhibiting Formation, Accumulation or Aggregation of Amyloid Beta Peptides
CN102670631A (zh) * 2011-12-01 2012-09-19 河南科技大学 一种四楞麻总苯乙醇苷组合物、制备方法及应用

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KR100500584B1 (ko) * 2002-08-12 2005-07-12 경희대학교 산학협력단 신경성장인자와 유사 작용을 갖는 육종용 추출물 및 이를함유하는 조성물
KR100514076B1 (ko) * 2003-01-10 2005-09-13 주식회사 엘컴사이언스 페닐에타노이드 유도체를 포함하는 퇴행성 뇌신경계질환의 예방 및 치료용 조성물
TW200416036A (en) * 2003-02-18 2004-09-01 Sinphar Pharmaceutical Co Ltd Medicinal preparation containing phenylethanoid glycosides extracted from herbaceous plant, cistanche tubulosa (schenk.) wight, process of making the same, and uses of the same
EP1736167B1 (en) * 2005-06-20 2018-03-21 I.R.B. Istituto Di Ricerche Biotecnologiche S.r.l. Extracts obtained from cell line cultures from Syringa vulgaris IRB-SV25/B (DMS:16857), their preparation and use
JP5410683B2 (ja) 2008-02-19 2014-02-05 学校法人近畿大学 カンカニクジュヨウから得られる肝保護剤及び抗TNF−α作用剤

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CN1721425A (zh) * 2004-07-16 2006-01-18 北京华医神农医药科技有限公司 一种从肉苁蓉药材中提取、分离松果菊苷的方法
CN101411753A (zh) * 2008-12-04 2009-04-22 闫明 列当提取物、列当总苷和列当多糖及其制备方法和用途
CN101797307A (zh) * 2010-04-09 2010-08-11 广州中医药大学 一种含苯乙醇苷的枇杷叶紫珠提取物及其制备方法
EP2397144A1 (en) * 2010-06-16 2011-12-21 Sinphar Tian-li Pharmaceutical Co., Ltd. (Hangzhou) Use of Isoacteoside in Preventing or Treating Amyloid Beta Peptide-Associated Diseases or Conditions, and Method for Inhibiting Formation, Accumulation or Aggregation of Amyloid Beta Peptides
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CA2859227C (en) 2019-01-22
EP2792361A4 (en) 2015-05-13
EP2792361B1 (en) 2019-03-27
AU2012350437B2 (en) 2017-06-29
KR20150002576A (ko) 2015-01-07
CA2859227A1 (en) 2013-06-20
MY171048A (en) 2019-09-23
TWI488630B (zh) 2015-06-21
JP6134331B2 (ja) 2017-05-24
JP2015500300A (ja) 2015-01-05
EP2792361A1 (en) 2014-10-22
CN103156867A (zh) 2013-06-19
SG11201403265VA (en) 2014-09-26
TW201325597A (zh) 2013-07-01
AU2012350437A1 (en) 2014-07-31
KR102048289B1 (ko) 2020-01-08
US20150087606A1 (en) 2015-03-26
WO2013087042A1 (zh) 2013-06-20

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