CN103143023A - α7烟碱激动剂和抗精神病药的组合 - Google Patents

α7烟碱激动剂和抗精神病药的组合 Download PDF

Info

Publication number
CN103143023A
CN103143023A CN2013100500436A CN201310050043A CN103143023A CN 103143023 A CN103143023 A CN 103143023A CN 2013100500436 A CN2013100500436 A CN 2013100500436A CN 201310050043 A CN201310050043 A CN 201310050043A CN 103143023 A CN103143023 A CN 103143023A
Authority
CN
China
Prior art keywords
methyl
azabicyclo
oct
pyridine radicals
urea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2013100500436A
Other languages
English (en)
Chinese (zh)
Inventor
M·本切里夫
G·J·加托
T·豪瑟
K·G·乔丹
S·R·莱特克沃斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gyre Therapeutics Inc
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of CN103143023A publication Critical patent/CN103143023A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
CN2013100500436A 2008-02-13 2009-02-13 α7烟碱激动剂和抗精神病药的组合 Pending CN103143023A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2828208P 2008-02-13 2008-02-13
US61/028,282 2008-02-13

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2009801102033A Division CN101977628A (zh) 2008-02-13 2009-02-13 α7烟碱激动剂和抗精神病药的组合

Publications (1)

Publication Number Publication Date
CN103143023A true CN103143023A (zh) 2013-06-12

Family

ID=40902222

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2009801102033A Pending CN101977628A (zh) 2008-02-13 2009-02-13 α7烟碱激动剂和抗精神病药的组合
CN2013100500436A Pending CN103143023A (zh) 2008-02-13 2009-02-13 α7烟碱激动剂和抗精神病药的组合

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN2009801102033A Pending CN101977628A (zh) 2008-02-13 2009-02-13 α7烟碱激动剂和抗精神病药的组合

Country Status (25)

Country Link
US (1) US20110059947A1 (enExample)
EP (2) EP2633868A1 (enExample)
JP (1) JP2011511845A (enExample)
KR (1) KR20100113163A (enExample)
CN (2) CN101977628A (enExample)
AU (1) AU2009214625A1 (enExample)
BR (1) BRPI0907570A2 (enExample)
CA (1) CA2715268A1 (enExample)
CO (1) CO6290706A2 (enExample)
CY (1) CY1114492T1 (enExample)
DK (1) DK2254598T3 (enExample)
EC (1) ECSP10010471A (enExample)
ES (1) ES2430622T3 (enExample)
HR (1) HRP20130749T1 (enExample)
IL (1) IL207389A0 (enExample)
MX (1) MX2010008875A (enExample)
NZ (1) NZ587312A (enExample)
PL (1) PL2254598T3 (enExample)
PT (1) PT2254598E (enExample)
RS (1) RS52941B (enExample)
RU (1) RU2481123C2 (enExample)
SG (1) SG188144A1 (enExample)
SI (1) SI2254598T1 (enExample)
WO (1) WO2009102962A2 (enExample)
ZA (1) ZA201005999B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108727416A (zh) * 2017-04-20 2018-11-02 北京大学 三环杂芳香体系酰胺衍生物及其制备和用途

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8314119B2 (en) 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
SA08290475B1 (ar) * 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
PE20131394A1 (es) 2010-09-23 2014-01-11 Abbvie Inc Monohidrato de derivados de aza-adamantano
AU2012207499A1 (en) * 2011-01-18 2013-08-15 Targacept, Inc. Treatment of cognitive dysfunction in schizophrenia
EP2704573A4 (en) * 2011-05-03 2014-10-15 Merck Sharp & Dohme AMINOMETHYL biaryl BENZOTRIAZOL DERIVATIVES
MX2015004285A (es) * 2012-10-02 2015-08-06 Sumitomo Dainippon Pharma Co Ltd Derivado de imidazol.
JP6807094B2 (ja) * 2016-04-29 2021-01-06 国立大学法人秋田大学 クロザピン又はその誘導体の血中薬剤濃度上昇リスク判定方法及び薬剤投与量判定方法
US11337932B2 (en) 2016-12-20 2022-05-24 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
CN110087640A (zh) 2016-12-20 2019-08-02 罗曼治疗系统股份公司 包含阿塞那平的透皮治疗系统
JP2020525545A (ja) 2017-06-26 2020-08-27 エルテーエス ローマン テラピー−ジステーメ アーゲー アセナピンおよびシリコーンアクリルハイブリッドポリマーを含有する経皮治療システム
CN107469087A (zh) * 2017-09-10 2017-12-15 孙永丽 用于治疗精神病的制剂
US12329862B2 (en) 2018-06-20 2025-06-17 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
CN112704672A (zh) 2018-06-20 2021-04-27 罗曼治疗系统股份公司 含有阿塞那平的透皮治疗系统
CN117480169A (zh) * 2021-01-08 2024-01-30 艾福姆德尤股份有限公司 用于治疗与sting活性有关的疾病的化合物和组合物
WO2022150585A1 (en) 2021-01-08 2022-07-14 Ifm Due, Inc. Heterobicyclic compounds having an urea or analogue and their compositions for treating conditions associated with sting activity
DE102022114269A1 (de) 2022-06-07 2023-12-07 Rational Aktiengesellschaft Gargerät mit einem Selbstreinigungssystem sowie ein Verfahren zum Ändern von Reinigungsparametern für das Gargerät

