CN103096913B - 与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 - Google Patents

与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 Download PDF

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CN103096913B
CN103096913B CN201180031503.XA CN201180031503A CN103096913B CN 103096913 B CN103096913 B CN 103096913B CN 201180031503 A CN201180031503 A CN 201180031503A CN 103096913 B CN103096913 B CN 103096913B
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polypeptide
protein
cell
sequence
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CN103096913A (zh
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莱斯利·安·格林尼
凯尔·P·基昂格
洪非
阿兰·P·瓦瑟洛特
罗咏诗
杰弗里·D·沃特金斯
谢丽尔·L·奎恩
约翰·D·门德莱恩
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Pangu Biopharma Ltd
aTyr Pharma Inc
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
    • C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/9015—Ligases (6)

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CN201180031503.XA 2010-05-27 2011-05-26 与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 Active CN103096913B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US34914310P 2010-05-27 2010-05-27
US34914110P 2010-05-27 2010-05-27
US34914010P 2010-05-27 2010-05-27
US61/349,141 2010-05-27
US61/349,143 2010-05-27
US61/349,140 2010-05-27
PCT/US2011/038240 WO2011150279A2 (en) 2010-05-27 2011-05-26 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases

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CN103096913A CN103096913A (zh) 2013-05-08
CN103096913B true CN103096913B (zh) 2017-07-18

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US (4) US9068177B2 (enExample)
EP (1) EP2575856B1 (enExample)
JP (2) JP6046607B2 (enExample)
CN (1) CN103096913B (enExample)
AU (1) AU2011258106B2 (enExample)
CA (1) CA2800375C (enExample)
WO (1) WO2011150279A2 (enExample)

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WO2011139714A2 (en) 2010-04-26 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase
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AU2011248614B2 (en) 2010-04-27 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases
US8993723B2 (en) 2010-04-28 2015-03-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases
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JP5976638B2 (ja) 2010-05-03 2016-08-23 エータイアー ファーマ， インコーポレイテッド アルギニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
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