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5597919A (en) 1995-01-06 1997-01-28 Dull; Gary M. Pyrimidinyl or Pyridinyl alkenyl amine compounds
US5712270A (en) * 1995-11-06 1998-01-27 American Home Products Corporation 2-arylamidothiazole derivatives with CNS activity
US5616716A (en) * 1996-01-06 1997-04-01 Dull; Gary M. (3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds
SE9600683D0 (sv) 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
US5663356A (en) * 1996-04-23 1997-09-02 Ruecroft; Graham Method for preparation of aryl substituted alefinic secondary amino compounds
AR013184A1 (es) 1997-07-18 2000-12-13 Astrazeneca Ab Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis
ATE255888T1 (de) 1998-06-01 2003-12-15 Ortho Mcneil Pharm Inc Tetrahydronaphtalene verbindungen und deren verwendung zur behandlung von neurodegenerativen krankheiten
US6953855B2 (en) * 1998-12-11 2005-10-11 Targacept, Inc. 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
SE9904176D0 (sv) 1999-11-18 1999-11-18 Astra Ab New use
CZ20021880A3 (cs) * 1999-12-10 2002-08-14 Wyeth Farmaceutický prostředek
IL153707A0 (en) * 2000-06-27 2003-07-06 S A L V A T Lab Sa Carbamates derived from arylalkylamines
AU2001282873A1 (en) 2000-08-18 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
US6492386B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted aryl compounds for treatment of disease
JP2004506735A (ja) 2000-08-18 2004-03-04 ファルマシア・アンド・アップジョン・カンパニー 疾患治療用キヌクリジン置換アリール化合物
WO2002017358A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
EP1311505A2 (en) 2000-08-21 2003-05-21 PHARMACIA & UPJOHN COMPANY Quinuclidine-substituted heteroaryl moieties for treatment of disease ( nicotinic acetylcholine receptor ligands )
WO2002015662A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists
US6554086B1 (en) * 2000-10-27 2003-04-29 Invacare Corporation Obstacle traversing wheelchair
AU2002228015B2 (en) 2000-12-22 2007-08-23 Almirall, S.A. Quinuclidine carbamate derivatives and their use as M3 antagonists
MXPA04008152A (es) * 2002-02-19 2005-09-08 Upjohn Co Compuestos azabiciclicos para el tratamiento de enfermedades.
MXPA05005943A (es) * 2002-12-06 2005-08-18 Pharmacia & Upjohn Co Llc Sales fumarato cristalinas de furo[2,3-c]piridinilcarboxamida sustituida con 1-azabiciclo[2.2.2]octilo y composiciones y preparaciones de las mismas.
TW200502222A (en) * 2003-04-02 2005-01-16 Novartis Ag Use of 10-hydroxy-10,11-dihydrocarbamazepine derivatives for the treatment of affective disorders
WO2004099202A1 (en) * 2003-05-05 2004-11-18 Pharmacia & Upjohn Company Llc Quinuclidines substituted bentodioxine carboxamides for the treatment of neurodegenerative diseases
US7309699B2 (en) * 2003-12-22 2007-12-18 Abbott Laboratories 3-Quinuclidinyl amino-substituted biaryl derivatives
CA2549638A1 (en) * 2003-12-23 2005-07-14 Pfizer Products Inc. Therapeutic combination for cognition enhancement and psychotic disorders
WO2006101745A2 (en) * 2005-03-18 2006-09-28 Abbott Laboratories Alpha7 neuronal nicotinic receptor ligand and antipsychotic compositions

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108727416A (zh) * 2017-04-20 2018-11-02 北京大学 三环杂芳香体系酰胺衍生物及其制备和用途
CN108727416B (zh) * 2017-04-20 2021-03-09 北京大学 三环杂芳香体系酰胺衍生物及其制备和用途

Also Published As

Publication number Publication date
DK2254598T3 (da) 2013-07-29
CN101977628A (zh) 2011-02-16
HRP20130749T1 (en) 2013-10-11
RS52941B (sr) 2014-02-28
PL2254598T3 (pl) 2013-12-31
BRPI0907570A2 (pt) 2019-09-24
RU2481123C2 (ru) 2013-05-10
NZ587312A (en) 2011-12-22
EP2254598A2 (en) 2010-12-01
ES2430622T3 (es) 2013-11-21
CY1114492T1 (el) 2016-10-05
MX2010008875A (es) 2010-08-31
ZA201005999B (en) 2011-05-25
KR20100113163A (ko) 2010-10-20
JP2011511845A (ja) 2011-04-14
EP2633868A1 (en) 2013-09-04
AU2009214625A1 (en) 2009-08-20
CA2715268A1 (en) 2009-08-20
RU2010137787A (ru) 2012-03-20
HK1147954A1 (en) 2011-08-26
CO6290706A2 (es) 2011-06-20
ECSP10010471A (es) 2010-10-30
PT2254598E (pt) 2013-10-16
SG188144A1 (en) 2013-03-28
US20110059947A1 (en) 2011-03-10
WO2009102962A2 (en) 2009-08-20
EP2254598B1 (en) 2013-07-10
SI2254598T1 (sl) 2013-10-30
IL207389A0 (en) 2010-12-30
WO2009102962A3 (en) 2009-10-08

Similar Documents

Publication Publication Date Title
CN103143023A (zh) α7烟碱激动剂和抗精神病药的组合
Carli et al. Dissociable contribution of 5-HT1A and 5-HT2A receptors in the medial prefrontal cortex to different aspects of executive control such as impulsivity and compulsive perseveration in rats
Hauser et al. TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia
Mirjana et al. The serotonin 5-HT2A receptors antagonist M100907 prevents impairment in attentional performance by NMDA receptor blockade in the rat prefrontal cortex
Ulloa The vagus nerve and the nicotinic anti-inflammatory pathway
Dubois et al. Chemotherapy-induced long-term alteration of executive functions and hippocampal cell proliferation: role of glucose as adjuvant
US20100178277A1 (en) Methods and compositions for stimulating cells
Weng et al. Rett syndrome: from bed to bench
Manis et al. Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat
Kucinski et al. α7 neuronal nicotinic receptor agonist (TC-7020) reverses increased striatal dopamine release during acoustic PPI testing in a transgenic mouse model of schizophrenia
Barrett et al. Therapeutic approaches to cholinergic deficiency in Lewy body diseases
Singer et al. Tourette syndrome: circuits and neurotransmitters
Castillo Clinical neurobiology of sleep and wakefulness
Liu et al. A missense variant in DEPDC5 resulted in abnormal morphology and increased seizure susceptibility and mortality through regulating mTOR signaling
Adlan Electrophysiological and pharmacological characterization of a new schizophrenia rat model (Wisket)
Osugo Neurobiology of negative and cognitive symptoms of schizophrenia
HK1185794A (en) Combination of alpha 7 nicotinic agonists and antipsychotics
Sarwary Comparison of cognitive decline medications of Alzheimer´ s disease: Efficacy and safety of Donepezil, Galantamine, Rivastigmine and Memantine
Chan et al. Second International Workshop for Glycosylation Defects in Muscular Dystrophies, 11–12 November, 2010, Charlotte, USA
McKowen et al. Psychosis in Youth
Volpicelli-daley Reducing tau as a Therapeutic Strategy for Improving Cognitive Dysfunction in Parkinson's Disease
Millman et al. Ataxia UK Ataxia Ireland GoFAR (Italy) FARA (US)
Hori Developmental Effects of Bilateral Ventral Hippocampal Lesions on Neocortical [capital Delta] FosB Expression and Cognition: Reversal of Cognitive Deficits by Darbepoetin Alfa But Not Clozapine
HK1147954B (en) Combination of alpha 7 nicotinic agonists and antipsychotics
Selvaraj et al. Imaging Translocator Protein (TSPO) in Subjects at High Risk of Psychosis and in Schizophrenia: An\[\11C] PBR28 Pet Brain Imaging Study

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20130612